Q9NP62 (GCM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorion-specific transcription factor GCMa
Short name=hGCMa

Alternative name(s):
GCM motif protein 1
Glial cells missing homolog 1

Gene names

Name:	GCM1
Synonyms:	GCMA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.
Subcellular location	Nucleus Potential.
Tissue specificity	Placenta specific.
Post-translational modification	Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).
Sequence similarities	Contains 1 GCM DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	transcription factor complex Inferred from direct assay. Source: MGI
Molecular function	DNA binding Traceable author statement. Source: ProtInc sequence-specific DNA binding transcription factor activity Inferred from direct assay. Source: MGI transcription factor binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Chorion-specific transcription factor GCMa		PRO_0000126647
Regions
	DNA binding	14 – 169	156	GCM
Sites
	Metal binding	76	1	Zinc 1 By similarity
	Metal binding	82	1	Zinc 2 By similarity
	Metal binding	86	1	Zinc 2 By similarity
	Metal binding	113	1	Zinc 2 By similarity
	Metal binding	116	1	Zinc 2 By similarity
	Metal binding	125	1	Zinc 1 By similarity
	Metal binding	152	1	Zinc 1 By similarity
	Metal binding	154	1	Zinc 1 By similarity
Experimental info
	Sequence conflict	6	1	F → S in BAA13651. Ref.1
	Sequence conflict	386	1	E → G in BAA13651. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9NP62 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: E16CDD2DDEB25678	FASTA	436	49,268
	10 20 30 40 50 60 MEPDDFDSED KEILSWDIND VKLPQNVKKT DWFQEWPDSY AKHIYSSEDK NAQRHLSSWA 70 80 90 100 110 120 MRNTNNHNSR ILKKSCLGVV VCGRDCLAEE GRKIYLRPAI CDKARQKQQR KRCPNCDGPL 130 140 150 160 170 180 KLIPCRGHGG FPVTNFWRHD GRFIFFQSKG EHDHPKPETK LEAEARRAMK KVNTAPSSVS 190 200 210 220 230 240 LSLKGSTETR SLPGETQSQG SLPLTWSFQE GVQLPGSYSG HLIANTPQQN SLNDCFSFSK 250 260 270 280 290 300 SYGLGGITDL TDQTSTVDPM KLYEKRKLSS SRTYSSGDLL PPSASGVYSD HGDLQAWSKN 310 320 330 340 350 360 AALGRNHLAD NCYSNYPFPL TSWPCSFSPS QNSSEPFYQQ LPLEPPAAKT GCPPLWPNPA 370 380 390 400 410 420 GNLYEEKVHV DFNSYVQSPA YHSPQEDPFL FTYASHPHQQ YSLPSKSSKW DFEEEMTYLG 430 LDHCNNDMLL NLCPLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals." Akiyama Y., Hosoya T., Poole A.M., Hotta Y. Proc. Natl. Acad. Sci. U.S.A. 93:14912-14916(1996) [PubMed: 8962155] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Structure of human GCMa cDNA and gene." Nishizawa M., Ito S. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Liver and Placenta.
[3]	"A GCM motif protein is involved in placenta-specific expression of human aromatase gene." Yamada K., Ogawa H., Honda S., Harada N., Okazaki T. J. Biol. Chem. 274:32279-32286(1999) [PubMed: 10542267] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[4]	"Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene." Yamada K., Ogawa H., Tamiya G., Ikeno M., Morita M., Asakawa S., Shimizu N., Okazaki T. Biochem. Biophys. Res. Commun. 278:134-139(2000) [PubMed: 11071865] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation." Chiang M.H., Chen L.F., Chen H. Biol. Reprod. 79:914-920(2008) [PubMed: 18703417] [Abstract] Cited for: POLYUBIQUITINATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88613 mRNA. Translation: BAA13651.1. AB041714 mRNA. Translation: BAA94757.1. AB041716 Genomic DNA. Translation: BAA94758.1. AB026493 mRNA. Translation: BAA77250.2. AB047819 Genomic DNA. Translation: BAB18039.1. AL512347 Genomic DNA. No translation available. BC096288 mRNA. Translation: AAH96288.1.
IPI	IPI00413627.
RefSeq	NP_003634.2. NM_003643.3.
UniGene	Hs.28346.
3D structure databases
ProteinModelPortal	Q9NP62.
SMR	Q9NP62. Positions 14-170.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NP62.
PTM databases
PhosphoSite	Q9NP62.
Polymorphism databases
DMDM	33516903.
Proteomic databases
PRIDE	Q9NP62.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259803; ENSP00000259803; ENSG00000137270.
GeneID	8521.
KEGG	hsa:8521.
UCSC	uc003pbp.1. human.
Organism-specific databases
CTD	8521.
GeneCards	GC06M052991.
H-InvDB	HIX0032747.
HGNC	HGNC:4197. GCM1.
MIM	603715. gene.
neXtProt	NX_Q9NP62.
PharmGKB	PA28614.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10654.
GeneTree	ENSGT00390000006777.
HOGENOM	HBG267490.
HOVERGEN	HBG039460.
InParanoid	Q9NP62.
OMA	EKVHVDF.
OrthoDB	EOG43XV39.
PhylomeDB	Q9NP62.
Gene expression databases
ArrayExpress	Q9NP62.
Bgee	Q9NP62.
CleanEx	HS_GCM1.
Genevestigator	Q9NP62.
GermOnline	ENSG00000137270. Homo sapiens.
Family and domain databases
InterPro	IPR003902. Tscrpt_reg_GCM_motif. [Graphical view]
PANTHER	PTHR12414. GCM_motif. 1 hit.
Pfam	PF03615. GCM. 1 hit. [Graphical view]
ProDom	PD014393. GCM_motif. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF90073. GCM_motif. 1 hit.
PROSITE	PS50807. GCM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	31904.
SOURCE	Search...

Entry information

Entry name

GCM1_HUMAN

Accession

Primary (citable) accession number: Q9NP62
Secondary accession number(s): Q4VAQ7 , Q5T0X0, Q99468, Q9P1X3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.