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Protein

BPI fold-containing family A member 1

Gene

BPIFA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.5 Publications

GO - Molecular functioni

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • innate immune response Source: UniProtKB
  • multicellular organismal water homeostasis Source: UniProtKB
  • negative regulation of single-species biofilm formation in or on host organism Source: UniProtKB
  • regulation of liquid surface tension Source: UniProtKB
  • regulation of sodium ion transmembrane transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:G66-32709-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family A member 1
Alternative name(s):
Lung-specific protein X
Nasopharyngeal carcinoma-related protein
Palate lung and nasal epithelium clone protein
Secretory protein in upper respiratory tracts
Short PLUNC1
Short name:
SPLUNC1
Tracheal epithelium-enriched protein
Von Ebner protein Hl
Gene namesi
Name:BPIFA1
Synonyms:LUNX, NASG, PLUNC, SPLUNC1, SPURT
ORF Names:UNQ787/PRO1606
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15749. BPIFA1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51297.
OpenTargetsiENSG00000198183.
PharmGKBiPA33423.

Polymorphism and mutation databases

BioMutaiBPIFA1.
DMDMi17380173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001717520 – 256BPI fold-containing family A member 1Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi180 ↔ 2241 Publication

Post-translational modificationi

May be N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NP55.
PeptideAtlasiQ9NP55.
PRIDEiQ9NP55.

PTM databases

iPTMnetiQ9NP55.
PhosphoSitePlusiQ9NP55.

Expressioni

Tissue specificityi

Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer.4 Publications

Inductioni

By all-trans retinoic acid (ATRA).1 Publication

Gene expression databases

BgeeiENSG00000198183.
CleanExiHS_PLUNC.
GenevisibleiQ9NP55. HS.

Organism-specific databases

HPAiCAB025669.

Interactioni

Subunit structurei

Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX0-23EBI-953896,EBI-10173939

Protein-protein interaction databases

BioGridi119448. 13 interactors.
IntActiQ9NP55. 5 interactors.
MINTiMINT-2873129.
STRINGi9606.ENSP00000346251.

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 61Combined sources15
Helixi64 – 69Combined sources6
Helixi73 – 75Combined sources3
Helixi92 – 96Combined sources5
Beta strandi99 – 101Combined sources3
Beta strandi109 – 115Combined sources7
Beta strandi119 – 122Combined sources4
Beta strandi124 – 127Combined sources4
Beta strandi129 – 140Combined sources12
Turni144 – 146Combined sources3
Beta strandi152 – 167Combined sources16
Beta strandi169 – 171Combined sources3
Beta strandi173 – 177Combined sources5
Turni184 – 186Combined sources3
Beta strandi188 – 191Combined sources4
Beta strandi193 – 196Combined sources4
Helixi200 – 202Combined sources3
Helixi206 – 232Combined sources27
Helixi236 – 247Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KEGX-ray2.50A43-256[»]
4KGHX-ray2.81A/B19-256[»]
4KGOX-ray3.19A/B19-256[»]
4N4XX-ray2.50A43-256[»]
5I7JX-ray2.54A/B19-256[»]
5I7KX-ray2.55A/B19-256[»]
5I7LX-ray2.60A/B19-256[»]
ProteinModelPortaliQ9NP55.
SMRiQ9NP55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWYF. Eukaryota.
ENOG41114MD. LUCA.
GeneTreeiENSGT00840000129898.
HOGENOMiHOG000231510.
HOVERGENiHBG045573.
InParanoidiQ9NP55.
OMAiQGKVCPL.
OrthoDBiEOG091G048N.
PhylomeDBiQ9NP55.
TreeFamiTF337052.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR032953. BPIFA1/Latherin.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF70. PTHR10504:SF70. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQTGGLIVF YGLLAQTMAQ FGGLPVPLDQ TLPLNVNPAL PLSPTGLAGS
60 70 80 90 100
LTNALSNGLL SGGLLGILEN LPLLDILKPG GGTSGGLLGG LLGKVTSVIP
110 120 130 140 150
GLNNIIDIKV TDPQLLELGL VQSPDGHRLY VTIPLGIKLQ VNTPLVGASL
160 170 180 190 200
LRLAVKLDIT AEILAVRDKQ ERIHLVLGDC THSPGSLQIS LLDGLGPLPI
210 220 230 240 250
QGLLDSLTGI LNKVLPELVQ GNVCPLVNEV LRGLDITLVH DIVNMLIHGL

QFVIKV
Length:256
Mass (Da):26,713
Last modified:October 1, 2000 - v1
Checksum:iEDF152FBC35315BC
GO
Isoform 2 (identifier: Q9NP55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-29: Missing.

