Unreviewed, UniProtKB/TrEMBL Q9NHP8 (Q9NHP8_DROME)

Names and origin

Protein names

Submitted name:
    HGTX, isoform A EMBL AAF49729.3
Submitted name:
    GTX/Nkx6B-like homeodomain protein EMBL AAF33780.1
    IP01125p EMBL AAY51592.1
    RE53769p EMBL AAV36877.1

Gene names

Name:	HGTX FlyBase FBgn0040318
Synonyms:	NK6 EMBL AAF33780.1
ORF Names:	CG13475 FlyBase FBgn0040318, Dmel_CG13475 EMBL AAF49729.3

Organism

Drosophila melanogaster (Fruit fly) EMBL AAF33780.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location

Nucleus By similarity. RuleBase RU000682V4

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682V4 Spearmint SPM000047
Domain	Homeobox RuleBase RU000682V4 Spearmint SPM000047
Ligand	DNA-binding RuleBase RU000682V4 Spearmint SPM000047
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9NHP8-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A44659A1DD4090D9	FASTA	513	54,573
	10 20 30 40 50 60 MDLINPYMRH HSFAAAAQGS PPSAAQRHHL AAAMSNGFAD VHAHAMAAAD YQQQLADYHS 70 80 90 100 110 120 AAAAAAVYAN NNNNNNNNSS NNNNSSPLML LKAAHGGGLK DSDSPSTTPP PASSRLHSDS 130 140 150 160 170 180 SPSPRYEHNS SPGVDSAKSY ALSQRSSGAE DPCQTSESAS PPPQGQNDYS PENLSSQRAK 190 200 210 220 230 240 FQHHHGVNPL ALHNANHAGN PGCHNNNNHM DHKLPLSFLG PPLAALHSMT TEMKGQGVGG 250 260 270 280 290 300 SSASANGLSY SHSPNSHLIS DRGSGGSSSS SSTTTTNTNS QGAPNPHGID TILSKPPPVT 310 320 330 340 350 360 SAGLSALTGA GIPRFSIAAA AAGMAQYLSQ SQGAPLKTHA GHIVDRTHLY WPGLQGLVAN 370 380 390 400 410 420 PIAWRERLSN TMSANLSQSH QHHPSNDKDG KKKHTRPTFS GQQIFALEKT FEQTKYLAGP 430 440 450 460 470 480 ERAKLAYALG MSESQVKVWF QNRRTKWRKR HAAEMATAKR KQDDMGGDND GDCSETMDSD 490 500 510 NESLDMGESP AQNKRCRSNS SGSSQQQQDN YRH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nk6, a novel Drosophila homeobox gene regulated by vnd." Uhler J., Garbern J., Yang L., Kamholz J., Mellerick D.M. Mech. Dev. 116:105-116(2002) [PubMed: 12128210] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Garbern J.Y., Wu R.-P., Yang L., Kamholz J. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAV36877.1.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[6]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF220236 mRNA. Translation: AAF33780.1. AE014296 Genomic DNA. Translation: AAF49729.3. BT015992 mRNA. Translation: AAV36877.1. BT022198 mRNA. Translation: AAY51592.1.
RefSeq	NP_652614.1.
UniGene	Dm.3490
3D structure databases
HSSP	HSSP built from PDB template 9ANT based on UniProtKB P02833.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NHP8. 1 interaction.
Proteomic databases
PRIDE	Q9NHP8.
Genome annotation databases
Ensembl	FBgn0040318. Drosophila melanogaster. [Contig view]
GeneID	53446.
KEGG	dme:Dmel_CG13475.
NMPDR	fig|7227.3.peg.9823.
Organism-specific databases
FlyBase	FBgn0040318. HGTX.
Phylogenomic databases
HOGENOM	Q9NHP8.
OMA	Q9NHP8. THAGHIV.
Gene expression databases
ArrayExpress	Q9NHP8.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00031. HTHREPRESSR.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	841198.

Entry information

Entry name

Q9NHP8_DROME

Accession

Primary (citable) accession number: Q9NHP8
Secondary accession number(s): Q9VUF6

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)