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Q9NFT9

- HXK1_DROME

UniProt

Q9NFT9 - HXK1_DROME

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Protein
Hexokinase type 1
Gene
Hex-t1, Hex, CG33102
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: RefGenome
  3. glucokinase activity Source: RefGenome
  4. mannokinase activity Source: RefGenome

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: RefGenome
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: UniProtKB-KW
  5. hexose metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_218382. Glucose transport.
REACT_80959. Regulation of Glucokinase by Glucokinase Regulatory Protein.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase type 1 (EC:2.7.1.1)
Gene namesi
Name:Hex-t1
Synonyms:Hex
ORF Names:CG33102
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0042711. Hex-t1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Hexokinase type 1
PRO_0000197596Add
BLAST

Proteomic databases

PRIDEiQ9NFT9.

Expressioni

Gene expression databases

BgeeiQ9NFT9.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0084382.

Structurei

3D structure databases

ProteinModelPortaliQ9NFT9.
SMRiQ9NFT9. Positions 21-449.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 209197Hexokinase type-1
Add
BLAST
Domaini214 – 449236Hexokinase type-2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 16527Glucose-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
InParanoidiQ9NFT9.
KOiK00844.
OMAiPTNCRIM.
OrthoDBiEOG7TBC24.
PhylomeDBiQ9NFT9.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.

Sequencei

Sequence statusi: Complete.

Q9NFT9-1 [UniParc]FASTAAdd to Basket

« Hide

MANTFNPEED FPEVYKVCKL FNPSIDDLEK IKNAMDREIT MGLSRDHHDR    50
STVPCHLSYV QDLPTGRERG QFLALEMMPT NCRIMLVKFS SERDIYTSSK 100
CVIMPHTVAA GRGTEVFTFL ATSIANFVKE KKVDKDNLPL GIAFAFTLKK 150
LALDVGILVS WTKEFGAQGA IGKDVVQLLR DALAKFPEIS VDVMGIINVG 200
AGSLLALCWA QPDTRIGLIM GSIANSCYVE RVERCETYEG DEYRKLMIIN 250
SDWAHFGDTG QLDFIRNEYD RQLDTESINP GTRIYEKFSG ALCMGELVRI 300
IVLRLMKSGA IFAEDRRDYI GIQWKLDMVS LIEIVSDPPG VYTKAQEVMD 350
KFRIRHCKER DLAALKYICD TVTNRAAMLV ASGVSCLIDR MRLPQISIAV 400
DGGIYRLHPT FSTVLNKYTR LLADPNYNFE FVITQDSCGV GAAIMAGMAH 450
ANKYKTDAKL FTMDY 465
Length:465
Mass (Da):52,260
Last modified:October 1, 2000 - v1
Checksum:i67B611920D56B6DD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331N → H in strain: HFL97e3_12 and ZIM(S)e3_24. 1 Publication
Natural varianti243 – 2431Y → F in strain: DPF96e3_3.0, DPF96e3_4.2, DPF96e3_23.1, DPF96e3_74.2, VT97e3_41, SC96e3_12.3, HFL97e3_8, HFL97e3_12, HFL97e3_15, ZIM(S)e3_24 and ZIM(S)e3_35. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF257590 Genomic DNA. Translation: AAG22891.1.
AF257591 Genomic DNA. Translation: AAG22893.1.
AF257592 Genomic DNA. Translation: AAG22895.1.
AF257593 Genomic DNA. Translation: AAG22897.1.
AF257594 Genomic DNA. Translation: AAG22899.1.
AF257595 Genomic DNA. Translation: AAG22901.1.
AF257596 Genomic DNA. Translation: AAG22903.1.
AF257597 Genomic DNA. Translation: AAG22905.1.
AF257598 Genomic DNA. Translation: AAG22907.1.
AF257599 Genomic DNA. Translation: AAG22909.1.
AF257600 Genomic DNA. Translation: AAG22911.1.
AF257601 Genomic DNA. Translation: AAG22913.1.
AF257602 Genomic DNA. Translation: AAG22915.1.
AF257603 Genomic DNA. Translation: AAG22917.1.
AF257604 Genomic DNA. Translation: AAG22919.1.
AF257605 Genomic DNA. Translation: AAG22921.1.
AF257606 Genomic DNA. Translation: AAG22923.1.
AF257607 Genomic DNA. Translation: AAG22925.1.
AF257608 Genomic DNA. Translation: AAG22927.1.
AJ271350 Genomic DNA. Translation: CAB72131.1.
AE014297 Genomic DNA. Translation: AAF56591.2.
BT015307 mRNA. Translation: AAT94535.1.
RefSeqiNP_788744.1. NM_176567.2.
UniGeneiDm.21469.

Genome annotation databases

EnsemblMetazoaiFBtr0085010; FBpp0084382; FBgn0042711.
GeneIDi117364.
KEGGidme:Dmel_CG33102.
UCSCiCG33102-RA. d. melanogaster.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF257590 Genomic DNA. Translation: AAG22891.1 .
AF257591 Genomic DNA. Translation: AAG22893.1 .
AF257592 Genomic DNA. Translation: AAG22895.1 .
AF257593 Genomic DNA. Translation: AAG22897.1 .
AF257594 Genomic DNA. Translation: AAG22899.1 .
AF257595 Genomic DNA. Translation: AAG22901.1 .
AF257596 Genomic DNA. Translation: AAG22903.1 .
AF257597 Genomic DNA. Translation: AAG22905.1 .
AF257598 Genomic DNA. Translation: AAG22907.1 .
AF257599 Genomic DNA. Translation: AAG22909.1 .
AF257600 Genomic DNA. Translation: AAG22911.1 .
AF257601 Genomic DNA. Translation: AAG22913.1 .
AF257602 Genomic DNA. Translation: AAG22915.1 .
AF257603 Genomic DNA. Translation: AAG22917.1 .
AF257604 Genomic DNA. Translation: AAG22919.1 .
AF257605 Genomic DNA. Translation: AAG22921.1 .
AF257606 Genomic DNA. Translation: AAG22923.1 .
AF257607 Genomic DNA. Translation: AAG22925.1 .
AF257608 Genomic DNA. Translation: AAG22927.1 .
AJ271350 Genomic DNA. Translation: CAB72131.1 .
AE014297 Genomic DNA. Translation: AAF56591.2 .
BT015307 mRNA. Translation: AAT94535.1 .
RefSeqi NP_788744.1. NM_176567.2.
UniGenei Dm.21469.

3D structure databases

ProteinModelPortali Q9NFT9.
SMRi Q9NFT9. Positions 21-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0084382.

Proteomic databases

PRIDEi Q9NFT9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0085010 ; FBpp0084382 ; FBgn0042711 .
GeneIDi 117364.
KEGGi dme:Dmel_CG33102.
UCSCi CG33102-RA. d. melanogaster.

Organism-specific databases

CTDi 117364.
FlyBasei FBgn0042711. Hex-t1.

Phylogenomic databases

eggNOGi COG5026.
GeneTreei ENSGT00390000017159.
InParanoidi Q9NFT9.
KOi K00844.
OMAi PTNCRIM.
OrthoDBi EOG7TBC24.
PhylomeDBi Q9NFT9.

Enzyme and pathway databases

UniPathwayi UPA00242 .
Reactomei REACT_218382. Glucose transport.
REACT_80959. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Miscellaneous databases

GenomeRNAii 117364.
NextBioi 841931.

Gene expression databases

Bgeei Q9NFT9.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba."
    Duvernell D.D., Eanes W.F.
    Genetics 156:1191-1201(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-33 AND PHE-243.
    Strain: DPF96e3_23.1, DPF96e3_3.0, DPF96e3_4.2, DPF96e3_74.2, DPF96e3_84.3, HFL97e3_12, HFL97e3_13, HFL97e3_15, HFL97e3_16, HFL97e3_8, SC96e3_12.3, SC96e3_19.4, VT97e3_1, VT97e3_39, VT97e3_41, ZIM(H)e3_38.4, ZIM(H)e3_39, ZIM(S)e3_24 and ZIM(S)e3_35.
  2. Deobagkar D.D., Kulkarni G.V., Deobagkar D.N.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-K.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Testis.

Entry informationi

Entry nameiHXK1_DROME
AccessioniPrimary (citable) accession number: Q9NFT9
Secondary accession number(s): Q6AWE1, Q9VBF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi