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Protein
Submitted name:

IGF1 protein

Gene

IGF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
IGF1 proteinImported
Gene namesi
Name:IGF1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Protein family/group databases

Allergomei11751. Hom s IGF-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 PotentialImportedAdd
BLAST
Chaini26 – 130105 PotentialImportedPRO_5000143246Add
BLAST
Chaini26 – 9570 PotentialImportedPRO_5000143247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 73Combined sources
Disulfide bondi43 ↔ 86Combined sources
Disulfide bondi72 ↔ 77Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiQ9NP10.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302665.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DSPX-ray2.50I26-95[»]
2DSQX-ray2.80C/I26-95[»]
ProteinModelPortaliQ9NP10.
SMRiQ9NP10. Positions 26-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

HOVERGENiHBG006137.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NP10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTMSSSHLF YLALCLLTFT SSATAGPETL CGAELVDALQ FVCGDRGFYF
60 70 80 90 100
NKPTGYGSSS RRAPQTGIVD ECCFRSCDLR RLEMYCAPLK PAKSARSVRA
110 120 130
QRHTDMPKTQ KEVHLKNASR GSAGNKNYRM
Length:130
Mass (Da):14,407
Last modified:October 1, 2000 - v1
Checksum:i970FBAAECFA0352D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29644 mRNA. Translation: AAA52543.1.
UniGeneiHs.160562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29644 mRNA. Translation: AAA52543.1.
UniGeneiHs.160562.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DSPX-ray2.50I26-95[»]
2DSQX-ray2.80C/I26-95[»]
ProteinModelPortaliQ9NP10.
SMRiQ9NP10. Positions 26-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302665.

Protein family/group databases

Allergomei11751. Hom s IGF-1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006137.

Miscellaneous databases

ChiTaRSiIGF1. human.

Gene expression databases

BgeeiQ9NP10.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Human insulin-like growth factor I and II messenger RNA: isolation of complementary DNA and analysis of expression."
    Rall L.B., Scott J., Bell G.I.
    Methods Enzymol. 146:239-248(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins."
    Sitar T., Popowicz G.M., Siwanowicz I., Huber R., Holak T.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:13028-13033(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 26-95, DISULFIDE BONDS.

Entry informationi

Entry nameiQ9NP10_HUMAN
AccessioniPrimary (citable) accession number: Q9NP10
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.