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Protein
Submitted name:

IGF1 protein

Gene

IGF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • positive regulation of glycoprotein biosynthetic process Source: AgBase
  • positive regulation of protein secretion Source: AgBase
  • protein stabilization Source: AgBase
  • proteoglycan biosynthetic process Source: AgBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
IGF1 proteinImported
Gene namesi
Name:IGF1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Protein family/group databases

Allergomei11751. Hom s IGF-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 130105Sequence analysisPRO_5004330741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 73Combined sources
Disulfide bondi43 ↔ 86Combined sources
Disulfide bondi72 ↔ 77Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ9NP10.
PeptideAtlasiQ9NP10.

Expressioni

Gene expression databases

BgeeiQ9NP10.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302665.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DSPX-ray2.50I26-95[»]
2DSQX-ray2.80C/I26-95[»]
ProteinModelPortaliQ9NP10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 8659IlGFInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOVERGENiHBG006137.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NP10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTMSSSHLF YLALCLLTFT SSATAGPETL CGAELVDALQ FVCGDRGFYF
60 70 80 90 100
NKPTGYGSSS RRAPQTGIVD ECCFRSCDLR RLEMYCAPLK PAKSARSVRA
110 120 130
QRHTDMPKTQ KEVHLKNASR GSAGNKNYRM
Length:130
Mass (Da):14,407
Last modified:October 1, 2000 - v1
Checksum:i970FBAAECFA0352D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29644 mRNA. Translation: AAA52543.1.
UniGeneiHs.160562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29644 mRNA. Translation: AAA52543.1.
UniGeneiHs.160562.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DSPX-ray2.50I26-95[»]
2DSQX-ray2.80C/I26-95[»]
ProteinModelPortaliQ9NP10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302665.

Protein family/group databases

Allergomei11751. Hom s IGF-1.

Proteomic databases

PaxDbiQ9NP10.
PeptideAtlasiQ9NP10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOVERGENiHBG006137.

Miscellaneous databases

ChiTaRSiIGF1. human.

Gene expression databases

BgeeiQ9NP10.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Human insulin-like growth factor I and II messenger RNA: isolation of complementary DNA and analysis of expression."
    Rall L.B., Scott J., Bell G.I.
    Methods Enzymol. 146:239-248(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins."
    Sitar T., Popowicz G.M., Siwanowicz I., Huber R., Holak T.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:13028-13033(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 26-95, DISULFIDE BONDS.

Entry informationi

Entry nameiQ9NP10_HUMAN
AccessioniPrimary (citable) accession number: Q9NP10
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.