Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carbohydrate-responsive element-binding protein

Gene

MLXIPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate response element binding Source: BHF-UCL
  • DNA binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: Ensembl
  • transcription factor activity, sequence-specific DNA binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • cellular response to carbohydrate stimulus Source: GO_Central
  • fatty acid homeostasis Source: UniProtKB
  • glucose homeostasis Source: BHF-UCL
  • glucose mediated signaling pathway Source: BHF-UCL
  • intracellular signal transduction Source: Reactome
  • negative regulation of cell cycle arrest Source: BHF-UCL
  • negative regulation of oxidative phosphorylation Source: BHF-UCL
  • negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of fatty acid biosynthetic process Source: BHF-UCL
  • positive regulation of glycolytic process Source: BHF-UCL
  • positive regulation of lipid biosynthetic process Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • regulation of energy homeostasis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: BHF-UCL
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
  • triglyceride homeostasis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-163358. PKA-mediated phosphorylation of key metabolic factors.
R-HSA-163680. AMPK inhibits chREBP transcriptional activation activity.
R-HSA-163765. ChREBP activates metabolic gene expression.
R-HSA-163767. PP2A-mediated dephosphorylation of key metabolic factors.
SIGNORiQ9NP71.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate-responsive element-binding protein
Short name:
ChREBP
Alternative name(s):
Class D basic helix-loop-helix protein 14
Short name:
bHLHd14
MLX interactor
MLX-interacting protein-like
WS basic-helix-loop-helix leucine zipper protein
Short name:
WS-bHLH
Williams-Beuren syndrome chromosomal region 14 protein
Gene namesi
Name:MLXIPL
Synonyms:BHLHD14, MIO, WBSCR14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12744. MLXIPL.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytosol Source: Reactome
  • nucleoplasm Source: Reactome
  • nucleus Source: BHF-UCL
  • transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

WBSCR14 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

PharmGKBiPA37353.

Polymorphism and mutation databases

BioMutaiMLXIPL.
DMDMi20140871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852Carbohydrate-responsive element-binding proteinPRO_0000127504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphoserineCombined sources
Modified residuei23 – 231PhosphoserineCombined sources
Modified residuei25 – 251PhosphoserineCombined sources
Modified residuei27 – 271PhosphothreonineCombined sources
Modified residuei29 – 291PhosphoserineCombined sources
Modified residuei196 – 1961PhosphoserineCombined sources
Modified residuei556 – 5561Phosphoserine; by AMPKBy similarity
Modified residuei602 – 6021PhosphoserineCombined sources
Modified residuei614 – 6141PhosphoserineCombined sources
Modified residuei631 – 6311PhosphoserineCombined sources

Post-translational modificationi

Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NP71.
PaxDbiQ9NP71.
PeptideAtlasiQ9NP71.
PRIDEiQ9NP71.

PTM databases

iPTMnetiQ9NP71.
PhosphoSiteiQ9NP71.

Expressioni

Tissue specificityi

Expressed in liver, heart, kidney, cerebellum and intestinal tissues.

Gene expression databases

BgeeiQ9NP71.
CleanExiHS_MLXIPL.
ExpressionAtlasiQ9NP71. baseline and differential.
GenevisibleiQ9NP71. HS.

Interactioni

Subunit structurei

Binds DNA as a heterodimer with TCFL4/MLX.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi119275. 5 interactions.
IntActiQ9NP71. 4 interactions.
STRINGi9606.ENSP00000320886.

