Q9NII1 (ADAR_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Double-stranded RNA-specific editase Adar
EC=3.5.-.-

Alternative name(s):
Adenosine deaminase that act on RNA
Pre-mRNA adenosine deaminase
RNA-editing deaminase 1
RNA-editing enzyme 1
dADAR
dsRNA adenosine deaminase

Gene names

Name:	Adar
Synonyms:	hypnos-2
ORF Names:	CG12598

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	676 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets. Ref.1 Ref.2 Ref.7 Ref.8
Tissue specificity	Expressed in embryonic nervous system; late stage 13 sees ventral nerve cord expression which spreads to brain by stage 16. Expression is maintained through to adulthood. Ref.1 Ref.2 Ref.7
Developmental stage	Expressed throughout development, highest expression is during pupal stage. Isoforms A, C and D have lowest expression levels. Ref.1
Disruption phenotype	Adult flies are morphologically wild-type but exhibit extreme behavioral defects including temperature-sensitive paralysis, locomotor uncoordination, and tremors which increase in severity with age. Ref.7
Sequence similarities	Contains 1 A to I editase domain. Contains 2 DRBM (double-stranded RNA-binding) domains.
RNA editing	Edited at position 437. Partially edited. Editing is low in embryos and pupae and increases dramatically upon eclosion. Ref.1
Sequence caution	The sequence AAM50022.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	mRNA processing
Coding sequence diversity	Alternative initiation Alternative splicing RNA editing
Domain	Repeat
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenosine to inosine editing Inferred from direct assay Ref.1. Source: UniProtKB adult locomotory behavior Inferred from mutant phenotype Ref.7Ref.2. Source: FlyBase mRNA modification Inferred from direct assay. Source: FlyBase mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW regulation of membrane potential Inferred from mutant phenotype Ref.2. Source: FlyBase response to heat Inferred from mutant phenotype Ref.2. Source: FlyBase response to hypoxia Inferred from mutant phenotype Ref.2. Source: FlyBase response to oxidative stress Inferred from mutant phenotype Ref.2. Source: UniProtKB
Cellular component	intracellular Inferred by curator Ref.1. Source: UniProtKB
Molecular function	double-stranded RNA adenosine deaminase activity Inferred from direct assay Ref.1. Source: FlyBase double-stranded RNA binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing and alternative initiation. [Align] [Select]

Isoform C Ref.1 (identifier: Q9NII1-1)

Also known as: b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A Ref.1 (identifier: Q9NII1-2)

Also known as: a;

The sequence of this isoform differs from the canonical sequence as follows:
     154-191: GIENLSSSKMFEIIQTMLTEKLSNPTSLEQPTFCMSQN → D

Isoform B Ref.3 (identifier: Q9NII1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MKFDSRVMLNSANNNSPQH → MTLCRYSE
     154-191: GIENLSSSKMFEIIQTMLTEKLSNPTSLEQPTFCMSQN → D

Isoform D Ref.1 (identifier: Q9NII1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MKFDSRVMLNSANNNSPQH → MKFECFSLYCTVLK

Isoform F Ref.1 (identifier: Q9NII1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Isoform G Ref.1 (identifier: Q9NII1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     154-191: GIENLSSSKMFEIIQTMLTEKLSNPTSLEQPTFCMSQN → D

Isoform E (identifier: Q9NII1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Note: Produced by alternative initiation at Met-8 of isoform C.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 676	676	Double-stranded RNA-specific editase Adar Ref.1		PRO_0000004790
Regions
	Domain	61 – 127	67	DRBM 1
	Domain	197 – 272	76	DRBM 2
	Domain	348 – 672	325	A to I editase
Sites
	Active site	374	1	Proton donor By similarity UniProtKB P78563
	Metal binding	372	1	Zinc By similarity UniProtKB P78563
	Metal binding	430	1	Zinc By similarity UniProtKB P78563
	Metal binding	493	1	Zinc By similarity UniProtKB P78563
Natural variations
	Alternative sequence	1 – 28	28	Missing in isoform F and isoform G. Ref.1		VSP_051650
	Alternative sequence	1 – 19	19	MKFDS…NSPQH → MTLCRYSE in isoform B. Ref.3		VSP_051649
	Alternative sequence	1 – 19	19	MKFDS…NSPQH → MKFECFSLYCTVLK in isoform D. Ref.1		VSP_051648
	Alternative sequence	1 – 7	7	Missing in isoform E.		VSP_018700
	Alternative sequence	154 – 191	38	GIENL…CMSQN → D in isoform A, isoform B and isoform G. Ref.1 Ref.3		VSP_051651
	Natural variant	437	1	S → G in RNA edited version. Ref.1
Experimental info
	Sequence conflict	346	1	V → VSPQPAKHCETNYNAKPILD QV in CAA22774. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform C (b) [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 6570D16D25D1C9F4	FASTA	676	74,978
	10 20 30 40 50 60 MKFDSRVMLN SANNNSPQHP VSAPSDINMN GYNRKLPQKR GYEMPKYSDP KKKMCKERIP 70 80 90 100 110 120 QPKNTVAMLN ELRHGLIYKL ESQTGPVHAP LFTISVEVDG QKYLGQGRSK KVARIEAAAT 130 140 150 160 170 180 ALRSFIQFKD GAVLSPLKPA GNLDFTSDEH LENGIENLSS SKMFEIIQTM LTEKLSNPTS 190 200 210 220 230 240 LEQPTFCMSQ NVSKSAITVD GQKKVPDKGP VMLLYELFND VNFECINIDG AQNNCRFKMT 250 260 270 280 290 300 VTINEKKFDG TGPSKKTAKN AAAKAALASL CNISYSPMVV PQKNVPLPID DKSSSMELPQ 310 320 330 340 350 360 IHADTIGRLV LEKFMEVIKG QEAYSRRKVL AGIVMTENMN FCEAKVISVS TGTKCVSGEH 370 380 390 400 410 420 MSVNGAVLND SHAEIVSRRC LLKYLYAQLD LQCNQATAYQ SIFVRNTDGQ YPYKLKSGVH 430 440 450 460 470 480 FHLYINTAPC GDARIFSPHE NDTGVDKHPN RKARGQLRTK IESGEGTIPV KSSDGIQTWD 490 500 510 520 530 540 GVLQGQRLLT MSCSDKIARW NIVGIQGSLL SSIIEPVYLH SIVLGSLLHP EHMYRAVCGR 550 560 570 580 590 600 IEKSIQGLPP PYHLNKPRLA LVTSAEPRNQ AKAPNFGINW TIGDTELEVV NSLTGRTIGG 610 620 630 640 650 660 QVSRITKQAF FVKYGFLMAN LPGILVRKVT TDYGQTKANV KDYQIAKLEL FSAFKREDLG 670 SWLKKPIEQD EFGLAE
	Isoform A (a) [UniParc]. Checksum: B1FD5629F6836008	FASTA	639	70,832
