ID   ALL22_GLYDO             Reviewed;         125 AA.
AC   Q9NFQ4;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=Mite group 2 allergen Gly d 2.02;
DE   AltName: Allergen=Gly d 2.02;
OS   Glycyphagus domesticus (House itch mite) (Acarus domesticus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Glycyphagoidea; Glycyphagidae;
OC   Glycyphagus.
OX   NCBI_TaxID=105145;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1-18.
RX   PubMed=11240953; DOI=10.1067/mai.2001.112264;
RA   Gafvelin G., Johansson E., Lundin A., Smith A.M., Chapman M.D.,
RA   Benjamin D.C., Derewenda U., van Hage-Hamsten M.;
RT   "Cross-reactivity studies of a new group 2 allergen from the dust mite
RT   Glycyphagus domesticus, Gly d 2, and group 2 allergens from
RT   Dermatophagoides pteronyssinus, Lepidoglyphus destructor, and Tyrophagus
RT   putrescentiae with recombinant allergens.";
RL   J. Allergy Clin. Immunol. 107:511-518(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC       allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; AJ272216; CAB76459.1; -; mRNA.
DR   AlphaFoldDB; Q9NFQ4; -.
DR   SMR; Q9NFQ4; -.
DR   Allergome; 365; Gly d 2.
DR   Allergome; 367; Gly d 2.0201.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR   GO; GO:0015918; P:sterol transport; IEA:InterPro.
DR   CDD; cd00918; Der-p2_like; 1.
DR   Gene3D; 2.60.40.770; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED; 1.
DR   PANTHER; PTHR11306:SF73; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Secreted.
FT   CHAIN           1..125
FT                   /note="Mite group 2 allergen Gly d 2.02"
FT                   /id="PRO_0000221049"
SQ   SEQUENCE   125 AA;  13366 MW;  63607D3C6BF0AAE0 CRC64;
     GKMKFKDCGK GEVTELDITD CSGDFCVIHR GKPLTLEAKF AANQDTTKAT IKVLAKVAGT
     PIQVPGLETD GCKFVKCPIK KGDPIDFKYT TTVPAILPKV KAEVTAELVG DHGVLACGRF
     GRQVE
//