Structurei

3D structure databases

ProteinModelPortaliQ9NP71.
SMRiQ9NP71. Positions 658-706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini649 – 70355bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni703 – 72422Leucine-zipperAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi387 – 3948Poly-Pro
Compositional biasi409 – 4179Poly-Pro

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3582. Eukaryota.
ENOG410XTA5. LUCA.
GeneTreeiENSGT00530000063219.
HOVERGENiHBG073589.
InParanoidiQ9NP71.
KOiK09113.
OMAiQKFREYV.
PhylomeDBiQ9NP71.
TreeFamiTF324749.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP71-1) [UniParc]FASTAAdd to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGALAGLAA GLQVPRVAPS PDSDSDTDSE DPSLRRSAGG LLRSQVIHSG
60 70 80 90 100
HFMVSSPHSD SLPRRRDQEG SVGPSDFGPR SIDPTLTRLF ECLSLAYSGK
110 120 130 140 150
LVSPKWKNFK GLKLLCRDKI RLNNAIWRAW YIQYVKRRKS PVCGFVTPLQ
160 170 180 190 200
GPEADAHRKP EAVVLEGNYW KRRIEVVMRE YHKWRIYYKK RLRKPSREDD
210 220 230 240 250
LLAPKQAEGR WPPPEQWCKQ LFSSVVPVLL GDPEEEPGGR QLLDLNCFLS
260 270 280 290 300
DISDTLFTMT QSGPSPLQLP PEDAYVGNAD MIQPDLTPLQ PSLDDFMDIS
310 320 330 340 350
DFFTNSRLPQ PPMPSNFPEP PSFSPVVDSL FSSGTLGPEV PPASSAMTHL
360 370 380 390 400
SGHSRLQARN SCPGPLDSSA FLSSDFLLPE DPKPRLPPPP VPPPLLHYPP
410 420 430 440 450
PAKVPGLEPC PPPPFPPMAP PTALLQEEPL FSPRFPFPTV PPAPGVSPLP
460 470 480 490 500
APAAFPPTPQ SVPSPAPTPF PIELLPLGYS EPAFGPCFSM PRGKPPAPSP
510 520 530 540 550
RGQKASPPTL APATASPPTT AGSNNPCLTQ LLTAAKPEQA LEPPLVSSTL
560 570 580 590 600
LRSPGSPQET VPEFPCTFLP PTPAPTPPRP PPGPATLAPS RPLLVPKAER
610 620 630 640 650
LSPPAPSGSE RRLSGDLSSM PGPGTLSVRV SPPQPILSRG RPDSNKTENR
660 670 680 690 700
RITHISAEQK RRFNIKLGFD TLHGLVSTLS AQPSLKVSKA TTLQKTAEYI
710 720 730 740 750
LMLQQERAGL QEEAQQLRDE IEELNAAINL CQQQLPATGV PITHQRFDQM
760 770 780 790 800
RDMFDDYVRT RTLHNWKFWV FSILIRPLFE SFNGMVSTAS VHTLRQTSLA
810 820 830 840 850
WLDQYCSLPA LRPTVLNSLR QLGTSTSILT DPGRIPEQAT RAVTEGTLGK

PL
Length:852
Mass (Da):93,073
Last modified:October 1, 2000 - v1
Checksum:iD49E5C3D7C0A72EC
GO
Isoform 2 (identifier: Q9NP71-2) [UniParc]FASTAAdd to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     687-705: Missing.

Show »
Length:833
Mass (Da):90,924
Checksum:i1A521C119FEFB2A4
GO
Isoform 3 (identifier: Q9NP71-3) [UniParc]FASTAAdd to basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     647-648: Missing.

Show »
Length:850
Mass (Da):92,842
Checksum:i5E09A4F5461A569A
GO
Isoform 4 (identifier: Q9NP71-4) [UniParc]FASTAAdd to basket

Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     647-648: Missing.
     687-705: Missing.

Show »
Length:831
Mass (Da):90,694
Checksum:i5D385F9A8B65646B
GO
Isoform 5 (identifier: Q9NP71-5) [UniParc]FASTAAdd to basket

Also known as: Epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     558-575: QETVPEFPCTFLPPTPAP → AVNGGCQGTSAPCQALGL
     576-852: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:575
Mass (Da):62,026
Checksum:i246DF8F3B31D36B6
GO
Isoform 6 (identifier: Q9NP71-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-268: Missing.
     814-815: TV → ST
     816-852: Missing.

