Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chorion-specific transcription factor GCMa

Gene

GCM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Zinc 1PROSITE-ProRule annotation
Metal bindingi82 – 821Zinc 2PROSITE-ProRule annotation
Metal bindingi86 – 861Zinc 2PROSITE-ProRule annotation
Metal bindingi113 – 1131Zinc 2PROSITE-ProRule annotation
Metal bindingi116 – 1161Zinc 2PROSITE-ProRule annotation
Metal bindingi125 – 1251Zinc 1PROSITE-ProRule annotation
Metal bindingi152 – 1521Zinc 1PROSITE-ProRule annotation
Metal bindingi154 – 1541Zinc 1PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi14 – 169156GCMPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • histone deacetylase binding Source: UniProtKB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: MGI
  • transcription factor binding Source: MGI
  • zinc ion binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Chorion-specific transcription factor GCMa
Short name:
hGCMa
Alternative name(s):
GCM motif protein 1
Glial cells missing homolog 1
Gene namesi
Name:GCM1
Synonyms:GCMA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4197. GCM1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28614.

Polymorphism and mutation databases

BioMutaiGCM1.
DMDMi33516903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Chorion-specific transcription factor GCMaPRO_0000126647Add
BLAST

Post-translational modificationi

Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9NP62.
PRIDEiQ9NP62.

PTM databases

iPTMnetiQ9NP62.
PhosphoSiteiQ9NP62.

Expressioni

Tissue specificityi

Placenta specific.

Gene expression databases

BgeeiQ9NP62.
CleanExiHS_GCM1.
GenevisibleiQ9NP62. HS.

Organism-specific databases

HPAiHPA011343.

Interactioni

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi114093. 12 interactions.
STRINGi9606.ENSP00000259803.

Structurei

3D structure databases

ProteinModelPortaliQ9NP62.
SMRiQ9NP62. Positions 14-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 GCM DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKM6. Eukaryota.
ENOG4110IIJ. LUCA.
GeneTreeiENSGT00390000006777.
HOGENOMiHOG000112700.
HOVERGENiHBG039460.
InParanoidiQ9NP62.
OMAiWDFDEEM.
OrthoDBiEOG7M3J08.
PhylomeDBiQ9NP62.
TreeFamiTF324146.

Family and domain databases

InterProiIPR003902. Tscrpt_reg_GCM.
[Graphical view]
PfamiPF03615. GCM. 1 hit.
[Graphical view]
ProDomiPD014393. GCM_motif. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF90073. SSF90073. 1 hit.
PROSITEiPS50807. GCM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NP62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPDDFDSED KEILSWDIND VKLPQNVKKT DWFQEWPDSY AKHIYSSEDK
60 70 80 90 100
NAQRHLSSWA MRNTNNHNSR ILKKSCLGVV VCGRDCLAEE GRKIYLRPAI
110 120 130 140 150
CDKARQKQQR KRCPNCDGPL KLIPCRGHGG FPVTNFWRHD GRFIFFQSKG
160 170 180 190 200
EHDHPKPETK LEAEARRAMK KVNTAPSSVS LSLKGSTETR SLPGETQSQG
210 220 230 240 250
SLPLTWSFQE GVQLPGSYSG HLIANTPQQN SLNDCFSFSK SYGLGGITDL
260 270 280 290 300
TDQTSTVDPM KLYEKRKLSS SRTYSSGDLL PPSASGVYSD HGDLQAWSKN
310 320 330 340 350
AALGRNHLAD NCYSNYPFPL TSWPCSFSPS QNSSEPFYQQ LPLEPPAAKT
360 370 380 390 400
GCPPLWPNPA GNLYEEKVHV DFNSYVQSPA YHSPQEDPFL FTYASHPHQQ
410 420 430
YSLPSKSSKW DFEEEMTYLG LDHCNNDMLL NLCPLR
Length:436
Mass (Da):49,268
Last modified:October 1, 2000 - v1
Checksum:iE16CDD2DDEB25678
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61F → S in BAA13651 (PubMed:8962155).Curated
Sequence conflicti386 – 3861E → G in BAA13651 (PubMed:8962155).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88613 mRNA. Translation: BAA13651.1.
AB041714 mRNA. Translation: BAA94757.1.
AB041716 Genomic DNA. Translation: BAA94758.1.
AB026493 mRNA. Translation: BAA77250.2.
AB047819 Genomic DNA. Translation: BAB18039.1.
AL512347 Genomic DNA. No translation available.
BC096288 mRNA. Translation: AAH96288.1.
CCDSiCCDS4950.1.
RefSeqiNP_003634.2. NM_003643.3.
UniGeneiHs.28346.

