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Protein

ADP-ribosylation factor GTPase-activating protein 3

Gene

ARFGAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.1 Publication

Enzyme regulationi

GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri25 – 4824C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: Reactome
  • intracellular protein transport Source: UniProtKB
  • protein secretion Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: Reactome
  • vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor GTPase-activating protein 3
Short name:
ARF GAP 3
Gene namesi
Name:ARFGAP3
Synonyms:ARFGAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:661. ARFGAP3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • Golgi apparatus Source: HPA
  • Golgi membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35024.

Polymorphism and mutation databases

BioMutaiARFGAP3.
DMDMi21263420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516ADP-ribosylation factor GTPase-activating protein 3PRO_0000074193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311PhosphoserineCombined sources
Modified residuei270 – 2701PhosphoserineCombined sources
Modified residuei274 – 2741PhosphoserineCombined sources
Modified residuei331 – 3311PhosphoserineCombined sources
Modified residuei370 – 3701PhosphoserineCombined sources
Modified residuei428 – 4281PhosphoserineCombined sources
Modified residuei451 – 4511PhosphoserineCombined sources
Modified residuei453 – 4531PhosphoserineCombined sources
Modified residuei455 – 4551PhosphoserineCombined sources
Modified residuei457 – 4571PhosphoserineCombined sources
Modified residuei458 – 4581PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NP61.
MaxQBiQ9NP61.
PaxDbiQ9NP61.
PeptideAtlasiQ9NP61.
PRIDEiQ9NP61.
TopDownProteomicsiQ9NP61-1. [Q9NP61-1]

PTM databases

iPTMnetiQ9NP61.
PhosphoSiteiQ9NP61.

Expressioni

Tissue specificityi

Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary.1 Publication

Developmental stagei

Expressed at higher level in adult thymus, brain and lung, than in corresponding fetal tissues. Expressed at lower level in spleen, heart, kidney and liver during development.

Gene expression databases

BgeeiQ9NP61.
CleanExiHS_ARFGAP1.
HS_ARFGAP3.
ExpressionAtlasiQ9NP61. baseline and differential.
GenevisibleiQ9NP61. HS.

Organism-specific databases

HPAiHPA000638.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZDHHC17Q8IUH52EBI-2875816,EBI-524753

Protein-protein interaction databases

BioGridi117668. 19 interactions.
IntActiQ9NP61. 12 interactions.
STRINGi9606.ENSP00000263245.

Structurei

Secondary structure

1
516
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1813Combined sources
Turni20 – 223Combined sources
Beta strandi26 – 283Combined sources
Turni38 – 414Combined sources
Helixi46 – 5510Combined sources
Turni57 – 593Combined sources
Beta strandi65 – 673Combined sources
Helixi73 – 808Combined sources
Helixi84 – 9411Combined sources
Helixi101 – 1044Combined sources
Helixi108 – 12619Combined sources
Beta strandi129 – 1313Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRWNMR-A1-136[»]
ProteinModelPortaliQ9NP61.
SMRiQ9NP61. Positions 3-136.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NP61.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 126117Arf-GAPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili243 – 26321Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi348 – 37730Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri25 – 4824C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG0706. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00390000005436.
HOVERGENiHBG050563.
InParanoidiQ9NP61.
KOiK12493.
OMAiNTNAIAF.
OrthoDBiEOG7B8S42.
PhylomeDBiQ9NP61.
TreeFamiTF313985.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDPSKQDIL TIFKRLRSVP TNKVCFDCGA KNPSWASITY GVFLCIDCSG
60 70 80 90 100
SHRSLGVHLS FIRSTELDSN WSWFQLRCMQ VGGNASASSF FHQHGCSTND
110 120 130 140 150
TNAKYNSRAA QLYREKIKSL ASQATRKHGT DLWLDSCVVP PLSPPPKEED
160 170 180 190 200
FFASHVSPEV SDTAWASAIA EPSSLTSRPV ETTLENNEGG QEQGPSVEGL
210 220 230 240 250
NVPTKATLEV SSIIKKKPNQ AKKGLGAKKG SLGAQKLANT CFNEIEKQAQ
260 270 280 290 300
AADKMKEQED LAKVVSKEES IVSSLRLAYK DLEIQMKKDE KMNISGKKNV
310 320 330 340 350
DSDRLGMGFG NCRSVISHSV TSDMQTIEQE SPIMAKPRKK YNDDSDDSYF
360 370 380 390 400
TSSSSYFDEP VELRSSSFSS WDDSSDSYWK KETSKDTETV LKTTGYSDRP
410 420 430 440 450
TARRKPDYEP VENTDEAQKK FGNVKAISSD MYFGRQSQAD YETRARLERL
460 470 480 490 500
SASSSISSAD LFEEPRKQPA GNYSLSSVLP NAPDMAQFKQ GVRSVAGKLS
510
VFANGVVTSI QDRYGS
Length:516
Mass (Da):56,928
Last modified:October 1, 2000 - v1
Checksum:iE355E56A5D867F8E
GO
Isoform 2 (identifier: Q9NP61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-131: Missing.