Show »
Length:722
Mass (Da):78,360
Checksum:iC78F185EFC7CE8F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti558 – 5581Missing in AAH12925 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411Q → H.
Corresponds to variant rs3812316 [ dbSNP | Ensembl ].
VAR_049556
Natural varianti244 – 2441D → E.
Corresponds to variant rs34922362 [ dbSNP | Ensembl ].
VAR_049557

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 26893Missing in isoform 6. 1 PublicationVSP_002167Add
BLAST
Alternative sequencei558 – 57518QETVP…PTPAP → AVNGGCQGTSAPCQALGL in isoform 5. 1 PublicationVSP_002168Add
BLAST
Alternative sequencei576 – 852277Missing in isoform 5. 1 PublicationVSP_002169Add
BLAST
Alternative sequencei647 – 6482Missing in isoform 3 and isoform 4. 2 PublicationsVSP_002170
Alternative sequencei687 – 70519Missing in isoform 2 and isoform 4. 2 PublicationsVSP_002171Add
BLAST
Alternative sequencei814 – 8152TV → ST in isoform 6. 1 PublicationVSP_002172
Alternative sequencei816 – 85237Missing in isoform 6. 1 PublicationVSP_002173Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156673 Genomic DNA. Translation: AAF68176.1.
AF156603 mRNA. Translation: AAF68174.1.
AF245470 mRNA. Translation: AAK20935.1.
AF245471 mRNA. Translation: AAK20936.1.
AF245472 mRNA. Translation: AAK20937.1.
AF245473 mRNA. Translation: AAK20938.1.
AF245474 mRNA. Translation: AAK20939.1.
FJ515858 Genomic DNA. Translation: ACS13745.1.
FJ515858 Genomic DNA. Translation: ACS13746.1.
FJ515858 Genomic DNA. Translation: ACS13748.1.
AF056184 mRNA. Translation: AAD28084.1.
CH471200 Genomic DNA. Translation: EAW69660.1.
CH471200 Genomic DNA. Translation: EAW69661.1.
CH471200 Genomic DNA. Translation: EAW69662.1.
BC012925 mRNA. Translation: AAH12925.1.
CCDSiCCDS47605.1. [Q9NP71-2]
CCDS47606.1. [Q9NP71-3]
CCDS5553.1. [Q9NP71-1]
CCDS5554.1. [Q9NP71-4]
RefSeqiNP_116569.1. NM_032951.2. [Q9NP71-1]
NP_116570.1. NM_032952.2. [Q9NP71-2]
NP_116571.1. NM_032953.2. [Q9NP71-3]
NP_116572.1. NM_032954.2. [Q9NP71-4]
UniGeneiHs.647055.

Genome annotation databases

EnsembliENST00000313375; ENSP00000320886; ENSG00000009950. [Q9NP71-1]
ENST00000345114; ENSP00000343767; ENSG00000009950. [Q9NP71-5]
ENST00000354613; ENSP00000346629; ENSG00000009950. [Q9NP71-4]
ENST00000414749; ENSP00000412330; ENSG00000009950. [Q9NP71-3]
ENST00000429400; ENSP00000406296; ENSG00000009950. [Q9NP71-2]
GeneIDi51085.
KEGGihsa:51085.
UCSCiuc003tyk.1. human. [Q9NP71-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156673 Genomic DNA. Translation: AAF68176.1.
AF156603 mRNA. Translation: AAF68174.1.
AF245470 mRNA. Translation: AAK20935.1.
AF245471 mRNA. Translation: AAK20936.1.
AF245472 mRNA. Translation: AAK20937.1.
AF245473 mRNA. Translation: AAK20938.1.
AF245474 mRNA. Translation: AAK20939.1.
FJ515858 Genomic DNA. Translation: ACS13745.1.
FJ515858 Genomic DNA. Translation: ACS13746.1.
FJ515858 Genomic DNA. Translation: ACS13748.1.
AF056184 mRNA. Translation: AAD28084.1.
CH471200 Genomic DNA. Translation: EAW69660.1.
CH471200 Genomic DNA. Translation: EAW69661.1.
CH471200 Genomic DNA. Translation: EAW69662.1.
BC012925 mRNA. Translation: AAH12925.1.
CCDSiCCDS47605.1. [Q9NP71-2]
CCDS47606.1. [Q9NP71-3]
CCDS5553.1. [Q9NP71-1]
CCDS5554.1. [Q9NP71-4]
RefSeqiNP_116569.1. NM_032951.2. [Q9NP71-1]
NP_116570.1. NM_032952.2. [Q9NP71-2]
NP_116571.1. NM_032953.2. [Q9NP71-3]
NP_116572.1. NM_032954.2. [Q9NP71-4]
UniGeneiHs.647055.

