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Protein

DnaJ homolog subfamily C member 4

Gene

DNAJC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • protein folding Source: UniProtKB
  • response to unfolded protein Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 4
Alternative name(s):
DnaJ-like protein HSPF2
Multiple endocrine neoplasia type 1 candidate protein number 18
Gene namesi
Name:DNAJC4
Synonyms:HSPF2, MCG18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:5271. DNAJC4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei156 – 17520HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27421.

Polymorphism and mutation databases

BioMutaiDNAJC4.
DMDMi18203312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241DnaJ homolog subfamily C member 4PRO_0000071049Add
BLAST

Proteomic databases

PaxDbiQ9NNZ3.
PRIDEiQ9NNZ3.

PTM databases

PhosphoSiteiQ9NNZ3.

Expressioni

Gene expression databases

BgeeiQ9NNZ3.
CleanExiHS_DNAJC4.
ExpressionAtlasiQ9NNZ3. baseline and differential.
GenevisibleiQ9NNZ3. HS.

Organism-specific databases

HPAiHPA011947.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-4397791,EBI-466029

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109570. 3 interactions.
IntActiQ9NNZ3. 2 interactions.
STRINGi9606.ENSP00000396896.

Structurei

3D structure databases

ProteinModelPortaliQ9NNZ3.
SMRiQ9NNZ3. Positions 35-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 9966JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDCY. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00510000048574.
HOGENOMiHOG000112242.
HOVERGENiHBG051375.
InParanoidiQ9NNZ3.
KOiK09524.
OrthoDBiEOG7XSTFZ.
PhylomeDBiQ9NNZ3.
TreeFamiTF105163.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NNZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV
60 70 80 90 100
KRAFFSKSKE LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR
110 120 130 140 150
SGSPPKSPRT TVHDKSAHQT HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH
160 170 180 190 200
KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ MHLNFMDEKD RIITAFYNEA
210 220 230 240
RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG P
Length:241
Mass (Da):27,593
Last modified:October 1, 2000 - v1
Checksum:iEA186D2FA6C2E179
GO

Sequence cautioni

The sequence AAB82426.1 differs from that shown.Several sequence rearrangements.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036874 mRNA. Translation: AAF97845.1.
BC044584 mRNA. Translation: AAH44584.1.
BC057849 mRNA. Translation: AAH57849.1.
AF012106 mRNA. Translation: AAB82426.1. Sequence problems.
CCDSiCCDS41666.1.
PIRiJE0169.
RefSeqiNP_001294909.1. NM_001307980.1.
NP_001294910.1. NM_001307981.1.
NP_005519.2. NM_005528.3.
UniGeneiHs.172847.

Genome annotation databases

EnsembliENST00000321685; ENSP00000396896; ENSG00000110011.
GeneIDi3338.
KEGGihsa:3338.
UCSCiuc001nys.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036874 mRNA. Translation: AAF97845.1.
BC044584 mRNA. Translation: AAH44584.1.
BC057849 mRNA. Translation: AAH57849.1.
AF012106 mRNA. Translation: AAB82426.1. Sequence problems.
CCDSiCCDS41666.1.
PIRiJE0169.
RefSeqiNP_001294909.1. NM_001307980.1.
NP_001294910.1. NM_001307981.1.
NP_005519.2. NM_005528.3.
UniGeneiHs.172847.

3D structure databases

ProteinModelPortaliQ9NNZ3.
SMRiQ9NNZ3. Positions 35-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109570. 3 interactions.
IntActiQ9NNZ3. 2 interactions.
STRINGi9606.ENSP00000396896.

PTM databases

PhosphoSiteiQ9NNZ3.

Polymorphism and mutation databases

BioMutaiDNAJC4.
DMDMi18203312.

Proteomic databases

PaxDbiQ9NNZ3.
PRIDEiQ9NNZ3.

Protocols and materials databases

DNASUi3338.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321685; ENSP00000396896; ENSG00000110011.
GeneIDi3338.
KEGGihsa:3338.
UCSCiuc001nys.4. human.

Organism-specific databases

CTDi3338.
GeneCardsiDNAJC4.
HGNCiHGNC:5271. DNAJC4.
HPAiHPA011947.
MIMi604189. gene.
neXtProtiNX_Q9NNZ3.
PharmGKBiPA27421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDCY. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00510000048574.
HOGENOMiHOG000112242.
HOVERGENiHBG051375.
InParanoidiQ9NNZ3.
KOiK09524.
OrthoDBiEOG7XSTFZ.
PhylomeDBiQ9NNZ3.
TreeFamiTF105163.

Miscellaneous databases

ChiTaRSiDNAJC4. human.
GenomeRNAii3338.
NextBioi13212.
PROiQ9NNZ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NNZ3.
CleanExiHS_DNAJC4.
ExpressionAtlasiQ9NNZ3. baseline and differential.
GenevisibleiQ9NNZ3. HS.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterisation of a new human and murine member of the DnaJ family of proteins."
    Silins G., Grimmond S., Hayward N.
    Biochem. Biophys. Res. Commun. 243:273-276(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  3. "Identification and characterisation of a novel human Dnaj gene, HSPF2, mapping to chromosome 11q13."
    Lloyd S.E., Thakker R.V.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiDNJC4_HUMAN
AccessioniPrimary (citable) accession number: Q9NNZ3
Secondary accession number(s): O14716
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.