Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase cypE

Gene

cypE

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: dictyBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase cypE (EC:5.2.1.8)
Short name:
PPIase cypE
Alternative name(s):
Cyclophilin cypE
Rotamase cypE
Gene namesi
Name:cypE
ORF Names:DDB_G0269216
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269216. cypE.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytosol Source: dictyBase
  • nucleus Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Peptidyl-prolyl cis-trans isomerase cypEPRO_0000064170Add
BLAST

Proteomic databases

PaxDbiQ9NI62.
PRIDEiQ9NI62.

Interactioni

Subunit structurei

Interacts with snwA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
snwAP547055EBI-1810601,EBI-1810591

Protein-protein interaction databases

IntActiQ9NI62. 1 interaction.
STRINGi44689.DDB0191208.

Structurei

3D structure databases

ProteinModelPortaliQ9NI62.
SMRiQ9NI62. Positions 6-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 155154PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0881. Eukaryota.
COG0652. LUCA.
InParanoidiQ9NI62.
KOiK12733.
OMAiIELYWKH.
PhylomeDBiQ9NI62.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NI62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQTVTLQT TVGDITLELY YNHAPKACKN FYELSKRGYY DNTIFHRLIK
60 70 80 90 100
DFMIQGGDPL GNGRGGESIY GKKFEDEITK ELKHTGAGIL SMANSGVNSN
110 120 130 140 150
GSQFFITFGP TPWLDGKHTI FGRVKSGMKV VQKMNAMQTN NDKPIDEIRI

IKATAN
Length:156
Mass (Da):17,415
Last modified:October 1, 2000 - v1
Checksum:iD0E02E03DBA06DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215865 mRNA. Translation: AAF28343.2.
AAFI02000005 Genomic DNA. Translation: EAL71958.1.
RefSeqiXP_646239.1. XM_641147.1.

Genome annotation databases

EnsemblProtistsiDDB0191208; DDB0191208; DDB_G0269216.
GeneIDi8617195.
KEGGiddi:DDB_G0269216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215865 mRNA. Translation: AAF28343.2.
AAFI02000005 Genomic DNA. Translation: EAL71958.1.
RefSeqiXP_646239.1. XM_641147.1.

3D structure databases

ProteinModelPortaliQ9NI62.
SMRiQ9NI62. Positions 6-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NI62. 1 interaction.
STRINGi44689.DDB0191208.

Proteomic databases

PaxDbiQ9NI62.
PRIDEiQ9NI62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0191208; DDB0191208; DDB_G0269216.
GeneIDi8617195.
KEGGiddi:DDB_G0269216.

Organism-specific databases

dictyBaseiDDB_G0269216. cypE.

Phylogenomic databases

eggNOGiKOG0881. Eukaryota.
COG0652. LUCA.
InParanoidiQ9NI62.
KOiK12733.
OMAiIELYWKH.
PhylomeDBiQ9NI62.

Miscellaneous databases

PROiQ9NI62.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYPE_DICDI
AccessioniPrimary (citable) accession number: Q9NI62
Secondary accession number(s): Q55D92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.