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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-46

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299308. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).
R-CEL-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-46Imported
ORF Names:CELE_Y39B6A.19Imported, Y39B6A.19Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiY39B6A.19a; CE29861; WBGene00006696; twk-46.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4822HelicalSequence analysisAdd
BLAST
Transmembranei108 – 12619HelicalSequence analysisAdd
BLAST
Transmembranei138 – 16023HelicalSequence analysisAdd
BLAST
Transmembranei188 – 21023HelicalSequence analysisAdd
BLAST
Transmembranei222 – 23817HelicalSequence analysisAdd
BLAST
Transmembranei250 – 27526HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9NEV3.

Expressioni

Gene expression databases

BgeeiWBGene00006696.
ExpressionAtlasiQ9NEV3. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y39B6A.19a.

Structurei

3D structure databases

ProteinModelPortaliQ9NEV3.
SMRiQ9NEV3. Positions 41-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 16357Ion_trans_2InterPro annotationAdd
BLAST
Domaini199 – 27678Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
InParanoidiQ9NEV3.
KOiK04912.
OMAiNGMEGRM.
OrthoDBiEOG091G0DIX.
PhylomeDBiQ9NEV3.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9NEV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEMFTMHT KVLNGMEGRM RESNMRILVG LGVAVVYLFV GAIVFVRIEY
60 70 80 90 100
PLEKIEREAY LDYQNQWRDR LIQLDIDESE IDKLFLNIRE AALNGIWMDR
110 120 130 140 150
NLTSDPNWTF GQAFFFAGTL ISTVGYGRVS PRTEYGKLFT ILYCVIGIPL
160 170 180 190 200
TLALLSAIVA RMREPSHKLR GLLNQRLGHL FTVNHIQLIH VGVVFASLLL
210 220 230 240 250
FVFAIPAWVF SSIETDWSYL DAFYYCFVSL TTIGLGDFEP GDDPNQSFRG
260 270 280 290 300
LYKIGATVYL MGGLCCMMLF LATLYDIPQF NLTSFFVKSD EEMRFSEEDG
310
KYGTLDSNVV ENGFYSADH
Length:319
Mass (Da):36,372
Last modified:October 1, 2002 - v2
Checksum:iDC2F109A7B77CD9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAD31817.1.
RefSeqiNP_741678.1. NM_171588.4.
UniGeneiCel.1815.

Genome annotation databases

EnsemblMetazoaiY39B6A.19a; Y39B6A.19a; WBGene00006696.
GeneIDi180252.
KEGGicel:CELE_Y39B6A.19.
UCSCiY39B6A.19. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAD31817.1.
RefSeqiNP_741678.1. NM_171588.4.
UniGeneiCel.1815.

3D structure databases

ProteinModelPortaliQ9NEV3.
SMRiQ9NEV3. Positions 41-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y39B6A.19a.

Proteomic databases

PaxDbiQ9NEV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY39B6A.19a; Y39B6A.19a; WBGene00006696.
GeneIDi180252.
KEGGicel:CELE_Y39B6A.19.
UCSCiY39B6A.19. c. elegans.

Organism-specific databases

CTDi180252.
WormBaseiY39B6A.19a; CE29861; WBGene00006696; twk-46.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
InParanoidiQ9NEV3.
KOiK04912.
OMAiNGMEGRM.
OrthoDBiEOG091G0DIX.
PhylomeDBiQ9NEV3.

Enzyme and pathway databases

ReactomeiR-CEL-1299308. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).
R-CEL-5576886. Phase 4 - resting membrane potential.

Gene expression databases

BgeeiWBGene00006696.
ExpressionAtlasiQ9NEV3. baseline.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01586. TWIKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9NEV3_CAEEL
AccessioniPrimary (citable) accession number: Q9NEV3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.