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Q9NP56

- PDE7B_HUMAN

UniProt

Q9NP56 - PDE7B_HUMAN

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Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 7B

Gene

PDE7B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Enzyme regulationi

Inhibited by dipyridamole, IBMX and SCH 51866. Insensitive to zaprinast, rolipram, and milrinone.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei173 – 1731Proton donorBy similarity
Metal bindingi177 – 1771Divalent metal cation 1By similarity
Metal bindingi213 – 2131Divalent metal cation 1By similarity
Metal bindingi214 – 2141Divalent metal cation 1By similarity
Metal bindingi214 – 2141Divalent metal cation 2By similarity
Metal bindingi323 – 3231Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cAMP catabolic process Source: UniProtKB-UniPathway
  2. signal transduction Source: ProtInc
  3. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19327. G alpha (s) signalling events.
UniPathwayiUPA00762; UER00747.

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC:3.1.4.53)
Gene namesi
Name:PDE7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:8792. PDE7B.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450cAMP-specific 3',5'-cyclic phosphodiesterase 7BPRO_0000198836Add
BLAST

Proteomic databases

MaxQBiQ9NP56.
PaxDbiQ9NP56.
PRIDEiQ9NP56.

PTM databases

PhosphoSiteiQ9NP56.

Expressioni

Tissue specificityi

Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas.

Gene expression databases

BgeeiQ9NP56.
CleanExiHS_PDE7B.
ExpressionAtlasiQ9NP56. baseline and differential.
GenevestigatoriQ9NP56.

Organism-specific databases

HPAiHPA023967.

Interactioni

Protein-protein interaction databases

BioGridi118010. 2 interactions.
IntActiQ9NP56. 1 interaction.
STRINGi9606.ENSP00000310661.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LXWmodel-A104-433[»]
ProteinModelPortaliQ9NP56.
SMRiQ9NP56. Positions 100-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 410239CatalyticBy similarityAdd
BLAST

Domaini

Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG300643.
GeneTreeiENSGT00760000118889.
HOGENOMiHOG000220881.
HOVERGENiHBG053543.
KOiK18436.
OMAiNNTTHSG.
OrthoDBiEOG7M98G3.
PhylomeDBiQ9NP56.
TreeFamiTF314638.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NP56-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSCLMVERCG EILFENPDQN AKCVCMLGDI RLRGQTGVRA ERRGSYPFID
60 70 80 90 100
FRLLNSTTYS GEIGTKKKVK RLLSFQRYFH ASRLLRGIIP QAPLHLLDED
110 120 130 140 150
YLGQARHMLS KVGMWDFDIF LFDRLTNGNS LVTLLCHLFN THGLIHHFKL
160 170 180 190 200
DMVTLHRFLV MVQEDYHSQN PYHNAVHAAD VTQAMHCYLK EPKLASFLTP
210 220 230 240 250
LDIMLGLLAA AAHDVDHPGV NQPFLIKTNH HLANLYQNMS VLENHHWRST
260 270 280 290 300
IGMLRESRLL AHLPKEMTQD IEQQLGSLIL ATDINRQNEF LTRLKAHLHN
310 320 330 340 350
KDLRLEDAQD RHFMLQIALK CADICNPCRI WEMSKQWSER VCEEFYRQGE
360 370 380 390 400
LEQKFELEIS PLCNQQKDSI PSIQIGFMSY IVEPLFREWA HFTGNSTLSE
410 420 430 440 450
NMLGHLAHNK AQWKSLLPRQ HRSRGSSGSG PDHDHAGQGT ESEEQEGDSP
Length:450
Mass (Da):51,835
Last modified:October 1, 2000 - v1
Checksum:iEC142BF3E28D0028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038040 mRNA. Translation: BAA96537.1.
AJ251860 mRNA. Translation: CAB92441.1.
AL360178, AL133319, AL138828 Genomic DNA. Translation: CAH73075.1.
AL133319, AL138828, AL360178 Genomic DNA. Translation: CAH73332.1.
AL138828, AL133319, AL360178 Genomic DNA. Translation: CAI95287.1.
CH471051 Genomic DNA. Translation: EAW47957.1.
BC075082 mRNA. Translation: AAH75082.1.
BC075083 mRNA. Translation: AAH75083.1.
CCDSiCCDS5175.1.
PIRiJC7266.
RefSeqiNP_061818.1. NM_018945.3.
UniGeneiHs.744230.

Genome annotation databases

EnsembliENST00000308191; ENSP00000310661; ENSG00000171408.
GeneIDi27115.
KEGGihsa:27115.
UCSCiuc003qgp.3. human.

Polymorphism databases

DMDMi13626185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038040 mRNA. Translation: BAA96537.1 .
AJ251860 mRNA. Translation: CAB92441.1 .
AL360178 , AL133319 , AL138828 Genomic DNA. Translation: CAH73075.1 .
AL133319 , AL138828 , AL360178 Genomic DNA. Translation: CAH73332.1 .
AL138828 , AL133319 , AL360178 Genomic DNA. Translation: CAI95287.1 .
CH471051 Genomic DNA. Translation: EAW47957.1 .
BC075082 mRNA. Translation: AAH75082.1 .
BC075083 mRNA. Translation: AAH75083.1 .
CCDSi CCDS5175.1.
PIRi JC7266.
RefSeqi NP_061818.1. NM_018945.3.
UniGenei Hs.744230.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LXW model - A 104-433 [» ]
ProteinModelPortali Q9NP56.
SMRi Q9NP56. Positions 100-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118010. 2 interactions.
IntActi Q9NP56. 1 interaction.
STRINGi 9606.ENSP00000310661.

Chemistry

BindingDBi Q9NP56.
ChEMBLi CHEMBL2111411.
DrugBanki DB00201. Caffeine.
DB00651. Dyphylline.
DB00920. Ketotifen.
GuidetoPHARMACOLOGYi 1306.

PTM databases

PhosphoSitei Q9NP56.

Polymorphism databases

DMDMi 13626185.

Proteomic databases

MaxQBi Q9NP56.
PaxDbi Q9NP56.
PRIDEi Q9NP56.

Protocols and materials databases

DNASUi 27115.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308191 ; ENSP00000310661 ; ENSG00000171408 .
GeneIDi 27115.
KEGGi hsa:27115.
UCSCi uc003qgp.3. human.

Organism-specific databases

CTDi 27115.
GeneCardsi GC06P136214.
HGNCi HGNC:8792. PDE7B.
HPAi HPA023967.
MIMi 604645. gene.
neXtProti NX_Q9NP56.
PharmGKBi PA33140.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300643.
GeneTreei ENSGT00760000118889.
HOGENOMi HOG000220881.
HOVERGENi HBG053543.
KOi K18436.
OMAi NNTTHSG.
OrthoDBi EOG7M98G3.
PhylomeDBi Q9NP56.
TreeFami TF314638.

Enzyme and pathway databases

UniPathwayi UPA00762 ; UER00747 .
Reactomei REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GenomeRNAii 27115.
NextBioi 49800.
PROi Q9NP56.
SOURCEi Search...

Gene expression databases

Bgeei Q9NP56.
CleanExi HS_PDE7B.
ExpressionAtlasi Q9NP56. baseline and differential.
Genevestigatori Q9NP56.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
InterProi IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of human PDE7B, a cAMP-specific phosphodiesterase."
    Sasaki T., Kotera J., Yuasa K., Omori K.
    Biochem. Biophys. Res. Commun. 271:575-583(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cloning and characterisation of the human and mouse PDE7B, a novel cAMP-specific nucleotide phosphodiesterase."
    Gardner C.E., Robas N.M., Cawkill D., Fidock M.D.
    Biochem. Biophys. Res. Commun. 272:186-192(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiPDE7B_HUMAN
AccessioniPrimary (citable) accession number: Q9NP56
Secondary accession number(s): Q5W154
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3