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Protein

DnaJ homolog subfamily C member 4

Gene

DNAJC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • protein folding Source: UniProtKB
  • response to unfolded protein Source: ProtInc

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 4
Alternative name(s):
DnaJ-like protein HSPF2
Multiple endocrine neoplasia type 1 candidate protein number 18
Gene namesi
Name:DNAJC4
Synonyms:HSPF2, MCG18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110011.13.
HGNCiHGNC:5271. DNAJC4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei156 – 175HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3338.
OpenTargetsiENSG00000110011.
PharmGKBiPA27421.

Polymorphism and mutation databases

BioMutaiDNAJC4.
DMDMi18203312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710491 – 241DnaJ homolog subfamily C member 4Add BLAST241

Proteomic databases

EPDiQ9NNZ3.
PaxDbiQ9NNZ3.
PRIDEiQ9NNZ3.

PTM databases

iPTMnetiQ9NNZ3.
PhosphoSitePlusiQ9NNZ3.

Expressioni

Gene expression databases

BgeeiENSG00000110011.
CleanExiHS_DNAJC4.
ExpressionAtlasiQ9NNZ3. baseline and differential.
GenevisibleiQ9NNZ3. HS.

Organism-specific databases

HPAiHPA011947.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-4397791,EBI-466029

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109570. 3 interactors.
IntActiQ9NNZ3. 2 interactors.
STRINGi9606.ENSP00000396896.

Structurei

3D structure databases

ProteinModelPortaliQ9NNZ3.
SMRiQ9NNZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 99JPROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDCY. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00510000048574.
HOGENOMiHOG000112242.
HOVERGENiHBG051375.
InParanoidiQ9NNZ3.
KOiK09524.
PhylomeDBiQ9NNZ3.
TreeFamiTF105163.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR036869. DnaJ_dom_sf.
IPR001623. DnaJ_domain.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiView protein in PROSITE
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NNZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV
60 70 80 90 100
KRAFFSKSKE LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR
110 120 130 140 150
SGSPPKSPRT TVHDKSAHQT HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH
160 170 180 190 200
KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ MHLNFMDEKD RIITAFYNEA
210 220 230 240
RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG P
Length:241
Mass (Da):27,593
Last modified:October 1, 2000 - v1
Checksum:iEA186D2FA6C2E179
GO

Sequence cautioni

The sequence AAB82426 differs from that shown. Several sequence rearrangements.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036874 mRNA. Translation: AAF97845.1.
BC044584 mRNA. Translation: AAH44584.1.
BC057849 mRNA. Translation: AAH57849.1.
AF012106 mRNA. Translation: AAB82426.1. Sequence problems.
CCDSiCCDS41666.1.
PIRiJE0169.
RefSeqiNP_001294909.1. NM_001307980.1.
NP_001294910.1. NM_001307981.1.
NP_005519.2. NM_005528.3.
UniGeneiHs.172847.

Genome annotation databases

EnsembliENST00000321685; ENSP00000396896; ENSG00000110011.
GeneIDi3338.
KEGGihsa:3338.
UCSCiuc001nys.4. human.

Similar proteinsi

Entry informationi

Entry nameiDNJC4_HUMAN
AccessioniPrimary (citable) accession number: Q9NNZ3
Secondary accession number(s): O14716
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot