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Q9NHV9

- VAV_DROME

UniProt

Q9NHV9 - VAV_DROME

Protein

Protein vav

Gene

Vav

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (11 Jul 2002)
      Previous versions | rss
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    Functioni

    Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases. Probably plays a pivotal role as a signal transducer protein during fruit fly development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri552 – 60150Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. Rac guanyl-nucleotide exchange factor activity Source: FlyBase

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: FlyBase
    2. actin filament organization Source: FlyBase
    3. activation of Rac GTPase activity Source: FlyBase
    4. axon guidance Source: FlyBase
    5. axonogenesis Source: FlyBase
    6. cell adhesion Source: FlyBase
    7. cell migration Source: FlyBase
    8. central nervous system development Source: FlyBase
    9. dorsal closure Source: FlyBase
    10. intracellular signal transduction Source: InterPro
    11. melanotic encapsulation of foreign target Source: FlyBase
    12. myoblast fusion Source: FlyBase
    13. open tracheal system development Source: FlyBase
    14. photoreceptor cell axon guidance Source: FlyBase
    15. regulation of cell shape Source: FlyBase

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_180243. Regulation of signaling by CBL.
    REACT_181514. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_184384. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_202927. Signal transduction by L1.
    REACT_213797. G alpha (12/13) signalling events.
    REACT_213859. Signaling by SCF-KIT.
    REACT_219214. GPVI-mediated activation cascade.
    REACT_85224. Interleukin-3, 5 and GM-CSF signaling.
    SignaLinkiQ9NHV9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein vav
    Short name:
    DroVav
    Short name:
    dVAV
    Gene namesi
    Name:Vav
    ORF Names:CG7893
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0040068. Vav.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 793793Protein vavPRO_0000080983Add
    BLAST

    Post-translational modificationi

    Phosphorylated on tyrosine residues.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9NHV9.
    PRIDEiQ9NHV9.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Developmental stagei

    Expressed both maternally and zygotically in all stages of development.1 Publication

    Gene expression databases

    BgeeiQ9NHV9.

    Interactioni

    Subunit structurei

    Interacts (via SH2 domain) with Egfr (when phosphorylated on tyrosine residues).1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NHV9.
    SMRiQ9NHV9. Positions 12-601, 618-787.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 136119CHPROSITE-ProRule annotationAdd
    BLAST
    Domaini216 – 396181DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini432 – 541110PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini622 – 726105SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini726 – 78863SH3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri552 – 60150Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG326494.
    GeneTreeiENSGT00740000115307.
    InParanoidiQ9NHV9.
    KOiK05730.
    OrthoDBiEOG78SQH7.
    PhylomeDBiQ9NHV9.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR001715. CH-domain.
    IPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF00307. CH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00017. SH2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 1 hit.
    SM00033. CH. 1 hit.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50021. CH. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q9NHV9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSSSSNSF GGVAGVNGDL WRECVAWLTR CKVIPPDHKA AQPDAEIRIL    50
    AMTLRDGVLL CNLVIHLDPS SLDPREFNRK PQMAQFLCSK NIKLFLDVCH 100
    NNFGIRDADL FEPTMLYDLT NFHRVLITLS KLSQCRKVQQ LHPDLIGFNL 150
    QLSPTERSHS DEAIYKDLHS TTTDNIACNG TGYDHTNTKE EEVYQDLCAL 200
    HRTSRSQTAS STSFEQRDYV IRELIDTESN YLDVLTALKT KFMGPLERHL 250
    NQDELRLIFP RIRELVDIHT KFLDKLRESL TPNAKVKMAQ VFLDFREPFL 300
    IYGEFCSLLL GAIDYLADVC KKNQIIDQLV QKCERDYNVG KLQLRDILSV 350
    PMQRILKYHL LLDKLVKETS PLHDDYRSLE RAKEAMIDVS QYINEVKRDS 400
    DHLVIIQKVK DSICDIHLLQ NGNGSDLLQY GRLLLDGELH IKAHEDQKTK 450
    LRYAFVFDKI LIMVKALHIK TGDMQYTYRD SHNLADYRVE QSHSRRTIGR 500
    DTRFKYQLLL ARKSGKTAFT LYLKSEHERD KWRKALTEAM ESLEPPGCQS 550
    TDHKMEIYTF DAPTTCRHCS KFLKGRIHQG YRCKVCQISV HKGCISSTGR 600
    CKQNPVSVPP PVCDRQLSEF NWFAGNMDRE TAAHRLENRR IGTYLLRVRP 650
    QGPSTAHETM YALSLKTDDN VIKHMKINQE NSGDSMLYCL SSRRHFKTIV 700
    ELVSYYERND LGENFAGLNQ SLQWPYKEVI ATALYDYEPK AGSNQLQLRT 750
    DCQVLVIGKD GDSKGWWRGK IGDTVGYFPK EYVQEQKLAS EEL 793
    Length:793
    Mass (Da):91,355
    Last modified:July 11, 2002 - v2
    Checksum:i1031929FE4FB8BF3
    GO
    Isoform B (identifier: Q9NHV9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-171: MASSSSSNSF...EAIYKDLHST → MRRMRASRRP...LPSRRRPNPS

    Note: No experimental confirmation available.

