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Q9NII5

- KAX16_MESMA

UniProt

Q9NII5 - KAX16_MESMA

Protein

Potassium channel toxin alpha-KTx 1.6

Gene
N/A
Organism
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Potent blocker of both large-conductance calcium-activated potassium channels (BKCa channels) and voltage-gated potassium channels (Kv1.3/KCNA3).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei48 – 481Basic residue of the functional dyadBy similarity
    Sitei57 – 571Aromatic residue of the functional dyadBy similarity

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 1.6
    Alternative name(s):
    BmTX2
    Neurotoxin TX2
    OrganismiMesobuthus martensii (Manchurian scorpion) (Buthus martensii)
    Taxonomic identifieri34649 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 5837Potassium channel toxin alpha-KTx 1.6PRO_0000035318Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221Pyrrolidone carboxylic acid
    Disulfide bondi28 ↔ 491 Publication
    Disulfide bondi34 ↔ 541 Publication
    Disulfide bondi38 ↔ 561 Publication

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    Secondary structure

    1
    58
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi23 – 275
    Helixi32 – 343
    Helixi35 – 417
    Beta strandi47 – 504
    Beta strandi53 – 564

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BMTNMR-A23-58[»]
    ProteinModelPortaliQ9NII5.
    SMRiQ9NII5. Positions 22-58.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NII5.

    Family & Domainsi

    Domaini

    Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view]
    PfamiPF00451. Toxin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00286. CHARYBDTOXIN.
    ProDomiPD003586. Scorpion_toxinS. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57095. SSF57095. 1 hit.
    PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NII5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISFLLLLA IVICSIGWTE AQFTNVSCSA SSQCWPVCKK LFGTYRGKCM   50
    NSKCRCYS 58
    Length:58
    Mass (Da):6,507
    Last modified:October 1, 2000 - v1
    Checksum:iF19AA7351B9708B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208300 Genomic DNA. Translation: AAF63972.1.
    AF151537 mRNA. Translation: AAQ13576.1.
    AF247058 Genomic DNA. Translation: AAK73518.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208300 Genomic DNA. Translation: AAF63972.1 .
    AF151537 mRNA. Translation: AAQ13576.1 .
    AF247058 Genomic DNA. Translation: AAK73518.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BMT NMR - A 23-58 [» ]
    ProteinModelPortali Q9NII5.
    SMRi Q9NII5. Positions 22-58.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q9NII5.

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view ]
    Pfami PF00451. Toxin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00286. CHARYBDTOXIN.
    ProDomi PD003586. Scorpion_toxinS. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of three novel toxins from the scorpion Buthus martensi Karsch that are active on potassium channels."
      Dai L., Wu J.-J., Gu Y.-H., Lan Z.-D., Ling M.-H., Chi C.-W.
      Biochem. J. 346:805-809(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular cloning and genomic organization of a K(+) channel toxin from the Chinese scorpion Buthus martensii Karsch."
      Zeng X.-C., Zhu Z.-H., Li W.-X., Zhu S.-Y., Peng F., Mao X., Liu H.
      Toxicon 39:407-410(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels."
      Romi-Lebrun R., Lebrun B., Martin-Eauclaire M.-F., Ishiguro M., Escoubas P., Wu F.Q., Hisada M., Pongs O., Nakajima T.
      Biochemistry 36:13473-13482(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-58, SYNTHESIS, CHARACTERIZATION.
    4. "Solution structure of two new toxins from the venom of the Chinese scorpion Buthus martensi Karsch blockers of potassium channels."
      Blanc E., Romi-Lebrun R., Bornet O., Nakajima T., Darbon H.
      Biochemistry 37:12412-12418(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 22-58, DISULFIDE BONDS.

    Entry informationi

    Entry nameiKAX16_MESMA
    AccessioniPrimary (citable) accession number: Q9NII5
    Secondary accession number(s): P58489
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3