Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NFT9 (HXK1_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase type 1

EC=2.7.1.1
Gene names
Name:Hex-t1
Synonyms:Hex
ORF Names:CG33102
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathway

Carbohydrate metabolism; hexose metabolism.

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Hexokinase type 1
PRO_0000197596

Regions

Domain13 – 209197Hexokinase type-1
Domain214 – 449236Hexokinase type-2
Region139 – 16527Glucose-binding Potential

Sites

Binding site881ATP By similarity

Natural variations

Natural variant331N → H in strain: HFL97e3_12 and ZIM(S)e3_24. Ref.1
Natural variant2431Y → F in strain: DPF96e3_3.0, DPF96e3_4.2, DPF96e3_23.1, DPF96e3_74.2, VT97e3_41, SC96e3_12.3, HFL97e3_8, HFL97e3_12, HFL97e3_15, ZIM(S)e3_24 and ZIM(S)e3_35. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9NFT9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 67B611920D56B6DD

FASTA46552,260
        10         20         30         40         50         60 
MANTFNPEED FPEVYKVCKL FNPSIDDLEK IKNAMDREIT MGLSRDHHDR STVPCHLSYV 

        70         80         90        100        110        120 
QDLPTGRERG QFLALEMMPT NCRIMLVKFS SERDIYTSSK CVIMPHTVAA GRGTEVFTFL 

       130        140        150        160        170        180 
ATSIANFVKE KKVDKDNLPL GIAFAFTLKK LALDVGILVS WTKEFGAQGA IGKDVVQLLR 

       190        200        210        220        230        240 
DALAKFPEIS VDVMGIINVG AGSLLALCWA QPDTRIGLIM GSIANSCYVE RVERCETYEG 

       250        260        270        280        290        300 
DEYRKLMIIN SDWAHFGDTG QLDFIRNEYD RQLDTESINP GTRIYEKFSG ALCMGELVRI 

       310        320        330        340        350        360 
IVLRLMKSGA IFAEDRRDYI GIQWKLDMVS LIEIVSDPPG VYTKAQEVMD KFRIRHCKER 

       370        380        390        400        410        420 
DLAALKYICD TVTNRAAMLV ASGVSCLIDR MRLPQISIAV DGGIYRLHPT FSTVLNKYTR 

       430        440        450        460 
LLADPNYNFE FVITQDSCGV GAAIMAGMAH ANKYKTDAKL FTMDY 

« Hide

References

« Hide 'large scale' references
[1]"Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba."
Duvernell D.D., Eanes W.F.
Genetics 156:1191-1201(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-33 AND PHE-243.
Strain: DPF96e3_23.1, DPF96e3_3.0, DPF96e3_4.2, DPF96e3_74.2, DPF96e3_84.3, HFL97e3_12, HFL97e3_13, HFL97e3_15, HFL97e3_16, HFL97e3_8, SC96e3_12.3, SC96e3_19.4, VT97e3_1, VT97e3_39, VT97e3_41, ZIM(H)e3_38.4, ZIM(H)e3_39, ZIM(S)e3_24 and ZIM(S)e3_35.
[2]Deobagkar D.D., Kulkarni G.V., Deobagkar D.N.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Oregon-K.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[5]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF257590 Genomic DNA. Translation: AAG22891.1.
AF257591 Genomic DNA. Translation: AAG22893.1.
AF257592 Genomic DNA. Translation: AAG22895.1.
AF257593 Genomic DNA. Translation: AAG22897.1.
AF257594 Genomic DNA. Translation: AAG22899.1.
AF257595 Genomic DNA. Translation: AAG22901.1.
AF257596 Genomic DNA. Translation: AAG22903.1.
AF257597 Genomic DNA. Translation: AAG22905.1.
AF257598 Genomic DNA. Translation: AAG22907.1.
AF257599 Genomic DNA. Translation: AAG22909.1.
AF257600 Genomic DNA. Translation: AAG22911.1.
AF257601 Genomic DNA. Translation: AAG22913.1.
AF257602 Genomic DNA. Translation: AAG22915.1.
AF257603 Genomic DNA. Translation: AAG22917.1.
AF257604 Genomic DNA. Translation: AAG22919.1.
AF257605 Genomic DNA. Translation: AAG22921.1.
AF257606 Genomic DNA. Translation: AAG22923.1.
AF257607 Genomic DNA. Translation: AAG22925.1.
AF257608 Genomic DNA. Translation: AAG22927.1.
AJ271350 Genomic DNA. Translation: CAB72131.1.
AE014297 Genomic DNA. Translation: AAF56591.2.
BT015307 mRNA. Translation: AAT94535.1.
RefSeqNP_788744.1. NM_176567.2.
UniGeneDm.21469.

3D structure databases

ProteinModelPortalQ9NFT9.
SMRQ9NFT9. Positions 21-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7227.FBpp0084382.

Proteomic databases

PRIDEQ9NFT9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0085010; FBpp0084382; FBgn0042711.
GeneID117364.
KEGGdme:Dmel_CG33102.
UCSCCG33102-RA. d. melanogaster.

Organism-specific databases

CTD117364.
FlyBaseFBgn0042711. Hex-t1.

Phylogenomic databases

eggNOGCOG5026.
GeneTreeENSGT00390000017159.
InParanoidQ9NFT9.
KOK00844.
OMAPTNCRIM.
OrthoDBEOG7TBC24.
PhylomeDBQ9NFT9.

Enzyme and pathway databases

UniPathwayUPA00242.

Gene expression databases

BgeeQ9NFT9.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
ProtoNetSearch...

Other

GenomeRNAi117364.
NextBio841931.

Entry information

Entry nameHXK1_DROME
AccessionPrimary (citable) accession number: Q9NFT9
Secondary accession number(s): Q6AWE1, Q9VBF1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase