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Q9NJA9 (MYSP_ANISI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paramyosin
Alternative name(s):
Allergen=Ani s 2
Gene names
Name:PARA
OrganismAnisakis simplex (Herring worm)
Taxonomic identifier6269 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAnisakidaeAnisakisAnisakis simplex complex

Protein attributes

Sequence length869 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasmmyofibril. Note: Thick filaments of the myofibrils.

Allergenic properties

Causes an allergic reaction in human. Binds to IgE. A.simplex is a fish parasite that, when accidentally ingested by humans, may cause allergic reactions in sensitized individuals.

Sequence similarities

Belongs to the paramyosin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Thick filament
   DiseaseAllergen
   DomainCoiled coil
   Molecular functionMotor protein
Muscle protein
Myosin
Gene Ontology (GO)
   Cellular_componentmyofibril

Inferred from electronic annotation. Source: UniProtKB-SubCell

myosin filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmotor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 869869Paramyosin
PRO_0000211242

Regions

Region1 – 3131Nonhelical region Potential
Region856 – 86914Nonhelical region Potential
Coiled coil32 – 855824 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9NJA9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: EEC4A0446FAD4915

FASTA869100,461
        10         20         30         40         50         60 
MSDTLYRSPS MAIRSSTADM GALTSMSVAD LGSLTRLEDK IRLLQDDFES ERELRNRIER 

        70         80         90        100        110        120 
ERADLSVQLI ALTDRLQDAE CATDSQIESN RKREVELSKL RKLLEESQLE NEDAMNVLRK 

       130        140        150        160        170        180 
KHQDVCLDYT EQIEQLQKKN SKIDRERQRL QHEVIELTAT IDQLQKDKHV AEKMAQKFEQ 

       190        200        210        220        230        240 
QTIELSNKVE DLNKHVNDLA QQRQRLQAEN SDLLAEIHDQ KVQLDNLQHV KYQLAQQLEE 

       250        260        270        280        290        300 
SRRRLEDAER ERSQMQAQLH QVQLELDSVR VALDEESAAR VEAEHKLSLA NTEITQWKSK 

       310        320        330        340        350        360 
FDAEVALHHE EVEDLRKKMM QKQAEYEEQI EIMLQKVSQL EKAKARLQSE VEVLIVDLEK 

       370        380        390        400        410        420 
AQNTIAILER AKEQLEKQVL EMKSRIDELL VELEAAQREA RAALAELQKM KQLYEKAVEQ 

       430        440        450        460        470        480 
KEALARENKK LQDDLHEANE ALADANRKLH ELDLENARLA GEIRDLQVAL KESEAARRDA 

       490        500        510        520        530        540 
EARAQRALAE LQQVRIEMER RLQEKEEEME ALRKSMQFEI DRLTAALADA EARMKAEIAR 

       550        560        570        580        590        600 
LRKKYQAEIA ELEMTVDNLN RANLEAQKTI KKQSEQIIQL QANLEDTQRQ LQQTLDQYAL 

       610        620        630        640        650        660 
AQRKISALSA ELEECKTALD NAIRARKQAE ADLEEAHVRI SDLTSINSNL TAIKNKLETE 

       670        680        690        700        710        720 
LSTAQADLDE VTKELHAADE RANRALADAA RAVQELHEEQ EHSMKIDALR KSLEEQVKQL 

       730        740        750        760        770        780 
QVQIQEAEAA ALLGGKRVIA KLETRIRDLE VALDEETRRH KETQSALRKK DRRIKEVQMQ 

       790        800        810        820        830        840 
IDEEHKMFVM AQDTADRMLE KLNIQKRQLG EAEAMTMQNL QRVRRYQREL EDAEGRADQA 

       850        860 
ESSLNLIRAK HRGTVAVGKA TDVYVVEED 

« Hide

References

[1]"Molecular cloning of paramyosin, a new allergen of Anisakis simplex."
Perez-Perez J., Fernandez-Caldas E., Maranon F., Sastre J., Bernal M.L., Rodriguez J., Bedate C.A.
Int. Arch. Allergy Immunol. 123:120-129(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF173004 mRNA. Translation: AAF72796.1.

3D structure databases

ProteinModelPortalQ9NJA9.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3080. Ani s 2.0101.
36. Ani s 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002928. Myosin_tail.
[Graphical view]
PfamPF01576. Myosin_tail_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMYSP_ANISI
AccessionPrimary (citable) accession number: Q9NJA9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries