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Protein

40S ribosomal protein S6

Gene

RPS6

Organism
Leishmania major
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S6
Gene namesi
Name:RPS6
ORF Names:L3640.11, Lmj_1130, LmjF21.1780, LmjF_21_1780
OrganismiLeishmania major
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 21

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001373281 – 24940S ribosomal protein S6Add BLAST249

Post-translational modificationi

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi5664.LmjF.35.2010.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S6e family.Curated

Phylogenomic databases

eggNOGiKOG1646. Eukaryota.
COG2125. LUCA.
HOGENOMiHOG000190952.
InParanoidiQ9NE83.
KOiK02991.
OMAiMTRNSEP.

Family and domain databases

InterProiIPR014401. Ribosomal_S6_euk.
IPR001377. Ribosomal_S6e.
IPR018282. Ribosomal_S6e_CS.
[Graphical view]
PANTHERiPTHR11502. PTHR11502. 1 hit.
PfamiPF01092. Ribosomal_S6e. 1 hit.
[Graphical view]
PIRSFiPIRSF002129. Ribosom_S6_euk. 1 hit.
SMARTiSM01405. Ribosomal_S6e. 1 hit.
[Graphical view]
PROSITEiPS00578. RIBOSOMAL_S6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NE83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNIAYPRN GTVKQFEISD EVLRRVQLQD YRLGNEVDGA IFGSEFKGYI
60 70 80 90 100
FRLRGGSDKD GFPMVPGVLA SSRVSLLVKR GAIGFNTFRG YQGERRRKNV
110 120 130 140 150
RGCVLASDIA LVNVTISKVG DQPIEGVTDT TAPRRLGPKR ASKIRKLFNL
160 170 180 190 200
SRTEDVRKYV VRRRVVKSGK KDRLKAPKIQ RLITPRVKAR RAKKAKDAIA
210 220 230 240
KVRASAAERR EYLRLIASNR RALRQRDHSK KHTRKVHAQR AEVAAFQKK
Length:249
Mass (Da):28,304
Last modified:October 1, 2000 - v1
Checksum:iE9920868375AC7CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796417 Genomic DNA. Translation: CAJ05109.1.
RefSeqiXP_001683143.1. XM_001683091.1.
XP_003722593.1. XM_003722545.1.

Genome annotation databases

GeneIDi12982497.
5651750.
KEGGilma:LMJF_21_1780.
lma:LMJF_35_2010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796417 Genomic DNA. Translation: CAJ05109.1.
RefSeqiXP_001683143.1. XM_001683091.1.
XP_003722593.1. XM_003722545.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.35.2010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12982497.
5651750.
KEGGilma:LMJF_21_1780.
lma:LMJF_35_2010.

Phylogenomic databases

eggNOGiKOG1646. Eukaryota.
COG2125. LUCA.
HOGENOMiHOG000190952.
InParanoidiQ9NE83.
KOiK02991.
OMAiMTRNSEP.

Family and domain databases

InterProiIPR014401. Ribosomal_S6_euk.
IPR001377. Ribosomal_S6e.
IPR018282. Ribosomal_S6e_CS.
[Graphical view]
PANTHERiPTHR11502. PTHR11502. 1 hit.
PfamiPF01092. Ribosomal_S6e. 1 hit.
[Graphical view]
PIRSFiPIRSF002129. Ribosom_S6_euk. 1 hit.
SMARTiSM01405. Ribosomal_S6e. 1 hit.
[Graphical view]
PROSITEiPS00578. RIBOSOMAL_S6E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS6_LEIMA
AccessioniPrimary (citable) accession number: Q9NE83
Secondary accession number(s): Q4FWR9, Q4QC05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.