Reviewed, UniProtKB/Swiss-Prot Q9NNZ3 (DNJC4_HUMAN)

Names and origin

Protein names

Recommended name:
    DnaJ homolog subfamily C member 4
Alternative name(s):
    Multiple endocrine neoplasia type 1 candidate protein number 18
    DnaJ-like protein HSPF2

Gene names

Name:	DNAJC4
Synonyms:	HSPF2, MCG18

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 J domain.
Sequence caution	The sequence AAB82426.1 differs from that shown. Reason: Miscellaneous discrepancy. Several sequence rearrangements.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Chaperone
Gene Ontology (GO)
Biological process	protein folding Ref.1 Non-traceable author statement. Source: UniProtKB response to unfolded protein Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane fraction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	DnaJ homolog subfamily C member 4		PRO_0000071049
Regions
	Transmembrane	156 – 175	20	Potential
	Domain	34 – 99	66	J

Sequences

	Sequence		Length	Mass (Da)
	Q9NNZ3-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: EA186D2FA6C2E179	FASTA	241	27,593
	10 20 30 40 50 60 MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE 70 80 90 100 110 120 LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT 130 140 150 160 170 180 HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ 190 200 210 220 230 240 MHLNFMDEKD RIITAFYNEA RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterisation of a new human and murine member of the DnaJ family of proteins." Silins G., Grimmond S., Hayward N. Biochem. Biophys. Res. Commun. 243:273-276(1998) [PubMed: 9473517] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Placenta.
[3]	"Identification and characterisation of a novel human Dnaj gene, HSPF2, mapping to chromosome 11q13." Lloyd S.E., Thakker R.V. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF036874 mRNA. Translation: AAF97845.1. BC044584 mRNA. Translation: AAH44584.1. BC057849 mRNA. Translation: AAH57849.1. AF012106 mRNA. Translation: AAB82426.1. Sequence problems.
IPI	IPI00328890.
PIR	JE0169.
RefSeq	NP_005519.2.
UniGene	Hs.172847
3D structure databases
HSSP	HSSP built from PDB template 1HDJ based on UniProtKB P25685.
ModBase	Search...
PTM databases
PhosphoSite	Q9NNZ3.
Proteomic databases
PRIDE	Q9NNZ3.
Genome annotation databases
Ensembl	ENSG00000110011. Homo sapiens. [Contig view]
GeneID	3338.
KEGG	hsa:3338.
Organism-specific databases
GeneCards	GC11P063754.
H-InvDB	HIX0009754.
HGNC	HGNC:5271. DNAJC4.
HPA	HPA011947.
MIM	604189. gene.
PharmGKB	PA27421.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9NNZ3.
HOVERGEN	Q9NNZ3.
OMA	Q9NNZ3. SAHQTHS.
Gene expression databases
ArrayExpress	Q9NNZ3.
Bgee	Q9NNZ3.
CleanEx	HS_DNAJC4.
GermOnline	ENSG00000110011. Homo sapiens.
Family and domain databases
InterPro	IPR001623. DnaJ_N. IPR018253. Heat_shock_DnaJ_CS. IPR015609. Hsp40/DnaJ_Rel. IPR003095. Hsp_DnaJ. [Graphical view]
Gene3D	G3DSA:1.10.287.110. DnaJ_N. 1 hit.
PANTHER	PTHR11821. Hsp40/DnaJ_Rel. 1 hit.
Pfam	PF00226. DnaJ. 1 hit. [Graphical view]
PRINTS	PR00625. DNAJPROTEIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
PROSITE	PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	13212.
SOURCE	Search...

Entry information

Entry name

DNJC4_HUMAN

Accession

Primary (citable) accession number: Q9NNZ3
Secondary accession number(s): O14716

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	October 1, 2000
Last modified:	May 26, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)