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Q9NP66

- HM20A_HUMAN

UniProt

Q9NP66 - HM20A_HUMAN

Protein

High mobility group protein 20A

Gene

HMG20A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi103 – 17169HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. chromatin organization Source: UniProtKB
    3. negative regulation of neuron differentiation Source: Ensembl
    4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. regulation of transcription, DNA-templated Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High mobility group protein 20A
    Alternative name(s):
    HMG box-containing protein 20A
    HMG domain-containing protein 1
    HMG domain-containing protein HMGX1
    Gene namesi
    Name:HMG20A
    Synonyms:HMGX1, HMGXB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:5001. HMG20A.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29331.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347High mobility group protein 20APRO_0000238649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei105 – 1051Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NP66.
    PaxDbiQ9NP66.
    PeptideAtlasiQ9NP66.
    PRIDEiQ9NP66.

    PTM databases

    PhosphoSiteiQ9NP66.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9NP66.
    BgeeiQ9NP66.
    CleanExiHS_HMG20A.
    GenevestigatoriQ9NP66.

    Organism-specific databases

    HPAiHPA008126.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HTTP428582EBI-740641,EBI-466029
    TESCQ96BS22EBI-740641,EBI-740653

    Protein-protein interaction databases

    BioGridi115643. 17 interactions.
    IntActiQ9NP66. 14 interactions.
    MINTiMINT-1198360.
    STRINGi9606.ENSP00000336856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NP66.
    SMRiQ9NP66. Positions 100-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili229 – 27345Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5648.
    HOGENOMiHOG000247029.
    HOVERGENiHBG059870.
    InParanoidiQ9NP66.
    OMAiDKERYMR.
    PhylomeDBiQ9NP66.
    TreeFamiTF106440.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NP66-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENLMTSSTL PPLFADEDGS KESNDLATTG LNHPEVPYSS GATSSTNNPE    50
    FVEDLSQGQL LQSESSNAAE GNEQRHEDEQ RSKRGGWSKG RKRKKPLRDS 100
    NAPKSPLTGY VRFMNERREQ LRAKRPEVPF PEITRMLGNE WSKLPPEEKQ 150
    RYLDEADRDK ERYMKELEQY QKTEAYKVFS RKTQDRQKGK SHRQDAARQA 200
    THDHEKETEV KERSVFDIPI FTEEFLNHSK AREAELRQLR KSNMEFEERN 250
    AALQKHVESM RTAVEKLEVD VIQERSRNTV LQQHLETLRQ VLTSSFASMP 300
    LPGSGETPTV DTIDSYMNRL HSIILANPQD NENFIATVRE VVNRLDR 347
    Length:347
    Mass (Da):40,144
    Last modified:October 1, 2000 - v1
    Checksum:iD8632FFAAA162587
    GO
    Isoform 2 (identifier: Q9NP66-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         80-81: QR → VS
         82-347: Missing.

    Show »
    Length:81
    Mass (Da):8,671
    Checksum:i053ED03B6B492E96
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti320 – 3201L → P in BAD96820. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei80 – 812QR → VS in isoform 2. 1 PublicationVSP_018621
    Alternative sequencei82 – 347266Missing in isoform 2. 1 PublicationVSP_018622Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146222 mRNA. Translation: AAF66706.1.
    AL355736 mRNA. Translation: CAB90815.1. Different termination.
    AL355737 mRNA. Translation: CAB90816.1.
    AK001601 mRNA. Translation: BAA91782.1.
    BT006716 mRNA. Translation: AAP35362.1.
    AK223100 mRNA. Translation: BAD96820.1.
    AC090984 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99201.1.
    CH471136 Genomic DNA. Translation: EAW99202.1.
    CH471136 Genomic DNA. Translation: EAW99203.1.
    BC021959 mRNA. Translation: AAH21959.1.
    CCDSiCCDS10295.1. [Q9NP66-1]
    RefSeqiNP_060670.1. NM_018200.2. [Q9NP66-1]
    XP_005254180.1. XM_005254123.2. [Q9NP66-1]
    UniGeneiHs.69594.

    Genome annotation databases

    EnsembliENST00000336216; ENSP00000336856; ENSG00000140382. [Q9NP66-1]
    ENST00000381714; ENSP00000371133; ENSG00000140382. [Q9NP66-1]
    GeneIDi10363.
    KEGGihsa:10363.
    UCSCiuc002bcq.1. human. [Q9NP66-2]
    uc002bcr.3. human. [Q9NP66-1]

    Polymorphism databases

    DMDMi74734297.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146222 mRNA. Translation: AAF66706.1 .
    AL355736 mRNA. Translation: CAB90815.1 . Different termination.
    AL355737 mRNA. Translation: CAB90816.1 .
    AK001601 mRNA. Translation: BAA91782.1 .
    BT006716 mRNA. Translation: AAP35362.1 .
    AK223100 mRNA. Translation: BAD96820.1 .
    AC090984 Genomic DNA. No translation available.
    CH471136 Genomic DNA. Translation: EAW99201.1 .
    CH471136 Genomic DNA. Translation: EAW99202.1 .
    CH471136 Genomic DNA. Translation: EAW99203.1 .
    BC021959 mRNA. Translation: AAH21959.1 .
    CCDSi CCDS10295.1. [Q9NP66-1 ]
    RefSeqi NP_060670.1. NM_018200.2. [Q9NP66-1 ]
    XP_005254180.1. XM_005254123.2. [Q9NP66-1 ]
    UniGenei Hs.69594.

    3D structure databases

    ProteinModelPortali Q9NP66.
    SMRi Q9NP66. Positions 100-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115643. 17 interactions.
    IntActi Q9NP66. 14 interactions.
    MINTi MINT-1198360.
    STRINGi 9606.ENSP00000336856.

    PTM databases

    PhosphoSitei Q9NP66.

    Polymorphism databases

    DMDMi 74734297.

    Proteomic databases

    MaxQBi Q9NP66.
    PaxDbi Q9NP66.
    PeptideAtlasi Q9NP66.
    PRIDEi Q9NP66.

    Protocols and materials databases

    DNASUi 10363.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336216 ; ENSP00000336856 ; ENSG00000140382 . [Q9NP66-1 ]
    ENST00000381714 ; ENSP00000371133 ; ENSG00000140382 . [Q9NP66-1 ]
    GeneIDi 10363.
    KEGGi hsa:10363.
    UCSCi uc002bcq.1. human. [Q9NP66-2 ]
    uc002bcr.3. human. [Q9NP66-1 ]

    Organism-specific databases

    CTDi 10363.
    GeneCardsi GC15P077712.
    HGNCi HGNC:5001. HMG20A.
    HPAi HPA008126.
    MIMi 605534. gene.
    neXtProti NX_Q9NP66.
    PharmGKBi PA29331.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5648.
    HOGENOMi HOG000247029.
    HOVERGENi HBG059870.
    InParanoidi Q9NP66.
    OMAi DKERYMR.
    PhylomeDBi Q9NP66.
    TreeFami TF106440.

    Miscellaneous databases

    ChiTaRSi HMG20A. human.
    GeneWikii HMG20A.
    GenomeRNAii 10363.
    NextBioi 39285.
    PROi Q9NP66.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NP66.
    Bgeei Q9NP66.
    CleanExi HS_HMG20A.
    Genevestigatori Q9NP66.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression."
      Sumoy L., Carim-Todd L., Escarceller M., Nadal M., Gratacos M., Pujana M.A., Estivill X., Peral B.
      Cytogenet. Cell Genet. 88:62-67(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHM20A_HUMAN
    AccessioniPrimary (citable) accession number: Q9NP66
    Secondary accession number(s): A6NHY3
    , D3DW78, Q53G31, Q9NSF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3