Reviewed, UniProtKB/Swiss-Prot Q9NG40 (ADH_DROIN)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase
    EC=1.1.1.1

Gene names

Name:

Adh

Organism

Drosophila insularis (Fruit fly)

Taxonomic identifier

46792 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	alcohol catabolic process Inferred from sequence or structural similarity. Source: UniProtKB oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from sequence or structural similarity. Source: UniProtKB binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Alcohol dehydrogenase		PRO_0000054469
Regions
	Nucleotide binding	9 – 32	24	NAD By similarity UniProtKB Q05114
Sites
	Active site	151	1	Proton acceptor By similarity UniProtKB Q05114
	Binding site	138	1	Substrate By similarity
Experimental info
	Sequence conflict	35	1	I → V in AAF72718. Ref.2
	Sequence conflict	156 – 157	2	AA → ED in AAF72718. Ref.2
	Sequence conflict	164	1	S → C in AAF72718. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9NG40-1 [UniParc]. Last modified March 15, 2004. Version 2. Checksum: C20FDF95E89D6E16	FASTA	254	27,620
	10 20 30 40 50 60 MALTNKNIIF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA INPKVTVTFY 70 80 90 100 110 120 PYDVTTPLTE TTKLLKTIFA QLKTVDVLIN GAGILDDHQI ERTIAVNFTG LVNTTTAILD 130 140 150 160 170 180 FWDKRKGGPG GVICNIGSVT GFNAIYQVPV YSASKAAVVS FTQSIAKLAN VTGVTAFTVN 190 200 210 220 230 240 PGITKTTLVH KFNSWLDVET RVAEKLLEHP TQTTLACAQN FVKAIELNKN GAIWKLDLGT 250 LEPIEWTKHW DSGI

References

[1]	"A molecular phylogeny of the Drosophila willistoni group: conflicts between species concepts?" Gleason J.M., Griffith E.C., Powell J.R. Evolution 52:1093-1103(1998) [Agricola: IND21806050] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FA.
[2]	"Phylogenetic relationships of flies in family Drosophilidae inferred by combined analysis of morphological and molecular characters." O'Grady P.M. Thesis (2000), University of Arizona / Tucson, United States Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-166.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U95273 Genomic DNA. Translation: AAD00799.1. AF264076 Genomic DNA. Translation: AAF72718.1.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
SMR	Q9NG40. Positions 3-254.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0016214. Dins\Adh.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002425. Insect_ADH. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROIN

Accession

Primary (citable) accession number: Q9NG40

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	March 15, 2004
Last modified:	June 16, 2009
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project