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Protein

Nucleolar protein of 40 kDa

Gene

ZCCHC17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 148CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein of 40 kDa
Short name:
pNO40
Alternative name(s):
Pnn-interacting nucleolar protein
Putative S1 RNA-binding domain protein
Short name:
PS1D protein
Zinc finger CCHC domain-containing protein 17
Gene namesi
Name:ZCCHC17
Synonyms:PS1D
ORF Names:HSPC243, HSPC251, LDC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121766.14
HGNCiHGNC:30246 ZCCHC17
neXtProtiNX_Q9NP64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121766
PharmGKBiPA142670539

Polymorphism and mutation databases

DMDMi73921227

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000969021 – 241Nucleolar protein of 40 kDaAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineCombined sources1
Modified residuei144N6-acetyllysineBy similarity1
Modified residuei183PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NP64
PaxDbiQ9NP64
PeptideAtlasiQ9NP64
PRIDEiQ9NP64
ProteomicsDBi81894
81895 [Q9NP64-2]

PTM databases

iPTMnetiQ9NP64
PhosphoSitePlusiQ9NP64

Expressioni

Gene expression databases

BgeeiENSG00000121766
CleanExiHS_ZCCHC17
ExpressionAtlasiQ9NP64 baseline and differential
GenevisibleiQ9NP64 HS

Organism-specific databases

HPAiHPA053727

Interactioni

Subunit structurei

Interacts with PNN. Associates with the 60S ribosomal subunit (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119598, 57 interactors
IntActiQ9NP64, 26 interactors
MINTiQ9NP64
STRINGi9606.ENSP00000343557

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 27Combined sources10
Beta strandi30 – 34Combined sources5
Beta strandi42 – 45Combined sources4
Helixi46 – 49Combined sources4
Helixi57 – 60Combined sources4
Beta strandi66 – 76Combined sources11
Beta strandi81 – 87Combined sources7
Beta strandi92 – 94Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQONMR-A1-106[»]
ProteinModelPortaliQ9NP64
SMRiQ9NP64
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NP64

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 88S1 motifPROSITE-ProRule annotationAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi110 – 113Poly-Arg4
Compositional biasi161 – 167Poly-Glu7
Compositional biasi185 – 240Lys-richAdd BLAST56

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 148CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410INHE Eukaryota
COG1185 LUCA
GeneTreeiENSGT00510000047363
HOGENOMiHOG000113809
HOVERGENiHBG080343
InParanoidiQ9NP64
PhylomeDBiQ9NP64
TreeFamiTF332136

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR037320 pNO40
IPR022967 S1_dom
IPR003029 S1_domain
IPR001878 Znf_CCHC
PANTHERiPTHR15838 PTHR15838, 1 hit
PfamiView protein in Pfam
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS50126 S1, 1 hit
PS50158 ZF_CCHC, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP64-1) [UniParc]FASTAAdd to basket
Also known as: hpNO40

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSGRPETME NLPALYTIFQ GEVAMVTDYG AFIKIPGCRK QGLVHRTHMS
60 70 80 90 100
SCRVDKPSEI VDVGDKVWVK LIGREMKNDR IKVSLSMKVV NQGTGKDLDP
110 120 130 140 150
NNVIIEQEER RRRSFQDYTG QKITLEAVLN TTCKKCGCKG HFAKDCFMQP
160 170 180 190 200
GGTKYSLIPD EEEEKEEAKS AEFEKPDPTR NPSRKRKKEK KKKKHRDRKS
210 220 230 240
SDSDSSDSES DTGKRARHTS KDSKAAKKKK KKKKHKKKHK E
Length:241
Mass (Da):27,570
Last modified:October 1, 2000 - v1
Checksum:iDA1B039DAC5F4A1D
GO
Isoform 2 (identifier: Q9NP64-2) [UniParc]FASTAAdd to basket
Also known as: hpNO40s

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:217
Mass (Da):24,919
Checksum:i9082B1330EE4DAAF
GO
Isoform 3 (identifier: Q9NP64-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MNSGRPETMENLPALYTIFQGE → MKQLIEDTEKNKVY

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):26,810
Checksum:iB474CB5DC1AF7600
GO

Sequence cautioni

The sequence AAF36171 differs from that shown. Reason: Frameshift at position 48.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217R → G in AAF36171 (PubMed:11042152).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0153081 – 24Missing in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0545311 – 22MNSGR…IFQGE → MKQLIEDTEKNKVY in isoform 3. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247661 mRNA Translation: AAF72518.3
AF151077 mRNA Translation: AAF36163.1
AF151085 mRNA Translation: AAF36171.1 Frameshift.
AK001929 mRNA Translation: BAA91984.1
AK022506 mRNA Translation: BAB14066.1
AK024049 mRNA Translation: BAB14799.1
AK302248 mRNA Translation: BAG63600.1
AL451070 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07620.1
CH471059 Genomic DNA Translation: EAX07621.1
CH471059 Genomic DNA Translation: EAX07622.1
CH471059 Genomic DNA Translation: EAX07624.1
BC000685 mRNA Translation: AAH00685.1
BC007446 mRNA Translation: AAH07446.1
BC050609 mRNA Translation: AAH50609.1
CCDSiCCDS341.1 [Q9NP64-1]
CCDS60061.1 [Q9NP64-3]
RefSeqiNP_001269495.1, NM_001282566.1
NP_001269496.1, NM_001282567.1
NP_001269497.1, NM_001282568.1 [Q9NP64-1]
NP_001269498.1, NM_001282569.1 [Q9NP64-3]
NP_001269499.1, NM_001282570.1 [Q9NP64-2]
NP_001269500.1, NM_001282571.1
NP_001269501.1, NM_001282572.1
NP_001269502.1, NM_001282573.1
NP_001269503.1, NM_001282574.1
NP_057589.2, NM_016505.3 [Q9NP64-1]
XP_006710744.1, XM_006710681.3 [Q9NP64-3]
XP_011539869.1, XM_011541567.2 [Q9NP64-1]
UniGeneiHs.524094

Genome annotation databases

EnsembliENST00000344147; ENSP00000343557; ENSG00000121766 [Q9NP64-1]
ENST00000373714; ENSP00000362819; ENSG00000121766 [Q9NP64-1]
ENST00000546109; ENSP00000444742; ENSG00000121766 [Q9NP64-3]
GeneIDi51538
KEGGihsa:51538
UCSCiuc001bsp.3 human [Q9NP64-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiNO40_HUMAN
AccessioniPrimary (citable) accession number: Q9NP64
Secondary accession number(s): B4DY38
, D3DPN4, Q6PKH4, Q9NYG4, Q9P0M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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