Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tropomyosin

Gene
N/A
Organism
Lepidoglyphus destructor (Storage mite) (Glycyphagus destructor)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
Alternative name(s):
Allergen: Lep d 10
OrganismiLepidoglyphus destructor (Storage mite) (Glycyphagus destructor)
Taxonomic identifieri36936 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataGlycyphagoideaGlycyphagidaeLepidoglyphus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3349. Lep d 10.0101.
437. Lep d 10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284TropomyosinPRO_0000205681Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9NFZ4.
SMRiQ9NFZ4. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 284284By similarityAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NFZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAIKNKMQA MKLEKDNAID RAEIAEQKSR DANLRAEKSE EEVRGLQKKI
60 70 80 90 100
QQIENELDQV QESLTQANTK LEEKEKSLQT AEGDVAALNR RIQLIEEDLE
110 120 130 140 150
RSEGRLKIAT SKLEEASQSA DESERMRKML EHRSITDEER MEGLESQLKE
160 170 180 190 200
ARMMAEDADR KYDEVARKLA MVEADLERAE ERAETGESKI VELEEELRVV
210 220 230 240 250
GNNLKSLEVS EEKAQQREEA YEQQIRIMTT KLKEAEARAE FAERSVQKLQ
260 270 280
KEVDRLEDEL VHEKEKYKSI SDELDQTFAE LTGY
Length:284
Mass (Da):32,950
Last modified:October 1, 2000 - v1
Checksum:i05EED5298696EA08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250096 mRNA. Translation: CAB71342.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250096 mRNA. Translation: CAB71342.1.

3D structure databases

ProteinModelPortaliQ9NFZ4.
SMRiQ9NFZ4. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3349. Lep d 10.0101.
437. Lep d 10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterisation of two IgE-binding proteins, homologous to tropomyosin and alpha-tubulin, from the mite Lepidoglyphus destructor."
    Saarne T., Kaiser L., Rasool O., Huecas S., van Hage-Hamsten M., Gafvelin G.
    Int. Arch. Allergy Immunol. 130:258-265(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTPM_LEPDS
AccessioniPrimary (citable) accession number: Q9NFZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: October 14, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.