Q9NJA9 (MYSP_ANISI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Paramyosin

Alternative name(s):
Allergen=Ani s 2

Gene names

Name:

PARA

Organism

Anisakis simplex (Herring worm)

Taxonomic identifier

6269 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Ascaridida › Ascaridoidea › Anisakidae › Anisakis › Anisakis simplex complex

Protein attributes

Sequence length	869 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm › myofibril. Note: Thick filaments of the myofibrils.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE. A.simplex is a fish parasite that, when accidentally ingested by humans, may cause allergic reactions in sensitized individuals.
Sequence similarities	Belongs to the paramyosin family.

Ontologies

Keywords
Cellular component	Cytoplasm Thick filament
Disease	Allergen
Domain	Coiled coil
Molecular function	Motor protein Muscle protein Myosin
Gene Ontology (GO)
Cellular_component	myofibril Inferred from electronic annotation. Source: UniProtKB-SubCell myosin filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 869	869	Paramyosin		PRO_0000211242
Regions
	Region	1 – 31	31	Nonhelical region Potential
	Region	856 – 869	14	Nonhelical region Potential
	Coiled coil	32 – 855	824	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9NJA9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: EEC4A0446FAD4915	FASTA	869	100,461
	10 20 30 40 50 60 MSDTLYRSPS MAIRSSTADM GALTSMSVAD LGSLTRLEDK IRLLQDDFES ERELRNRIER 70 80 90 100 110 120 ERADLSVQLI ALTDRLQDAE CATDSQIESN RKREVELSKL RKLLEESQLE NEDAMNVLRK 130 140 150 160 170 180 KHQDVCLDYT EQIEQLQKKN SKIDRERQRL QHEVIELTAT IDQLQKDKHV AEKMAQKFEQ 190 200 210 220 230 240 QTIELSNKVE DLNKHVNDLA QQRQRLQAEN SDLLAEIHDQ KVQLDNLQHV KYQLAQQLEE 250 260 270 280 290 300 SRRRLEDAER ERSQMQAQLH QVQLELDSVR VALDEESAAR VEAEHKLSLA NTEITQWKSK 310 320 330 340 350 360 FDAEVALHHE EVEDLRKKMM QKQAEYEEQI EIMLQKVSQL EKAKARLQSE VEVLIVDLEK 370 380 390 400 410 420 AQNTIAILER AKEQLEKQVL EMKSRIDELL VELEAAQREA RAALAELQKM KQLYEKAVEQ 430 440 450 460 470 480 KEALARENKK LQDDLHEANE ALADANRKLH ELDLENARLA GEIRDLQVAL KESEAARRDA 490 500 510 520 530 540 EARAQRALAE LQQVRIEMER RLQEKEEEME ALRKSMQFEI DRLTAALADA EARMKAEIAR 550 560 570 580 590 600 LRKKYQAEIA ELEMTVDNLN RANLEAQKTI KKQSEQIIQL QANLEDTQRQ LQQTLDQYAL 610 620 630 640 650 660 AQRKISALSA ELEECKTALD NAIRARKQAE ADLEEAHVRI SDLTSINSNL TAIKNKLETE 670 680 690 700 710 720 LSTAQADLDE VTKELHAADE RANRALADAA RAVQELHEEQ EHSMKIDALR KSLEEQVKQL 730 740 750 760 770 780 QVQIQEAEAA ALLGGKRVIA KLETRIRDLE VALDEETRRH KETQSALRKK DRRIKEVQMQ 790 800 810 820 830 840 IDEEHKMFVM AQDTADRMLE KLNIQKRQLG EAEAMTMQNL QRVRRYQREL EDAEGRADQA 850 860 ESSLNLIRAK HRGTVAVGKA TDVYVVEED

References

[1]	"Molecular cloning of paramyosin, a new allergen of Anisakis simplex." Perez-Perez J., Fernandez-Caldas E., Maranon F., Sastre J., Bernal M.L., Rodriguez J., Bedate C.A. Int. Arch. Allergy Immunol. 123:120-129(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF173004 mRNA. Translation: AAF72796.1.
3D structure databases
ProteinModelPortal	Q9NJA9.
ModBase	Search...
Protein family/group databases
Allergome	3080. Ani s 2.0101. 36. Ani s 2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002928. Myosin_tail. [Graphical view]
Pfam	PF01576. Myosin_tail_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MYSP_ANISI

Accession

Primary (citable) accession number: Q9NJA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)