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Protein

Cardio acceleratory peptide 2b

Gene

Capa

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CAP-1 and CAP-2, but not CAP-3 are ligands for the Capa receptor (PubMed:12177421, PubMed:12459185). CAP-1 and CAP-2 are probably components of the signal transduction pathway that leads to Malpighian tubule fluid secretion via the second messenger nitric oxide (PubMed:11959669). CAP-3 is a ligand for the PK1-R G-protein coupled receptor (PubMed:16054112).4 Publications

GO - Molecular functioni

  • diuretic hormone activity Source: FlyBase
  • myostimulatory hormone activity Source: UniProtKB
  • neuropeptide hormone activity Source: UniProtKB
  • neuropeptide receptor binding Source: FlyBase
  • receptor binding Source: FlyBase

GO - Biological processi

  • cation transport Source: FlyBase
  • epithelial fluid transport Source: FlyBase
  • neuropeptide signaling pathway Source: FlyBase
  • nitric oxide-cGMP-mediated signaling pathway Source: FlyBase
  • positive regulation of cytosolic calcium ion concentration Source: FlyBase

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Cardio acceleratory peptide 2b
Alternative name(s):
Capability protein
Myotropin-CAP2b-like protein
Cleaved into the following 3 chains:
Alternative name(s):
CAP2b-1
Capa-1
Alternative name(s):
CAP2b-2
Capa-2
Alternative name(s):
CAP2b-3
Capa-3
Myotropin
Pyrokinin-1
Gene namesi
Name:Capa
Synonyms:MT-CAP2b
ORF Names:CG15520
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039722 Capa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002990122 – 287
PeptideiPRO_000002990231 – 42CAP-1Add BLAST12
PropeptideiPRO_000002990345 – 80Add BLAST36
PeptideiPRO_000002990483 – 92CAP-210
PropeptideiPRO_000002990595 – 113Add BLAST19
PeptideiPRO_0000029906116 – 130CAP-3Add BLAST15
PropeptideiPRO_0000029907134 – 151Add BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42Valine amide1 Publication1
Modified residuei92Valine amide1 Publication1
Modified residuei130Leucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9NIP6
PRIDEiQ9NIP6

Expressioni

Tissue specificityi

In larvae, the precursor peptide is exclusively present in a single pair of neuroendocrine cells in the labial neuromere (subesophageal ganglion) and three pairs of cells in the ventral ganglion abdominal neuromeres.1 Publication

Gene expression databases

BgeeiFBgn0039722
ExpressionAtlasiQ9NIP6 differential
GenevisibleiQ9NIP6 DM

Interactioni

GO - Molecular functioni

  • diuretic hormone activity Source: FlyBase
  • myostimulatory hormone activity Source: UniProtKB
  • neuropeptide hormone activity Source: UniProtKB
  • neuropeptide receptor binding Source: FlyBase
  • receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi68398, 4 interactors
DIPiDIP-22273N
IntActiQ9NIP6, 1 interactor
STRINGi7227.FBpp0084880

Structurei

3D structure databases

ProteinModelPortaliQ9NIP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyrokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J786 Eukaryota
ENOG410Y3PV LUCA
InParanoidiQ9NIP6
OMAiYNEADFQ
OrthoDBiEOG091G16SI
PhylomeDBiQ9NIP6

Family and domain databases

PROSITEiView protein in PROSITE
PS00539 PYROKININ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NIP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSMLVHIVL VIFIIAEFST AETDHDKNRR GANMGLYAFP RVGRSDPSLA
60 70 80 90 100
NSLRDGLEAG VLDGIYGDAS QEDYNEADFQ KKASGLVAFP RVGRGDAELR
110 120 130 140 150
KWAHLLALQQ VLDKRTGPSA SSGLWFGPRL GKRSVDAKSF ADISKGQKEL

N
Length:151
Mass (Da):16,507
Last modified:October 1, 2000 - v1
Checksum:iF9E97535665B37E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203878 mRNA Translation: AAF62876.1
AJ291724 mRNA Translation: CAC17603.1
AE014297 Genomic DNA Translation: AAF56969.2
AY069234 mRNA Translation: AAL39379.1
RefSeqiNP_524552.1, NM_079828.3
UniGeneiDm.2221

Genome annotation databases

EnsemblMetazoaiFBtr0085514; FBpp0084880; FBgn0039722
GeneIDi43541
KEGGidme:Dmel_CG15520

Similar proteinsi

Entry informationi

Entry nameiCP2B_DROME
AccessioniPrimary (citable) accession number: Q9NIP6
Secondary accession number(s): Q9VAE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health