Q9NNX9 (VCX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Variable charge X-linked protein 3

Alternative name(s):
Variable charge protein on X with eight repeats
Short name=VCX-8r
Variably charged protein X-A
Short name=VCX-A

Gene names

Name:	VCX3A
Synonyms:	VCX3, VCX8R, VCXA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
Tissue specificity	Expressed exclusively in testis.
Sequence similarities	Belongs to the VCX/VCY family.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	brain development Inferred from mutant phenotype Ref.1. Source: UniProtKB
Cellular component	nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Variable charge X-linked protein 3		PRO_0000184661
Regions
	Repeat	104 – 113	10	1
	Repeat	114 – 123	10	2
	Repeat	124 – 133	10	3
	Repeat	134 – 143	10	4
	Repeat	144 – 153	10	5
	Repeat	154 – 163	10	6
	Repeat	164 – 173	10	7
	Repeat	174 – 183	10	8
	Region	104 – 183	80	8 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-P
	Compositional bias	82 – 186	105	Glu-rich
Experimental info
	Sequence conflict	108	1	S → A in AAF28173. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9NNX9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 8C9C5F66FB97EE9A	FASTA	186	20,020
	10 20 30 40 50 60 MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA 70 80 90 100 110 120 AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEL EEPLSQESEV 130 140 150 160 170 180 EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEM EELPSV

References

[1]	"A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation." Fukami M., Kirsch S., Schiller S., Richter A., Benes V., Franco B., Muroya K., Rao E., Merker S., Niesler B., Ballabio A., Ansorge W., Ogata T., Rappold G.A. Am. J. Hum. Genet. 67:563-573(2000) [PubMed: 10903929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins." Lahn B.T., Page D.C. Hum. Mol. Genet. 9:311-319(2000) [PubMed: 10607842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ243947 Genomic DNA. Translation: CAB56197.1. AF167078 mRNA. Translation: AAG41764.1. AF159128 mRNA. Translation: AAF28173.1.
IPI	IPI00292843.
RefSeq	NP_057463.2. NM_016379.3.
UniGene	Hs.170076. Hs.278906.
3D structure databases
ProteinModelPortal	Q9NNX9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NNX9.
Polymorphism databases
DMDM	17369277.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381089; ENSP00000370479; ENSG00000169059.
GeneID	51481.
KEGG	hsa:51481.
UCSC	uc004crs.1. human.
Organism-specific databases
CTD	51481.
GeneCards	GC0XM006461.
H-InvDB	HIX0056150. HIX0056154.
HGNC	HGNC:18159. VCX3A.
MIM	300229. gene.
neXtProt	NX_Q9NNX9.
PharmGKB	PA134936169.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00440000034745.
InParanoid	Q9NNX9.
OMA	VWTVEYF.
Gene expression databases
Bgee	Q9NNX9.
CleanEx	HS_VCX3A.
Genevestigator	Q9NNX9.
GermOnline	ENSG00000169059. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	55140.
SOURCE	Search...

Entry information

Entry name

VCX3_HUMAN

Accession

Primary (citable) accession number: Q9NNX9
Secondary accession number(s): Q9P0H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.