Q9NP55 (BPIA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BPI fold-containing family A member 1

Alternative name(s):
Lung-specific protein X
Nasopharyngeal carcinoma-related protein
Palate lung and nasal epithelium clone protein
Secretory protein in upper respiratory tracts
Tracheal epithelium-enriched protein
Von Ebner protein Hl

Gene names

Name:	BPIFA1
Synonyms:	LUNX, NASG, PLUNC, SPURT
ORF Names:	UNQ787/PRO1606

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the airway inflammatory response after exposure to irritants. May be associated with tumor progression. May play a role in innate immune responses of the upper airways. Ref.11
Subcellular location	Secreted By similarity. Note: Found in the nasal mucus By similarity. Apical side of airway epithelial cells. Detected in nasal mucus By similarity. Ref.11 Ref.13
Tissue specificity	Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer. Ref.1 Ref.3 Ref.5 Ref.13
Induction	By all-trans retinoic acid (ATRA). Ref.5
Post-translational modification	May be N-glycosylated. Ref.12
Miscellaneous	Binds lipopolysaccharides.
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. Plunc family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	innate immune response Non-traceable author statement. Source: UniProtKB
Cellular component	extracellular region Inferred from direct assay Ref.11. Source: UniProtKB
Molecular function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 256	237	BPI fold-containing family A member 1		PRO_0000017175
Experimental info
	Sequence conflict	220	1	Q → K in AAF70860. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9NP55 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: EDF152FBC35315BC	FASTA	256	26,713
	10 20 30 40 50 60 MFQTGGLIVF YGLLAQTMAQ FGGLPVPLDQ TLPLNVNPAL PLSPTGLAGS LTNALSNGLL 70 80 90 100 110 120 SGGLLGILEN LPLLDILKPG GGTSGGLLGG LLGKVTSVIP GLNNIIDIKV TDPQLLELGL 130 140 150 160 170 180 VQSPDGHRLY VTIPLGIKLQ VNTPLVGASL LRLAVKLDIT AEILAVRDKQ ERIHLVLGDC 190 200 210 220 230 240 THSPGSLQIS LLDGLGPLPI QGLLDSLTGI LNKVLPELVQ GNVCPLVNEV LRGLDITLVH 250 DIVNMLIHGL QFVIKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern." Bingle C.D., Bingle L. Biochim. Biophys. Acta 1493:363-367(2000) [PubMed: 11018263] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[2]	"Cloning of a novel gene associated with human nasopharyngeal carcinoma." He Z.W., Xie L., Xu L.G., Lan K., Liu W., Zhang L., Ren C., Shi J., Zhou W., Yao K. Chin. Sci. Bull. 45:2267-2272(2000) Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer." Iwao K., Watanabe T., Fujiwara Y., Takami K., Kodama K., Higashiyama M., Yokouchi H., Ozaki K., Monden M., Tanigami A. Int. J. Cancer 91:433-437(2001) [PubMed: 11251963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Lung.
[4]	"Isolation of nasopharynx-specific gene and nasopharyngeal carcinoma (NPC) susceptibility gene by suppression subtractive hybridization and cDNA microarray technique." Zhang B., Yu Y., Li G. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts." Di Y.-P., Harper R., Zhao Y., Pahlavan N., Finkbeiner W., Wu R. J. Biol. Chem. 278:1165-1173(2003) [PubMed: 12409287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION BY ATRA. Tissue: Tracheobronchial epithelium.
[6]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[8]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[11]	"Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight." Lindahl M., Stahlbom B., Tagesson C. Electrophoresis 22:1795-1800(2001) [PubMed: 11425234] [Abstract] Cited for: PROTEIN SEQUENCE OF 95-152; 157-167 AND 214-232, FUNCTION, SUBCELLULAR LOCATION.
[12]	"PLUNC in human nasal lavage fluid: multiple isoforms that bind to lipopolysaccharide." Ghafouri B., Kihlstroem E., Tagesson C., Lindahl M. Biochim. Biophys. Acta 1699:57-63(2004) [PubMed: 15158712] [Abstract] Cited for: PROTEIN SEQUENCE OF 95-102; 115-152 AND 157-167, BINDING TO LIPOPOLYSACCHARIDES, GLYCOSYLATION.
[13]	"Purification and characterization of PLUNC from human tracheobronchial secretions." Campos M.A., Abreu A.R., Nlend M.C., Cobas M.A., Conner G.E., Whitney P.L. Am. J. Respir. Cell Mol. Biol. 30:184-192(2004) [PubMed: 12920053] [Abstract] Cited for: PROTEIN SEQUENCE OF 110-121, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF214562 Genomic DNA. Translation: AAG13653.1. AF172993 mRNA. Translation: AAF70860.1. AF158745 mRNA. Translation: AAF82622.1. AB024937 mRNA. Translation: BAA93633.1. AF439448 mRNA. Translation: AAL87636.1. AF417256 mRNA. Translation: AAO12198.1. AF417257 mRNA. Translation: AAO12199.1. AF421369 Genomic DNA. Translation: AAO12200.1. AY359020 mRNA. Translation: AAQ89379.1. AK292778 mRNA. Translation: BAF85467.1. AL121901 Genomic DNA. Translation: CAC03549.1. CH471077 Genomic DNA. Translation: EAW76327.1. CH471077 Genomic DNA. Translation: EAW76328.1. CH471077 Genomic DNA. Translation: EAW76329.1. BC012549 mRNA. Translation: AAH12549.1.
IPI	IPI00009856.
RefSeq	NP_001230122.1. NM_001243193.1. NP_057667.1. NM_016583.3. NP_570913.1. NM_130852.2.
UniGene	Hs.211092.
3D structure databases
ProteinModelPortal	Q9NP55.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NP55. 2 interactions.
MINT	MINT-2873129.
STRING	Q9NP55.
Polymorphism databases
DMDM	17380173.
Proteomic databases
PeptideAtlas	Q9NP55.
PRIDE	Q9NP55.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354297; ENSP00000346251; ENSG00000198183. ENST00000375413; ENSP00000364562; ENSG00000198183. ENST00000375422; ENSP00000364571; ENSG00000198183.
GeneID	51297.
KEGG	hsa:51297.
UCSC	uc002wyt.2. human.
Organism-specific databases
CTD	51297.
GeneCards	GC20P031825.
H-InvDB	HIX0015733.
HGNC	HGNC:15749. BPIFA1.
HPA	CAB025669.
MIM	607412. gene.
neXtProt	NX_Q9NP55.
PharmGKB	PA33423.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05909.
GeneTree	ENSGT00530000063815.
HOGENOM	HBG126052.
HOVERGEN	HBG045573.
InParanoid	Q9NP55.
OMA	HSPGSLQ.
OrthoDB	EOG4FXR8V.
PhylomeDB	Q9NP55.
Gene expression databases
ArrayExpress	Q9NP55.
Bgee	Q9NP55.
CleanEx	HS_PLUNC.
Genevestigator	Q9NP55.
GermOnline	ENSG00000198183. Homo sapiens.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR017942. Lipid-bd_serum_glycop_N. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. [Graphical view]
SUPFAM	SSF55394. Bactericidal_perm-incr_a/b_dom. 1 hit.
ProtoNet	Search...
Other
NextBio	54581.
SOURCE	Search...

Entry information

Entry name

BPIA1_HUMAN

Accession

Primary (citable) accession number: Q9NP55
Secondary accession number(s): A8K9R3, E1P5M9, Q9NZT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.