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Q9NNW5

- WDR6_HUMAN

UniProt

Q9NNW5 - WDR6_HUMAN

Protein

WD repeat-containing protein 6

Gene

WDR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.2 Publications

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle arrest Source: UniProtKB
    2. negative regulation of autophagy Source: BHF-UCL
    3. negative regulation of cell proliferation Source: UniProtKB

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    SignaLinkiQ9NNW5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 6
    Gene namesi
    Name:WDR6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:12758. WDR6.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Colocalizes in the cytoplasm with STK11/LKB1.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. plasma membrane Source: HPA
    3. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37362.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11211121WD repeat-containing protein 6PRO_0000051352Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9NNW5.
    PaxDbiQ9NNW5.
    PRIDEiQ9NNW5.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9NNW5.
    BgeeiQ9NNW5.
    CleanExiHS_WDR6.
    GenevestigatoriQ9NNW5.

    Organism-specific databases

    HPAiHPA042622.

    Interactioni

    Subunit structurei

    Interacts with IRS4 By similarity. Interacts with STK11/LKB1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    STK11Q158313EBI-1568315,EBI-306838

    Protein-protein interaction databases

    BioGridi116350. 15 interactions.
    IntActiQ9NNW5. 15 interactions.
    MINTiMINT-1441188.
    STRINGi9606.ENSP00000378857.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NNW5.
    SMRiQ9NNW5. Positions 119-146, 175-327, 489-522, 1044-1078.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati89 – 13042WD 1Add
    BLAST
    Repeati155 – 19743WD 2Add
    BLAST
    Repeati207 – 24640WD 3Add
    BLAST
    Repeati256 – 29439WD 4Add
    BLAST
    Repeati295 – 33541WD 5Add
    BLAST
    Repeati346 – 38439WD 6Add
    BLAST
    Repeati433 – 47543WD 7Add
    BLAST
    Repeati489 – 52840WD 8Add
    BLAST
    Repeati567 – 60539WD 9Add
    BLAST
    Repeati611 – 65040WD 10Add
    BLAST
    Repeati652 – 69241WD 11Add
    BLAST
    Repeati747 – 79347WD 12Add
    BLAST
    Repeati860 – 90142WD 13Add
    BLAST
    Repeati908 – 95447WD 14Add
    BLAST
    Repeati978 – 102043WD 15Add
    BLAST
    Repeati1043 – 108139WD 16Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat WDR6 family.Curated
    Contains 16 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG303025.
    HOGENOMiHOG000008701.
    HOVERGENiHBG004019.
    InParanoidiQ9NNW5.
    PhylomeDBiQ9NNW5.
    TreeFamiTF313984.

    Family and domain databases

    Gene3Di2.130.10.10. 5 hits.
    InterProiIPR011043. Gal_Oxase/kelch_b-propeller.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 4 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50965. SSF50965. 1 hit.
    SSF50978. SSF50978. 4 hits.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NNW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDALEDYVWP RATSELILLP VTGLECVGDR LLAGEGPDVL VYSLDFGGHL     50
    RMIKRVQNLL GHYLIHGFRV RPEPNGDLDL EAMVAVFGSK GLRVVKISWG 100
    QGHFWELWRS GLWNMSDWIW DARWLEGNIA LALGHNSVVL YDPVVGCILQ 150
    EVPCTDRCTL SSACLIGDAW KELTIVAGAV SNQLLVWYPA TALADNKPVA 200
    PDRRISGHVG IIFSMSYLES KGLLATASED RSVRIWKVGD LRVPGGRVQN 250
    IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG 300
    IRAIAAHERQ AWVITGGDDS GIRLWHLVGR GYRGLGVSAL CFKSRSRPGT 350
    LKAVTLAGSW RLLAVTDTGA LYLYDVEVKC WEQLLEDKHF QSYCLLEAAP 400
    GPEGFGLCAM ANGEGRVKVV PINTPTAAVD QTLFPGKVHS LSWALRGYEE 450
    LLLLASGPGG VVACLEISAA PSGKAIFVKE RCRYLLPPSK QRWHTCSAFL 500
    PPGDFLVCGD RRGSVLLFPS RPGLLKDPGV GGKARAGAGA PVVGSGSSGG 550
    GNAFTGLGPV STLPSLHGKQ GVTSVTCHGG YVYTTGRDGA YYQLFVRDGQ 600
    LQPVLRQKSC RGMNWLAGLR IVPDGSMVIL GFHANEFVVW NPRSHEKLHI 650
    VNCGGGHRSW AFSDTEAAMA FAYLKDGDVM LYRALGGCTR PHVILREGLH 700
    GREITCVKRV GTITLGPEYG VPSFMQPDDL EPGSEGPDLT DIVITCSEDT 750
    TVCVLALPTT TGSAHALTAV CNHISSVRAV AVWGIGTPGG PQDPQPGLTA 800
    HVVSAGGRAE MHCFSIMVTP DPSTPSRLAC HVMHLSSHRL DEYWDRQRNR 850
    HRMVKVDPET RYMSLAVCEL DQPGLGPLVA AACSDGAVRL FLLQDSGRIL 900
    QLLAETFHHK RCVLKVHSFT HEAPNQRRRL LLCSAATDGS LAFWDLTTML 950
    DHDSTVLEPP VDPGLPYRLG TPSLTLQAHS CGINSLHTLP TREGHHLVAS 1000
    GSEDGSLHVF VLAVEMLQLE EAVGEAGLVP QLRVLEEYSV PCAHAAHVTG 1050
    LKILSPSIMV SASIDQRLTF WRLGHGEPTF MNSTVFHVPD VADMDCWPVS 1100
    PEFGHRCALG GQGLEVYNWY D 1121
    Length:1,121
    Mass (Da):121,725
    Last modified:October 1, 2000 - v1
    Checksum:i4E408D5D893FF005
    GO

