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Q9NP10

- Q9NP10_HUMAN

UniProt

Q9NP10 - Q9NP10_HUMAN

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Protein
Submitted name:

IGF1 protein

Gene

IGF1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
IGF1 proteinImported
Gene namesi
Name:IGF1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 PotentialImportedAdd
BLAST
Chaini26 – 130105 PotentialImportedPRO_5000143246Add
BLAST
Chaini26 – 9570 PotentialImportedPRO_5000143247Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiQ9NP10.
ExpressionAtlasiQ9NP10. baseline and differential.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DSPX-ray2.50I26-95[»]
2DSQX-ray2.80C/I26-95[»]
ProteinModelPortaliQ9NP10.
SMRiQ9NP10. Positions 26-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

HOVERGENiHBG006137.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NP10-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHTMSSSHLF YLALCLLTFT SSATAGPETL CGAELVDALQ FVCGDRGFYF
60 70 80 90 100
NKPTGYGSSS RRAPQTGIVD ECCFRSCDLR RLEMYCAPLK PAKSARSVRA
110 120 130
QRHTDMPKTQ KEVHLKNASR GSAGNKNYRM
Length:130
Mass (Da):14,407
Last modified:October 1, 2000 - v1
Checksum:i970FBAAECFA0352D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29644 mRNA. Translation: AAA52543.1.
UniGeneiHs.160562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29644 mRNA. Translation: AAA52543.1 .
UniGenei Hs.160562.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DSP X-ray 2.50 I 26-95 [» ]
2DSQ X-ray 2.80 C/I 26-95 [» ]
ProteinModelPortali Q9NP10.
SMRi Q9NP10. Positions 26-95.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006137.

Miscellaneous databases

ChiTaRSi IGF1. human.

Gene expression databases

Bgeei Q9NP10.
ExpressionAtlasi Q9NP10. baseline and differential.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 2 hits.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Human insulin-like growth factor I and II messenger RNA: isolation of complementary DNA and analysis of expression."
    Rall L.B., Scott J., Bell G.I.
    Methods Enzymol. 146:239-248(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins."
    Sitar T., Popowicz G.M., Siwanowicz I., Huber R., Holak T.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:13028-13033(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 26-95.

Entry informationi

Entry nameiQ9NP10_HUMAN
AccessioniPrimary (citable) accession number: Q9NP10
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3