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Protein

Centaurin-gamma-1A

Gene

CenG1A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GTPase-activating protein for the ADP ribosylation factor family.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi149 – 156GTPSequence analysis8
Nucleotide bindingi193 – 197GTPSequence analysis5
Nucleotide bindingi249 – 252GTPSequence analysis4
Zinc fingeri717 – 740C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • GTPase activator activity Source: FlyBase
  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • medium-term memory Source: FlyBase
  • positive regulation of GTPase activity Source: FlyBase
  • regulation of GTPase activity Source: FlyBase
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Centaurin-gamma-1A
Gene namesi
Name:CenG1A
ORF Names:CG31811
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0028509. CenG1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000742211 – 995Centaurin-gamma-1AAdd BLAST995

Proteomic databases

PaxDbiQ9NGC3.
PRIDEiQ9NGC3.

Expressioni

Gene expression databases

BgeeiFBgn0028509.
GenevisibleiQ9NGC3. DM.

Interactioni

Protein-protein interaction databases

BioGridi60833. 50 interactors.
DIPiDIP-21141N.
IntActiQ9NGC3. 41 interactors.
MINTiMINT-300715.
STRINGi7227.FBpp0080123.

Structurei

3D structure databases

ProteinModelPortaliQ9NGC3.
SMRiQ9NGC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini453 – 682PHPROSITE-ProRule annotationAdd BLAST230
Domaini679 – 822Arf-GAPPROSITE-ProRule annotationAdd BLAST144
Repeati866 – 898ANKAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 340Small GTPase-likeAdd BLAST204

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated
Contains 1 ANK repeat.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri717 – 740C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

ANK repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0705. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
InParanoidiQ9NGC3.
KOiK12491.
OMAiDQWSEAA.
OrthoDBiEOG091G123A.
PhylomeDBiQ9NGC3.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS51419. RAB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: Q9NGC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNYHPHSHP HALSHPHPQQ VHNQLQNPHQ NQLPPPQRHN HAAPTAAASA
60 70 80 90 100
SGAPSSSASA SASASILVAH PPQPLISNSL AIRQEIQRFE SVHPSIYAIY
110 120 130 140 150
ELIDLLPMAD AQIAQSIRDH VVCIEDSFVN SQEWTISRSV PDLRLGIVGS
160 170 180 190 200
LNSGKSALVH RYLTGSYMQE ESPEGGRFKK EVFIDGQSYL LLIRDEGGAP
210 220 230 240 250
EMQFAGWVDA VIFVFSLENE GSFNTVYNYY TKMAHFRNGQ EIPMILVGTQ
260 270 280 290 300
DAISERNPRV IDDTRARKLA SDLKRCSYYE TCATYGLNVE RVFQDACQKI
310 320 330 340 350
LSQRLPLPPQ VQPARPTTPQ GNRLGLAPYQ APTNGQRGQQ QLPLRMSADF
360 370 380 390 400
AQAEQKLWSL QAASSSTINE NNNITKYNPG AANSLQGDCS QVQLRDPRDL
410 420 430 440 450
APPPGKELPT PTSTPTTSRK SRRRSNLFIP SSSKKADKEK EPKSSELGSG
460 470 480 490 500
RSIPIKQGYL YKRSSKSLNK EWKKKYVTLC DDGRLTYHPS LHDYMDDVHG
510 520 530 540 550
KEIPLQYVTV KVPGQKPRGS KSIITNSALT SSLMANGQRA QNTLSDGIGC
560 570 580 590 600
LTLAKDNQRK LSEKLSLLGA GSIAAGAGGE PLKSNSSQQT SGDEGIAMSN
610 620 630 640 650
SNSQTFIAGE VANAGNKLEA QTPNVKKRHR RMKSSSVKAN EADDNDGYEF
660 670 680 690 700
YIVSLDSKQW HFEAANSEER DEWVAAVEQE IFKSLQSIES SKTKQATSTD
710 720 730 740 750
LAAMLAIRQR VPGNGFCVDC GAPNPEWASL NLGVLMCIEC SGVHRNLGSH
760 770 780 790 800
ISKVRSLGLD DWPSPHLSVM LAIGNSLANS VWESNTRQRV KPTSQASRED
810 820 830 840 850
KERWVRSKYE AKEFLTPLGN GSSAHPSPSP GQQLIEAVIR ADIKSIVSIL
860 870 880 890 900
ANCPSEVTNA NVSARDVRTP LLLACAIGNL AIAQLLIWNG ANIKHTDHEG
910 920 930 940 950
RTCLAYARAA QSLATAKSIK AAAAAQAGTT IPAPAPPTNG GIPAPQYNVE
960 970 980 990
DTTALVELLE GLGCPEAAPL TASGTLPRRR DTLGTPYEKS VSGVI
Note: No experimental confirmation available.
Length:995
Mass (Da):108,044
Last modified:January 27, 2003 - v2
Checksum:iE2376662937C328F
GO
Isoform A (identifier: Q9NGC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     69-125: AHPPQPLISN...SIRDHVVCIE → MLAVKNFFLP...VPDRSEKRKS

Show »
Length:927
Mass (Da):101,282
Checksum:iC21F862D0D7BFA89
GO
Isoform C (identifier: Q9NGC3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: Missing.

Note: No experimental confirmation available.
Show »
Length:763
Mass (Da):82,506
Checksum:iA108BCCB57496A48
GO

Sequence cautioni

Isoform A : The sequence AAF66064 differs from that shown. a duplication of 79 residues inserted in position 130Curated
The sequence AAL28369 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAT27272 differs from that shown. Reason: Frameshift at position 251.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti334N → D in AAO39542 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0003141 – 232Missing in isoform C. 1 PublicationAdd BLAST232
Alternative sequenceiVSP_0003121 – 68Missing in isoform A. 3 PublicationsAdd BLAST68
Alternative sequenceiVSP_00031369 – 125AHPPQ…VVCIE → MLAVKNFFLPERAKAPETPQ RFSRMPEAFLRSIRRRSLRV KRAKSLVVPDRSEKRKS in isoform A. 3 PublicationsAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254741 mRNA. Translation: AAF66064.1. Sequence problems.
AE014134 Genomic DNA. Translation: AAF53343.2.
AE014134 Genomic DNA. Translation: AAF53349.2.
AE014134 Genomic DNA. Translation: AAF53350.2.
AY122158 mRNA. Translation: AAM52670.1.
AY060821 mRNA. Translation: AAL28369.1. Sequence problems.
BT003538 mRNA. Translation: AAO39542.1.
BT014648 mRNA. Translation: AAT27272.1. Frameshift.
BT053695 mRNA. Translation: ACK77612.1.
BT133428 mRNA. Translation: AFH68352.1.
RefSeqiNP_523562.2. NM_078838.3. [Q9NGC3-2]
NP_723849.1. NM_165067.2. [Q9NGC3-1]
NP_723850.1. NM_165068.2. [Q9NGC3-3]
UniGeneiDm.1977.

Genome annotation databases

EnsemblMetazoaiFBtr0080546; FBpp0080123; FBgn0028509. [Q9NGC3-1]
GeneIDi34803.
KEGGidme:Dmel_CG31811.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254741 mRNA. Translation: AAF66064.1. Sequence problems.
AE014134 Genomic DNA. Translation: AAF53343.2.
AE014134 Genomic DNA. Translation: AAF53349.2.
AE014134 Genomic DNA. Translation: AAF53350.2.
AY122158 mRNA. Translation: AAM52670.1.
AY060821 mRNA. Translation: AAL28369.1. Sequence problems.
BT003538 mRNA. Translation: AAO39542.1.
BT014648 mRNA. Translation: AAT27272.1. Frameshift.
BT053695 mRNA. Translation: ACK77612.1.
BT133428 mRNA. Translation: AFH68352.1.
RefSeqiNP_523562.2. NM_078838.3. [Q9NGC3-2]
NP_723849.1. NM_165067.2. [Q9NGC3-1]
NP_723850.1. NM_165068.2. [Q9NGC3-3]
UniGeneiDm.1977.

3D structure databases

ProteinModelPortaliQ9NGC3.
SMRiQ9NGC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60833. 50 interactors.
DIPiDIP-21141N.
IntActiQ9NGC3. 41 interactors.
MINTiMINT-300715.
STRINGi7227.FBpp0080123.

Proteomic databases

PaxDbiQ9NGC3.
PRIDEiQ9NGC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080546; FBpp0080123; FBgn0028509. [Q9NGC3-1]
GeneIDi34803.
KEGGidme:Dmel_CG31811.

Organism-specific databases

CTDi34803.
FlyBaseiFBgn0028509. CenG1A.

Phylogenomic databases

eggNOGiKOG0705. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
InParanoidiQ9NGC3.
KOiK12491.
OMAiDQWSEAA.
OrthoDBiEOG091G123A.
PhylomeDBiQ9NGC3.

Miscellaneous databases

ChiTaRSicenG1A. fly.
GenomeRNAii34803.
PROiQ9NGC3.

Gene expression databases

BgeeiFBgn0028509.
GenevisibleiQ9NGC3. DM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEG1A_DROME
AccessioniPrimary (citable) accession number: Q9NGC3
Secondary accession number(s): B7FNK5
, I0C0M3, Q6IDF7, Q86P12, Q8MR30, Q95SF3, Q9NKE5, Q9VJV4, Q9VJV5, Q9VJV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 27, 2003
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.