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Protein
Submitted name:

IGF1 protein

Gene

IGF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • positive regulation of glycoprotein biosynthetic process Source: AgBase
  • positive regulation of protein secretion Source: AgBase
  • protein stabilization Source: AgBase
  • proteoglycan biosynthetic process Source: AgBase

Names & Taxonomyi

Protein namesi
Submitted name:
IGF1 proteinImported
Gene namesi
Name:IGF1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Protein family/group databases

Allergomei11751. Hom s IGF-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500433074126 – 130Sequence analysisAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 73Combined sources
Disulfide bondi43 ↔ 86Combined sources
Disulfide bondi72 ↔ 77Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ9NP10.
PeptideAtlasiQ9NP10.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DSPX-ray2.50I26-95[»]
2DSQX-ray2.80C/I26-95[»]
ProteinModelPortaliQ9NP10.
SMRiQ9NP10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 86IlGFInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOVERGENiHBG006137.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF00049. Insulin. 2 hits.
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NP10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTMSSSHLF YLALCLLTFT SSATAGPETL CGAELVDALQ FVCGDRGFYF
60 70 80 90 100
NKPTGYGSSS RRAPQTGIVD ECCFRSCDLR RLEMYCAPLK PAKSARSVRA
110 120 130
QRHTDMPKTQ KEVHLKNASR GSAGNKNYRM
Length:130
Mass (Da):14,407
Last modified:October 1, 2000 - v1
Checksum:i970FBAAECFA0352D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29644 mRNA. Translation: AAA52543.1.
UniGeneiHs.160562.

Similar proteinsi

Entry informationi

Entry nameiQ9NP10_HUMAN
AccessioniPrimary (citable) accession number: Q9NP10
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources