Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cardio acceleratory peptide 2b

Gene

Capa

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CAP-1 and CAP-2, but not CAP-3 are ligands for the Capa receptor (PubMed:12177421, PubMed:12459185). CAP-1 and CAP-2 are probably components of the signal transduction pathway that leads to Malpighian tubule fluid secretion via the second messenger nitric oxide (PubMed:11959669). CAP-3 is a ligand for the PK1-R G-protein coupled receptor (PubMed:16054112).4 Publications

GO - Molecular functioni

  • diuretic hormone activity Source: FlyBase
  • myostimulatory hormone activity Source: UniProtKB
  • neuropeptide hormone activity Source: UniProtKB
  • neuropeptide receptor binding Source: FlyBase
  • receptor binding Source: FlyBase

GO - Biological processi

  • cation transport Source: FlyBase
  • epithelial fluid transport Source: FlyBase
  • neuropeptide signaling pathway Source: FlyBase
  • nitric oxide-cGMP-mediated signaling pathway Source: FlyBase
  • positive regulation of cytosolic calcium ion concentration Source: FlyBase

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Cardio acceleratory peptide 2b
Alternative name(s):
Capability protein
Myotropin-CAP2b-like protein
Cleaved into the following 3 chains:
Alternative name(s):
CAP2b-1
Capa-1
Alternative name(s):
CAP2b-2
Capa-2
Alternative name(s):
CAP2b-3
Capa-3
Myotropin
Pyrokinin-1
Gene namesi
Name:Capa
Synonyms:MT-CAP2b
ORF Names:CG15520
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039722. Capa.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: FlyBase
  • intracellular Source: GOC

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002990122 – 287
PeptideiPRO_000002990231 – 42CAP-1Add BLAST12
PropeptideiPRO_000002990345 – 80Add BLAST36
PeptideiPRO_000002990483 – 92CAP-210
PropeptideiPRO_000002990595 – 113Add BLAST19
PeptideiPRO_0000029906116 – 130CAP-3Add BLAST15
PropeptideiPRO_0000029907134 – 151Add BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42Valine amide1 Publication1
Modified residuei92Valine amide1 Publication1
Modified residuei130Leucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9NIP6.
PRIDEiQ9NIP6.

Expressioni

Tissue specificityi

In larvae, the precursor peptide is exclusively present in a single pair of neuroendocrine cells in the labial neuromere (subesophageal ganglion) and three pairs of cells in the ventral ganglion abdominal neuromeres.1 Publication

Gene expression databases

BgeeiFBgn0039722.
ExpressionAtlasiQ9NIP6. differential.
GenevisibleiQ9NIP6. DM.

Interactioni

GO - Molecular functioni

  • diuretic hormone activity Source: FlyBase
  • myostimulatory hormone activity Source: UniProtKB
  • neuropeptide hormone activity Source: UniProtKB
  • neuropeptide receptor binding Source: FlyBase
  • receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi68398. 4 interactors.
DIPiDIP-22273N.
IntActiQ9NIP6. 1 interactor.
MINTiMINT-783841.
STRINGi7227.FBpp0084880.

Structurei

3D structure databases

ProteinModelPortaliQ9NIP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyrokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J786. Eukaryota.
ENOG410Y3PV. LUCA.
InParanoidiQ9NIP6.
OMAiYNEADFQ.
OrthoDBiEOG091G16SI.
PhylomeDBiQ9NIP6.

Family and domain databases

PROSITEiView protein in PROSITE
PS00539. PYROKININ. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NIP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSMLVHIVL VIFIIAEFST AETDHDKNRR GANMGLYAFP RVGRSDPSLA
60 70 80 90 100
NSLRDGLEAG VLDGIYGDAS QEDYNEADFQ KKASGLVAFP RVGRGDAELR
110 120 130 140 150
KWAHLLALQQ VLDKRTGPSA SSGLWFGPRL GKRSVDAKSF ADISKGQKEL

N
Length:151
Mass (Da):16,507
Last modified:October 1, 2000 - v1
Checksum:iF9E97535665B37E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203878 mRNA. Translation: AAF62876.1.
AJ291724 mRNA. Translation: CAC17603.1.
AE014297 Genomic DNA. Translation: AAF56969.2.
AY069234 mRNA. Translation: AAL39379.1.
RefSeqiNP_524552.1. NM_079828.3.
UniGeneiDm.2221.

Genome annotation databases

EnsemblMetazoaiFBtr0085514; FBpp0084880; FBgn0039722.
GeneIDi43541.
KEGGidme:Dmel_CG15520.

Similar proteinsi

Entry informationi

Entry nameiCP2B_DROME
AccessioniPrimary (citable) accession number: Q9NIP6
Secondary accession number(s): Q9VAE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: October 1, 2000
Last modified: July 5, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families