Q9NG42 (ADH_DROEQ) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 52.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Alcohol dehydrogenase EC=1.1.1.1 | ||
| Gene names |
| ||
| Organism | Drosophila equinoxialis (Fruit fly) | ||
| Taxonomic identifier | 46790 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 254 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | An alcohol + NAD+ = an aldehyde or ketone + NADH. |
| Subunit structure | Homodimer. |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | alcohol catabolic process Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | alcohol dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 254 | 254 | Alcohol dehydrogenase | PRO_0000054459 | |||||
Regions | |||||||||
| Nucleotide binding | 9 – 32 | 24 | NAD By similarity UniProtKB Q05114 | ||||||
Sites | |||||||||
| Active site | 151 | 1 | Proton acceptor By similarity UniProtKB Q05114 | ||||||
| Binding site | 138 | 1 | Substrate By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 157 | 1 | A → R in AAF72716. Ref.2 | ||||||
Sequences
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References
| [1] | "A molecular phylogeny of the Drosophila willistoni group: conflicts between species concepts?" Gleason J.M., Griffith E.C., Powell J.R. Evolution 52:1093-1103(1998) [Agricola: IND21806050] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 0741.0 and Puerto Rico. |
| [2] | "Phylogenetic relationships of flies in family Drosophilidae inferred by combined analysis of morphological and molecular characters." O'Grady P.M. Thesis (2000), University of Arizona / Tucson, United States Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-166. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U95268 Genomic DNA. Translation: AAD00794.1. U95269 Genomic DNA. Translation: AAD00795.1. AF264074 Genomic DNA. Translation: AAF72716.1. |
3D structure databases | |
| ProteinModelPortal | Q9NG42. |
| SMR | Q9NG42. Positions 3-254. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Organism-specific databases | |
| FlyBase | FBgn0016178. Dequ\Adh. |
Family and domain databases | |
| InterPro | IPR002425. ADH_Drosophila-type. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY. |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADH_DROEQ | ||||||||
| Accession | Primary (citable) accession number: Q9NG42 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

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