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Q9NP10

- Q9NP10_HUMAN

UniProt

Q9NP10 - Q9NP10_HUMAN

Protein
Submitted name:

IGF1 protein

Gene

IGF1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Submitted name:
    IGF1 proteinImported
    Gene namesi
    Name:IGF1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Secreted UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525 PotentialImportedAdd
    BLAST
    Chaini26 – 130105 PotentialImportedPRO_5000143246Add
    BLAST
    Chaini26 – 9570 PotentialImportedPRO_5000143247Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NP10.
    BgeeiQ9NP10.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DSPX-ray2.50I26-95[»]
    2DSQX-ray2.80C/I26-95[»]
    ProteinModelPortaliQ9NP10.
    SMRiQ9NP10. Positions 26-95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    HOVERGENiHBG006137.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022341. IGF-I.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 2 hits.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02005. INSLNLIKEGF1.
    PR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NP10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHTMSSSHLF YLALCLLTFT SSATAGPETL CGAELVDALQ FVCGDRGFYF    50
    NKPTGYGSSS RRAPQTGIVD ECCFRSCDLR RLEMYCAPLK PAKSARSVRA 100
    QRHTDMPKTQ KEVHLKNASR GSAGNKNYRM 130
    Length:130
    Mass (Da):14,407
    Last modified:October 1, 2000 - v1
    Checksum:i970FBAAECFA0352D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29644 mRNA. Translation: AAA52543.1.
    UniGeneiHs.160562.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29644 mRNA. Translation: AAA52543.1 .
    UniGenei Hs.160562.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DSP X-ray 2.50 I 26-95 [» ]
    2DSQ X-ray 2.80 C/I 26-95 [» ]
    ProteinModelPortali Q9NP10.
    SMRi Q9NP10. Positions 26-95.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006137.

    Miscellaneous databases

    ChiTaRSi IGF1. human.

    Gene expression databases

    ArrayExpressi Q9NP10.
    Bgeei Q9NP10.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022341. IGF-I.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 2 hits.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02005. INSLNLIKEGF1.
    PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human insulin-like growth factor I and II messenger RNA: isolation of complementary DNA and analysis of expression."
      Rall L.B., Scott J., Bell G.I.
      Methods Enzymol. 146:239-248(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins."
      Sitar T., Popowicz G.M., Siwanowicz I., Huber R., Holak T.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:13028-13033(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 26-95.

    Entry informationi

    Entry nameiQ9NP10_HUMAN
    AccessioniPrimary (citable) accession number: Q9NP10
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3