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Protein
Submitted name:

Hypoxanthine-guanine phosphoribosyltransferase

Gene

hgprt

Organism
Leishmania tarentolae (Sauroleishmania tarentolae)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BRENDAi2.4.2.8. 2956.
SABIO-RKQ9NJI5.

Names & Taxonomyi

Protein namesi
Submitted name:
Hypoxanthine-guanine phosphoribosyltransferaseImported
Gene namesi
Name:hgprtImported
OrganismiLeishmania tarentolae (Sauroleishmania tarentolae)Imported
Taxonomic identifieri5689 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmanializard Leishmania

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PZMX-ray2.10A/B1-210[»]
ProteinModelPortaliQ9NJI5.
SMRiQ9NJI5. Positions 20-201.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NJI5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 175136PribosyltranInterPro annotationAdd
BLAST

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NJI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSVKSPSD HVGDVGRRNY PMSARTLVTQ EQVWAATAKC AKKIAADYKD
60 70 80 90 100
FHLTADNPLY LLCVLKGSFI FTADLARFLA DEGVPVKVEF ICASSYGSGV
110 120 130 140 150
ETSGQVRMLL DVRDSVENRH IMLVEDIVDS AITLQYLMRF MLAKKPASLK
160 170 180 190 200
TVVLLDKPSG RKVDVLVDYP VITIPHAFVI GYVWTFADLR GVPDICVLKK
210
EYYEKAESKL
Length:210
Mass (Da):23,397
Last modified:October 1, 2000 - v1
Checksum:i643042423F95054D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139722 Genomic DNA. Translation: AAF61462.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139722 Genomic DNA. Translation: AAF61462.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PZMX-ray2.10A/B1-210[»]
ProteinModelPortaliQ9NJI5.
SMRiQ9NJI5. Positions 20-201.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.4.2.8. 2956.
SABIO-RKQ9NJI5.

Miscellaneous databases

EvolutionaryTraceiQ9NJI5.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning, expression and characterization of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase."
    Thiemann O.H., Juan A.D., Larry S., Glaucius O.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase."
    Monzani P.S., Trapani S., Thiemann O.H., Oliva G.
    BMC Struct. Biol. 7:59-59(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Entry informationi

Entry nameiQ9NJI5_LEITA
AccessioniPrimary (citable) accession number: Q9NJI5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.