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Protein

40S ribosomal protein S6

Gene

rps-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Negatively regulates lifespan (PubMed:23879233).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • ribosomal small subunit biogenesis Source: GO_Central
  • rRNA processing Source: GO_Central
  • translation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-166208. mTORC1-mediated signalling.
R-CEL-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CEL-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-CEL-72702. Ribosomal scanning and start codon recognition.
R-CEL-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S6
Gene namesi
Name:rps-6Imported
ORF Names:Y71A12B.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY71A12B.1a; CE24592; WBGene00004475; rps-6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001373261 – 24640S ribosomal protein S6Add BLAST246

Post-translational modificationi

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NEN6.
PaxDbiQ9NEN6.
PeptideAtlasiQ9NEN6.
PRIDEiQ9NEN6.

PTM databases

iPTMnetiQ9NEN6.

Expressioni

Gene expression databases

BgeeiWBGene00004475.
ExpressionAtlasiQ9NEN6. baseline.

Interactioni

Protein-protein interaction databases

BioGridi38651. 5 interactors.
DIPiDIP-25007N.
IntActiQ9NEN6. 4 interactors.
MINTiMINT-1038237.
STRINGi6239.Y71A12B.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ9NEN6.
SMRiQ9NEN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS6 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1646. Eukaryota.
COG2125. LUCA.
GeneTreeiENSGT00390000009819.
HOGENOMiHOG000190952.
InParanoidiQ9NEN6.
KOiK02991.
OMAiKGYIFRI.
OrthoDBiEOG091G089B.
PhylomeDBiQ9NEN6.

Family and domain databases

InterProiView protein in InterPro
IPR014401. Ribosomal_S6_euk.
IPR001377. Ribosomal_S6e.
PANTHERiPTHR11502. PTHR11502. 1 hit.
PfamiView protein in Pfam
PF01092. Ribosomal_S6e. 1 hit.
PIRSFiPIRSF002129. Ribosom_S6_euk. 1 hit.
SMARTiView protein in SMART
SM01405. Ribosomal_S6e. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NEN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLNFAYPAT GLQKSFEVDE EKKLRLFFEK RMSQEVAIDA LGDEWKGYVV
60 70 80 90 100
RIGGGNDKQG FPMKQGILTN GRVRLLLKKG QSCYRERKNG ERKRKSVRGC
110 120 130 140 150
IVDANMSALS LVIVKKGDGE IEGLTDSVLP RKLGPKRASK IRKLFNLTKH
160 170 180 190 200
DDVTKYVITH DKTFPDGVTK TIAPKIQRLI TPARIARKKY LLRQKRNQKI
210 220 230 240
KMRDDAAAYH KLLAKYSKEE HDAKIARRRS SASHHSESEV KKTSKK
Length:246
Mass (Da):28,136
Last modified:October 1, 2000 - v1
Checksum:i4D2F142DFAA55F59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132902 Genomic DNA. Translation: CAB81996.1.
RefSeqiNP_493435.1. NM_061034.6.
UniGeneiCel.8960.

Genome annotation databases

EnsemblMetazoaiY71A12B.1a; Y71A12B.1a; WBGene00004475.
GeneIDi173260.
KEGGicel:CELE_Y71A12B.1.
UCSCiY71A12B.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiRS6_CAEEL
AccessioniPrimary (citable) accession number: Q9NEN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families