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Protein

Hexokinase type 1

Gene

Hex-t1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-DME-6798695. Neutrophil degranulation.
R-DME-70153. Glucose transport.
R-DME-70171. Glycolysis.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase type 1 (EC:2.7.1.1)
Gene namesi
Name:Hex-t1
Synonyms:Hex
ORF Names:CG33102
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0042711. Hex-t1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975961 – 465Hexokinase type 1Add BLAST465

Proteomic databases

PaxDbiQ9NFT9.
PRIDEiQ9NFT9.

Expressioni

Gene expression databases

BgeeiFBgn0042711.
GenevisibleiQ9NFT9. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9NFT9. 1 interactor.
STRINGi7227.FBpp0084382.

Structurei

3D structure databases

ProteinModelPortaliQ9NFT9.
SMRiQ9NFT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 447HexokinasePROSITE-ProRule annotationAdd BLAST440

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 197Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST133
Regioni139 – 165Glucose-bindingSequence analysisAdd BLAST27
Regioni198 – 436Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.
InParanoidiQ9NFT9.
KOiK00844.
OMAiDAKLFTM.
OrthoDBiEOG091G0937.
PhylomeDBiQ9NFT9.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NFT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTFNPEED FPEVYKVCKL FNPSIDDLEK IKNAMDREIT MGLSRDHHDR
60 70 80 90 100
STVPCHLSYV QDLPTGRERG QFLALEMMPT NCRIMLVKFS SERDIYTSSK
110 120 130 140 150
CVIMPHTVAA GRGTEVFTFL ATSIANFVKE KKVDKDNLPL GIAFAFTLKK
160 170 180 190 200
LALDVGILVS WTKEFGAQGA IGKDVVQLLR DALAKFPEIS VDVMGIINVG
210 220 230 240 250
AGSLLALCWA QPDTRIGLIM GSIANSCYVE RVERCETYEG DEYRKLMIIN
260 270 280 290 300
SDWAHFGDTG QLDFIRNEYD RQLDTESINP GTRIYEKFSG ALCMGELVRI
310 320 330 340 350
IVLRLMKSGA IFAEDRRDYI GIQWKLDMVS LIEIVSDPPG VYTKAQEVMD
360 370 380 390 400
KFRIRHCKER DLAALKYICD TVTNRAAMLV ASGVSCLIDR MRLPQISIAV
410 420 430 440 450
DGGIYRLHPT FSTVLNKYTR LLADPNYNFE FVITQDSCGV GAAIMAGMAH
460
ANKYKTDAKL FTMDY
Length:465
Mass (Da):52,260
Last modified:October 1, 2000 - v1
Checksum:i67B611920D56B6DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti33N → H in strain: HFL97e3_12 and ZIM(S)e3_24. 1 Publication1
Natural varianti243Y → F in strain: DPF96e3_3.0, DPF96e3_4.2, DPF96e3_23.1, DPF96e3_74.2, VT97e3_41, SC96e3_12.3, HFL97e3_8, HFL97e3_12, HFL97e3_15, ZIM(S)e3_24 and ZIM(S)e3_35. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257590 Genomic DNA. Translation: AAG22891.1.
AF257591 Genomic DNA. Translation: AAG22893.1.
AF257592 Genomic DNA. Translation: AAG22895.1.
AF257593 Genomic DNA. Translation: AAG22897.1.
AF257594 Genomic DNA. Translation: AAG22899.1.
AF257595 Genomic DNA. Translation: AAG22901.1.
AF257596 Genomic DNA. Translation: AAG22903.1.
AF257597 Genomic DNA. Translation: AAG22905.1.
AF257598 Genomic DNA. Translation: AAG22907.1.
AF257599 Genomic DNA. Translation: AAG22909.1.
AF257600 Genomic DNA. Translation: AAG22911.1.
AF257601 Genomic DNA. Translation: AAG22913.1.
AF257602 Genomic DNA. Translation: AAG22915.1.
AF257603 Genomic DNA. Translation: AAG22917.1.
AF257604 Genomic DNA. Translation: AAG22919.1.
AF257605 Genomic DNA. Translation: AAG22921.1.
AF257606 Genomic DNA. Translation: AAG22923.1.
AF257607 Genomic DNA. Translation: AAG22925.1.
AF257608 Genomic DNA. Translation: AAG22927.1.
AJ271350 Genomic DNA. Translation: CAB72131.1.
AE014297 Genomic DNA. Translation: AAF56591.2.
BT015307 mRNA. Translation: AAT94535.1.
RefSeqiNP_788744.1. NM_176567.2.
UniGeneiDm.21469.

Genome annotation databases

EnsemblMetazoaiFBtr0085010; FBpp0084382; FBgn0042711.
GeneIDi117364.
KEGGidme:Dmel_CG33102.
UCSCiCG33102-RA. d. melanogaster.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257590 Genomic DNA. Translation: AAG22891.1.
AF257591 Genomic DNA. Translation: AAG22893.1.
AF257592 Genomic DNA. Translation: AAG22895.1.
AF257593 Genomic DNA. Translation: AAG22897.1.
AF257594 Genomic DNA. Translation: AAG22899.1.
AF257595 Genomic DNA. Translation: AAG22901.1.
AF257596 Genomic DNA. Translation: AAG22903.1.
AF257597 Genomic DNA. Translation: AAG22905.1.
AF257598 Genomic DNA. Translation: AAG22907.1.
AF257599 Genomic DNA. Translation: AAG22909.1.
AF257600 Genomic DNA. Translation: AAG22911.1.
AF257601 Genomic DNA. Translation: AAG22913.1.
AF257602 Genomic DNA. Translation: AAG22915.1.
AF257603 Genomic DNA. Translation: AAG22917.1.
AF257604 Genomic DNA. Translation: AAG22919.1.
AF257605 Genomic DNA. Translation: AAG22921.1.
AF257606 Genomic DNA. Translation: AAG22923.1.
AF257607 Genomic DNA. Translation: AAG22925.1.
AF257608 Genomic DNA. Translation: AAG22927.1.
AJ271350 Genomic DNA. Translation: CAB72131.1.
AE014297 Genomic DNA. Translation: AAF56591.2.
BT015307 mRNA. Translation: AAT94535.1.
RefSeqiNP_788744.1. NM_176567.2.
UniGeneiDm.21469.

3D structure databases

ProteinModelPortaliQ9NFT9.
SMRiQ9NFT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NFT9. 1 interactor.
STRINGi7227.FBpp0084382.

Proteomic databases

PaxDbiQ9NFT9.
PRIDEiQ9NFT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085010; FBpp0084382; FBgn0042711.
GeneIDi117364.
KEGGidme:Dmel_CG33102.
UCSCiCG33102-RA. d. melanogaster.

Organism-specific databases

CTDi117364.
FlyBaseiFBgn0042711. Hex-t1.

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.
InParanoidiQ9NFT9.
KOiK00844.
OMAiDAKLFTM.
OrthoDBiEOG091G0937.
PhylomeDBiQ9NFT9.

Enzyme and pathway databases

UniPathwayiUPA00242.
ReactomeiR-DME-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-DME-6798695. Neutrophil degranulation.
R-DME-70153. Glucose transport.
R-DME-70171. Glycolysis.

Miscellaneous databases

GenomeRNAii117364.
PROiQ9NFT9.

Gene expression databases

BgeeiFBgn0042711.
GenevisibleiQ9NFT9. DM.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXK1_DROME
AccessioniPrimary (citable) accession number: Q9NFT9
Secondary accession number(s): Q6AWE1, Q9VBF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.