Q9NFQ4 (ALL22_GLYDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Mite group 2 allergen Gly d 2.02 Alternative name(s): Allergen=Gly d 2.02
Organism	Glycyphagus domesticus (House itch mite)
Taxonomic identifier	105145 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Glycyphagoidea › Glycyphagidae › Glycyphagus

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Allergenic properties	Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
Sequence similarities	Belongs to the NPC2 family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Mite group 2 allergen Gly d 2.02		PRO_0000221049

Sequences

	Sequence		Length	Mass (Da)
	Q9NFQ4 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 63607D3C6BF0AAE0	FASTA	125	13,366
	10 20 30 40 50 60 GKMKFKDCGK GEVTELDITD CSGDFCVIHR GKPLTLEAKF AANQDTTKAT IKVLAKVAGT 70 80 90 100 110 120 PIQVPGLETD GCKFVKCPIK KGDPIDFKYT TTVPAILPKV KAEVTAELVG DHGVLACGRF GRQVE

References

[1]

"Cross-reactivity studies of a new group 2 allergen from the dust mite Glycyphagus domesticus, Gly d 2, and group 2 allergens from Dermatophagoides pteronyssinus, Lepidoglyphus destructor, and Tyrophagus putrescentiae with recombinant allergens." Gafvelin G., Johansson E., Lundin A., Smith A.M., Chapman M.D., Benjamin D.C., Derewenda U., van Hage-Hamsten M. J. Allergy Clin. Immunol. 107:511-518(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ272216 mRNA. Translation: CAB76459.1.
3D structure databases
ProteinModelPortal	Q9NFQ4.
ModBase	Search...
Protein family/group databases
Allergome	365. Gly d 2. 367. Gly d 2.0201.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.40.770. 1 hit.
InterPro	IPR014756. Ig_E-set. IPR003172. MD-2_lipid-recog_dom. [Graphical view]
Pfam	PF02221. E1_DerP2_DerF2. 1 hit. [Graphical view]
SMART	SM00737. ML. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALL22_GLYDO

Accession

Primary (citable) accession number: Q9NFQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)