    Show »
    Length:766
    Mass (Da):88,953
    Checksum:iA53E704D4DEEF085
    GO

    Sequence cautioni

    The sequence AAM12266.1 differs from that shown. Reason:

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531T → M in AAF28765. (PubMed:10781813)Curated
    Sequence conflicti148 – 1481F → L in AAF28765. (PubMed:10781813)Curated
    Sequence conflicti372 – 3721L → M in AAF28765. (PubMed:10781813)Curated
    Sequence conflicti503 – 5031R → E in AAF28765. (PubMed:10781813)Curated
    Sequence conflicti645 – 66420LLRVR…MYALS → PVASSSAGPIHCPRDDVCAY in AAF28765. (PubMed:10781813)CuratedAdd
    BLAST
    Sequence conflicti739 – 7391P → Q in AAF28765. (PubMed:10781813)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 171171MASSS…DLHST → MRRMRASRRPCFPTARAAMC ASYPSISPWMWLAPRRMPHP MRSHPRRNRMPANRNHRWPP QRQAFLCPLHRGHLWAVWCP PPPHRRRFWSARASGCSERP PPSTTTAPRWRPPSTSMPTS TARTTRRSTRICATLPSRRR PNPS in isoform B. 1 PublicationVSP_027801Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218780 mRNA. Translation: AAF28765.1.
    AE014298 Genomic DNA. Translation: AAF48943.3.
    AE014298 Genomic DNA. Translation: AAN09485.1.
    AY069536 mRNA. Translation: AAL39681.1.
    AY095173 mRNA. Translation: AAM12266.1. Sequence problems.
    BT029984 mRNA. Translation: ABM92858.1.
    RefSeqiNP_573372.1. NM_133144.4. [Q9NHV9-1]
    NP_728235.1. NM_167642.3. [Q9NHV9-1]
    UniGeneiDm.218.

    Genome annotation databases

    EnsemblMetazoaiFBtr0074677; FBpp0074448; FBgn0040068. [Q9NHV9-1]
    FBtr0074678; FBpp0074449; FBgn0040068. [Q9NHV9-1]
    GeneIDi32920.
    KEGGidme:Dmel_CG7893.
    UCSCiCG7893-RA. d. melanogaster. [Q9NHV9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218780 mRNA. Translation: AAF28765.1 .
    AE014298 Genomic DNA. Translation: AAF48943.3 .
    AE014298 Genomic DNA. Translation: AAN09485.1 .
    AY069536 mRNA. Translation: AAL39681.1 .
    AY095173 mRNA. Translation: AAM12266.1 . Sequence problems.
    BT029984 mRNA. Translation: ABM92858.1 .
    RefSeqi NP_573372.1. NM_133144.4. [Q9NHV9-1 ]
    NP_728235.1. NM_167642.3. [Q9NHV9-1 ]
    UniGenei Dm.218.

    3D structure databases

    ProteinModelPortali Q9NHV9.
    SMRi Q9NHV9. Positions 12-601, 618-787.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9NHV9.
    PRIDEi Q9NHV9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0074677 ; FBpp0074448 ; FBgn0040068 . [Q9NHV9-1 ]
    FBtr0074678 ; FBpp0074449 ; FBgn0040068 . [Q9NHV9-1 ]
    GeneIDi 32920.
    KEGGi dme:Dmel_CG7893.
    UCSCi CG7893-RA. d. melanogaster. [Q9NHV9-1 ]

    Organism-specific databases

    CTDi 32920.
    FlyBasei FBgn0040068. Vav.

    Phylogenomic databases

    eggNOGi NOG326494.
    GeneTreei ENSGT00740000115307.
    InParanoidi Q9NHV9.
    KOi K05730.
    OrthoDBi EOG78SQH7.
    PhylomeDBi Q9NHV9.

    Enzyme and pathway databases

    Reactomei REACT_180243. Regulation of signaling by CBL.
    REACT_181514. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_184384. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_202927. Signal transduction by L1.
    REACT_213797. G alpha (12/13) signalling events.
    REACT_213859. Signaling by SCF-KIT.
    REACT_219214. GPVI-mediated activation cascade.
    REACT_85224. Interleukin-3, 5 and GM-CSF signaling.
    SignaLinki Q9NHV9.

    Miscellaneous databases

    GenomeRNAii 32920.
    NextBioi 781038.

    Gene expression databases

    Bgeei Q9NHV9.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR001715. CH-domain.
    IPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF00307. CH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00017. SH2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 1 hit.
    SM00033. CH. 1 hit.
    SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50021. CH. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav."
      Dekel I., Russek N., Jones T., Mortin M.A., Katzav S.
      FEBS Lett. 472:99-104(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), PROBABLE FUNCTION, INTERACTION WITH EGFR, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, PHOSPHORYLATION.
      Tissue: Embryo.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Strain: Berkeley.
      Tissue: Embryo.
    5. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Strain: Berkeley.
      Tissue: Head, Larva and Pupae.

    Entry informationi

    Entry nameiVAV_DROME
    AccessioniPrimary (citable) accession number: Q9NHV9
    Secondary accession number(s): A2RVJ3
    , A4V4R6, Q8SWT3, Q8T061, Q9VWJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: July 11, 2002
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3