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Protein

High mobility group protein 20A

Gene

HMG20A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi103 – 171HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein 20A
Alternative name(s):
HMG box-containing protein 20A
HMG domain-containing protein 1
HMG domain-containing protein HMGX1
Gene namesi
Name:HMG20A
Synonyms:HMGX1, HMGXB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140382.14
HGNCiHGNC:5001 HMG20A
MIMi605534 gene
neXtProtiNX_Q9NP66

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10363
OpenTargetsiENSG00000140382
PharmGKBiPA29331

Polymorphism and mutation databases

BioMutaiHMG20A
DMDMi74734297

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002386491 – 347High mobility group protein 20AAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NP66
MaxQBiQ9NP66
PaxDbiQ9NP66
PeptideAtlasiQ9NP66
PRIDEiQ9NP66

PTM databases

iPTMnetiQ9NP66
PhosphoSitePlusiQ9NP66

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000140382
CleanExiHS_HMG20A
ExpressionAtlasiQ9NP66 baseline and differential
GenevisibleiQ9NP66 HS

Organism-specific databases

HPAiHPA008126

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: Ensembl

Protein-protein interaction databases

BioGridi115643, 103 interactors
CORUMiQ9NP66
IntActiQ9NP66, 99 interactors
MINTiQ9NP66
STRINGi9606.ENSP00000336856

Structurei

3D structure databases

ProteinModelPortaliQ9NP66
SMRiQ9NP66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili229 – 273Sequence analysisAdd BLAST45

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00730000110938
HOGENOMiHOG000247029
HOVERGENiHBG059870
InParanoidiQ9NP66
OMAiSYMKKLH
OrthoDBiEOG091G0IHZ
PhylomeDBiQ9NP66
TreeFamiTF106440

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENLMTSSTL PPLFADEDGS KESNDLATTG LNHPEVPYSS GATSSTNNPE
60 70 80 90 100
FVEDLSQGQL LQSESSNAAE GNEQRHEDEQ RSKRGGWSKG RKRKKPLRDS
110 120 130 140 150
NAPKSPLTGY VRFMNERREQ LRAKRPEVPF PEITRMLGNE WSKLPPEEKQ
160 170 180 190 200
RYLDEADRDK ERYMKELEQY QKTEAYKVFS RKTQDRQKGK SHRQDAARQA
210 220 230 240 250
THDHEKETEV KERSVFDIPI FTEEFLNHSK AREAELRQLR KSNMEFEERN
260 270 280 290 300
AALQKHVESM RTAVEKLEVD VIQERSRNTV LQQHLETLRQ VLTSSFASMP
310 320 330 340
LPGSGETPTV DTIDSYMNRL HSIILANPQD NENFIATVRE VVNRLDR
Length:347
Mass (Da):40,144
Last modified:October 1, 2000 - v1
Checksum:iD8632FFAAA162587
GO
Isoform 2 (identifier: Q9NP66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-81: QR → VS
     82-347: Missing.

Show »
Length:81
Mass (Da):8,671
Checksum:i053ED03B6B492E96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti320L → P in BAD96820 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01862180 – 81QR → VS in isoform 2. 1 Publication2
Alternative sequenceiVSP_01862282 – 347Missing in isoform 2. 1 PublicationAdd BLAST266

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146222 mRNA Translation: AAF66706.1
AL355736 mRNA Translation: CAB90815.1 Different termination.
AL355737 mRNA Translation: CAB90816.1
AK001601 mRNA Translation: BAA91782.1
BT006716 mRNA Translation: AAP35362.1
AK223100 mRNA Translation: BAD96820.1
AC090984 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99201.1
CH471136 Genomic DNA Translation: EAW99202.1
CH471136 Genomic DNA Translation: EAW99203.1
BC021959 mRNA Translation: AAH21959.1
CCDSiCCDS10295.1 [Q9NP66-1]
RefSeqiNP_001291433.1, NM_001304504.1 [Q9NP66-1]
NP_001291434.1, NM_001304505.1
NP_060670.1, NM_018200.3 [Q9NP66-1]
XP_011519460.1, XM_011521158.2 [Q9NP66-1]
UniGeneiHs.69594

Genome annotation databases

EnsembliENST00000336216; ENSP00000336856; ENSG00000140382 [Q9NP66-1]
ENST00000381714; ENSP00000371133; ENSG00000140382 [Q9NP66-1]
GeneIDi10363
KEGGihsa:10363
UCSCiuc002bcr.4 human [Q9NP66-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHM20A_HUMAN
AccessioniPrimary (citable) accession number: Q9NP66
Secondary accession number(s): A6NHY3
, D3DW78, Q53G31, Q9NSF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health