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Protein

Endoplasmin homolog

Gene

grp94

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in late differentiation as well as in starvation response. When overexpressed, suppresses the ability to form normal fruiting bodies and impairs prespore differentiation as well as maturation into spores.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83ATPBy similarity1
Binding sitei127ATPBy similarity1
Binding sitei140ATPBy similarity1
Binding sitei173ATP; via amide nitrogenBy similarity1
Binding sitei426ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-6785807 Interleukin-4 and 13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmin homolog
Alternative name(s):
92 kDa phosphoprotein
Glucose-regulated protein 94 homolog
Short name:
GRP-94 homolog
Gene namesi
Name:grp94
ORF Names:DDB_G0280057
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280057 grp94

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • Golgi-associated vesicle Source: dictyBase

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000032769029 – 768Endoplasmin homologAdd BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi423N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9NKX1
PRIDEiQ9NKX1

Expressioni

Inductioni

Expression is greatly reduced following starvation.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0215015

Structurei

3D structure databases

ProteinModelPortaliQ9NKX1
SMRiQ9NKX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi765 – 768Prevents secretion from ERSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi260 – 315Glu-richAdd BLAST56
Compositional biasi283 – 287Poly-Thr5

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0020 Eukaryota
COG0326 LUCA
InParanoidiQ9NKX1
KOiK09487
PhylomeDBiQ9NKX1

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NKX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSITKIFLI LGLFAFLLVA FAPSSSVATV NLESDGYTEA EAKLIEEKGE
60 70 80 90 100
KFTFQTEVNK LMNIIINSLY SKKEIFLREL ISNASDALDK IRFLALTNAD
110 120 130 140 150
LLGEGEQSNL DIHIKIDKAN NVLHITDRGV GMTKDELVRN LGTIAQSGTK
160 170 180 190 200
EFIKKVSDSA ESSNLIGQFG VGFYSLFLVA DSVVVTSKSN DDDQYVWTSD
210 220 230 240 250
SQSSYTIAKD PKGNTLGRGT RISLHIKDDS KEFLDQEVIK QLVKKYSQFI
260 270 280 290 300
NFPIYLYVSE EVEIPKEEQE DSKPITDDQV EETTTTTEEG EEETTTEEEG
310 320 330 340 350
QTEEKKTKTV YKWEELNDSK PLWMKAAKDV TKEEYTEFFR SLSKTQDTPI
360 370 380 390 400
TYSHFKTEGD TEFRSILYIP ENPPSNMFDL EAAGSGLKLF VRRVFITDNL
410 420 430 440 450
KELVPNWLRF LVGVIDSDDL PLNVSREMLQ QNKILDAIKK KVILVKFISM
460 470 480 490 500
IKELSEDEDK TKYNEFFKKF GSSMKLGAIE DQANKKRLTK YLLFPSSKEE
510 520 530 540 550
LTTFAGYVER MKEGQDQIYF ITGKSKDSVE ASPLIEQAIK KGYEVLFLVD
560 570 580 590 600
PIDEYLVPQL DKFDDKYKFT NLARSGVKFN EDKEEEDQRK QTAEEFKPLL
610 620 630 640 650
SYLKKTLSDK LEKVVISKVL ADSPSILVSN SWGVTANQER IMKAQAHQAN
660 670 680 690 700
AQPQFNSKKI MEINPSHPLI KKLLNRLNEF GEEDETTKVS AHVLYETSAL
710 720 730 740 750
TAGYSIDNPT NFADFIYKLM MINGDSLAQT NFETTKNENS GPSVSFGDDD
760
ENQQQDFQQP PQSTHDEL
Length:768
Mass (Da):87,269
Last modified:April 29, 2008 - v2
Checksum:i7EB40FDDC56059E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309T → I in BAA94290 (PubMed:10913338).Curated1
Sequence conflicti444 – 445LV → G in EAL67255 (PubMed:15875012).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040814 mRNA Translation: BAA94290.2
AAFI02000035 Genomic DNA Translation: EAL67255.1
PIRiJC7352
RefSeqiXP_641313.1, XM_636221.1

Genome annotation databases

EnsemblProtistsiEAL67255; EAL67255; DDB_G0280057
GeneIDi8622445
KEGGiddi:DDB_G0280057

Similar proteinsi

Entry informationi

Entry nameiENPL_DICDI
AccessioniPrimary (citable) accession number: Q9NKX1
Secondary accession number(s): Q54VP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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