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Protein

Hypoxanthine phosphoribosyltransferase

Gene

hgprt

Organism
Leishmania tarentolae (Sauroleishmania tarentolae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine phosphoribosyltransferase (hgprt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
Biological processPurine salvageUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

BRENDAi2.4.2.8. 2956.
SABIO-RKiQ9NJI5.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Gene namesi
Name:hgprtImported
OrganismiLeishmania tarentolae (Sauroleishmania tarentolae)Imported
Taxonomic identifieri5689 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmanializard Leishmania

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PZMX-ray2.10A/B1-188[»]
A/B190-210[»]
ProteinModelPortaliQ9NJI5.
SMRiQ9NJI5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NJI5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 175PribosyltranInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
InterProiView protein in InterPro
IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NJI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSVKSPSD HVGDVGRRNY PMSARTLVTQ EQVWAATAKC AKKIAADYKD
60 70 80 90 100
FHLTADNPLY LLCVLKGSFI FTADLARFLA DEGVPVKVEF ICASSYGSGV
110 120 130 140 150
ETSGQVRMLL DVRDSVENRH IMLVEDIVDS AITLQYLMRF MLAKKPASLK
160 170 180 190 200
TVVLLDKPSG RKVDVLVDYP VITIPHAFVI GYVWTFADLR GVPDICVLKK
210
EYYEKAESKL
Length:210
Mass (Da):23,397
Last modified:October 1, 2000 - v1
Checksum:i643042423F95054D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139722 Genomic DNA. Translation: AAF61462.1.

Similar proteinsi

Entry informationi

Entry nameiQ9NJI5_LEITA
AccessioniPrimary (citable) accession number: Q9NJI5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources