Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein subunit gamma-e

Gene

Ggamma30A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye.

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • protein heterodimerization activity Source: FlyBase

GO - Biological processi

  • cellular response to carbon dioxide Source: FlyBase
  • G-protein coupled receptor signaling pathway Source: FlyBase
  • phototransduction Source: FlyBase
  • visual perception Source: UniProtKB-KW

Keywordsi

Molecular functionTransducer
Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gamma-e
Short name:
Ggamma(e)
Gene namesi
Name:Ggamma30AImported
Synonyms:Gy30A
ORF Names:CG3694Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0267252 Ggamma30A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi69C → G: Loss of farnesylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000126792 – 69Guanine nucleotide-binding protein subunit gamma-eAdd BLAST68
PropeptideiPRO_000001268070 – 72Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylaspartate1 Publication1
Modified residuei69Cysteine methyl ester1 Publication1
Lipidationi69S-farnesyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ9NFZ3
PRIDEiQ9NFZ3

PTM databases

iPTMnetiQ9NFZ3

Expressioni

Gene expression databases

BgeeiFBgn0267252
ExpressionAtlasiQ9NFZ3 baseline and differential
GenevisibleiQ9NFZ3 DM

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
Gbeta76CP298292EBI-2695634,EBI-128499

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi69527, 1 interactor
IntActiQ9NFZ3, 1 interactor
STRINGi7227.FBpp0291070

Structurei

3D structure databases

ProteinModelPortaliQ9NFZ3
SMRiQ9NFZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000064157
InParanoidiQ9NFZ3
KOiK04547
OMAiTDPLIHA
OrthoDBiEOG091G17J0
PhylomeDBiQ9NFZ3

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NFZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSALQNMD RDALKKQIEN MKYQASMERW PLSKSIAEMR SFIEENEKND
60 70
PLINAPDKKN NPWAEKGKCV IM
Length:72
Mass (Da):8,398
Last modified:October 1, 2000 - v1
Checksum:iB0FC6DC9170EDA70
GO

Sequence cautioni

The sequence AAL28579 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250440 mRNA Translation: CAB70093.1
AE014134 Genomic DNA Translation: AAF52759.2
AE014134 Genomic DNA Translation: AAF52760.2
AE014134 Genomic DNA Translation: AAF52761.2
AY061031 mRNA Translation: AAL28579.1 Sequence problems.
RefSeqiNP_001162918.1, NM_001169447.2
NP_001188749.1, NM_001201820.2
NP_001245950.1, NM_001259021.2
NP_524807.1, NM_080068.4
NP_723451.1, NM_164851.3
NP_723452.1, NM_164852.3
UniGeneiDm.1453

Genome annotation databases

EnsemblMetazoaiFBtr0079795; FBpp0079395; FBgn0267252
FBtr0079796; FBpp0079396; FBgn0267252
FBtr0079797; FBpp0079397; FBgn0267252
FBtr0303895; FBpp0292898; FBgn0267252
FBtr0309247; FBpp0301186; FBgn0267252
FBtr0330019; FBpp0303053; FBgn0267252
GeneIDi45234
KEGGidme:Dmel_CG3694

Similar proteinsi

Entry informationi

Entry nameiGBGE_DROME
AccessioniPrimary (citable) accession number: Q9NFZ3
Secondary accession number(s): A4V0H1, Q95RZ3, Q9VLD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health