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Q9NII5 (KAX16_MESMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 1.6
Alternative name(s):
BmTX2
Neurotoxin TX2
OrganismMesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Taxonomic identifier34649 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

Protein attributes

Sequence length58 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potent blocker of both large-conductance calcium-activated potassium channels (BKCa channels) and voltage-gated potassium channels (Kv1.3/KCNA3).

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.3
Chain22 – 5837Potassium channel toxin alpha-KTx 1.6
PRO_0000035318

Sites

Site481Basic residue of the functional dyad By similarity
Site571Aromatic residue of the functional dyad By similarity

Amino acid modifications

Modified residue221Pyrrolidone carboxylic acid
Disulfide bond28 ↔ 49 Ref.4
Disulfide bond34 ↔ 54 Ref.4
Disulfide bond38 ↔ 56 Ref.4

Secondary structure

.......... 58
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NII5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F19AA7351B9708B8

FASTA586,507
        10         20         30         40         50 
MKISFLLLLA IVICSIGWTE AQFTNVSCSA SSQCWPVCKK LFGTYRGKCM NSKCRCYS 

« Hide

References

[1]"Genomic organization of three novel toxins from the scorpion Buthus martensi Karsch that are active on potassium channels."
Dai L., Wu J.-J., Gu Y.-H., Lan Z.-D., Ling M.-H., Chi C.-W.
Biochem. J. 346:805-809(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning and genomic organization of a K(+) channel toxin from the Chinese scorpion Buthus martensii Karsch."
Zeng X.-C., Zhu Z.-H., Li W.-X., Zhu S.-Y., Peng F., Mao X., Liu H.
Toxicon 39:407-410(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels."
Romi-Lebrun R., Lebrun B., Martin-Eauclaire M.-F., Ishiguro M., Escoubas P., Wu F.Q., Hisada M., Pongs O., Nakajima T.
Biochemistry 36:13473-13482(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-58, SYNTHESIS, CHARACTERIZATION.
[4]"Solution structure of two new toxins from the venom of the Chinese scorpion Buthus martensi Karsch blockers of potassium channels."
Blanc E., Romi-Lebrun R., Bornet O., Nakajima T., Darbon H.
Biochemistry 37:12412-12418(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 22-58, DISULFIDE BONDS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF208300 Genomic DNA. Translation: AAF63972.1.
AF151537 mRNA. Translation: AAQ13576.1.
AF247058 Genomic DNA. Translation: AAK73518.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BMTNMR-A23-58[»]
ProteinModelPortalQ9NII5.
SMRQ9NII5. Positions 22-58.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9NII5.

Entry information

Entry nameKAX16_MESMA
AccessionPrimary (citable) accession number: Q9NII5
Secondary accession number(s): P58489
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references