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Protein

Guanine nucleotide-binding protein subunit gamma-e

Gene

Ggamma30A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye.

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  • cellular response to carbon dioxide Source: FlyBase
  • G-protein coupled receptor signaling pathway Source: FlyBase
  • phototransduction Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • visual perception Source: UniProtKB-KW

Keywordsi

Molecular functionTransducer
Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gamma-e
Short name:
Ggamma(e)
Gene namesi
Name:Ggamma30AImported
Synonyms:Gy30A
ORF Names:CG3694Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0267252. Ggamma30A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • heterotrimeric G-protein complex Source: FlyBase
  • plasma membrane Source: FlyBase
  • rhabdomere Source: FlyBase

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi69C → G: Loss of farnesylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000126792 – 69Guanine nucleotide-binding protein subunit gamma-eAdd BLAST68
PropeptideiPRO_000001268070 – 72Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylaspartate1 Publication1
Modified residuei69Cysteine methyl ester1 Publication1
Lipidationi69S-farnesyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ9NFZ3.
PRIDEiQ9NFZ3.

Expressioni

Gene expression databases

BgeeiFBgn0267252.
ExpressionAtlasiQ9NFZ3. differential.
GenevisibleiQ9NFZ3. DM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
Gbeta76CP298292EBI-2695634,EBI-128499

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi69527. 1 interactor.
IntActiQ9NFZ3. 1 interactor.
STRINGi7227.FBpp0291070.

Structurei

3D structure databases

ProteinModelPortaliQ9NFZ3.
SMRiQ9NFZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00530000064157.
InParanoidiQ9NFZ3.
KOiK04547.
OrthoDBiEOG091G17J0.
PhylomeDBiQ9NFZ3.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiView protein in InterPro
IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
PfamiView protein in Pfam
PF00631. G-gamma. 1 hit.
PRINTSiPR00321. GPROTEING.
SMARTiView protein in SMART
SM00224. GGL. 1 hit.
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiView protein in PROSITE
PS50058. G_PROTEIN_GAMMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NFZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSALQNMD RDALKKQIEN MKYQASMERW PLSKSIAEMR SFIEENEKND
60 70
PLINAPDKKN NPWAEKGKCV IM
Length:72
Mass (Da):8,398
Last modified:October 1, 2000 - v1
Checksum:iB0FC6DC9170EDA70
GO

Sequence cautioni

The sequence AAL28579 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250440 mRNA. Translation: CAB70093.1.
AE014134 Genomic DNA. Translation: AAF52759.2.
AE014134 Genomic DNA. Translation: AAF52760.2.
AE014134 Genomic DNA. Translation: AAF52761.2.
AY061031 mRNA. Translation: AAL28579.1. Sequence problems.
RefSeqiNP_001162918.1. NM_001169447.2.
NP_001188749.1. NM_001201820.2.
NP_001245950.1. NM_001259021.2.
NP_524807.1. NM_080068.4.
NP_723451.1. NM_164851.3.
NP_723452.1. NM_164852.3.
UniGeneiDm.1453.

Genome annotation databases

EnsemblMetazoaiFBtr0079795; FBpp0079395; FBgn0267252.
FBtr0079796; FBpp0079396; FBgn0267252.
FBtr0079797; FBpp0079397; FBgn0267252.
FBtr0303895; FBpp0292898; FBgn0267252.
FBtr0309247; FBpp0301186; FBgn0267252.
FBtr0330019; FBpp0303053; FBgn0267252.
GeneIDi45234.
KEGGidme:Dmel_CG3694.

Similar proteinsi

Entry informationi

Entry nameiGBGE_DROME
AccessioniPrimary (citable) accession number: Q9NFZ3
Secondary accession number(s): A4V0H1, Q95RZ3, Q9VLD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families