Note: Gene prediction based on EST data.
Show »
Length:472
Mass (Da):51,990
Checksum:i6F3600081545890B
GO

Sequence cautioni

The sequence BAA92076.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14236.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti339 – 3391K → R in BAA92076 (PubMed:14702039).Curated
Sequence conflicti401 – 4011T → A in BAA92076 (PubMed:14702039).Curated
Sequence conflicti458 – 4581S → P in BAB14236 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti231 – 2311S → G.
Corresponds to variant rs9607957 [ dbSNP | Ensembl ].
VAR_055523
Natural varianti290 – 2901E → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_036177
Natural varianti355 – 3551S → R.Combined sources3 Publications
Corresponds to variant rs1018448 [ dbSNP | Ensembl ].
VAR_013447
Natural varianti370 – 3701S → G.
Corresponds to variant rs16986123 [ dbSNP | Ensembl ].
VAR_055524
Natural varianti468 – 4681Q → H.
Corresponds to variant rs35498349 [ dbSNP | Ensembl ].
VAR_055525
Natural varianti482 – 4821A → T.
Corresponds to variant rs36003980 [ dbSNP | Ensembl ].
VAR_055526
Natural varianti490 – 4901Q → R.
Corresponds to variant rs11551619 [ dbSNP | Ensembl ].
VAR_055527

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei88 – 13144Missing in isoform 2. CuratedVSP_046888Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111847 mRNA. Translation: AAF40310.1.
AL159143 mRNA. Translation: CAB76901.1.
CR456382 mRNA. Translation: CAG30268.1.
AL049757, AL049758 Genomic DNA. Translation: CAI21510.1.
AL049758, AL049757 Genomic DNA. Translation: CAI20950.1.
BC005122 mRNA. Translation: AAH05122.1.
AL137598 mRNA. Translation: CAB70834.1.
AK002083 mRNA. Translation: BAA92076.1. Different initiation.
AK022768 mRNA. Translation: BAB14236.1. Different initiation.
CCDSiCCDS14042.1. [Q9NP61-1]
CCDS46722.1. [Q9NP61-2]
PIRiT46305.
RefSeqiNP_001135765.1. NM_001142293.1. [Q9NP61-2]
NP_055385.3. NM_014570.4. [Q9NP61-1]
UniGeneiHs.685225.

