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Q9NFZ3 (GBGE_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein subunit gamma-e

Short name=Ggamma(e)
Gene names
Name:Ggamma30A
ORF Names:CG3694
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length72 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the G protein gamma family.

Sequence caution

The sequence AAL28579.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Gbeta76CP298292EBI-2695634,EBI-128499

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 6968Guanine nucleotide-binding protein subunit gamma-e
PRO_0000012679
Propeptide70 – 723Removed in mature form By similarity
PRO_0000012680

Amino acid modifications

Modified residue21N-acetylaspartate Ref.5
Modified residue691Cysteine methyl ester Ref.5
Lipidation691S-farnesyl cysteine Ref.5

Experimental info

Mutagenesis691C → G: Loss of farnesylation. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9NFZ3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: B0FC6DC9170EDA70

FASTA728,398
        10         20         30         40         50         60 
MDPSALQNMD RDALKKQIEN MKYQASMERW PLSKSIAEMR SFIEENEKND PLINAPDKKN 

        70 
NPWAEKGKCV IM 

« Hide

References

« Hide 'large scale' references
[1]"A novel Ggamma isolated from Drosophila constitutes a visual G protein gamma subunit of the fly compound eye."
Schulz S., Huber A., Schwab K., Paulsen R.
J. Biol. Chem. 274:37605-37610(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Eye.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[5]"Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system."
Schillo S., Belusic G., Hartmann K., Franz C., Kuhl B., Brenner-Weiss G., Paulsen R., Huber A.
J. Biol. Chem. 279:36309-36316(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION AT ASP-2, ISOPRENYLATION AT CYS-69, METHYLATION AT CYS-69, MUTAGENESIS OF CYS-69.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250440 mRNA. Translation: CAB70093.1.
AE014134 Genomic DNA. Translation: AAF52759.2.
AE014134 Genomic DNA. Translation: AAF52760.2.
AE014134 Genomic DNA. Translation: AAF52761.2.
AY061031 mRNA. Translation: AAL28579.1. Sequence problems.
RefSeqNP_001162918.1. NM_001169447.2.
NP_001188749.1. NM_001201820.2.
NP_001245950.1. NM_001259021.2.
NP_001260281.1. NM_001273352.1.
NP_001260282.1. NM_001273353.1.
NP_001260283.1. NM_001273354.1.
NP_001260284.1. NM_001273355.1.
NP_524807.1. NM_080068.4.
NP_723451.1. NM_164851.3.
NP_723452.1. NM_164852.3.
UniGeneDm.1453.

3D structure databases

ProteinModelPortalQ9NFZ3.
SMRQ9NFZ3. Positions 8-65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid69527. 1 interaction.
IntActQ9NFZ3. 1 interaction.

Proteomic databases

PaxDbQ9NFZ3.
PRIDEQ9NFZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0079795; FBpp0079395; FBgn0028433.
FBtr0079796; FBpp0079396; FBgn0028433.
FBtr0079797; FBpp0079397; FBgn0028433.
FBtr0301856; FBpp0291070; FBgn0028433.
FBtr0303895; FBpp0292898; FBgn0028433.
FBtr0309247; FBpp0301186; FBgn0028433.
FBtr0330019; FBpp0303053; FBgn0028433.
GeneID14462729.
45234.
KEGGdme:Dmel_CG3694.
dme:Dmel_CG43733.

Organism-specific databases

CTD45234.
FlyBaseFBgn0028433. Ggamma30A.

Phylogenomic databases

eggNOGNOG293449.
GeneTreeENSGT00730000114118.
InParanoidQ9NFZ3.
KOK04547.
OMAWIEEGIP.
OrthoDBEOG7H1JP7.
PhylomeDBQ9NFZ3.

Gene expression databases

BgeeQ9NFZ3.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio837925.
PROQ9NFZ3.

Entry information

Entry nameGBGE_DROME
AccessionPrimary (citable) accession number: Q9NFZ3
Secondary accession number(s): A4V0H1, Q95RZ3, Q9VLD3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase