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Q9NP66

- HM20A_HUMAN

UniProt

Q9NP66 - HM20A_HUMAN

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Protein

High mobility group protein 20A

Gene

HMG20A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi103 – 17169HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. chromatin organization Source: UniProtKB
  3. negative regulation of neuron differentiation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. regulation of transcription, DNA-templated Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein 20A
Alternative name(s):
HMG box-containing protein 20A
HMG domain-containing protein 1
HMG domain-containing protein HMGX1
Gene namesi
Name:HMG20A
Synonyms:HMGX1, HMGXB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:5001. HMG20A.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29331.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347High mobility group protein 20APRO_0000238649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051Phosphoserine4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NP66.
PaxDbiQ9NP66.
PeptideAtlasiQ9NP66.
PRIDEiQ9NP66.

PTM databases

PhosphoSiteiQ9NP66.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9NP66.
CleanExiHS_HMG20A.
ExpressionAtlasiQ9NP66. baseline and differential.
GenevestigatoriQ9NP66.

Organism-specific databases

HPAiHPA008126.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428582EBI-740641,EBI-466029
TESCQ96BS22EBI-740641,EBI-740653

Protein-protein interaction databases

BioGridi115643. 23 interactions.
IntActiQ9NP66. 14 interactions.
MINTiMINT-1198360.
STRINGi9606.ENSP00000336856.

Structurei

3D structure databases

ProteinModelPortaliQ9NP66.
SMRiQ9NP66. Positions 100-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili229 – 27345Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5648.
GeneTreeiENSGT00730000110938.
HOGENOMiHOG000247029.
HOVERGENiHBG059870.
InParanoidiQ9NP66.
OMAiDKERYMR.
PhylomeDBiQ9NP66.
TreeFamiTF106440.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NP66-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENLMTSSTL PPLFADEDGS KESNDLATTG LNHPEVPYSS GATSSTNNPE
60 70 80 90 100
FVEDLSQGQL LQSESSNAAE GNEQRHEDEQ RSKRGGWSKG RKRKKPLRDS
110 120 130 140 150
NAPKSPLTGY VRFMNERREQ LRAKRPEVPF PEITRMLGNE WSKLPPEEKQ
160 170 180 190 200
RYLDEADRDK ERYMKELEQY QKTEAYKVFS RKTQDRQKGK SHRQDAARQA
210 220 230 240 250
THDHEKETEV KERSVFDIPI FTEEFLNHSK AREAELRQLR KSNMEFEERN
260 270 280 290 300
AALQKHVESM RTAVEKLEVD VIQERSRNTV LQQHLETLRQ VLTSSFASMP
310 320 330 340
LPGSGETPTV DTIDSYMNRL HSIILANPQD NENFIATVRE VVNRLDR
Length:347
Mass (Da):40,144
Last modified:October 1, 2000 - v1
Checksum:iD8632FFAAA162587
GO
Isoform 2 (identifier: Q9NP66-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-81: QR → VS
     82-347: Missing.

Show »
Length:81
Mass (Da):8,671
Checksum:i053ED03B6B492E96
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti320 – 3201L → P in BAD96820. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei80 – 812QR → VS in isoform 2. 1 PublicationVSP_018621
Alternative sequencei82 – 347266Missing in isoform 2. 1 PublicationVSP_018622Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146222 mRNA. Translation: AAF66706.1.
AL355736 mRNA. Translation: CAB90815.1. Different termination.
AL355737 mRNA. Translation: CAB90816.1.
AK001601 mRNA. Translation: BAA91782.1.
BT006716 mRNA. Translation: AAP35362.1.
AK223100 mRNA. Translation: BAD96820.1.
AC090984 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99201.1.
CH471136 Genomic DNA. Translation: EAW99202.1.
CH471136 Genomic DNA. Translation: EAW99203.1.
BC021959 mRNA. Translation: AAH21959.1.
CCDSiCCDS10295.1. [Q9NP66-1]
RefSeqiNP_060670.1. NM_018200.2. [Q9NP66-1]
XP_005254180.1. XM_005254123.2. [Q9NP66-1]
UniGeneiHs.69594.

Genome annotation databases

EnsembliENST00000336216; ENSP00000336856; ENSG00000140382. [Q9NP66-1]
ENST00000381714; ENSP00000371133; ENSG00000140382. [Q9NP66-1]
GeneIDi10363.
KEGGihsa:10363.
UCSCiuc002bcq.1. human. [Q9NP66-2]
uc002bcr.3. human. [Q9NP66-1]

Polymorphism databases

DMDMi74734297.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146222 mRNA. Translation: AAF66706.1 .
AL355736 mRNA. Translation: CAB90815.1 . Different termination.
AL355737 mRNA. Translation: CAB90816.1 .
AK001601 mRNA. Translation: BAA91782.1 .
BT006716 mRNA. Translation: AAP35362.1 .
AK223100 mRNA. Translation: BAD96820.1 .
AC090984 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99201.1 .
CH471136 Genomic DNA. Translation: EAW99202.1 .
CH471136 Genomic DNA. Translation: EAW99203.1 .
BC021959 mRNA. Translation: AAH21959.1 .
CCDSi CCDS10295.1. [Q9NP66-1 ]
RefSeqi NP_060670.1. NM_018200.2. [Q9NP66-1 ]
XP_005254180.1. XM_005254123.2. [Q9NP66-1 ]
UniGenei Hs.69594.

3D structure databases

ProteinModelPortali Q9NP66.
SMRi Q9NP66. Positions 100-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115643. 23 interactions.
IntActi Q9NP66. 14 interactions.
MINTi MINT-1198360.
STRINGi 9606.ENSP00000336856.

PTM databases

PhosphoSitei Q9NP66.

Polymorphism databases

DMDMi 74734297.

Proteomic databases

MaxQBi Q9NP66.
PaxDbi Q9NP66.
PeptideAtlasi Q9NP66.
PRIDEi Q9NP66.

Protocols and materials databases

DNASUi 10363.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336216 ; ENSP00000336856 ; ENSG00000140382 . [Q9NP66-1 ]
ENST00000381714 ; ENSP00000371133 ; ENSG00000140382 . [Q9NP66-1 ]
GeneIDi 10363.
KEGGi hsa:10363.
UCSCi uc002bcq.1. human. [Q9NP66-2 ]
uc002bcr.3. human. [Q9NP66-1 ]

Organism-specific databases

CTDi 10363.
GeneCardsi GC15P077712.
HGNCi HGNC:5001. HMG20A.
HPAi HPA008126.
MIMi 605534. gene.
neXtProti NX_Q9NP66.
PharmGKBi PA29331.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5648.
GeneTreei ENSGT00730000110938.
HOGENOMi HOG000247029.
HOVERGENi HBG059870.
InParanoidi Q9NP66.
OMAi DKERYMR.
PhylomeDBi Q9NP66.
TreeFami TF106440.

Miscellaneous databases

ChiTaRSi HMG20A. human.
GeneWikii HMG20A.
GenomeRNAii 10363.
NextBioi 39285.
PROi Q9NP66.
SOURCEi Search...

Gene expression databases

Bgeei Q9NP66.
CleanExi HS_HMG20A.
ExpressionAtlasi Q9NP66. baseline and differential.
Genevestigatori Q9NP66.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression."
    Sumoy L., Carim-Todd L., Escarceller M., Nadal M., Gratacos M., Pujana M.A., Estivill X., Peral B.
    Cytogenet. Cell Genet. 88:62-67(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHM20A_HUMAN
AccessioniPrimary (citable) accession number: Q9NP66
Secondary accession number(s): A6NHY3
, D3DW78, Q53G31, Q9NSF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3