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Reviewed, UniProtKB/Swiss-Prot Q9NHA8 (BGBP3_DROME)

Last modified June 16, 2009. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Gram-negative bacteria-binding protein 3
Gene names
Name: GNBP3
ORF Names: CG5008
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Involved in the recognition of invading micro-organisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade By similarity. UniProtKB Q8MU95

Subcellular location

Secreted By similarity. UniProtKB Q8MU95

Developmental stage

Expressed at very low levels during embryonic development. Expression increases during the larva stages and peaks at a moderate level during the late larval, prepupal and pupal stages, before decreasing in the adult. Ref.1

Sequence similarities

Belongs to the insect beta-1,3-glucan binding protein family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 490465Gram-negative bacteria-binding protein 3
PRO_0000002819

Amino acid modifications

Glycosylation3621N-linked (GlcNAc...) Potential
Glycosylation3731N-linked (GlcNAc...) Potential

Natural variations

Natural variant161L → Q in strain: Netherlands line N22.
Natural variant1421P → T in strain: Netherlands line N02 and Netherlands line N30.
Natural variant2131P → L in strain: Netherlands line N02, Netherlands line N07, Netherlands line N17 and Netherlands line N30.
Natural variant2921A → V in strain: Netherlands line N02 and Netherlands line N30.
Natural variant3991K → I in strain: Netherlands line N22.
Natural variant4041E → G in strain: Netherlands line N02 and Netherlands line N30.
Natural variant4081A → G in strain: Netherlands line N22.
Natural variant4791H → N in strain: Netherlands line N22.

Experimental info

Sequence conflict1961R → K in AAF33851. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q9NHA8-1 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: B442E16CC027D849

FASTA49055,211
        10         20         30         40         50         60 
MADALRFVAW SCCLQLLFLL LGVQGYEVPK AKIDVFYPKG FEVSIPDEEG ITLFAFHGKL 

        70         80         90        100        110        120 
NEEMEGLEAG TWARDIVKAK NGRWTFRDRI TALKPGDTLY YWTYVIYNGL GYREDDGSFV 

       130        140        150        160        170        180 
VNGYSGNNAS PHPPVVPVST TPWTPPADPD IDIRLGCTTP KTEVNGAPTR CAGQLVFVDE 

       190        200        210        220        230        240 
FNAAKLDPNK WKAERRFSGQ PDYEFNVYVD DAPETLCLAN GHVVLSTNTM KKQFKKGSGE 

       250        260        270        280        290        300 
SLDLGEKCTG QANTHDCVRN GRTLNDGLPP MVTAQFSSKD FSFKYGRVEV RAKMPRAQWV 

       310        320        330        340        350        360 
TPQIWLQPRR PIYGVDDYRS GQLRIAYTRP NGGNLDLYGA AVLFADEPLR SVKNCLKPGT 

       370        380        390        400        410        420 
GNNSEDWSDS FHNYTLEWTP RELRWLVDGK EWCVQGSAKG SFSETTAAGK SLPQAQKLEE 

       430        440        450        460        470        480 
GTGLAPFDQE FYLTFGLSVG GFNEYQHEIK PWNERAPQAQ KAFWKEVKKI RDHWLDEGHM 

       490 
KIDYVKVYSL

« Hide

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References

« Hide 'large scale' references
[1]"Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells."
Kim Y.-S., Ryu J.-H., Han S.-J., Choi K.-H., Nam K.-B., Jang I.-H., Lemaitre B., Brey P.T., Lee W.-J.
J. Biol. Chem. 275:32721-32727(2000) [PubMed: 10827089] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
[2]"Contrasting evolutionary patterns in Drosophila immune receptors."
Jiggins F.M., Kim K.W.
J. Mol. Evol. 63:769-780(2006) [PubMed: 17103056] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Netherlands line N01, Netherlands line N02, Netherlands line N03, Netherlands line N06, Netherlands line N07, Netherlands line N14, Netherlands line N15, Netherlands line N16, Netherlands line N17, Netherlands line N22, Netherlands line N29 and Netherlands line N30.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF228474 mRNA. Translation: AAF33851.1.
AM050231 Genomic DNA. Translation: CAJ18903.1.
AM050232 Genomic DNA. Translation: CAJ18904.1.
AM050233 Genomic DNA. Translation: CAJ18905.1.
AM050234 Genomic DNA. Translation: CAJ18906.1.
AM050235 Genomic DNA. Translation: CAJ18907.1.
AM050236 Genomic DNA. Translation: CAJ18908.1.
AM050237 Genomic DNA. Translation: CAJ18909.1.
AM050238 Genomic DNA. Translation: CAJ18910.1.
AM050239 Genomic DNA. Translation: CAJ18911.1.
AM050240 Genomic DNA. Translation: CAJ18912.1.
AM050241 Genomic DNA. Translation: CAJ18913.1.
AM050242 Genomic DNA. Translation: CAJ18914.1.
AE014296 Genomic DNA. Translation: AAF50349.1.
RefSeqNP_523986.2.
UniGeneDm.898

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9NHA8. 1 interaction.

Protein family/group databases

CAZyCBM39. Carbohydrate-Binding Module Family 39.
GH16. Glycoside Hydrolase Family 16.

Proteomic databases

PRIDEQ9NHA8.

Genome annotation databases

EnsemblFBgn0040321. Drosophila melanogaster. [Contig view]
GeneID39020.
KEGGdme:Dmel_CG5008.

Organism-specific databases

FlyBaseFBgn0040321. GNBP3.

Phylogenomic databases

HOGENOMQ9NHA8.
OMAQ9NHA8. EWTPREL.

Gene expression databases

ArrayExpressQ9NHA8.
GermOnlineCG5008. Drosophila melanogaster.

Family and domain databases

InterProIPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
[Graphical view]
Gene3DG3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.
PfamPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio811505.

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Entry information

Entry nameBGBP3_DROME
AccessionPrimary (citable) accession number: Q9NHA8
Secondary accession number(s): A0ZX55 expand/collapse secondary AC list , A0ZX56, A0ZX59, A0ZX64, Q9VSR4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 10, 2007
Last modified: June 16, 2009
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents