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Protein

Hexokinase type 1

Gene

Hex-t1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathway: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_307214. Regulation of gene expression in beta cells.
REACT_319845. Glycolysis.
REACT_340255. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_342895. Glucose transport.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase type 1 (EC:2.7.1.1)
Gene namesi
Name:Hex-t1
Synonyms:Hex
ORF Names:CG33102
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0042711. Hex-t1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Hexokinase type 1PRO_0000197596Add
BLAST

Proteomic databases

PRIDEiQ9NFT9.

Expressioni

Gene expression databases

BgeeiQ9NFT9.
GenevisibleiQ9NFT9. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9NFT9. 1 interaction.
STRINGi7227.FBpp0084382.

Structurei

3D structure databases

ProteinModelPortaliQ9NFT9.
SMRiQ9NFT9. Positions 21-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 447440HexokinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 197133Hexokinase small subdomainPROSITE-ProRule annotationAdd
BLAST
Regioni139 – 16527Glucose-bindingSequence AnalysisAdd
BLAST
Regioni198 – 436239Hexokinase large subdomainPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
InParanoidiQ9NFT9.
KOiK00844.
OMAiPTNCRIM.
OrthoDBiEOG7TBC24.
PhylomeDBiQ9NFT9.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NFT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTFNPEED FPEVYKVCKL FNPSIDDLEK IKNAMDREIT MGLSRDHHDR
60 70 80 90 100
STVPCHLSYV QDLPTGRERG QFLALEMMPT NCRIMLVKFS SERDIYTSSK
110 120 130 140 150
CVIMPHTVAA GRGTEVFTFL ATSIANFVKE KKVDKDNLPL GIAFAFTLKK
160 170 180 190 200
LALDVGILVS WTKEFGAQGA IGKDVVQLLR DALAKFPEIS VDVMGIINVG
210 220 230 240 250
AGSLLALCWA QPDTRIGLIM GSIANSCYVE RVERCETYEG DEYRKLMIIN
260 270 280 290 300
SDWAHFGDTG QLDFIRNEYD RQLDTESINP GTRIYEKFSG ALCMGELVRI
310 320 330 340 350
IVLRLMKSGA IFAEDRRDYI GIQWKLDMVS LIEIVSDPPG VYTKAQEVMD
360 370 380 390 400
KFRIRHCKER DLAALKYICD TVTNRAAMLV ASGVSCLIDR MRLPQISIAV
410 420 430 440 450
DGGIYRLHPT FSTVLNKYTR LLADPNYNFE FVITQDSCGV GAAIMAGMAH
460
ANKYKTDAKL FTMDY
Length:465
Mass (Da):52,260
Last modified:October 1, 2000 - v1
Checksum:i67B611920D56B6DD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331N → H in strain: HFL97e3_12 and ZIM(S)e3_24. 1 Publication
Natural varianti243 – 2431Y → F in strain: DPF96e3_3.0, DPF96e3_4.2, DPF96e3_23.1, DPF96e3_74.2, VT97e3_41, SC96e3_12.3, HFL97e3_8, HFL97e3_12, HFL97e3_15, ZIM(S)e3_24 and ZIM(S)e3_35. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257590 Genomic DNA. Translation: AAG22891.1.
AF257591 Genomic DNA. Translation: AAG22893.1.
AF257592 Genomic DNA. Translation: AAG22895.1.
AF257593 Genomic DNA. Translation: AAG22897.1.
AF257594 Genomic DNA. Translation: AAG22899.1.
AF257595 Genomic DNA. Translation: AAG22901.1.
AF257596 Genomic DNA. Translation: AAG22903.1.
AF257597 Genomic DNA. Translation: AAG22905.1.
AF257598 Genomic DNA. Translation: AAG22907.1.
AF257599 Genomic DNA. Translation: AAG22909.1.
AF257600 Genomic DNA. Translation: AAG22911.1.
AF257601 Genomic DNA. Translation: AAG22913.1.
AF257602 Genomic DNA. Translation: AAG22915.1.
AF257603 Genomic DNA. Translation: AAG22917.1.
AF257604 Genomic DNA. Translation: AAG22919.1.
AF257605 Genomic DNA. Translation: AAG22921.1.
AF257606 Genomic DNA. Translation: AAG22923.1.
AF257607 Genomic DNA. Translation: AAG22925.1.
AF257608 Genomic DNA. Translation: AAG22927.1.
AJ271350 Genomic DNA. Translation: CAB72131.1.
AE014297 Genomic DNA. Translation: AAF56591.2.
BT015307 mRNA. Translation: AAT94535.1.
RefSeqiNP_788744.1. NM_176567.2.
UniGeneiDm.21469.

