Unreviewed, UniProtKB/TrEMBL Q9NHE9 (Q9NHE9_DROME)

Names and origin

Protein names

Submitted name:
    LDL-related protein LRP6 EMBL AAF28358.1

Gene names

Name:	arr FlyBase FBgn0000119
ORF Names:	CG5912 FlyBase FBgn0000119

Organism

Drosophila melanogaster (Fruit fly) EMBL AAF28358.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1678 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Domain	EGF-like domain RuleBase RU000460V1 Repeat Spearmint SPM000033
PTM	Disulfide bond Spearmint SPM006209
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from mutant phenotype. Source: FlyBase compound eye morphogenesis Inferred from mutant phenotype. Source: FlyBase protein targeting to lysosome Inferred from mutant phenotype. Source: FlyBase regulation of compound eye pigmentation Inferred from mutant phenotype. Source: FlyBase
Cellular component	plasma membrane Inferred from direct assay. Source: FlyBase
Molecular function	Wnt receptor activity Inferred from direct assay. Source: FlyBase protein binding Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9NHE9-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C8891D89E7F7F3AA	FASTA	1,678	187,486
	10 20 30 40 50 60 MALEPYTKSA EIEPQLCQVI DNNEDVTTKA TKCTKSNSGV GWRQMLIGFL LICFGISNSW 70 80 90 100 110 120 QYKNVHMPSS SSLIASPPAS AFVNTPATLL FTTRHDIQVA NITRPTGGPQ IDVIVRDLAE 130 140 150 160 170 180 AMAIDFYYAK NLVCWTDSGR EIIECAQTNS SALQPLLRAP KQTVISTGLD KPEGLAMDWY 190 200 210 220 230 240 TDKIYWTDGE KNRIEVATLD GRYQKVLFWT DLDQPRAVAV VPARKLLIWT DWGEYPKIER 250 260 270 280 290 300 ASMDGDPLSR MTLVKEHVFW PNGLAVDLKN ELIYWTDGKH HFIDVMRLDG SSRRTIVNNL 310 320 330 340 350 360 KYPFSLTFYD DRLYWTDWQR GSLNALDLQT RELKELIDTP KAPNSVRAWD PSLQPYEDNP 370 380 390 400 410 420 CAHNNGNCSH LCLLATNSQG FSCACPTGVK LISANTCANG SQEMMFIVQR TQISKISLDS 430 440 450 460 470 480 PDYTIFPLPL GKVKYAIAID YDPVEEHIYW SDVETYTIKR AHADGTGVTD FVTSEVRHPD 490 500 510 520 530 540 GLALDWLARN LYWTDTVXDR IEVCRLDGTA RKVLIYEHLE EPRAIAVAPS LGWMFWSDWN 550 560 570 580 590 600 ERKPKVERAS LDGSERVVLV SENLGWPNGI ALDIEAKAIY WCDGKTDKIE VANMDGSGRR 610 620 630 640 650 660 VVISDNLKHL FGLSILDDYL YWTDWQRRSI DRAHKITGNN RIVVVDQYPD LMGLKVTRLR 670 680 690 700 710 720 EVRGQNACAV RNGGCSHLCL NRPRDYVCRC AIDYELANDK RTCVVPAAFL LFSRQEHIGR 730 740 750 760 770 780 ISIEYNEGNH NDERIPFKDV RDAHALDVSV AERRIYWTDQ KSKCIFRAFL NGSYVQRIVD 790 800 810 820 830 840 SGLIGPDGIA VDWLANNIYW SDAEARRIEV ARLDGSSRRV LLWKGVEEPR SLVLEPRRGY 850 860 870 880 890 900 MYWTESPTDS IRRAAMDGSD LQTIVAGANH AAGLTFDQET RRLYWATQSR PAKIESADWD 910 920 930 940 950 960 GKKRQILVGS DMDEPYAVSL YQDYVYWSDW NTGDIERVHK TTGQNRSLVH SGMTYITSLL 970 980 990 1000 1010 1020 VFNDKRQTGV NPCKVNNGGC SHLCLAQPGR RGMTCACPTH YQLAKDGVSC IPPRNYIIFS 1030 1040 1050 1060 1070 1080 QRNCFGRLLP NTTDCPNIPL PVSGKNIRAV DYDPITHHIY WIEGRSHSIK RSLANGTKVS 1090 1100 1110 1120 1130 1140 LLANSGQPFD LAIDIIGRLL FWTCSQSNSI NVTSFLGESV GVIDTGDSEK PRNIAVHAMK 1150 1160 1170 1180 1190 1200 RLLFWTDVGS HQAIIRARVD GNERVELAYK LEGVTALALD QQSDMIYYAH GKRIDAIDIN 1210 1220 1230 1240 1250 1260 GKNKKTLVSM HISQVINIAA LGGFVYWLDD KTGVERITVN GERRSAELQR LPQITDIRAV 1270 1280 1290 1300 1310 1320 WTPDPKVLRN HTCMHSRTKC SHICIASGEG IARTRDVCSC PKHLMLLEDK ENCGAFPACG 1330 1340 1350 1360 1370 1380 PDHFTCAAPV SGISDVNKDC IPASWRCDGQ KDCPDKSDEV GCPTCRADQF SCQSGECIDK 1390 1400 1410 1420 1430 1440 SLVCDGTTNC ANGHDEADCC KRPGEFQCPI NKLCISAALL CDGWENCADG ADESSDICLQ 1450 1460 1470 1480 1490 1500 RRMAPATDKR AFMILIGATM ITIFSIVYLL QFCRTRIGKS RTEPKDDQAT DPLSPSTLSK 1510 1520 1530 1540 1550 1560 SQRVSKIASV ADAVRMSTLN SRNSMNSYDR NHITGASSST TNGSSMVAYP INPPPSPATR 1570 1580 1590 1600 1610 1620 SRRPYRHYKI INQPPPPTPC STDICDESDS NYTSKSNSNN SNGGATKHSS SSAAACLQYG 1630 1640 1650 1660 1670 YDSEPYPPPP TPRSHYHSDV RIVPESSCPP SPSSRSSTYF SPLPPPPSPV QSPSRGFT

