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Q9NJG8 (Q9NJG8_LEIDO) Unreviewed, UniProtKB/TrEMBL

Last modified September 21, 2011. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
DNA topoisomerase I EMBL AAF73185.1
Gene names
Name:TOP1 EMBL AAF73185.1
OrganismLeishmania donovani donovani EMBL AAF73185.1
Taxonomic identifier99875 [NCBI]
Taxonomic lineageEukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania

Protein attributes

Sequence length949 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the eukaryotic type I topoisomerase family. RuleBase RU004406

Ontologies

Keywords
   Molecular functionIsomerase EMBL AAF73185.1
Gene Ontology (GO)
   Biological processDNA topological change

Inferred from electronic annotation. Source: InterPro

   Cellular componentchromosome

Inferred from electronic annotation. Source: InterPro

   Molecular functionDNA topoisomerase (ATP-hydrolyzing) activity

Inferred from electronic annotation. Source: InterPro

DNA topoisomerase type I activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q9NJG8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 65A4ACFE4A687B84

FASTA949109,572
        10         20         30         40         50         60 
MPLPGGGTEV LKGITLLTQH HGLKPVQPMS FCYLSFLNRH THEHHLRLHC CRPHAYARAH 

        70         80         90        100        110        120 
PCTCLIDFPL TSYPISQQCA PRLLPLPRQP PLSSQPAEAP SQIGTKDGLL LFRVSNRPQW 

       130        140        150        160        170        180 
VFCVCVCVRA CPSFPLPRSC DFNRRGAVSP LSSPPRRAPV CCWRFFFHSC SFFFLVLYLL 

       190        200        210        220        230        240 
SAPYFCSLWA RCANEEDKQN KLRIKQHETK KETPFRVCGG DCPSCCVGLS SHLFFPRWRL 

       250        260        270        280        290        300 
LVPPLPYTLD SNNSIFCVFH LFIYFLVCLF VSLAPSTYPF VPLCQLRTLH LYEPRPHIGT 

       310        320        330        340        350        360 
PLRCFCCHRD SIRRIMKVEN SKMGVKREQS HSNEDEEINE EDLNWWEQEN LRIAMKGERR 

       370        380        390        400        410        420 
WETLAHNGVL FPPEYEPHGI PIFYDGREFK MTPEEEEVAT MFAVMKEHDY YRMEVFRRNF 

       430        440        450        460        470        480 
FESWREILDK RQHPIRRLEL CDFEPIYQWH LVQREKKLSR TKEEKKAIKE KQDAEAEPYR 

       490        500        510        520        530        540 
YCVWDGRREQ VANFRVEPPG LFRGRGKHPL MGKLKVRVQP EDITINIGET AEVPVPPAGH 

       550        560        570        580        590        600 
KWAAVQHDHT VTWLAMWRDS VAGNMKYVML APSSSVKGQS DMVKFEKARK LKDKVDDIRA 

       610        620        630        640        650        660 
SYMEDFKSND LHVAQRAVAM YIDRLALRVG NEKGEDEADT VGCCSLRVEH IQLMPDNIVR 

       670        680        690        700        710        720 
FDFLGKDSIR YQNDVAVLPE VYALLQRFTR RKSPGMDIFD QLNPTQLNDH LKSFMDGLSA 

       730        740        750        760        770        780 
KVFRTYNASI TLDRWFKEKP VDPKWSTADK LAYFNKANTE VAILCNHQKS VSKNFKLQMM 

       790        800        810        820        830        840 
QLTTKSEYTR KTIELLEKAE VTAKKKSVEE AAKEFLEEQD RMQREWLESY GTEEQKKEFE 

       850        860        870        880        890        900 
EIVAKRAAPR VRSEKKKSTS GAKKAESASG KKRAAKKKKS AKKGGKMLSK KAASKSSKKA 

       910        920        930        940 
PKKLKEEDED DVPLVSVAAK TKKTAGVKRQ RANKVVSDDD DVPLAALRV

« Hide

References

[1]"Molecular cloning of DNA topoisomerase I gene from Leishmania donovani."
Dasgupta A., Das A., Sarkar S., Majumder H.K.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: D1700 EMBL AAF73185.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF150877 Genomic DNA. Translation: AAF73185.1.

3D structure databases

ProteinModelPortalQ9NJG8.
SMRQ9NJG8. Positions 342-770.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011010. DNA_brk_join_enz.
IPR013034. DNA_topo_domain1.
IPR001631. TopoI_C.
IPR013499. TopoI_C_euk.
IPR014711. TopoI_cat_a-hlx-sub_euk.
IPR014727. TopoI_cat_a/b-sub_euk.
IPR013500. TopoI_cat_euk.
IPR008336. TopoI_DNA-bd_euk.
IPR013030. TopoI_DNA-bd_mixed-a/b_euk.
[Graphical view]
Gene3DG3DSA:3.90.15.10. TopoI_cat_a-hlx-sub_euk. 1 hit.
G3DSA:1.10.132.10. TopoI_cat_a/b-sub_euk. 1 hit.
G3DSA:1.10.10.41. TopoI_DNA-bd_a-hlx_euk. 1 hit.
G3DSA:2.170.11.10. TopoI_DNA-bd_mixed-a/b_euk. 2 hits.
PfamPF01028. Topoisom_I. 1 hit.
PF02919. Topoisom_I_N. 1 hit.
[Graphical view]
PRINTSPR00416. EUTPISMRASEI.
SMARTSM00435. TOPEUc. 1 hit.
[Graphical view]
SUPFAMSSF56349. DNA_brk_join_enz. 1 hit.
SSF56741. TopoI_DNA_bd_euk. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9NJG8_LEIDO
AccessionPrimary (citable) accession number: Q9NJG8
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: September 21, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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