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Q9NDJ2

- DOM_DROME

UniProt

Q9NDJ2 - DOM_DROME

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Protein

Helicase domino

Gene
dom, CG9696
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis.6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi939 – 9468ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. DNA-dependent ATPase activity Source: FlyBase
  4. helicase activity Source: UniProtKB-KW
  5. protein binding Source: FlyBase

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. cell cycle Source: UniProtKB-KW
  3. chromatin organization Source: FlyBase
  4. dendrite guidance Source: FlyBase
  5. dendrite morphogenesis Source: FlyBase
  6. gene silencing Source: FlyBase
  7. hemopoiesis Source: FlyBase
  8. histone acetylation Source: UniProtKB
  9. histone exchange Source: UniProtKB
  10. instar larval or pupal development Source: FlyBase
  11. negative regulation of gene expression Source: FlyBase
  12. negative regulation of hemocyte proliferation Source: FlyBase
  13. neurogenesis Source: FlyBase
  14. oogenesis Source: FlyBase
  15. positive regulation of gene silencing by miRNA Source: FlyBase
  16. positive regulation of Notch signaling pathway Source: FlyBase
  17. regulation of alternative mRNA splicing, via spliceosome Source: FlyBase
  18. regulation of transcription, DNA-templated Source: UniProtKB-KW
  19. transcription, DNA-templated Source: UniProtKB-KW
  20. wing disc pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein, Helicase, Hydrolase

Keywords - Biological processi

Cell cycle, Differentiation, Oogenesis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase domino (EC:3.6.4.-)
Gene namesi
Name:dom
ORF Names:CG9696
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0020306. dom.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. histone acetyltransferase complex Source: FlyBase
  2. NuA4 histone acetyltransferase complex Source: UniProtKB
  3. nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31983198Helicase dominoPRO_0000311238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei656 – 6561Phosphoserine1 Publication
Modified residuei664 – 6641Phosphoserine1 Publication
Modified residuei666 – 6661Phosphoserine1 Publication
Modified residuei729 – 7291Phosphothreonine1 Publication
Modified residuei733 – 7331Phosphoserine1 Publication
Modified residuei736 – 7361Phosphoserine1 Publication
Modified residuei744 – 7441Phosphoserine1 Publication
Modified residuei838 – 8381Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NDJ2.

Expressioni

Tissue specificityi

Isoform B is present at high levels in ovary, in follicle cells, nurse cells and oocyte. Isoform B is also present in germline and somatic stem cells from the germarium. Isoform A is undetectable in adult ovary (at protein level).2 Publications

Developmental stagei

Isoform A and isoform B are present in 0-12 hours embryonic extracts. During embryonic development, isoform A expression is restricted to the developing nervous system, whereas isoform B is ubiquitously expressed. During postembryonic development, isoform B is found in brain, imaginal disks, lymph glands and salivary glands and isoform A is found in some brain regions, photoreceptor cells and sensory organ precursors (at protein level).1 Publication

Gene expression databases

BgeeiQ9NDJ2.

Interactioni

Subunit structurei

Component of the Tip60 chromatin-remodeling complex which contains Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.1 Publication

Protein-protein interaction databases

BioGridi69802. 20 interactions.
IntActiQ9NDJ2. 1 interaction.
STRINGi7227.FBpp0071529.

Structurei

3D structure databases

ProteinModelPortaliQ9NDJ2.
SMRiQ9NDJ2. Positions 889-1204, 1644-1829.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini507 – 57973HSAAdd
BLAST
Domaini926 – 1091166Helicase ATP-bindingAdd
BLAST
Domaini1662 – 1812151Helicase C-terminalAdd
BLAST
Domaini2136 – 220570Myb-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili187 – 21226 Reviewed predictionAdd
BLAST
Coiled coili666 – 69631 Reviewed predictionAdd
BLAST
Coiled coili741 – 78444 Reviewed predictionAdd
BLAST
Coiled coili1951 – 199646 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 995Poly-Gln
Compositional biasi101 – 11111Poly-AlaAdd
BLAST
Compositional biasi425 – 4284Poly-Gly
Compositional biasi1242 – 12498Poly-Leu
Compositional biasi2322 – 3188867Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 HSA domain.
Contains 1 Myb-like domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00530000063427.
InParanoidiQ9NDJ2.
KOiK11320.
OMAiRYETHIQ.
OrthoDBiEOG79CXXJ.
PhylomeDBiQ9NDJ2.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR013999. HAS_subgr.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR017877. Myb-like_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9NDJ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNEGNSAGGG HEGLSPAPPA VPDRVTPHST EISVAPANST STTVRAAGSV     50
GAALPATRHH QHIATQVKGI ASSSSKQQKQ LASAQLPVPL SPLPQQQQQT 100
AEATAAAAAP AHSNVSVSSS TIEASVLPPQ AKRQRLDDNE DRTSAASIVG 150
PAESSNIVSS LLPASVASSS EVGGLSSTAL QDLNALKKRI LQQKLQILRN 200
LKERHLENVS EYFYLQNGGS MMDYPAWRKK TPTPQFISYS NANRIDQLIH 250
EDKPSTSAAA AAAQNQKYTT QQTDSVESSL VSGIGTGATK GAPLDGNISN 300
STVKTNTQSQ VPSKIGSFTE STPAATESNS STTVPGTATS GAATSTSATS 350
AEASGNVLAV EAEIKIPAVG ATPVAISTKL PAAVVQLTQQ GGTPLLPCNT 400
SAGSTALRRP QGQNNASSGS AAASGGGGSL TPTPLYTGNG PAALGGSGGL 450
TPGTPTSGSL LSPALGGGSG TPNSAAQEFS FKAKQEVYVM QRISELQREG 500
LWTERRLPKL QEPSRPKAHW DYLLEEMVWL AADFAQERKW KKNAAKKCAK 550
MVQKYFQDKA TAAQRAEKAQ ELQLKRVASF IAREVKSFWS NVEKLVEYKH 600
QTKIEEKRKQ ALDQHLSFIV DQTEKFSQQL VEGMNKSVAD TPSLNSSRLT 650
SPKRESDDDF RPESGSEDDE ETIAKAEEDA ADVKEEVTAL AKESEMDFDD 700
FLNDLPPGYL ENRDKLMKEE QSSAIKTETP DDSDDSEFEA KEASDDDENT 750
ISKQEEAEQE IDHKKEIDEL EADNDLSVEQ LLAKYKSEQP PSPKRRKLAP 800
RDPELDSDDD STAVDSTEES EDAATEDEED LSTVKTDTDM EEQDEQEDGL 850
KSLMADADAT SGAAGSGSTA GASGNKDDML NDAAALAESL QPKGNTLSST 900
NVVTPVPFLL KHSLREYQHI GLDWLVTMNE RKLNGILADE MGLGKTIQTI 950
ALLAHLACAK GNWGPHLIVV PSSVMLNWEM EFKKWCPGFK ILTYYGSQKE 1000
RKLKRVGWTK PNAFHVCITS YKLVVQDQQS FRRKKWKYLI LDEAQNIKNF 1050
KSQRWQLLLN FSTERRLLLT GTPLQNDLME LWSLMHFLMP YVFSSHREFK 1100
EWFSNPMTGM IEGNMEYNET LITRLHKVIR PFLLRRLKKE VEKQMPKKYE 1150
HVITCRLSNR QRYLYEDFMS RAKTRETLQT GNLLSVINVL MQLRKVCNHP 1200
NMFEARPTIS PFQMDGITFH TPRLVCDIME YDPFTQINLE TLNLLLLHLE 1250
QTMTAYVSHK SRLLAPPRKL IEDIDTAPLP APRCPNGKYR FHIRVRSAEL 1300
AQRIKLNAVK VGASPAMRLE GSKIMPMRNL LPSGRVLKRV SASINPVNMA 1350
LKPVVINSVV TTTSSSTTAS SPTGALSVLS NSKLLGARSQ INAPTPAKVA 1400
KTMQDGKPFF YLTPATNSGA AGARLTLTSK TTASASTTTS RTTVTASTTS 1450
GQQLIRDPIV KDLATHVKST VQKQSIANGK TEPEEETEAE DPYKVQELIQ 1500
MRKEQRLAAL KRMAMINRRR TDATPIYGED CREAIQRCMQ ATRSLKRSTW 1550
QTRGYANCCT AMAHRNGWSL NHLLKSFEER CADLKPVFAN FVIYVPSVCA 1600
PRIRRYVQNL SSTHWQHEQR IENIVDQALR PKLALLHPII SEMTTKFPDP 1650
RLIQYDCGKL QTMDRLLRQL KVNGHRVLIF TQMTKMLDVL EAFLNYHGHI 1700
YLRLDGSTRV EQRQILMERF NGDKRIFCFI LSTRSGGVGI NLTGADTVIF 1750
YDSDWNPTMD AQAQDRCHRI GQTRDVHIYR LVSERTIEVN ILKKANQKRM 1800
LSDMAIEGGN FTTTYFKSST IKDLFTMEQS EQDESSQEKS ENKDRIVATT 1850
TLSDTPSTVV ETEKQSLRAF EHALAAAEDE QDVQATKTAK AEVAADLAEF 1900
DENIPIATED PNAEGGPQVE LSKADLEMQN LVKQLSPIER YAMRFVEETG 1950
AAWTAEQLRA AEAELEAQKR EWEANRLAAM HKEEELLKQE TEAEEMLTYS 2000
RKDSSNQVWI SRNTMEQMPM WCPPTPPQDN DNDIYIDYSL SFMYELEPIA 2050
ETDLPPVYVR KEHKRSRTDA GYDGSRRPNK MRREDNYVPP RSLFDRPTPQ 2100
LARLRRELKS QRFRGSFKPN MPIPGLKPQL PTKPLTEPEA MAEWCVFEDM 2150
AILHVLVNLQ GLPCSLMLLS PGQTPNWDLV SEMVNFCSKT YRSARQCRWR 2200
YETHIQPREE GKVVESPKKQ KKLKPTLRTE YLKSPLRYLR TTQLYVSDNN 2250
ASFYKTMRSR FDSIKTAYLK KAPPPKRQFS APSLMNPKHM EVLQEFGILN 2300
YDQPVSPQNI AAMKANKIRE KQRGQQMSQP PVGVGVVQQM QQQSQQQQQP 2350
APPPLPQQQQ PQQVVQQVQQ QQQQQQQQQQ QQVVQQQLPT VSNVQQTLPV 2400
QQTVELVQQQ PTTTTTVAVP AAGGQLQQLQ IQHLTSSNVS PGQQTAILLH 2450
QPQQQLRTHP GQGGQSNTQQ LVKTIVGTSS SLTAGQLQQL AQQSAVASGG 2500
QSSVSVVLTT PVQTLPSVVQ PQIGSGAQIV SISSQTLPVN SSPQLGSIVQ 2550
TQSLPQVVSV STLPTVGTVL TTTANQPQQQ HQTTAVTTLN TTMLRGQRIV 2600
STAAGNTLQQ RTTAGGQSIV SMPNLGQGAS PSQFQTQLRL AAVPTSPATQ 2650
TTQLVTTKGI PVSALQQGGK TTVIPVTQQS GGAHIQLYRQ RSLKVLQTTT 2700
QAVPSGSAGA TGATANLVQA GGTIIQASNM ATHVTSQKVA VSGMPGTSTT 2750
VQAGNVVSSV QMHGQARTQF IKQMAAGKQQ LQRQVVSADG TTTTTAAGDM 2800
LLVKRHNILA AQKAQQASGA LFTTTTGQQQ QQQQQQGQLP VAGQPQQVTQ 2850
HQIASLVKAS TAAAASGSSV NAGGVTVSAT NPTVQAGSVN MTLPQLKPGS 2900
QIKVTMPNQM RHLQMQQQLT MPRKISRMTQ LVSASGQPTA TNIITTTGPQ 2950
QQQQGVTVSG GGTLPTVASQ QQQQQHQQKV GGGNSVQAQL LHIQNTKGLS 3000
NSVTMQQIQQ VMRSGQQGTL ATTNLVLGKT SVGRVIPVSV ASQANQRQTI 3050
QVVSAASAQA LAAGNLRTHV AGPSIASTLK VAAPGSAGGQ TTQQTLIAAL 3100
QHNQRQNASP VRLQTTAGGN LLAVVQQQQQ QQHTSIAGPT AGPAEVMTIT 3150
QTTTTLPTVG SLQQQQQQQQ QQGGISQPTT QQVRKLVQKK ILIRSEKE 3198
Length:3,198
Mass (Da):350,239
Last modified:November 13, 2007 - v2
Checksum:iE65C3E86E1E64AB7
GO
Isoform B (identifier: Q9NDJ2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2009-3198: WISRNTMEQM...KKILIRSEKE → NTKTDSNSNK...GNASSSGTAR

Show »
Length:2,497
Mass (Da):274,615
Checksum:i4A500F08369326EC
GO

Sequence cautioni

The sequence AAL13882.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2009 – 31981190WISRN…RSEKE → NTKTDSNSNKRRLVRENRRN SAQKLSRSVSSHSTGSNNKN SKSATTRGNSQNSLNQTVPV GSGISRVNRTGAGVSSSSRG KSNSTKSTGKGTDAAPQVRR QTRLHSLGAVNMASARTPPT RKTTRTALAASAAASTLEDA SLIVEERPKRQSANIAMSKM MKTPFKQNVPSNISIKTTPP KRGRRDSVAAAATRSKLLER RATIAAPLKHMDDESDQDEE EQEEQESEEDTEGEEANATV DDDEEGEEELASLDEETIQT GSQTNDEEDDDEEEVGEEGM VDIDTEDSEADVKSSSTYGT AADGKPEEAESLDGWDAHDQ VQDTTMTSSTYYNVSEESDT DEHHDSKAEAKEPPQNSDKS DESEAVGHTPRTRSRGTVKI NLWTLDVSPVANALNKSSAN RSLKKAPRTESTPKESQSEP RRKITQPKLPKKEETNNKSN SNIGTLHRWISKSPRVMLRS TPVTAASASSSAAVSGVSGG NASSSGTAR in isoform B. VSP_029443Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1598 – 15981V → G in AAF82185. 1 Publication
Sequence conflicti1598 – 15981V → G in AAK53539. 1 Publication
Sequence conflicti1611 – 16122SS → LL in AAF82185. 1 Publication
Sequence conflicti1611 – 16122SS → LL in AAK53539. 1 Publication
Sequence conflicti1619 – 16191Q → P in AAF82185. 1 Publication
Sequence conflicti1619 – 16191Q → P in AAK53539. 1 Publication
Sequence conflicti1631 – 16311P → A in AAF82185. 1 Publication
Sequence conflicti1631 – 16311P → A in AAK53539. 1 Publication
Sequence conflicti2157 – 21571V → G in AAF82185. 1 Publication
Sequence conflicti2198 – 21981R → P in AAF82185. 1 Publication
Sequence conflicti2340 – 23401M → MQQQSQQ in AAF82185. 1 Publication
Sequence conflicti2369 – 23713Missing in AAF82185. 1 Publication
Sequence conflicti2514 – 25141T → S in AAF82185. 1 Publication
Isoform B (identifier: Q9NDJ2-2)
Sequence conflicti2127 – 21271P → A in AAK53539. 1 Publication
Sequence conflicti2174 – 21741K → N in AAK53539. 1 Publication
Sequence conflicti2180 – 21801N → T in AAK53539. 1 Publication
Sequence conflicti2222 – 22221E → D in AAK53539. 1 Publication
Sequence conflicti2229 – 22291E → D in AAK53539. 1 Publication
Sequence conflicti2287 – 22871G → E in AAK53539. 1 Publication
Sequence conflicti2471 – 24711V → G in AAK53539. 1 Publication
Sequence conflicti2474 – 24741A → T in AAK53539. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF076776 mRNA. Translation: AAF82185.1.
AF254373 mRNA. Translation: AAK53539.1.
AE013599 Genomic DNA. Translation: AAM70871.1.
AE013599 Genomic DNA. Translation: AAM70872.2.
AY058653 mRNA. Translation: AAL13882.1. Different initiation.
RefSeqiNP_524833.2. NM_080094.3. [Q9NDJ2-1]
NP_788424.1. NM_176244.2. [Q9NDJ2-2]
UniGeneiDm.7802.

Genome annotation databases

EnsemblMetazoaiFBtr0071603; FBpp0071529; FBgn0020306. [Q9NDJ2-1]
GeneIDi45655.
KEGGidme:Dmel_CG9696.
UCSCiCG9696-RA. d. melanogaster. [Q9NDJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF076776 mRNA. Translation: AAF82185.1 .
AF254373 mRNA. Translation: AAK53539.1 .
AE013599 Genomic DNA. Translation: AAM70871.1 .
AE013599 Genomic DNA. Translation: AAM70872.2 .
AY058653 mRNA. Translation: AAL13882.1 . Different initiation.
RefSeqi NP_524833.2. NM_080094.3. [Q9NDJ2-1 ]
NP_788424.1. NM_176244.2. [Q9NDJ2-2 ]
UniGenei Dm.7802.

3D structure databases

ProteinModelPortali Q9NDJ2.
SMRi Q9NDJ2. Positions 889-1204, 1644-1829.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 69802. 20 interactions.
IntActi Q9NDJ2. 1 interaction.
STRINGi 7227.FBpp0071529.

Proteomic databases

PaxDbi Q9NDJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0071603 ; FBpp0071529 ; FBgn0020306 . [Q9NDJ2-1 ]
GeneIDi 45655.
KEGGi dme:Dmel_CG9696.
UCSCi CG9696-RA. d. melanogaster. [Q9NDJ2-1 ]

Organism-specific databases

CTDi 45655.
FlyBasei FBgn0020306. dom.

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00530000063427.
InParanoidi Q9NDJ2.
KOi K11320.
OMAi RYETHIQ.
OrthoDBi EOG79CXXJ.
PhylomeDBi Q9NDJ2.

Miscellaneous databases

GenomeRNAii 45655.
NextBioi 838265.
PROi Q9NDJ2.

Gene expression databases

Bgeei Q9NDJ2.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR013999. HAS_subgr.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR017877. Myb-like_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS50090. MYB_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes."
    Ruhf M.-L., Braun A., Papoulas O., Tamkun J.W., Randsholt N., Meister M.
    Development 128:1429-1441(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING (ISOFORMS AND B).
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 782-2046 (ISOFORM A).
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions."
    Kusch T., Florens L., Macdonald W.H., Swanson S.K., Glaser R.L., Yates J.R. III, Abmayr S.M., Washburn M.P., Workman J.L.
    Science 306:2084-2087(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE TIP60 COMPLEX.
  6. "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway."
    Eissenberg J.C., Wong M., Chrivia J.C.
    Mol. Cell. Biol. 25:6559-6569(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Stem cell self-renewal controlled by chromatin remodeling factors."
    Xi R., Xie T.
    Science 310:1487-1489(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  8. "Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development."
    Gause M., Eissenberg J.C., Macrae A.F., Dorsett M., Misulovin Z., Dorsett D.
    Mol. Cell. Biol. 26:2347-2359(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression."
    Lu J., Ruhf M.-L., Perrimon N., Leder P.
    Proc. Natl. Acad. Sci. U.S.A. 104:9381-9386(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-656; SER-664; SER-666; THR-729; SER-733; SER-736; SER-744 AND THR-838, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiDOM_DROME
AccessioniPrimary (citable) accession number: Q9NDJ2
Secondary accession number(s): Q7YZ94
, Q95TN6, Q968U6, Q9I7V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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