	10 20 30 40 50 60 MKFDSRVMLN SANNNSPQHP VSAPSDINMN GYNRKLPQKR GYEMPKYSDP KKKMCKERIP 70 80 90 100 110 120 QPKNTVAMLN ELRHGLIYKL ESQTGPVHAP LFTISVEVDG QKYLGQGRSK KVARIEAAAT 130 140 150 160 170 180 ALRSFIQFKD GAVLSPLKPA GNLDFTSDEH LENDVSKSAI TVDGQKKVPD KGPVMLLYEL 190 200 210 220 230 240 FNDVNFECIN IDGAQNNCRF KMTVTINEKK FDGTGPSKKT AKNAAAKAAL ASLCNISYSP 250 260 270 280 290 300 MVVPQKNVPL PIDDKSSSME LPQIHADTIG RLVLEKFMEV IKGQEAYSRR KVLAGIVMTE 310 320 330 340 350 360 NMNFCEAKVI SVSTGTKCVS GEHMSVNGAV LNDSHAEIVS RRCLLKYLYA QLDLQCNQAT 370 380 390 400 410 420 AYQSIFVRNT DGQYPYKLKS GVHFHLYINT APCGDARIFS PHENDTGVDK HPNRKARGQL 430 440 450 460 470 480 RTKIESGEGT IPVKSSDGIQ TWDGVLQGQR LLTMSCSDKI ARWNIVGIQG SLLSSIIEPV 490 500 510 520 530 540 YLHSIVLGSL LHPEHMYRAV CGRIEKSIQG LPPPYHLNKP RLALVTSAEP RNQAKAPNFG 550 560 570 580 590 600 INWTIGDTEL EVVNSLTGRT IGGQVSRITK QAFFVKYGFL MANLPGILVR KVTTDYGQTK 610 620 630 ANVKDYQIAK LELFSAFKRE DLGSWLKKPI EQDEFGLAE
	Isoform B [UniParc]. Checksum: CAC6899EB4812A5E	FASTA	628	69,644
	10 20 30 40 50 60 MTLCRYSEPV SAPSDINMNG YNRKLPQKRG YEMPKYSDPK KKMCKERIPQ PKNTVAMLNE 70 80 90 100 110 120 LRHGLIYKLE SQTGPVHAPL FTISVEVDGQ KYLGQGRSKK VARIEAAATA LRSFIQFKDG 130 140 150 160 170 180 AVLSPLKPAG NLDFTSDEHL ENDVSKSAIT VDGQKKVPDK GPVMLLYELF NDVNFECINI 190 200 210 220 230 240 DGAQNNCRFK MTVTINEKKF DGTGPSKKTA KNAAAKAALA SLCNISYSPM VVPQKNVPLP 250 260 270 280 290 300 IDDKSSSMEL PQIHADTIGR LVLEKFMEVI KGQEAYSRRK VLAGIVMTEN MNFCEAKVIS 310 320 330 340 350 360 VSTGTKCVSG EHMSVNGAVL NDSHAEIVSR RCLLKYLYAQ LDLQCNQATA YQSIFVRNTD 370 380 390 400 410 420 GQYPYKLKSG VHFHLYINTA PCGDARIFSP HENDTGVDKH PNRKARGQLR TKIESGEGTI 430 440 450 460 470 480 PVKSSDGIQT WDGVLQGQRL LTMSCSDKIA RWNIVGIQGS LLSSIIEPVY LHSIVLGSLL 490 500 510 520 530 540 HPEHMYRAVC GRIEKSIQGL PPPYHLNKPR LALVTSAEPR NQAKAPNFGI NWTIGDTELE 550 560 570 580 590 600 VVNSLTGRTI GGQVSRITKQ AFFVKYGFLM ANLPGILVRK VTTDYGQTKA NVKDYQIAKL 610 620 ELFSAFKRED LGSWLKKPIE QDEFGLAE
	Isoform D [UniParc]. Checksum: 747B60F654D2DF83	FASTA	671	74,500
	10 20 30 40 50 60 MKFECFSLYC TVLKPVSAPS DINMNGYNRK LPQKRGYEMP KYSDPKKKMC KERIPQPKNT 70 80 90 100 110 120 VAMLNELRHG LIYKLESQTG PVHAPLFTIS VEVDGQKYLG QGRSKKVARI EAAATALRSF 130 140 150 160 170 180 IQFKDGAVLS PLKPAGNLDF TSDEHLENGI ENLSSSKMFE IIQTMLTEKL SNPTSLEQPT 190 200 210 220 230 240 FCMSQNVSKS AITVDGQKKV PDKGPVMLLY ELFNDVNFEC INIDGAQNNC RFKMTVTINE 250 260 270 280 290 300 KKFDGTGPSK KTAKNAAAKA ALASLCNISY SPMVVPQKNV PLPIDDKSSS MELPQIHADT 310 320 330 340 350 360 IGRLVLEKFM EVIKGQEAYS RRKVLAGIVM TENMNFCEAK VISVSTGTKC VSGEHMSVNG 370 380 390 400 410 420 AVLNDSHAEI VSRRCLLKYL YAQLDLQCNQ ATAYQSIFVR NTDGQYPYKL KSGVHFHLYI 430 440 450 460 470 480 NTAPCGDARI FSPHENDTGV DKHPNRKARG QLRTKIESGE GTIPVKSSDG IQTWDGVLQG 490 500 510 520 530 540 QRLLTMSCSD KIARWNIVGI QGSLLSSIIE PVYLHSIVLG SLLHPEHMYR AVCGRIEKSI 550 560 570 580 590 600 QGLPPPYHLN KPRLALVTSA EPRNQAKAPN FGINWTIGDT ELEVVNSLTG RTIGGQVSRI 610 620 630 640 650 660 TKQAFFVKYG FLMANLPGIL VRKVTTDYGQ TKANVKDYQI AKLELFSAFK REDLGSWLKK 670 PIEQDEFGLA E
	Isoform F [UniParc]. Checksum: BDD164B681DEFD22	FASTA	648	71,925
	10 20 30 40 50 60 MNGYNRKLPQ KRGYEMPKYS DPKKKMCKER IPQPKNTVAM LNELRHGLIY KLESQTGPVH 70 80 90 100 110 120 APLFTISVEV DGQKYLGQGR SKKVARIEAA ATALRSFIQF KDGAVLSPLK PAGNLDFTSD 130 140 150 160 170 180 EHLENGIENL SSSKMFEIIQ TMLTEKLSNP TSLEQPTFCM SQNVSKSAIT VDGQKKVPDK 190 200 210 220 230 240 GPVMLLYELF NDVNFECINI DGAQNNCRFK MTVTINEKKF DGTGPSKKTA KNAAAKAALA 250 260 270 280 290 300 SLCNISYSPM VVPQKNVPLP IDDKSSSMEL PQIHADTIGR LVLEKFMEVI KGQEAYSRRK 310 320 330 340 350 360 VLAGIVMTEN MNFCEAKVIS VSTGTKCVSG EHMSVNGAVL NDSHAEIVSR RCLLKYLYAQ 370 380 390 400 410 420 LDLQCNQATA YQSIFVRNTD GQYPYKLKSG VHFHLYINTA PCGDARIFSP HENDTGVDKH 430 440 450 460 470 480 PNRKARGQLR TKIESGEGTI PVKSSDGIQT WDGVLQGQRL LTMSCSDKIA RWNIVGIQGS 490 500 510 520 530 540 LLSSIIEPVY LHSIVLGSLL HPEHMYRAVC GRIEKSIQGL PPPYHLNKPR LALVTSAEPR 550 560 570 580 590 600 NQAKAPNFGI NWTIGDTELE VVNSLTGRTI GGQVSRITKQ AFFVKYGFLM ANLPGILVRK 610 620 630 640 VTTDYGQTKA NVKDYQIAKL ELFSAFKRED LGSWLKKPIE QDEFGLAE
	Isoform G [UniParc]. Checksum: 02201A647CD817BC	FASTA	611	67,779
	10 20 30 40 50 60 MNGYNRKLPQ KRGYEMPKYS DPKKKMCKER IPQPKNTVAM LNELRHGLIY KLESQTGPVH 70 80 90 100 110 120 APLFTISVEV DGQKYLGQGR SKKVARIEAA ATALRSFIQF KDGAVLSPLK PAGNLDFTSD 130 140 150 160 170 180 EHLENDVSKS AITVDGQKKV PDKGPVMLLY ELFNDVNFEC INIDGAQNNC RFKMTVTINE 190 200 210 220 230 240 KKFDGTGPSK KTAKNAAAKA ALASLCNISY SPMVVPQKNV PLPIDDKSSS MELPQIHADT 250 260 270 280 290 300 IGRLVLEKFM EVIKGQEAYS RRKVLAGIVM TENMNFCEAK VISVSTGTKC VSGEHMSVNG 310 320 330 340 350 360 AVLNDSHAEI VSRRCLLKYL YAQLDLQCNQ ATAYQSIFVR NTDGQYPYKL KSGVHFHLYI 370 380 390 400 410 420 NTAPCGDARI FSPHENDTGV DKHPNRKARG QLRTKIESGE GTIPVKSSDG IQTWDGVLQG 430 440 450 460 470 480 QRLLTMSCSD KIARWNIVGI QGSLLSSIIE PVYLHSIVLG SLLHPEHMYR AVCGRIEKSI 490 500 510 520 530 540 QGLPPPYHLN KPRLALVTSA EPRNQAKAPN FGINWTIGDT ELEVVNSLTG RTIGGQVSRI 550 560 570 580 590 600 TKQAFFVKYG FLMANLPGIL VRKVTTDYGQ TKANVKDYQI AKLELFSAFK REDLGSWLKK 610 PIEQDEFGLA E
	Isoform E [UniParc]. Checksum: 0D601A34987E3508	FASTA	669	74,114
	10 20 30 40 50 60 MLNSANNNSP QHPVSAPSDI NMNGYNRKLP QKRGYEMPKY SDPKKKMCKE RIPQPKNTVA 70 80 90 100 110 120 MLNELRHGLI YKLESQTGPV HAPLFTISVE VDGQKYLGQG RSKKVARIEA AATALRSFIQ 130 140 150 160 170 180 FKDGAVLSPL KPAGNLDFTS DEHLENGIEN LSSSKMFEII QTMLTEKLSN PTSLEQPTFC 190 200 210 220 230 240 MSQNVSKSAI TVDGQKKVPD KGPVMLLYEL FNDVNFECIN IDGAQNNCRF KMTVTINEKK 250 260 270 280 290 300 FDGTGPSKKT AKNAAAKAAL ASLCNISYSP MVVPQKNVPL PIDDKSSSME LPQIHADTIG 310 320 330 340 350 360 RLVLEKFMEV IKGQEAYSRR KVLAGIVMTE NMNFCEAKVI SVSTGTKCVS GEHMSVNGAV 370 380 390 400 410 420 LNDSHAEIVS RRCLLKYLYA QLDLQCNQAT AYQSIFVRNT DGQYPYKLKS GVHFHLYINT 430 440 450 460 470 480 APCGDARIFS PHENDTGVDK HPNRKARGQL RTKIESGEGT IPVKSSDGIQ TWDGVLQGQR 490 500 510 520 530 540 LLTMSCSDKI ARWNIVGIQG SLLSSIIEPV YLHSIVLGSL LHPEHMYRAV CGRIEKSIQG 550 560 570 580 590 600 LPPPYHLNKP RLALVTSAEP RNQAKAPNFG