ID   Q9NJS1_ANOAL            Unreviewed;        83 AA.
AC   Q9NJS1;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   13-SEP-2023, entry version 79.
DE   SubName: Full=Salivary anti-thrombin peptide anophelin {ECO:0000313|EMBL:AAF29443.1, ECO:0000313|EnsemblMetazoa:AALB014019-PA};
GN   Name=AT {ECO:0000313|EMBL:AAF29443.1};
OS   Anopheles albimanus (New world malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7167 {ECO:0000313|EMBL:AAF29443.1};
RN   [1] {ECO:0000313|EMBL:AAF29443.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Santa Tecla {ECO:0000313|EMBL:AAF29443.1};
RC   TISSUE=Salivary gland {ECO:0000313|EMBL:AAF29443.1};
RX   PubMed=10460178; DOI=10.1021/bi990761i;
RA   Valenzuela J.G., Francischetti I.M., Ribeiro J.M.;
RT   "Purification, cloning, and synthesis of a novel salivary anti-thrombin
RT   from the mosquito Anopheles albimanus.";
RL   Biochemistry 38:11209-11215(1999).
RN   [2] {ECO:0007829|PDB:4E05, ECO:0007829|PDB:4E06}
RP   X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 23-83.
RX   PubMed=23223529; DOI=10.1073/pnas.1211614109;
RA   Figueiredo A.C., de Sanctis D., Gutierrez-Gallego R., Cereija T.B.,
RA   Macedo-Ribeiro S., Fuentes-Prior P., Pereira P.J.;
RT   "Unique thrombin inhibition mechanism by anophelin, an anticoagulant from
RT   the malaria vector.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E3649-E3658(2012).
RN   [3] {ECO:0000313|EMBL:AAF29443.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Santa Tecla {ECO:0000313|EMBL:AAF29443.1};
RC   TISSUE=Salivary gland {ECO:0000313|EMBL:AAF29443.1};
RA   Quirk P.G., Krulwich T.A.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EnsemblMetazoa:AALB014019-PA}
RP   IDENTIFICATION.
RC   STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB014019-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2023) to UniProtKB.
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DR   EMBL; AF125095; AAF29443.1; -; mRNA.
DR   PDB; 4E05; X-ray; 2.30 A; I=23-83.
DR   PDB; 4E06; X-ray; 3.20 A; I=23-83.
DR   PDBsum; 4E05; -.
DR   PDBsum; 4E06; -.
DR   AlphaFoldDB; Q9NJS1; -.
DR   SMR; Q9NJS1; -.
DR   MEROPS; I77.001; -.
DR   EnsemblMetazoa; AALB014019-RA; AALB014019-PA; AALB014019.
DR   VEuPathDB; VectorBase:AALB014019; -.
DR   VEuPathDB; VectorBase:AALB20_027800; -.
DR   OrthoDB; 5659707at2759; -.
DR   Proteomes; UP000069272; Chromosome 2L.
DR   GO; GO:0140678; F:molecular function inhibitor activity; EXP:DisProt.
DR   DisProt; DP00824; -.
DR   InterPro; IPR018932; Thrombin_inhibitor_anophelin.
DR   Pfam; PF10731; Anophelin; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4E05, ECO:0007829|PDB:4E06};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..83
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014589487"
FT   REGION          25..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          64..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   83 AA;  8862 MW;  E18F62275348EDC9 CRC64;
     MANKLVLISL LCVVLVAKIT QAAPQYAPGD EPSYDEDTDD SDKLVENDTS ITDEDYAAIE
     ASLSETFNTA ADPGRRLGEG SKP
//