3D structure databases

ProteinModelPortaliQ9NP71.
SMRiQ9NP71. Positions 658-706.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119275. 5 interactions.
IntActiQ9NP71. 4 interactions.
STRINGi9606.ENSP00000320886.

PTM databases

iPTMnetiQ9NP71.
PhosphoSiteiQ9NP71.

Polymorphism and mutation databases

BioMutaiMLXIPL.
DMDMi20140871.

Proteomic databases

MaxQBiQ9NP71.
PaxDbiQ9NP71.
PeptideAtlasiQ9NP71.
PRIDEiQ9NP71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313375; ENSP00000320886; ENSG00000009950. [Q9NP71-1]
ENST00000345114; ENSP00000343767; ENSG00000009950. [Q9NP71-5]
ENST00000354613; ENSP00000346629; ENSG00000009950. [Q9NP71-4]
ENST00000414749; ENSP00000412330; ENSG00000009950. [Q9NP71-3]
ENST00000429400; ENSP00000406296; ENSG00000009950. [Q9NP71-2]
GeneIDi51085.
KEGGihsa:51085.
UCSCiuc003tyk.1. human. [Q9NP71-1]

Organism-specific databases

CTDi51085.
GeneCardsiMLXIPL.
GeneReviewsiMLXIPL.
HGNCiHGNC:12744. MLXIPL.
MIMi605678. gene.
neXtProtiNX_Q9NP71.
PharmGKBiPA37353.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3582. Eukaryota.
ENOG410XTA5. LUCA.
GeneTreeiENSGT00530000063219.
HOVERGENiHBG073589.
InParanoidiQ9NP71.
KOiK09113.
OMAiQKFREYV.
PhylomeDBiQ9NP71.
TreeFamiTF324749.

Enzyme and pathway databases

ReactomeiR-HSA-163358. PKA-mediated phosphorylation of key metabolic factors.
R-HSA-163680. AMPK inhibits chREBP transcriptional activation activity.
R-HSA-163765. ChREBP activates metabolic gene expression.
R-HSA-163767. PP2A-mediated dephosphorylation of key metabolic factors.
SIGNORiQ9NP71.

Miscellaneous databases

ChiTaRSiMLXIPL. human.
GeneWikiiMLXIPL.
GenomeRNAii51085.
PROiQ9NP71.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NP71.
CleanExiHS_MLXIPL.
ExpressionAtlasiQ9NP71. baseline and differential.
GenevisibleiQ9NP71. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog."
    de Luis O., Valero M.C., Perez Jurado L.A.
    Eur. J. Hum. Genet. 8:215-222(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), INVOLVEMENT IN WBS.
  2. "WBSCR14, a gene mapping to the Williams-Beuren syndrome deleted region, is a new member of the Mlx transcription factor network."
    Cairo S., Merla G., Urbinati F., Ballabio A., Reymond A.
    Hum. Mol. Genet. 10:617-627(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), SUBUNIT.
  3. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes."
    Meng X., Lu X., Li Z., Green E.D., Massa H., Trask B.J., Morris C.A., Keating M.T.
    Hum. Genet. 103:590-599(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 620-852 (ISOFORM 4).
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Eye.
  7. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  8. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196; SER-602 AND SER-614, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-25; THR-27; SER-29; SER-602 AND SER-631, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMLXPL_HUMAN
AccessioniPrimary (citable) accession number: Q9NP71
Secondary accession number(s): C5HU02
, C5HU03, C5HU04, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.