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Protein

WD repeat-containing protein 6

Gene

WDR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.2 Publications

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • cell cycle arrest Source: UniProtKB
  • negative regulation of autophagy Source: BHF-UCL
  • negative regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

SignaLinkiQ9NNW5.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 6
Gene namesi
Name:WDR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12758. WDR6.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Colocalizes in the cytoplasm with STK11/LKB1.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37362.

Polymorphism and mutation databases

BioMutaiWDR6.
DMDMi12643813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11211121WD repeat-containing protein 6PRO_0000051352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NNW5.
PaxDbiQ9NNW5.
PRIDEiQ9NNW5.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9NNW5.
CleanExiHS_WDR6.
ExpressionAtlasiQ9NNW5. baseline and differential.
GenevestigatoriQ9NNW5.

Organism-specific databases

HPAiHPA042622.

Interactioni

Subunit structurei

Interacts with IRS4 (By similarity). Interacts with STK11/LKB1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN3P260453EBI-1568315,EBI-1047946
STK11Q158313EBI-1568315,EBI-306838

Protein-protein interaction databases

BioGridi116350. 20 interactions.
IntActiQ9NNW5. 16 interactions.
MINTiMINT-1441188.
STRINGi9606.ENSP00000378857.

Structurei

3D structure databases

ProteinModelPortaliQ9NNW5.
SMRiQ9NNW5. Positions 175-327, 1043-1077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati89 – 13042WD 1Add
BLAST
Repeati155 – 19743WD 2Add
BLAST
Repeati207 – 24640WD 3Add
BLAST
Repeati256 – 29439WD 4Add
BLAST
Repeati295 – 33541WD 5Add
BLAST
Repeati346 – 38439WD 6Add
BLAST
Repeati433 – 47543WD 7Add
BLAST
Repeati489 – 52840WD 8Add
BLAST
Repeati567 – 60539WD 9Add
BLAST
Repeati611 – 65040WD 10Add
BLAST
Repeati652 – 69241WD 11Add
BLAST
Repeati747 – 79347WD 12Add
BLAST
Repeati860 – 90142WD 13Add
BLAST
Repeati908 – 95447WD 14Add
BLAST
Repeati978 – 102043WD 15Add
BLAST
Repeati1043 – 108139WD 16Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR6 family.Curated
Contains 16 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG303025.
GeneTreeiENSGT00420000029923.
HOGENOMiHOG000008701.
HOVERGENiHBG004019.
InParanoidiQ9NNW5.
PhylomeDBiQ9NNW5.
TreeFamiTF313984.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR011043. Gal_Oxase/kelch_b-propeller.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 1 hit.
SSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NNW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALEDYVWP RATSELILLP VTGLECVGDR LLAGEGPDVL VYSLDFGGHL
60 70 80 90 100
RMIKRVQNLL GHYLIHGFRV RPEPNGDLDL EAMVAVFGSK GLRVVKISWG
110 120 130 140 150
QGHFWELWRS GLWNMSDWIW DARWLEGNIA LALGHNSVVL YDPVVGCILQ
160 170 180 190 200
EVPCTDRCTL SSACLIGDAW KELTIVAGAV SNQLLVWYPA TALADNKPVA
210 220 230 240 250
PDRRISGHVG IIFSMSYLES KGLLATASED RSVRIWKVGD LRVPGGRVQN
260 270 280 290 300
IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG
310 320 330 340 350
IRAIAAHERQ AWVITGGDDS GIRLWHLVGR GYRGLGVSAL CFKSRSRPGT
360 370 380 390 400
LKAVTLAGSW RLLAVTDTGA LYLYDVEVKC WEQLLEDKHF QSYCLLEAAP
410 420 430 440 450
GPEGFGLCAM ANGEGRVKVV PINTPTAAVD QTLFPGKVHS LSWALRGYEE
460 470 480 490 500
LLLLASGPGG VVACLEISAA PSGKAIFVKE RCRYLLPPSK QRWHTCSAFL
510 520 530 540 550
PPGDFLVCGD RRGSVLLFPS RPGLLKDPGV GGKARAGAGA PVVGSGSSGG
560 570 580 590 600
GNAFTGLGPV STLPSLHGKQ GVTSVTCHGG YVYTTGRDGA YYQLFVRDGQ
610 620 630 640 650
LQPVLRQKSC RGMNWLAGLR IVPDGSMVIL GFHANEFVVW NPRSHEKLHI
660 670 680 690 700
VNCGGGHRSW AFSDTEAAMA FAYLKDGDVM LYRALGGCTR PHVILREGLH
710 720 730 740 750
GREITCVKRV GTITLGPEYG VPSFMQPDDL EPGSEGPDLT DIVITCSEDT
760 770 780 790 800
TVCVLALPTT TGSAHALTAV CNHISSVRAV AVWGIGTPGG PQDPQPGLTA
810 820 830 840 850
HVVSAGGRAE MHCFSIMVTP DPSTPSRLAC HVMHLSSHRL DEYWDRQRNR
860 870 880 890 900
HRMVKVDPET RYMSLAVCEL DQPGLGPLVA AACSDGAVRL FLLQDSGRIL
910 920 930 940 950
QLLAETFHHK RCVLKVHSFT HEAPNQRRRL LLCSAATDGS LAFWDLTTML
960 970 980 990 1000
DHDSTVLEPP VDPGLPYRLG TPSLTLQAHS CGINSLHTLP TREGHHLVAS
1010 1020 1030 1040 1050
GSEDGSLHVF VLAVEMLQLE EAVGEAGLVP QLRVLEEYSV PCAHAAHVTG
1060 1070 1080 1090 1100
LKILSPSIMV SASIDQRLTF WRLGHGEPTF MNSTVFHVPD VADMDCWPVS
1110 1120
PEFGHRCALG GQGLEVYNWY D
Length:1,121
Mass (Da):121,725
Last modified:October 1, 2000 - v1
Checksum:i4E408D5D893FF005
GO

Sequence cautioni

The sequence BAG58164.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381D → N in BAG58164 (PubMed:14702039).Curated
Sequence conflicti545 – 5451S → R in BAG58164 (PubMed:14702039).Curated
Sequence conflicti651 – 6511V → I in BAG58164 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099100 mRNA. Translation: AAF80244.1.
AK295145 mRNA. Translation: BAG58164.1. Different initiation.
AC137630 Genomic DNA. No translation available.
BC101707 mRNA. Translation: AAI01708.1.
BC113467 mRNA. Translation: AAI13468.1.
AL133589 mRNA. Translation: CAB63730.1.
PIRiJC7329.
T43496.
RefSeqiNP_060501.3. NM_018031.3.
UniGeneiHs.654815.

Genome annotation databases

EnsembliENST00000608424; ENSP00000477389; ENSG00000178252.
GeneIDi11180.
KEGGihsa:11180.
UCSCiuc003cvj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099100 mRNA. Translation: AAF80244.1.
AK295145 mRNA. Translation: BAG58164.1. Different initiation.
AC137630 Genomic DNA. No translation available.
BC101707 mRNA. Translation: AAI01708.1.
BC113467 mRNA. Translation: AAI13468.1.
AL133589 mRNA. Translation: CAB63730.1.
PIRiJC7329.
T43496.
RefSeqiNP_060501.3. NM_018031.3.
UniGeneiHs.654815.

3D structure databases

ProteinModelPortaliQ9NNW5.
SMRiQ9NNW5. Positions 175-327, 1043-1077.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116350. 20 interactions.
IntActiQ9NNW5. 16 interactions.
MINTiMINT-1441188.
STRINGi9606.ENSP00000378857.

Polymorphism and mutation databases

BioMutaiWDR6.
DMDMi12643813.

Proteomic databases

MaxQBiQ9NNW5.
PaxDbiQ9NNW5.
PRIDEiQ9NNW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000608424; ENSP00000477389; ENSG00000178252.
GeneIDi11180.
KEGGihsa:11180.
UCSCiuc003cvj.2. human.

Organism-specific databases

CTDi11180.
GeneCardsiGC03P049044.
H-InvDBHIX0020752.
HGNCiHGNC:12758. WDR6.
HPAiHPA042622.
MIMi606031. gene.
neXtProtiNX_Q9NNW5.
PharmGKBiPA37362.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG303025.
GeneTreeiENSGT00420000029923.
HOGENOMiHOG000008701.
HOVERGENiHBG004019.
InParanoidiQ9NNW5.
PhylomeDBiQ9NNW5.
TreeFamiTF313984.

Enzyme and pathway databases

SignaLinkiQ9NNW5.

Miscellaneous databases

ChiTaRSiWDR6. human.
GeneWikiiWDR6.
GenomeRNAii11180.
NextBioi42543.
PROiQ9NNW5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NNW5.
CleanExiHS_WDR6.
ExpressionAtlasiQ9NNW5. baseline and differential.
GenevestigatoriQ9NNW5.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR011043. Gal_Oxase/kelch_b-propeller.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 1 hit.
SSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene."
    Li D., Burch P., Gonzalez O., Kashork C.D., Shaffer L.G., Bachinski L.L., Roberts R.
    Biochem. Biophys. Res. Commun. 274:117-123(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Heart atrium.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 618-1121.
    Tissue: Testis.
  6. "Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction."
    Xie X., Wang Z., Chen Y.
    Mol. Cell. Biochem. 301:115-122(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH STK11/LKB1, SUBCELLULAR LOCATION.
  7. "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."
    McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A.
    EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR6_HUMAN
AccessioniPrimary (citable) accession number: Q9NNW5
Secondary accession number(s): B4DHK2, Q3MIT1, Q9UF63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.