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):25,257
Checksum:iB2A38F50F8229D20
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220Q → K in AAF70860 (PubMed:11018263).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05734516 – 29Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214562 Genomic DNA. Translation: AAG13653.1.
AF172993 mRNA. Translation: AAF70860.1.
AF158745 mRNA. Translation: AAF82622.1.
AB024937 mRNA. Translation: BAA93633.1.
AF439448 mRNA. Translation: AAL87636.1.
AF417256 mRNA. Translation: AAO12198.1.
AF417257 mRNA. Translation: AAO12199.1.
AF421369 Genomic DNA. Translation: AAO12200.1.
AY359020 mRNA. Translation: AAQ89379.1.
AK292778 mRNA. Translation: BAF85467.1.
DQ846869 mRNA. Translation: ABI63356.1.
AL121901 Genomic DNA. Translation: CAC03549.1.
CH471077 Genomic DNA. Translation: EAW76327.1.
CH471077 Genomic DNA. Translation: EAW76328.1.
CH471077 Genomic DNA. Translation: EAW76329.1.
BC012549 mRNA. Translation: AAH12549.1.
CCDSiCCDS13217.1. [Q9NP55-1]
RefSeqiNP_001230122.1. NM_001243193.1. [Q9NP55-1]
NP_057667.1. NM_016583.3. [Q9NP55-1]
NP_570913.1. NM_130852.2. [Q9NP55-1]
UniGeneiHs.211092.

Genome annotation databases

EnsembliENST00000354297; ENSP00000346251; ENSG00000198183. [Q9NP55-1]
ENST00000375413; ENSP00000364562; ENSG00000198183. [Q9NP55-1]
ENST00000375422; ENSP00000364571; ENSG00000198183. [Q9NP55-1]
ENST00000618484; ENSP00000482297; ENSG00000198183. [Q9NP55-2]
GeneIDi51297.
KEGGihsa:51297.
UCSCiuc002wyt.5. human. [Q9NP55-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214562 Genomic DNA. Translation: AAG13653.1.
AF172993 mRNA. Translation: AAF70860.1.
AF158745 mRNA. Translation: AAF82622.1.
AB024937 mRNA. Translation: BAA93633.1.
AF439448 mRNA. Translation: AAL87636.1.
AF417256 mRNA. Translation: AAO12198.1.
AF417257 mRNA. Translation: AAO12199.1.
AF421369 Genomic DNA. Translation: AAO12200.1.
AY359020 mRNA. Translation: AAQ89379.1.
AK292778 mRNA. Translation: BAF85467.1.
DQ846869 mRNA. Translation: ABI63356.1.
AL121901 Genomic DNA. Translation: CAC03549.1.
CH471077 Genomic DNA. Translation: EAW76327.1.
CH471077 Genomic DNA. Translation: EAW76328.1.
CH471077 Genomic DNA. Translation: EAW76329.1.
BC012549 mRNA. Translation: AAH12549.1.
CCDSiCCDS13217.1. [Q9NP55-1]
RefSeqiNP_001230122.1. NM_001243193.1. [Q9NP55-1]
NP_057667.1. NM_016583.3. [Q9NP55-1]
NP_570913.1. NM_130852.2. [Q9NP55-1]
UniGeneiHs.211092.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KEGX-ray2.50A43-256[»]
4KGHX-ray2.81A/B19-256[»]
4KGOX-ray3.19A/B19-256[»]
4N4XX-ray2.50A43-256[»]
5I7JX-ray2.54A/B19-256[»]
5I7KX-ray2.55A/B19-256[»]
5I7LX-ray2.60A/B19-256[»]
ProteinModelPortaliQ9NP55.
SMRiQ9NP55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119448. 13 interactors.
IntActiQ9NP55. 5 interactors.
MINTiMINT-2873129.
STRINGi9606.ENSP00000346251.

PTM databases

iPTMnetiQ9NP55.
PhosphoSitePlusiQ9NP55.

Polymorphism and mutation databases

BioMutaiBPIFA1.
DMDMi17380173.

Proteomic databases

PaxDbiQ9NP55.
PeptideAtlasiQ9NP55.
PRIDEiQ9NP55.

Protocols and materials databases

DNASUi51297.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354297; ENSP00000346251; ENSG00000198183. [Q9NP55-1]
ENST00000375413; ENSP00000364562; ENSG00000198183. [Q9NP55-1]
ENST00000375422; ENSP00000364571; ENSG00000198183. [Q9NP55-1]
ENST00000618484; ENSP00000482297; ENSG00000198183. [Q9NP55-2]
GeneIDi51297.
KEGGihsa:51297.
UCSCiuc002wyt.5. human. [Q9NP55-1]

Organism-specific databases

CTDi51297.
DisGeNETi51297.
GeneCardsiBPIFA1.
HGNCiHGNC:15749. BPIFA1.
HPAiCAB025669.
MIMi607412. gene.
neXtProtiNX_Q9NP55.
OpenTargetsiENSG00000198183.
PharmGKBiPA33423.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWYF. Eukaryota.
ENOG41114MD. LUCA.
GeneTreeiENSGT00840000129898.
HOGENOMiHOG000231510.
HOVERGENiHBG045573.
InParanoidiQ9NP55.
OMAiQGKVCPL.
OrthoDBiEOG091G048N.
PhylomeDBiQ9NP55.
TreeFamiTF337052.

Enzyme and pathway databases

BioCyciZFISH:G66-32709-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.

Miscellaneous databases

ChiTaRSiBPIFA1. human.
GeneWikiiPlunc.
GenomeRNAii51297.
PROiQ9NP55.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198183.
CleanExiHS_PLUNC.
GenevisibleiQ9NP55. HS.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR032953. BPIFA1/Latherin.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF70. PTHR10504:SF70. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBPIA1_HUMAN
AccessioniPrimary (citable) accession number: Q9NP55
Secondary accession number(s): A6XMV5
, A8K9R3, E1P5M9, Q9NZT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.