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Q9NNW5 (WDR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat-containing protein 6
Gene names
Name:WDR6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1121 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy. Ref.6 Ref.7

Subunit structure

Interacts with IRS4 By similarity. Interacts with STK11/LKB1. Ref.6

Subcellular location

Cytoplasm. Note: Colocalizes in the cytoplasm with STK11/LKB1. Ref.6

Tissue specificity

Ubiquitous. Ref.1

Sequence similarities

Belongs to the WD repeat WDR6 family.

Contains 16 WD repeats.

Sequence caution

The sequence BAG58164.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

STK11Q158313EBI-1568315,EBI-306838

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11211121WD repeat-containing protein 6
PRO_0000051352

Regions

Repeat89 – 13042WD 1
Repeat155 – 19743WD 2
Repeat207 – 24640WD 3
Repeat256 – 29439WD 4
Repeat295 – 33541WD 5
Repeat346 – 38439WD 6
Repeat433 – 47543WD 7
Repeat489 – 52840WD 8
Repeat567 – 60539WD 9
Repeat611 – 65040WD 10
Repeat652 – 69241WD 11
Repeat747 – 79347WD 12
Repeat860 – 90142WD 13
Repeat908 – 95447WD 14
Repeat978 – 102043WD 15
Repeat1043 – 108139WD 16

Amino acid modifications

Modified residue11N-acetylmethionine Ref.8

Experimental info

Sequence conflict381D → N in BAG58164. Ref.2
Sequence conflict5451S → R in BAG58164. Ref.2
Sequence conflict6511V → I in BAG58164. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9NNW5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 4E408D5D893FF005

FASTA1,121121,725
        10         20         30         40         50         60 
MDALEDYVWP RATSELILLP VTGLECVGDR LLAGEGPDVL VYSLDFGGHL RMIKRVQNLL 

        70         80         90        100        110        120 
GHYLIHGFRV RPEPNGDLDL EAMVAVFGSK GLRVVKISWG QGHFWELWRS GLWNMSDWIW 

       130        140        150        160        170        180 
DARWLEGNIA LALGHNSVVL YDPVVGCILQ EVPCTDRCTL SSACLIGDAW KELTIVAGAV 

       190        200        210        220        230        240 
SNQLLVWYPA TALADNKPVA PDRRISGHVG IIFSMSYLES KGLLATASED RSVRIWKVGD 

       250        260        270        280        290        300 
LRVPGGRVQN IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG 

       310        320        330        340        350        360 
IRAIAAHERQ AWVITGGDDS GIRLWHLVGR GYRGLGVSAL CFKSRSRPGT LKAVTLAGSW 

       370        380        390        400        410        420 
RLLAVTDTGA LYLYDVEVKC WEQLLEDKHF QSYCLLEAAP GPEGFGLCAM ANGEGRVKVV 

       430        440        450        460        470        480 
PINTPTAAVD QTLFPGKVHS LSWALRGYEE LLLLASGPGG VVACLEISAA PSGKAIFVKE 

       490        500        510        520        530        540 
RCRYLLPPSK QRWHTCSAFL PPGDFLVCGD RRGSVLLFPS RPGLLKDPGV GGKARAGAGA 

       550        560        570        580        590        600 
PVVGSGSSGG GNAFTGLGPV STLPSLHGKQ GVTSVTCHGG YVYTTGRDGA YYQLFVRDGQ 

       610        620        630        640        650        660 
LQPVLRQKSC RGMNWLAGLR IVPDGSMVIL GFHANEFVVW NPRSHEKLHI VNCGGGHRSW 

       670        680        690        700        710        720 
AFSDTEAAMA FAYLKDGDVM LYRALGGCTR PHVILREGLH GREITCVKRV GTITLGPEYG 

       730        740        750        760        770        780 
VPSFMQPDDL EPGSEGPDLT DIVITCSEDT TVCVLALPTT TGSAHALTAV CNHISSVRAV 

       790        800        810        820        830        840 
AVWGIGTPGG PQDPQPGLTA HVVSAGGRAE MHCFSIMVTP DPSTPSRLAC HVMHLSSHRL 

       850        860        870        880        890        900 
DEYWDRQRNR HRMVKVDPET RYMSLAVCEL DQPGLGPLVA AACSDGAVRL FLLQDSGRIL 

       910        920        930        940        950        960 
QLLAETFHHK RCVLKVHSFT HEAPNQRRRL LLCSAATDGS LAFWDLTTML DHDSTVLEPP 

       970        980        990       1000       1010       1020 
VDPGLPYRLG TPSLTLQAHS CGINSLHTLP TREGHHLVAS GSEDGSLHVF VLAVEMLQLE 

      1030       1040       1050       1060       1070       1080 
EAVGEAGLVP QLRVLEEYSV PCAHAAHVTG LKILSPSIMV SASIDQRLTF WRLGHGEPTF 

      1090       1100       1110       1120 
MNSTVFHVPD VADMDCWPVS PEFGHRCALG GQGLEVYNWY D 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene."
Li D., Burch P., Gonzalez O., Kashork C.D., Shaffer L.G., Bachinski L.L., Roberts R.
Biochem. Biophys. Res. Commun. 274:117-123(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Heart atrium.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 618-1121.
Tissue: Testis.
[6]"Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction."
Xie X., Wang Z., Chen Y.
Mol. Cell. Biochem. 301:115-122(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH STK11/LKB1, SUBCELLULAR LOCATION.
[7]"Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."
McKnight N.C., Jefferies H.B., Alemu E.A., Saunders R.E., Howell M., Johansen T., Tooze S.A.
EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF099100 mRNA. Translation: AAF80244.1.
AK295145 mRNA. Translation: BAG58164.1. Different initiation.
AC137630 Genomic DNA. No translation available.
BC101707 mRNA. Translation: AAI01708.1.
BC113467 mRNA. Translation: AAI13468.1.
AL133589 mRNA. Translation: CAB63730.1.
PIRJC7329.
T43496.
RefSeqNP_060501.3. NM_018031.3.
UniGeneHs.654815.

3D structure databases

ProteinModelPortalQ9NNW5.
SMRQ9NNW5. Positions 119-146, 175-327, 489-522, 1044-1078.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116350. 17 interactions.
IntActQ9NNW5. 14 interactions.
MINTMINT-1441188.
STRING9606.ENSP00000378857.

Polymorphism databases

DMDM12643813.

Proteomic databases

MaxQBQ9NNW5.
PaxDbQ9NNW5.
PRIDEQ9NNW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000608424; ENSP00000477389; ENSG00000178252.
GeneID11180.
KEGGhsa:11180.
UCSCuc003cvj.2. human.

Organism-specific databases

CTD11180.
GeneCardsGC03P049044.
H-InvDBHIX0020752.
HGNCHGNC:12758. WDR6.
HPAHPA042622.
MIM606031. gene.
neXtProtNX_Q9NNW5.
PharmGKBPA37362.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303025.
HOGENOMHOG000008701.
HOVERGENHBG004019.
InParanoidQ9NNW5.
PhylomeDBQ9NNW5.
TreeFamTF313984.

Enzyme and pathway databases

SignaLinkQ9NNW5.

Gene expression databases

ArrayExpressQ9NNW5.
BgeeQ9NNW5.
CleanExHS_WDR6.
GenevestigatorQ9NNW5.

Family and domain databases

Gene3D2.130.10.10. 5 hits.
InterProIPR011043. Gal_Oxase/kelch_b-propeller.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 4 hits.
[Graphical view]
SMARTSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF50965. SSF50965. 1 hit.
SSF50978. SSF50978. 4 hits.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSWDR6. human.
GeneWikiWDR6.
GenomeRNAi11180.
NextBio42543.
PROQ9NNW5.
SOURCESearch...

Entry information

Entry nameWDR6_HUMAN
AccessionPrimary (citable) accession number: Q9NNW5
Secondary accession number(s): B4DHK2, Q3MIT1, Q9UF63
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM