Q9NH75 (VA4_SOLGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Venom allergen 4 Alternative name(s): Venom allergen IV Allergen=Sol g 4
Organism	Solenopsis geminata (Tropical fire ant)
Taxonomic identifier	121131 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Vespoidea › Formicidae › Myrmicinae › Solenopsidini › Solenopsis

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Monomer By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Allergenic properties	Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.
Sequence similarities	Belongs to the ant venom allergen 2/4 family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 137	118	Venom allergen 4		PRO_0000022647
Natural variations
	Natural variant	28	1	M → V in Sol g 4.02.
	Natural variant	33	1	E → K in Sol g 4.02.
	Natural variant	123	1	L → R in Sol g 4.02.

Sequences

	Sequence		Length	Mass (Da)
	Q9NH75 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F888BF6D11CCA082	FASTA	137	15,667
	10 20 30 40 50 60 MKTFVLVSCL LVFTQIIYAV DIKELKIMNR ILEKCIRTVP KGENDPINPL KNVNVLYCAF 70 80 90 100 110 120 SKRGIFTPKG VNTKQYINYC EKTIINPADI KQCKKLISKC IKKVYDRPGP IIERSKNLLS 130 CVLKKGVLEL TVYGKKK

References

[1]	"Allergens from tropical fire ant venom." Schmidt M., Hoffman D.R. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF230383 mRNA. Translation: AAF65312.1. AF230384 mRNA. Translation: AAF65313.1.
3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	3479. Sol g 4.0101. 3480. Sol g 4.0201. 629. Sol g 4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR020181. Ant_venom_allergen_Sol_i_2/4. [Graphical view]
ProDom	PD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

VA4_SOLGE

Accession

Primary (citable) accession number: Q9NH75
Secondary accession number(s): Q9NH74

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	October 1, 2000
Last modified:	October 3, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)