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Protein

X-linked interleukin-1 receptor accessory protein-like 2

Gene

IL1RAPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • interleukin-1, Type II, blocking receptor activity Source: InterPro
  • interleukin-1 receptor activity Source: ProtInc

GO - Biological processi

  • central nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:G66-33338-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
X-linked interleukin-1 receptor accessory protein-like 2
Short name:
IL-1 receptor accessory protein-like 2
Short name:
IL-1-RAPL-2
Short name:
IL-1RAPL-2
Short name:
IL1RAPL-2
Alternative name(s):
IL1RAPL-2-related protein
Interleukin-1 receptor 9
Short name:
IL-1R-9
Short name:
IL-1R9
Three immunoglobulin domain-containing IL-1 receptor-related 1
Short name:
TIGIRR-1
Gene namesi
Name:IL1RAPL2
Synonyms:IL1R9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:5997. IL1RAPL2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 354ExtracellularSequence analysisAdd BLAST338
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 686CytoplasmicSequence analysisAdd BLAST311

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26280.
OpenTargetsiENSG00000189108.
PharmGKBiPA29813.

Polymorphism and mutation databases

BioMutaiIL1RAPL2.
DMDMi34222651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001545917 – 686X-linked interleukin-1 receptor accessory protein-like 2Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 116PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi162 ↔ 214PROSITE-ProRule annotation
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi265 ↔ 331PROSITE-ProRule annotation
Glycosylationi328N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NP60.
PRIDEiQ9NP60.

PTM databases

iPTMnetiQ9NP60.
PhosphoSitePlusiQ9NP60.

Expressioni

Tissue specificityi

Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta.3 Publications

Gene expression databases

BgeeiENSG00000189108.
CleanExiHS_IL1RAPL2.
ExpressionAtlasiQ9NP60. baseline and differential.
GenevisibleiQ9NP60. HS.

Organism-specific databases

HPAiHPA036128.
HPA036129.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344976.

Structurei

3D structure databases

ProteinModelPortaliQ9NP60.
SMRiQ9NP60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 132Ig-like C2-type 1Add BLAST115
Domaini141 – 232Ig-like C2-type 2Add BLAST92
Domaini239 – 347Ig-like C2-type 3Add BLAST109
Domaini400 – 559TIRPROSITE-ProRule annotationAdd BLAST160

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000092977.
HOVERGENiHBG052148.
InParanoidiQ9NP60.
KOiK05170.
OMAiHEMPTTT.
OrthoDBiEOG091G0GXW.
PhylomeDBiQ9NP60.
TreeFamiTF333913.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NP60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPFLLALV VCSVVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR
60 70 80 90 100
VKCALFYSYI RTNYSTAQST GLRLMWYKNK GDLEEPIIFS EVRMSKEEDS
110 120 130 140 150
IWFHSAEAQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE
160 170 180 190 200
KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY KECKPKMWRS IIIQKGNALL
210 220 230 240 250
IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP
260 270 280 290 300
SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI
310 320 330 340 350
RLLKEHLGEK EVELALIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD
360 370 380 390 400
LIYKIELAGG LGAIFLLLVL LVVIYKCYNI ELMLFYRQHF GADETNDDNK
410 420 430 440 450
EYDAYLSYTK VDQDTLDCDN PEEEQFALEV LPDVLEKHYG YKLFIPERDL
460 470 480 490 500
IPSGTYMEDL TRYVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG
510 520 530 540 550
EIKVILIECT ELKGKVNCQE VESLKRSIKL LSLIKWKGSK SSKLNSKFWK
560 570 580 590 600
HLVYEMPIKK KEMLPRCHVL DSAEQGLFGE LQPIPSIAMT STSATLVSSQ
610 620 630 640 650
ADLPEFHPSD SMQIRHCCRG YKHEIPATTL PVPSLGNHHT YCNLPLTLLN
660 670 680
GQLPLNNTLK DTQEFHRNSS LLPLSSKELS FTSDIW
Length:686
Mass (Da):78,670
Last modified:October 1, 2000 - v1
Checksum:iE400F7ECD186957C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036592606F → L in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212016 mRNA. Translation: AAF61307.1.
AF284436 mRNA. Translation: AAG21370.1.
AJ272208 mRNA. Translation: CAB86868.1.
AJ290436 mRNA. Translation: CAB89867.1.
AK290196 mRNA. Translation: BAF82885.1.
Z81144
, AL050401, Z68328, Z68330, Z68908, Z69721, Z74477, Z74619 Genomic DNA. Translation: CAI41969.1.
Z69721
, AL050401, Z68328, Z68330, Z68908, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI41981.1.
Z68908
, AL050401, Z68328, Z68330, Z69721, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI41987.1.
Z74619
, AL050401, Z68328, Z68330, Z68908, Z69721, Z74477, Z81144 Genomic DNA. Translation: CAI41989.1.
Z68328
, AL050401, Z68330, Z68908, Z69721, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI42001.1.
Z68330
, AL050401, Z68328, Z68908, Z69721, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI42006.1.
AL050401
, Z68328, Z68330, Z68908, Z69721, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI42894.1.
AF181285 mRNA. Translation: AAF59412.1.
BC104784 mRNA. Translation: AAI04785.1.
BC104786 mRNA. Translation: AAI04787.1.
CCDSiCCDS14517.1.
RefSeqiNP_059112.1. NM_017416.1.
XP_016884892.1. XM_017029403.1.
UniGeneiHs.675519.

Genome annotation databases

EnsembliENST00000372582; ENSP00000361663; ENSG00000189108.
GeneIDi26280.
KEGGihsa:26280.
UCSCiuc004elz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212016 mRNA. Translation: AAF61307.1.
AF284436 mRNA. Translation: AAG21370.1.
AJ272208 mRNA. Translation: CAB86868.1.
AJ290436 mRNA. Translation: CAB89867.1.
AK290196 mRNA. Translation: BAF82885.1.
Z81144
, AL050401, Z68328, Z68330, Z68908, Z69721, Z74477, Z74619 Genomic DNA. Translation: CAI41969.1.
Z69721
, AL050401, Z68328, Z68330, Z68908, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI41981.1.
Z68908
, AL050401, Z68328, Z68330, Z69721, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI41987.1.
Z74619
, AL050401, Z68328, Z68330, Z68908, Z69721, Z74477, Z81144 Genomic DNA. Translation: CAI41989.1.
Z68328
, AL050401, Z68330, Z68908, Z69721, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI42001.1.
Z68330
, AL050401, Z68328, Z68908, Z69721, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI42006.1.
AL050401
, Z68328, Z68330, Z68908, Z69721, Z74477, Z74619, Z81144 Genomic DNA. Translation: CAI42894.1.
AF181285 mRNA. Translation: AAF59412.1.
BC104784 mRNA. Translation: AAI04785.1.
BC104786 mRNA. Translation: AAI04787.1.
CCDSiCCDS14517.1.
RefSeqiNP_059112.1. NM_017416.1.
XP_016884892.1. XM_017029403.1.
UniGeneiHs.675519.

3D structure databases

ProteinModelPortaliQ9NP60.
SMRiQ9NP60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344976.

PTM databases

iPTMnetiQ9NP60.
PhosphoSitePlusiQ9NP60.

Polymorphism and mutation databases

BioMutaiIL1RAPL2.
DMDMi34222651.

Proteomic databases

PaxDbiQ9NP60.
PRIDEiQ9NP60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372582; ENSP00000361663; ENSG00000189108.
GeneIDi26280.
KEGGihsa:26280.
UCSCiuc004elz.1. human.

Organism-specific databases

CTDi26280.
DisGeNETi26280.
GeneCardsiIL1RAPL2.
HGNCiHGNC:5997. IL1RAPL2.
HPAiHPA036128.
HPA036129.
MIMi300277. gene.
neXtProtiNX_Q9NP60.
OpenTargetsiENSG00000189108.
PharmGKBiPA29813.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000092977.
HOVERGENiHBG052148.
InParanoidiQ9NP60.
KOiK05170.
OMAiHEMPTTT.
OrthoDBiEOG091G0GXW.
PhylomeDBiQ9NP60.
TreeFamiTF333913.

Enzyme and pathway databases

BioCyciZFISH:G66-33338-MONOMER.

Miscellaneous databases

GeneWikiiIL1RAPL2.
GenomeRNAii26280.
PROiQ9NP60.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189108.
CleanExiHS_IL1RAPL2.
ExpressionAtlasiQ9NP60. baseline and differential.
GenevisibleiQ9NP60. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIRPL2_HUMAN
AccessioniPrimary (citable) accession number: Q9NP60
Secondary accession number(s): Q2M3U3, Q9NZN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.