Genome annotation databases

EnsembliENST00000263245; ENSP00000263245; ENSG00000242247. [Q9NP61-1]
ENST00000437119; ENSP00000388791; ENSG00000242247. [Q9NP61-2]
GeneIDi26286.
KEGGihsa:26286.
UCSCiuc003bdd.3. human. [Q9NP61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111847 mRNA. Translation: AAF40310.1.
AL159143 mRNA. Translation: CAB76901.1.
CR456382 mRNA. Translation: CAG30268.1.
AL049757, AL049758 Genomic DNA. Translation: CAI21510.1.
AL049758, AL049757 Genomic DNA. Translation: CAI20950.1.
BC005122 mRNA. Translation: AAH05122.1.
AL137598 mRNA. Translation: CAB70834.1.
AK002083 mRNA. Translation: BAA92076.1. Different initiation.
AK022768 mRNA. Translation: BAB14236.1. Different initiation.
CCDSiCCDS14042.1. [Q9NP61-1]
CCDS46722.1. [Q9NP61-2]
PIRiT46305.
RefSeqiNP_001135765.1. NM_001142293.1. [Q9NP61-2]
NP_055385.3. NM_014570.4. [Q9NP61-1]
UniGeneiHs.685225.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRWNMR-A1-136[»]
ProteinModelPortaliQ9NP61.
SMRiQ9NP61. Positions 3-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117668. 19 interactions.
IntActiQ9NP61. 12 interactions.
STRINGi9606.ENSP00000263245.

PTM databases

iPTMnetiQ9NP61.
PhosphoSiteiQ9NP61.

Polymorphism and mutation databases

BioMutaiARFGAP3.
DMDMi21263420.

Proteomic databases

EPDiQ9NP61.
MaxQBiQ9NP61.
PaxDbiQ9NP61.
PeptideAtlasiQ9NP61.
PRIDEiQ9NP61.
TopDownProteomicsiQ9NP61-1. [Q9NP61-1]

Protocols and materials databases

DNASUi26286.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263245; ENSP00000263245; ENSG00000242247. [Q9NP61-1]
ENST00000437119; ENSP00000388791; ENSG00000242247. [Q9NP61-2]
GeneIDi26286.
KEGGihsa:26286.
UCSCiuc003bdd.3. human. [Q9NP61-1]

Organism-specific databases

CTDi26286.
GeneCardsiARFGAP3.
HGNCiHGNC:661. ARFGAP3.
HPAiHPA000638.
MIMi612439. gene.
neXtProtiNX_Q9NP61.
PharmGKBiPA35024.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0706. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00390000005436.
HOVERGENiHBG050563.
InParanoidiQ9NP61.
KOiK12493.
OMAiNTNAIAF.
OrthoDBiEOG7B8S42.
PhylomeDBiQ9NP61.
TreeFamiTF313985.

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiARFGAP3. human.
EvolutionaryTraceiQ9NP61.
GeneWikiiARFGAP3.
GenomeRNAii26286.
PROiQ9NP61.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NP61.
CleanExiHS_ARFGAP1.
HS_ARFGAP3.
ExpressionAtlasiQ9NP61. baseline and differential.
GenevisibleiQ9NP61. HS.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family."
    Zhang C., Yu Y., Zhang S., Liu M., Xing G., Wei H., Bi J., Liu X., Zhou G., Dong C., Hu Z., Zhang Y., Luo L., Wu C., Zhao S., He F.
    Genomics 63:400-408(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
    Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
    Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-355.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-355.
    Tissue: Lung.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-516 (ISOFORM 1).
    Tissue: Testis.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 118-516 (ISOFORM 1), VARIANT ARG-355.
    Tissue: Placenta.
  8. "Functional characterization of novel human ARFGAP3."
    Liu X., Zhang C., Xing G., Chen Q., He F.
    FEBS Lett. 490:79-83(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION.
  9. "Two human ARFGAPs associated with COP-I-coated vesicles."
    Frigerio G., Grimsey N., Dale M., Majoul I., Duden R.
    Traffic 8:1644-1655(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331 AND SER-453, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370 AND SER-453, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274; SER-428; SER-451; SER-455; SER-457 AND SER-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-270 AND SER-451, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  16. "Solution structure of the ARFGAP domain of ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP 3)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-136.
  17. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-355, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-290.

Entry informationi

Entry nameiARFG3_HUMAN
AccessioniPrimary (citable) accession number: Q9NP61
Secondary accession number(s): E9PB03
, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally termed ARFGAP1.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.