References

[1]	"Full-length Drosophila melanogaster cDNA sequence for dLRP6." Avery B.J., Tsang G., Evans-Holm M., Skarnes W.C., Rubin G.M. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF223365 mRNA. Translation: AAF28358.1.
3D structure databases
HSSP	HSSP built from PDB template 1N7D based on UniProtKB P01130.
ModBase	Search...
Proteomic databases
PRIDE	Q9NHE9.
Genome annotation databases
Ensembl	FBgn0000119. Drosophila melanogaster. [Contig view]
Organism-specific databases
FlyBase	FBgn0000119. arr.
Gene expression databases
ArrayExpress	Q9NHE9.
Family and domain databases
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR006209. EGF. IPR006210. EGF-like. IPR000152. EGF-type_Asp/Asn_hydroxyl_CS. IPR002172. LDL_rcpt_classA_cys-rich. IPR000033. LDLR. IPR017049. Low_density_Lipo_rcpt-rel_p5/6. [Graphical view]
Gene3D	G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 4 hits. G3DSA:4.10.400.10. LDL_rcpt_classA_cys-rich. 2 hits.
Pfam	PF00008. EGF. 2 hits. PF00057. Ldl_recept_a. 3 hits. PF00058. Ldl_recept_b. 16 hits. [Graphical view]
PIRSF	PIRSF036314. LDL_recpt-rel_p5/6. 1 hit.
PRINTS	PR00261. LDLRECEPTOR.
SMART	SM00181. EGF. 3 hits. SM00192. LDLa. 3 hits. SM00135. LY. 20 hits. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. Uncertain. PS01209. LDLRA_1. 2 hits. PS50068. LDLRA_2. 1 hit. PS51120. LDLRB. 19 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9NHE9_DROME

Accession

Primary (citable) accession number: Q9NHE9

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)