Genome annotation databases

EnsemblMetazoaiFBtr0085010; FBpp0084382; FBgn0042711.
GeneIDi117364.
KEGGidme:Dmel_CG33102.
UCSCiCG33102-RA. d. melanogaster.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257590 Genomic DNA. Translation: AAG22891.1.
AF257591 Genomic DNA. Translation: AAG22893.1.
AF257592 Genomic DNA. Translation: AAG22895.1.
AF257593 Genomic DNA. Translation: AAG22897.1.
AF257594 Genomic DNA. Translation: AAG22899.1.
AF257595 Genomic DNA. Translation: AAG22901.1.
AF257596 Genomic DNA. Translation: AAG22903.1.
AF257597 Genomic DNA. Translation: AAG22905.1.
AF257598 Genomic DNA. Translation: AAG22907.1.
AF257599 Genomic DNA. Translation: AAG22909.1.
AF257600 Genomic DNA. Translation: AAG22911.1.
AF257601 Genomic DNA. Translation: AAG22913.1.
AF257602 Genomic DNA. Translation: AAG22915.1.
AF257603 Genomic DNA. Translation: AAG22917.1.
AF257604 Genomic DNA. Translation: AAG22919.1.
AF257605 Genomic DNA. Translation: AAG22921.1.
AF257606 Genomic DNA. Translation: AAG22923.1.
AF257607 Genomic DNA. Translation: AAG22925.1.
AF257608 Genomic DNA. Translation: AAG22927.1.
AJ271350 Genomic DNA. Translation: CAB72131.1.
AE014297 Genomic DNA. Translation: AAF56591.2.
BT015307 mRNA. Translation: AAT94535.1.
RefSeqiNP_788744.1. NM_176567.2.
UniGeneiDm.21469.

3D structure databases

ProteinModelPortaliQ9NFT9.
SMRiQ9NFT9. Positions 21-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NFT9. 1 interaction.
STRINGi7227.FBpp0084382.

Proteomic databases

PRIDEiQ9NFT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085010; FBpp0084382; FBgn0042711.
GeneIDi117364.
KEGGidme:Dmel_CG33102.
UCSCiCG33102-RA. d. melanogaster.

Organism-specific databases

CTDi117364.
FlyBaseiFBgn0042711. Hex-t1.

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
InParanoidiQ9NFT9.
KOiK00844.
OMAiPTNCRIM.
OrthoDBiEOG7TBC24.
PhylomeDBiQ9NFT9.

Enzyme and pathway databases

UniPathwayiUPA00242.
ReactomeiREACT_307214. Regulation of gene expression in beta cells.
REACT_319845. Glycolysis.
REACT_340255. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_342895. Glucose transport.

Miscellaneous databases

GenomeRNAii117364.
NextBioi841931.
PROiQ9NFT9.

Gene expression databases

BgeeiQ9NFT9.
GenevisibleiQ9NFT9. DM.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba."
    Duvernell D.D., Eanes W.F.
    Genetics 156:1191-1201(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-33 AND PHE-243.
    Strain: DPF96e3_23.1, DPF96e3_3.0, DPF96e3_4.2, DPF96e3_74.2, DPF96e3_84.3, HFL97e3_12, HFL97e3_13, HFL97e3_15, HFL97e3_16, HFL97e3_8, SC96e3_12.3, SC96e3_19.4, VT97e3_1, VT97e3_39, VT97e3_41, ZIM(H)e3_38.4, ZIM(H)e3_39, ZIM(S)e3_24 and ZIM(S)e3_35.
  2. Deobagkar D.D., Kulkarni G.V., Deobagkar D.N.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Oregon-K.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Testis.

Entry informationi

Entry nameiHXK1_DROME
AccessioniPrimary (citable) accession number: Q9NFT9
Secondary accession number(s): Q6AWE1, Q9VBF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.