    Sequence cautioni

    The sequence BAG58164.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381D → N in BAG58164. (PubMed:14702039)Curated
    Sequence conflicti545 – 5451S → R in BAG58164. (PubMed:14702039)Curated
    Sequence conflicti651 – 6511V → I in BAG58164. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF099100 mRNA. Translation: AAF80244.1.
    AK295145 mRNA. Translation: BAG58164.1. Different initiation.
    AC137630 Genomic DNA. No translation available.
    BC101707 mRNA. Translation: AAI01708.1.
    BC113467 mRNA. Translation: AAI13468.1.
    AL133589 mRNA. Translation: CAB63730.1.
    PIRiJC7329.
    T43496.
    RefSeqiNP_060501.3. NM_018031.3.
    UniGeneiHs.654815.

    Genome annotation databases

    EnsembliENST00000608424; ENSP00000477389; ENSG00000178252.
    GeneIDi11180.
    KEGGihsa:11180.
    UCSCiuc003cvj.2. human.

    Polymorphism databases

    DMDMi12643813.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF099100 mRNA. Translation: AAF80244.1 .
    AK295145 mRNA. Translation: BAG58164.1 . Different initiation.
    AC137630 Genomic DNA. No translation available.
    BC101707 mRNA. Translation: AAI01708.1 .
    BC113467 mRNA. Translation: AAI13468.1 .
    AL133589 mRNA. Translation: CAB63730.1 .
    PIRi JC7329.
    T43496.
    RefSeqi NP_060501.3. NM_018031.3.
    UniGenei Hs.654815.

    3D structure databases

    ProteinModelPortali Q9NNW5.
    SMRi Q9NNW5. Positions 119-146, 175-327, 489-522, 1044-1078.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116350. 15 interactions.
    IntActi Q9NNW5. 15 interactions.
    MINTi MINT-1441188.
    STRINGi 9606.ENSP00000378857.

    Polymorphism databases

    DMDMi 12643813.

    Proteomic databases

    MaxQBi Q9NNW5.
    PaxDbi Q9NNW5.
    PRIDEi Q9NNW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000608424 ; ENSP00000477389 ; ENSG00000178252 .
    GeneIDi 11180.
    KEGGi hsa:11180.
    UCSCi uc003cvj.2. human.

    Organism-specific databases

    CTDi 11180.
    GeneCardsi GC03P049044.
    H-InvDB HIX0020752.
    HGNCi HGNC:12758. WDR6.
    HPAi HPA042622.
    MIMi 606031. gene.
    neXtProti NX_Q9NNW5.
    PharmGKBi PA37362.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303025.
    HOGENOMi HOG000008701.
    HOVERGENi HBG004019.
    InParanoidi Q9NNW5.
    PhylomeDBi Q9NNW5.
    TreeFami TF313984.

    Enzyme and pathway databases

    SignaLinki Q9NNW5.

    Miscellaneous databases

    ChiTaRSi WDR6. human.
    GeneWikii WDR6.
    GenomeRNAii 11180.
    NextBioi 42543.
    PROi Q9NNW5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NNW5.
    Bgeei Q9NNW5.
    CleanExi HS_WDR6.
    Genevestigatori Q9NNW5.

    Family and domain databases

    Gene3Di 2.130.10.10. 5 hits.
    InterProi IPR011043. Gal_Oxase/kelch_b-propeller.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 4 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50965. SSF50965. 1 hit.
    SSF50978. SSF50978. 4 hits.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene."
      Li D., Burch P., Gonzalez O., Kashork C.D., Shaffer L.G., Bachinski L.L., Roberts R.
      Biochem. Biophys. Res. Commun. 274:117-123(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Heart atrium.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 618-1121.
      Tissue: Testis.
    6. "Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction."
      Xie X., Wang Z., Chen Y.
      Mol. Cell. Biochem. 301:115-122(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH STK11/LKB1, SUBCELLULAR LOCATION.
    7. "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."
      McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A.
      EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWDR6_HUMAN
    AccessioniPrimary (citable) accession number: Q9NNW5
    Secondary accession number(s): B4DHK2, Q3MIT1, Q9UF63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3