INWTIGDTEL EVVNSLTGRT IGGQVSRITK 610 620 630 640 650 660 QAFFVKYGFL MANLPGILVR KVTTDYGQTK ANVKDYQIAK LELFSAFKRE DLGSWLKKPI EQDEFGLAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing." Palladino M.J., Keegan L.P., O'Connell M.A., Reenan R.A. RNA 6:1004-1018(2000) [PubMed: 10917596] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A; C; D; E; F AND G), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, RNA EDITING OF POSITION 437. Strain: Canton-S.
[2]	"Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O(2) deprivation in Drosophila melanogaster." Ma E., Gu X.-Q., Wu X., Xu T., Haddad G.G. J. Clin. Invest. 107:685-693(2001) [PubMed: 11254668] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, TISSUE SPECIFICITY.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[5]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Oregon-R.
[6]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[7]	"A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity." Palladino M.J., Keegan L.P., O'Connell M.A., Reenan R.A. Cell 102:437-449(2000) [PubMed: 10966106] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[8]	"RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts." Peters N.T., Rohrbach J.A., Zalewski B.A., Byrkett C.M., Vaughn J.C. RNA 9:698-710(2003) [PubMed: 12756328] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF208535 Genomic DNA. Translation: AAF63702.1. AF208535 Genomic DNA. Translation: AAF63703.1. AF343579 mRNA. Translation: AAK26850.1. AE014298 Genomic DNA. Translation: AAF45665.2. AE014298 Genomic DNA. Translation: AAN09057.2. AL035207 Genomic DNA. Translation: CAA22774.1. AY118653 mRNA. Translation: AAM50022.1. Sequence problems.
RefSeq	NP_569940.2. NM_130584.2. NP_726761.2. NM_166903.1.
UniGene	Dm.5410.
3D structure databases
ProteinModelPortal	Q9NII1.
SMR	Q9NII1. Positions 23-277, 287-675.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NII1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	31130.
KEGG	dme:Dmel_CG12598.
Organism-specific databases
CTD	103.
FlyBase	FBgn0026086. Adar.
Phylogenomic databases
InParanoid	Q9NII1.
OrthoDB	EOG4VQ84C.
PhylomeDB	Q9NII1.
Gene expression databases
Bgee	Q9NII1.
Family and domain databases
InterPro	IPR002466. A_deamin. IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 2 hits.
Pfam	PF02137. A_deamin. 1 hit. PF00035. dsrm. 2 hits. [Graphical view]
SMART	SM00552. ADEAMc. 1 hit. SM00358. DSRM. 2 hits. [Graphical view]
PROSITE	PS50141. A_DEAMIN_EDITASE. 1 hit. PS50137. DS_RBD. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	772061.

Entry information

Entry name

ADAR_DROME

Accession

Primary (citable) accession number: Q9NII1
Secondary accession number(s): O96834 , Q8IRX2, Q8MSQ9, Q9BJ37, Q9NII2, Q9W562

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project