Genome annotation databases

EnsembliENST00000259803; ENSP00000259803; ENSG00000137270.
GeneIDi8521.
KEGGihsa:8521.
UCSCiuc003pbp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88613 mRNA. Translation: BAA13651.1.
AB041714 mRNA. Translation: BAA94757.1.
AB041716 Genomic DNA. Translation: BAA94758.1.
AB026493 mRNA. Translation: BAA77250.2.
AB047819 Genomic DNA. Translation: BAB18039.1.
AL512347 Genomic DNA. No translation available.
BC096288 mRNA. Translation: AAH96288.1.
CCDSiCCDS4950.1.
RefSeqiNP_003634.2. NM_003643.3.
UniGeneiHs.28346.

3D structure databases

ProteinModelPortaliQ9NP62.
SMRiQ9NP62. Positions 14-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114093. 12 interactions.
STRINGi9606.ENSP00000259803.

PTM databases

iPTMnetiQ9NP62.
PhosphoSiteiQ9NP62.

Polymorphism and mutation databases

BioMutaiGCM1.
DMDMi33516903.

Proteomic databases

PaxDbiQ9NP62.
PRIDEiQ9NP62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259803; ENSP00000259803; ENSG00000137270.
GeneIDi8521.
KEGGihsa:8521.
UCSCiuc003pbp.4. human.

Organism-specific databases

CTDi8521.
GeneCardsiGCM1.
HGNCiHGNC:4197. GCM1.
HPAiHPA011343.
MIMi603715. gene.
neXtProtiNX_Q9NP62.
PharmGKBiPA28614.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKM6. Eukaryota.
ENOG4110IIJ. LUCA.
GeneTreeiENSGT00390000006777.
HOGENOMiHOG000112700.
HOVERGENiHBG039460.
InParanoidiQ9NP62.
OMAiWDFDEEM.
OrthoDBiEOG7M3J08.
PhylomeDBiQ9NP62.
TreeFamiTF324146.

Miscellaneous databases

GeneWikiiGCM1.
GenomeRNAii8521.
PROiQ9NP62.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NP62.
CleanExiHS_GCM1.
GenevisibleiQ9NP62. HS.

Family and domain databases

InterProiIPR003902. Tscrpt_reg_GCM.
[Graphical view]
PfamiPF03615. GCM. 1 hit.
[Graphical view]
ProDomiPD014393. GCM_motif. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF90073. SSF90073. 1 hit.
PROSITEiPS50807. GCM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gcm-motif: a novel DNA binding motif conserved in Drosophila and mammals."
    Akiyama Y., Hosoya T., Poole A.M., Hotta Y.
    Proc. Natl. Acad. Sci. U.S.A. 93:14912-14916(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Structure of human GCMa cDNA and gene."
    Nishizawa M., Ito S.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Liver and Placenta.
  3. "A GCM motif protein is involved in placenta-specific expression of human aromatase gene."
    Yamada K., Ogawa H., Honda S., Harada N., Okazaki T.
    J. Biol. Chem. 274:32279-32286(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  4. "Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene."
    Yamada K., Ogawa H., Tamiya G., Ikeno M., Morita M., Asakawa S., Shimizu N., Okazaki T.
    Biochem. Biophys. Res. Commun. 278:134-139(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation."
    Chiang M.H., Chen L.F., Chen H.
    Biol. Reprod. 79:914-920(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYUBIQUITINATION.

Entry informationi

Entry nameiGCM1_HUMAN
AccessioniPrimary (citable) accession number: Q9NP62
Secondary accession number(s): Q4VAQ7
, Q5T0X0, Q99468, Q9P1X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.