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Protein

Protein FAM60A

Gene

FAM60A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway.2 Publications

GO - Biological processi

  • negative regulation of cell migration Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM60A
Alternative name(s):
Tera protein homolog
Gene namesi
Name:FAM60A
Synonyms:C12orf14
ORF Names:L4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30702. FAM60A.

Subcellular locationi

GO - Cellular componenti

  • Sin3 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921007.

Polymorphism and mutation databases

BioMutaiFAM60A.
DMDMi71151891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Protein FAM60APRO_0000187086Add
BLAST

Proteomic databases

EPDiQ9NP50.
MaxQBiQ9NP50.
PaxDbiQ9NP50.
PRIDEiQ9NP50.

PTM databases

iPTMnetiQ9NP50.
PhosphoSiteiQ9NP50.

Expressioni

Inductioni

Peaks during G1 and S phases of the cell cycle in U2OS cells. Up-regulated in squamous cell carcinoma (SCC), adenocarcinoma (AC), colon, ovary, rectum and stomach tumors.2 Publications

Gene expression databases

BgeeiQ9NP50.
CleanExiHS_FAM60A.
ExpressionAtlasiQ9NP50. baseline and differential.
GenevisibleiQ9NP50. HS.

Organism-specific databases

HPAiHPA038167.

Interactioni

Subunit structurei

Interacts with the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L and HDAC1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HDAC1Q135475EBI-741906,EBI-301834

Protein-protein interaction databases

BioGridi121842. 53 interactions.
IntActiQ9NP50. 6 interactions.
MINTiMINT-1446578.
STRINGi9606.ENSP00000337477.

Structurei

3D structure databases

ProteinModelPortaliQ9NP50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM60 family.Curated

Phylogenomic databases

eggNOGiENOG410IKPK. Eukaryota.
ENOG4111PRH. LUCA.
GeneTreeiENSGT00390000006485.
HOVERGENiHBG053413.
InParanoidiQ9NP50.
OMAiCCSNKKS.
OrthoDBiEOG75MVVX.
PhylomeDBiQ9NP50.
TreeFamiTF323911.

Family and domain databases

InterProiIPR026065. FAM60A.
[Graphical view]
PANTHERiPTHR13422. PTHR13422. 1 hit.
PfamiPF15396. FAM60A. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP50-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGFHKPKMY RSIEGCCICR AKSSSSRFTD SKRYEKDFQS CFGLHETRSG
60 70 80 90 100
DICNACVLLV KRWKKLPAGS KKNWNHVVDA RAGPSLKTTL KPKKVKTLSG
110 120 130 140 150
NRIKSNQISK LQKEFKRHNS DAHSTTSSAS PAQSPCYSNQ SDDGSDTEMA
160 170 180 190 200
SGSNRTPVFS FLDLTYWKRQ KICCGIIYKG RFGEVLIDTH LFKPCCSNKK
210 220
AAAEKPEEQG PEPLPISTQE W
Length:221
Mass (Da):24,852
Last modified:October 1, 2000 - v1
Checksum:iF5905C8AAC76AD45
GO
Isoform 2 (identifier: Q9NP50-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.

Show »
Length:73
Mass (Da):8,292
Checksum:i051702E1E409F11E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171R → H.
Corresponds to variant rs2304459 [ dbSNP | Ensembl ].
VAR_049027

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 148148Missing in isoform 2. 1 PublicationVSP_014705Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598323 mRNA. Translation: AAT06734.1.
AF087885 mRNA. Translation: AAP97184.1.
AF212220 mRNA. Translation: AAF87322.1.
AK026932 mRNA. Translation: BAB15592.1.
AL157432 mRNA. Translation: CAB75656.1.
AC024940 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88561.1.
CH471116 Genomic DNA. Translation: EAW88562.1.
CH471116 Genomic DNA. Translation: EAW88564.1.
CH471116 Genomic DNA. Translation: EAW88566.1.
CH471116 Genomic DNA. Translation: EAW88567.1.
BC000024 mRNA. Translation: AAH00024.1.
BC004462 mRNA. Translation: AAH04462.1.
BC071966 mRNA. Translation: AAH71966.1.
CCDSiCCDS8723.1. [Q9NP50-1]
PIRiT46918.
RefSeqiNP_001129283.1. NM_001135811.1. [Q9NP50-1]
NP_001129284.1. NM_001135812.1. [Q9NP50-1]
NP_067061.1. NM_021238.2. [Q9NP50-1]
XP_005253514.1. XM_005253457.3. [Q9NP50-1]
XP_005253515.1. XM_005253458.3. [Q9NP50-1]
XP_006725213.1. XM_006725150.2. [Q9NP50-1]
XP_006725214.1. XM_006725151.2. [Q9NP50-1]
UniGeneiHs.505154.

Genome annotation databases

EnsembliENST00000337682; ENSP00000337477; ENSG00000139146. [Q9NP50-1]
ENST00000454658; ENSP00000393279; ENSG00000139146. [Q9NP50-1]
ENST00000539409; ENSP00000443697; ENSG00000139146. [Q9NP50-2]
ENST00000542983; ENSP00000439952; ENSG00000139146. [Q9NP50-2]
ENST00000617411; ENSP00000479093; ENSG00000276371. [Q9NP50-1]
ENST00000631598; ENSP00000488852; ENSG00000276371. [Q9NP50-2]
ENST00000633702; ENSP00000488570; ENSG00000276371. [Q9NP50-1]
ENST00000633815; ENSP00000488406; ENSG00000276371. [Q9NP50-2]
GeneIDi58516.
KEGGihsa:58516.
UCSCiuc001rke.4. human. [Q9NP50-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598323 mRNA. Translation: AAT06734.1.
AF087885 mRNA. Translation: AAP97184.1.
AF212220 mRNA. Translation: AAF87322.1.
AK026932 mRNA. Translation: BAB15592.1.
AL157432 mRNA. Translation: CAB75656.1.
AC024940 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88561.1.
CH471116 Genomic DNA. Translation: EAW88562.1.
CH471116 Genomic DNA. Translation: EAW88564.1.
CH471116 Genomic DNA. Translation: EAW88566.1.
CH471116 Genomic DNA. Translation: EAW88567.1.
BC000024 mRNA. Translation: AAH00024.1.
BC004462 mRNA. Translation: AAH04462.1.
BC071966 mRNA. Translation: AAH71966.1.
CCDSiCCDS8723.1. [Q9NP50-1]
PIRiT46918.
RefSeqiNP_001129283.1. NM_001135811.1. [Q9NP50-1]
NP_001129284.1. NM_001135812.1. [Q9NP50-1]
NP_067061.1. NM_021238.2. [Q9NP50-1]
XP_005253514.1. XM_005253457.3. [Q9NP50-1]
XP_005253515.1. XM_005253458.3. [Q9NP50-1]
XP_006725213.1. XM_006725150.2. [Q9NP50-1]
XP_006725214.1. XM_006725151.2. [Q9NP50-1]
UniGeneiHs.505154.

3D structure databases

ProteinModelPortaliQ9NP50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121842. 53 interactions.
IntActiQ9NP50. 6 interactions.
MINTiMINT-1446578.
STRINGi9606.ENSP00000337477.

PTM databases

iPTMnetiQ9NP50.
PhosphoSiteiQ9NP50.

Polymorphism and mutation databases

BioMutaiFAM60A.
DMDMi71151891.

Proteomic databases

EPDiQ9NP50.
MaxQBiQ9NP50.
PaxDbiQ9NP50.
PRIDEiQ9NP50.

Protocols and materials databases

DNASUi58516.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337682; ENSP00000337477; ENSG00000139146. [Q9NP50-1]
ENST00000454658; ENSP00000393279; ENSG00000139146. [Q9NP50-1]
ENST00000539409; ENSP00000443697; ENSG00000139146. [Q9NP50-2]
ENST00000542983; ENSP00000439952; ENSG00000139146. [Q9NP50-2]
ENST00000617411; ENSP00000479093; ENSG00000276371. [Q9NP50-1]
ENST00000631598; ENSP00000488852; ENSG00000276371. [Q9NP50-2]
ENST00000633702; ENSP00000488570; ENSG00000276371. [Q9NP50-1]
ENST00000633815; ENSP00000488406; ENSG00000276371. [Q9NP50-2]
GeneIDi58516.
KEGGihsa:58516.
UCSCiuc001rke.4. human. [Q9NP50-1]

Organism-specific databases

CTDi58516.
GeneCardsiFAM60A.
HGNCiHGNC:30702. FAM60A.
HPAiHPA038167.
MIMi615027. gene.
neXtProtiNX_Q9NP50.
PharmGKBiPA134921007.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKPK. Eukaryota.
ENOG4111PRH. LUCA.
GeneTreeiENSGT00390000006485.
HOVERGENiHBG053413.
InParanoidiQ9NP50.
OMAiCCSNKKS.
OrthoDBiEOG75MVVX.
PhylomeDBiQ9NP50.
TreeFamiTF323911.

Miscellaneous databases

ChiTaRSiFAM60A. human.
GeneWikiiFAM60A.
GenomeRNAii58516.
NextBioi65062.
PROiQ9NP50.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NP50.
CleanExiHS_FAM60A.
ExpressionAtlasiQ9NP50. baseline and differential.
GenevisibleiQ9NP50. HS.

Family and domain databases

InterProiIPR026065. FAM60A.
[Graphical view]
PANTHERiPTHR13422. PTHR13422. 1 hit.
PfamiPF15396. FAM60A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
    Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
    Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
  2. "Cloning and expression of a new human cDNA homology to murine Tera mRNA."
    Zhou Y., Yu L., Dai F.Y., Li N.G., Zheng L.H., Zhap S.Y.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hepatoma.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Melanoma.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung, Lymph and Placenta.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. "Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex."
    Munoz I.M., Macartney T., Sanchez-Pulido L., Ponting C.P., Rocha S., Rouse J.
    J. Biol. Chem. 287:32346-32353(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SIN3/HDAC COMPLEX, INDUCTION, FUNCTION.
  11. "Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex."
    Smith K.T., Sardiu M.E., Martin-Brown S.A., Seidel C., Mushegian A., Egidy R., Florens L., Washburn M.P., Workman J.L.
    Mol. Cell. Proteomics 11:1815-1828(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SIN3/HDAC COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION.

Entry informationi

Entry nameiFA60A_HUMAN
AccessioniPrimary (citable) accession number: Q9NP50
Secondary accession number(s): D3DUV8, Q9BSZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: April 13, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.