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Protein

Venom allergen 4

Gene
N/A
Organism
Solenopsis geminata (Tropical fire ant)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 4
Alternative name(s):
Venom allergen IV
Allergen: Sol g 4
OrganismiSolenopsis geminata (Tropical fire ant)
Taxonomic identifieri121131 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3479. Sol g 4.0101.
3480. Sol g 4.0201.
629. Sol g 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002264720 – 137Venom allergen 4Add BLAST118

Proteomic databases

PRIDEiQ9NH75.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

SMRiQ9NH75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ant venom allergen 2/4 family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd12800. Sol_i_2. 1 hit.
Gene3Di1.10.238.20. 1 hit.
InterProiView protein in InterPro
IPR020181. Ant_venom_allergen_Sol_i_2/4.
IPR006170. PBP_GOBP.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
SUPFAMiSSF47565. SSF47565. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NH75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFVLVSCL LVFTQIIYAV DIKELKIMNR ILEKCIRTVP KGENDPINPL
60 70 80 90 100
KNVNVLYCAF SKRGIFTPKG VNTKQYINYC EKTIINPADI KQCKKLISKC
110 120 130
IKKVYDRPGP IIERSKNLLS CVLKKGVLEL TVYGKKK
Length:137
Mass (Da):15,667
Last modified:October 1, 2000 - v1
Checksum:iF888BF6D11CCA082
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti28M → V in Sol g 4.02. 1
Natural varianti33E → K in Sol g 4.02. 1
Natural varianti123L → R in Sol g 4.02. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230383 mRNA. Translation: AAF65312.1.
AF230384 mRNA. Translation: AAF65313.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVA4_SOLGE
AccessioniPrimary (citable) accession number: Q9NH75
Secondary accession number(s): Q9NH74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: April 12, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families