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Protein

Protamine-3

Gene

PRM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, DNA condensation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protamine-3
Alternative name(s):
Sperm protamine P3
Gene namesi
Name:PRM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13732. PRM3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33794.

Polymorphism and mutation databases

BioMutaiPRM3.
DMDMi74734290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103Protamine-3PRO_0000261158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NNZ6.
PeptideAtlasiQ9NNZ6.
PRIDEiQ9NNZ6.

PTM databases

PhosphoSiteiQ9NNZ6.

Expressioni

Gene expression databases

BgeeiENSG00000178257.
CleanExiHS_PRM3.
GenevisibleiQ9NNZ6. HS.

Organism-specific databases

HPAiHPA044152.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325638.

Structurei

3D structure databases

ProteinModelPortaliQ9NNZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 6717Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi74 – 774Poly-Leu

Sequence similaritiesi

Belongs to the protamine P3 family.Curated

Phylogenomic databases

eggNOGiENOG410JG0Q. Eukaryota.
ENOG41113QA. LUCA.
HOGENOMiHOG000246989.
HOVERGENiHBG082191.
InParanoidiQ9NNZ6.
OrthoDBiEOG091G19FN.
PhylomeDBiQ9NNZ6.

Family and domain databases

InterProiIPR026077. PRMP3.
[Graphical view]
PANTHERiPTHR14317. PTHR14317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NNZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRCAKLNT GQSPGHSPGH STGHGRGHES SMKKLMACVS QDNFSLSSAG
60 70 80 90 100
EEEEEEEEEG EEEEKEELPV QGKLLLLEPE RQEEGQKDNA EAQQSPEPKQ

TPS
Length:103
Mass (Da):11,232
Last modified:October 1, 2000 - v1
Checksum:iDB605870C7258601
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001Q → R.
Corresponds to variant rs429744 [ dbSNP | Ensembl ].
VAR_034414

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46940 Genomic DNA. Translation: CAB92526.1.
CCDSiCCDS76821.1.
UniGeneiHs.259636.

Genome annotation databases

EnsembliENST00000327157; ENSP00000325638; ENSG00000178257.
UCSCiuc002dat.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46940 Genomic DNA. Translation: CAB92526.1.
CCDSiCCDS76821.1.
UniGeneiHs.259636.

3D structure databases

ProteinModelPortaliQ9NNZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325638.

PTM databases

PhosphoSiteiQ9NNZ6.

Polymorphism and mutation databases

BioMutaiPRM3.
DMDMi74734290.

Proteomic databases

PaxDbiQ9NNZ6.
PeptideAtlasiQ9NNZ6.
PRIDEiQ9NNZ6.

Protocols and materials databases

DNASUi58531.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327157; ENSP00000325638; ENSG00000178257.
UCSCiuc002dat.3. human.

Organism-specific databases

GeneCardsiPRM3.
HGNCiHGNC:13732. PRM3.
HPAiHPA044152.
neXtProtiNX_Q9NNZ6.
PharmGKBiPA33794.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG0Q. Eukaryota.
ENOG41113QA. LUCA.
HOGENOMiHOG000246989.
HOVERGENiHBG082191.
InParanoidiQ9NNZ6.
OrthoDBiEOG091G19FN.
PhylomeDBiQ9NNZ6.

Miscellaneous databases

PROiQ9NNZ6.

Gene expression databases

BgeeiENSG00000178257.
CleanExiHS_PRM3.
GenevisibleiQ9NNZ6. HS.

Family and domain databases

InterProiIPR026077. PRMP3.
[Graphical view]
PANTHERiPTHR14317. PTHR14317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRM3_HUMAN
AccessioniPrimary (citable) accession number: Q9NNZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.