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Protein

Variable charge X-linked protein 3

Gene

VCX3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

GO - Biological processi

  • brain development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Variable charge X-linked protein 3
Alternative name(s):
Variable charge protein on X with eight repeats
Short name:
VCX-8r
Variably charged protein X-A
Short name:
VCX-A
Gene namesi
Name:VCX3A
Synonyms:VCX3, VCX8R, VCXA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18159. VCX3A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi51481.
OpenTargetsiENSG00000169059.
PharmGKBiPA134936169.

Polymorphism and mutation databases

BioMutaiVCX3A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846611 – 186Variable charge X-linked protein 3Add BLAST186

Proteomic databases

PaxDbiQ9NNX9.
PRIDEiQ9NNX9.

PTM databases

iPTMnetiQ9NNX9.
PhosphoSitePlusiQ9NNX9.

Expressioni

Tissue specificityi

Expressed exclusively in testis.

Gene expression databases

BgeeiENSG00000169059.
CleanExiHS_VCX3A.
ExpressionAtlasiQ9NNX9. baseline and differential.
GenevisibleiQ9NNX9. HS.

Organism-specific databases

HPAiHPA044996.
HPA049357.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370479.

Structurei

3D structure databases

ProteinModelPortaliQ9NNX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 113110
Repeati114 – 123210
Repeati124 – 133310
Repeati134 – 143410
Repeati144 – 153510
Repeati154 – 163610
Repeati164 – 173710
Repeati174 – 183810

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 1838 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-PAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 186Glu-richAdd BLAST105

Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9NNX9.
OMAiTQESQLE.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NNX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR
60 70 80 90 100
GKKGAATKMA AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ
110 120 130 140 150
HDPLSQESEL EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV
160 170 180
EEPLSQESEV EEPLSQESQV EEPLSQESEM EELPSV
Length:186
Mass (Da):20,020
Last modified:October 1, 2000 - v1
Checksum:i8C9C5F66FB97EE9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108S → A in AAF28173 (PubMed:10607842).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243947 Genomic DNA. Translation: CAB56197.1.
AF167078 mRNA. Translation: AAG41764.1.
AF159128 mRNA. Translation: AAF28173.1.
CCDSiCCDS35199.1.
RefSeqiNP_057463.2. NM_016379.3.
UniGeneiHs.170076.
Hs.278906.

Genome annotation databases

EnsembliENST00000381089; ENSP00000370479; ENSG00000169059.
GeneIDi51481.
KEGGihsa:51481.
UCSCiuc004crs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243947 Genomic DNA. Translation: CAB56197.1.
AF167078 mRNA. Translation: AAG41764.1.
AF159128 mRNA. Translation: AAF28173.1.
CCDSiCCDS35199.1.
RefSeqiNP_057463.2. NM_016379.3.
UniGeneiHs.170076.
Hs.278906.

3D structure databases

ProteinModelPortaliQ9NNX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370479.

PTM databases

iPTMnetiQ9NNX9.
PhosphoSitePlusiQ9NNX9.

Polymorphism and mutation databases

BioMutaiVCX3A.

Proteomic databases

PaxDbiQ9NNX9.
PRIDEiQ9NNX9.

Protocols and materials databases

DNASUi51481.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381089; ENSP00000370479; ENSG00000169059.
GeneIDi51481.
KEGGihsa:51481.
UCSCiuc004crs.3. human.

Organism-specific databases

CTDi51481.
DisGeNETi51481.
GeneCardsiVCX3A.
H-InvDBHIX0056154.
HGNCiHGNC:18159. VCX3A.
HPAiHPA044996.
HPA049357.
MIMi300533. gene.
neXtProtiNX_Q9NNX9.
OpenTargetsiENSG00000169059.
PharmGKBiPA134936169.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9NNX9.
OMAiTQESQLE.

Miscellaneous databases

GenomeRNAii51481.
PROiQ9NNX9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169059.
CleanExiHS_VCX3A.
ExpressionAtlasiQ9NNX9. baseline and differential.
GenevisibleiQ9NNX9. HS.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVCX3_HUMAN
AccessioniPrimary (citable) accession number: Q9NNX9
Secondary accession number(s): Q9P0H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.