Q9NDJ2 (DOM_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Helicase domino
EC=3.6.4.-

Gene names

Name:	dom
ORF Names:	CG9696

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	3198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis. Ref.1 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9
Subunit structure	Component of the Tip60 chromatin-remodeling complex which contains Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1. Ref.5
Subcellular location	Nucleus Ref.1.
Tissue specificity	Isoform B is present at high levels in ovary, in follicle cells, nurse cells and oocyte. Isoform B is also present in germline and somatic stem cells from the germarium. Isoform A is undetectable in adult ovary (at protein level). Ref.1 Ref.7
Developmental stage	Isoform A and isoform B are present in 0-12 hours embryonic extracts. During embryonic development, isoform A expression is restricted to the developing nervous system, whereas isoform B is ubiquitously expressed. During postembryonic development, isoform B is found in brain, imaginal disks, lymph glands and salivary glands and isoform A is found in some brain regions, photoreceptor cells and sensory organ precursors (at protein level). Ref.1
Sequence similarities	Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 HSA domain. Contains 1 Myb-like domain.
Sequence caution	The sequence AAL13882.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle Differentiation Oogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Chromatin regulator Developmental protein Helicase Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW dendrite guidance Inferred from mutant phenotype PubMed 21284845. Source: FlyBase gene silencing Inferred from genetic interaction Ref.1. Source: FlyBase hemopoiesis Traceable author statement PubMed 14602069PubMed 15199954. Source: FlyBase histone acetylation Inferred from direct assay Ref.5. Source: UniProtKB histone exchange Inferred from direct assay Ref.5. Source: UniProtKB instar larval or pupal development Inferred from mutant phenotype Ref.1. Source: FlyBase negative regulation of hemocyte proliferation Traceable author statement PubMed 14602069. Source: FlyBase oogenesis Inferred from mutant phenotype Ref.1. Source: FlyBase positive regulation of Notch signaling pathway Inferred from genetic interaction Ref.8. Source: FlyBase positive regulation of gene silencing by miRNA Inferred from mutant phenotype PubMed 22540035. Source: FlyBase regulation of alternative mRNA splicing, via spliceosome Inferred from mutant phenotype PubMed 15492211. Source: FlyBase regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW wing disc pattern formation Inferred from genetic interaction Ref.8. Source: FlyBase
Cellular_component	NuA4 histone acetyltransferase complex Inferred from direct assay Ref.5. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-dependent ATPase activity Inferred from sequence or structural similarity Ref.1. Source: FlyBase helicase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9NDJ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9NDJ2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2009-3198: WISRNTMEQM...KKILIRSEKE → NTKTDSNSNK...GNASSSGTAR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3198	3198	Helicase domino		PRO_0000311238
Regions
	Domain	507 – 579	73	HSA
	Domain	926 – 1091	166	Helicase ATP-binding
	Domain	1662 – 1812	151	Helicase C-terminal
	Domain	2136 – 2205	70	Myb-like
	Nucleotide binding	939 – 946	8	ATP By similarity
	Coiled coil	187 – 212	26	Potential
	Coiled coil	666 – 696	31	Potential
	Coiled coil	741 – 784	44	Potential
	Coiled coil	1951 – 1996	46	Potential
	Compositional bias	95 – 99	5	Poly-Gln
	Compositional bias	101 – 111	11	Poly-Ala
	Compositional bias	425 – 428	4	Poly-Gly
	Compositional bias	1242 – 1249	8	Poly-Leu
	Compositional bias	2322 – 3188	867	Gln-rich
Amino acid modifications
	Modified residue	656	1	Phosphoserine Ref.10
	Modified residue	664	1	Phosphoserine Ref.10
	Modified residue	666	1	Phosphoserine Ref.10
	Modified residue	729	1	Phosphothreonine Ref.10
	Modified residue	733	1	Phosphoserine Ref.10
	Modified residue	736	1	Phosphoserine Ref.10
	Modified residue	744	1	Phosphoserine Ref.10
	Modified residue	838	1	Phosphothreonine Ref.10
Natural variations
	Alternative sequence	2009 – 3198	1190	WISRN…RSEKE → NTKTDSNSNKRRLVRENRRN SAQKLSRSVSSHSTGSNNKN SKSATTRGNSQNSLNQTVPV GSGISRVNRTGAGVSSSSRG KSNSTKSTGKGTDAAPQVRR QTRLHSLGAVNMASARTPPT RKTTRTALAASAAASTLEDA SLIVEERPKRQSANIAMSKM MKTPFKQNVPSNISIKTTPP KRGRRDSVAAAATRSKLLER RATIAAPLKHMDDESDQDEE EQEEQESEEDTEGEEANATV DDDEEGEEELASLDEETIQT GSQTNDEEDDDEEEVGEEGM VDIDTEDSEADVKSSSTYGT AADGKPEEAESLDGWDAHDQ VQDTTMTSSTYYNVSEESDT DEHHDSKAEAKEPPQNSDKS DESEAVGHTPRTRSRGTVKI NLWTLDVSPVANALNKSSAN RSLKKAPRTESTPKESQSEP RRKITQPKLPKKEETNNKSN SNIGTLHRWISKSPRVMLRS TPVTAASASSSAAVSGVSGG NASSSGTAR in isoform B.		VSP_029443
Experimental info
	Sequence conflict	1598	1	V → G in AAF82185. Ref.1
	Sequence conflict	1598	1	V → G in AAK53539. Ref.1
	Sequence conflict	1611 – 1612	2	SS → LL in AAF82185. Ref.1
	Sequence conflict	1611 – 1612	2	SS → LL in AAK53539. Ref.1
	Sequence conflict	1619	1	Q → P in AAF82185. Ref.1
	Sequence conflict	1619	1	Q → P in AAK53539. Ref.1
	Sequence conflict	1631	1	P → A in AAF82185. Ref.1
	Sequence conflict	1631	1	P → A in AAK53539. Ref.1
	Sequence conflict	2157	1	V → G in AAF82185. Ref.1
	Sequence conflict	2198	1	R → P in AAF82185. Ref.1
	Sequence conflict	2340	1	M → MQQQSQQ in AAF82185. Ref.1
	Sequence conflict	2369 – 2371	3	Missing in AAF82185. Ref.1
	Sequence conflict	2514	1	T → S in AAF82185. Ref.1
Isoform B:
	Sequence conflict	2127	1	P → A in AAK53539. Ref.1
	Sequence conflict	2174	1	K → N in AAK53539. Ref.1
	Sequence conflict	2180	1	N → T in AAK53539. Ref.1
	Sequence conflict	2222	1	E → D in AAK53539. Ref.1
	Sequence conflict	2229	1	E → D in AAK53539. Ref.1
	Sequence conflict	2287	1	G → E in AAK53539. Ref.1
	Sequence conflict	2471	1	V → G in AAK53539. Ref.1
	Sequence conflict	2474	1	A → T in AAK53539. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified November 13, 2007. Version 2. Checksum: E65C3E86E1E64AB7	FASTA	3,198	350,239
	10 20 30 40 50 60 MNEGNSAGGG HEGLSPAPPA VPDRVTPHST EISVAPANST STTVRAAGSV GAALPATRHH 70 80 90 100 110 120 QHIATQVKGI ASSSSKQQKQ LASAQLPVPL SPLPQQQQQT AEATAAAAAP AHSNVSVSSS 130 140 150 160 170 180 TIEASVLPPQ AKRQRLDDNE DRTSAASIVG PAESSNIVSS LLPASVASSS EVGGLSSTAL 190 200 210 220 230 240 QDLNALKKRI LQQKLQILRN LKERHLENVS EYFYLQNGGS MMDYPAWRKK TPTPQFISYS 250 260 270 280 290 300 NANRIDQLIH EDKPSTSAAA AAAQNQKYTT QQTDSVESSL VSGIGTGATK GAPLDGNISN 310 320 330 340 350 360 STVKTNTQSQ VPSKIGSFTE STPAATESNS STTVPGTATS GAATSTSATS AEASGNVLAV 370 380 390 400 410 420 EAEIKIPAVG ATPVAISTKL PAAVVQLTQQ GGTPLLPCNT SAGSTALRRP QGQNNASSGS 430 440 450 460 470 480 AAASGGGGSL TPTPLYTGNG PAALGGSGGL TPGTPTSGSL LSPALGGGSG TPNSAAQEFS 490 500 510 520 530 540 FKAKQEVYVM QRISELQREG LWTERRLPKL QEPSRPKAHW DYLLEEMVWL AADFAQERKW 550 560 570 580 590 600 KKNAAKKCAK MVQKYFQDKA TAAQRAEKAQ ELQLKRVASF IAREVKSFWS NVEKLVEYKH 610 620 630 640 650 660 QTKIEEKRKQ ALDQHLSFIV DQTEKFSQQL VEGMNKSVAD TPSLNSSRLT SPKRESDDDF 670 680 690 700 710 720 RPESGSEDDE ETIAKAEEDA ADVKEEVTAL AKESEMDFDD FLNDLPPGYL ENRDKLMKEE 730 740 750 760 770 780 QSSAIKTETP DDSDDSEFEA KEASDDDENT ISKQEEAEQE IDHKKEIDEL EADNDLSVEQ 790 800 810 820 830 840 LLAKYKSEQP PSPKRRKLAP RDPELDSDDD STAVDSTEES EDAATEDEED LSTVKTDTDM 850 860 870 880 890 900 EEQDEQEDGL KSLMADADAT SGAAGSGSTA GASGNKDDML NDAAALAESL QPKGNTLSST 910 920 930 940 950 960 NVVTPVPFLL KHSLREYQHI GLDWLVTMNE RKLNGILADE MGLGKTIQTI ALLAHLACAK 970 980 990 1000 1010 1020 GNWGPHLIVV PSSVMLNWEM EFKKWCPGFK ILTYYGSQKE RKLKRVGWTK PNAFHVCITS 1030 1040 1050 1060 1070 1080 YKLVVQDQQS FRRKKWKYLI LDEAQNIKNF KSQRWQLLLN FSTERRLLLT GTPLQNDLME 1090 1100 1110 1120 1130 1140 LWSLMHFLMP YVFSSHREFK EWFSNPMTGM IEGNMEYNET LITRLHKVIR PFLLRRLKKE 1150 1160 1170 1180 1190 1200 VEKQMPKKYE HVITCRLSNR QRYLYEDFMS RAKTRETLQT GNLLSVINVL MQLRKVCNHP 1210 1220 1230 1240 1250 1260 NMFEARPTIS PFQMDGITFH TPRLVCDIME YDPFTQINLE TLNLLLLHLE QTMTAYVSHK 1270 1280 1290 1300 1310 1320 SRLLAPPRKL IEDIDTAPLP APRCPNGKYR FHIRVRSAEL AQRIKLNAVK VGASPAMRLE 1330 1340 1350 1360 1370 1380 GSKIMPMRNL LPSGRVLKRV SASINPVNMA LKPVVINSVV TTTSSSTTAS SPTGALSVLS 1390 1400 1410 1420 1430 1440 NSKLLGARSQ INAPTPAKVA KTMQDGKPFF YLTPATNSGA AGARLTLTSK TTASASTTTS 1450 1460 1470 1480 1490 1500 RTTVTASTTS GQQLIRDPIV KDLATHVKST VQKQSIANGK TEPEEETEAE DPYKVQELIQ 1510 1520 1530 1540 1550 1560 MRKEQRLAAL KRMAMINRRR TDATPIYGED CREAIQRCMQ ATRSLKRSTW QTRGYANCCT 1570 1580 1590 1600 1610 1620 AMAHRNGWSL NHLLKSFEER CADLKPVFAN FVIYVPSVCA PRIRRYVQNL SSTHWQHEQR 1630 1640 1650 1660 1670 1680 IENIVDQALR PKLALLHPII SEMTTKFPDP RLIQYDCGKL QTMDRLLRQL KVNGHRVLIF 1690 1700 1710 1720 1730 1740 TQMTKMLDVL EAFLNYHGHI YLRLDGSTRV EQRQILMERF NGDKRIFCFI LSTRSGGVGI 1750 1760 1770 1780 1790 1800 NLTGADTVIF YDSDWNPTMD AQAQDRCHRI GQTRDVHIYR LVSERTIEVN ILKKANQKRM 1810 1820 1830 1840 1850 1860 LSDMAIEGGN FTTTYFKSST IKDLFTMEQS EQDESSQEKS ENKDRIVATT TLSDTPSTVV 1870 1880 1890 1900 1910 1920 ETEKQSLRAF EHALAAAEDE QDVQATKTAK AEVAADLAEF DENIPIATED PNAEGGPQVE 1930 1940 1950 1960 1970 1980 LSKADLEMQN LVKQLSPIER YAMRFVEETG AAWTAEQLRA AEAELEAQKR EWEANRLAAM 1990 2000 2010 2020 2030 2040 HKEEELLKQE TEAEEMLTYS RKDSSNQVWI SRNTMEQMPM WCPPTPPQDN DNDIYIDYSL 2050 2060 2070 2080 2090 2100 SFMYELEPIA ETDLPPVYVR KEHKRSRTDA GYDGSRRPNK MRREDNYVPP RSLFDRPTPQ 2110 2120 2130 2140 2150 2160 LARLRRELKS QRFRGSFKPN MPIPGLKPQL PTKPLTEPEA MAEWCVFEDM AILHVLVNLQ 2170 2180 2190 2200 2210 2220 GLPCSLMLLS PGQTPNWDLV SEMVNFCSKT YRSARQCRWR YETHIQPREE GKVVESPKKQ 2230 2240 2250 2260 2270 2280 KKLKPTLRTE YLKSPLRYLR TTQLYVSDNN ASFYKTMRSR FDSIKTAYLK KAPPPKRQFS 2290 2300 2310 2320 2330 2340 APSLMNPKHM EVLQEFGILN YDQPVSPQNI AAMKANKIRE KQRGQQMSQP PVGVGVVQQM 2350 2360 2370 2380 2390 2400 QQQSQQQQQP APPPLPQQQQ PQQVVQQVQQ QQQQQQQQQQ QQVVQQQLPT VSNVQQTLPV 2410 2420 2430 2440 2450 2460 QQTVELVQQQ PTTTTTVAVP AAGGQLQQLQ IQHLTSSNVS PGQQTAILLH QPQQQLRTHP 2470 2480 2490 2500 2510 2520 GQGGQSNTQQ LVKTIVGTSS SLTAGQLQQL AQQSAVASGG QSSVSVVLTT PVQTLPSVVQ 2530 2540 2550 2560 2570 2580 PQIGSGAQIV SISSQTLPVN SSPQLGSIVQ TQSLPQVVSV STLPTVGTVL TTTANQPQQQ 2590 2600 2610 2620 2630 2640 HQTTAVTTLN TTMLRGQRIV STAAGNTLQQ RTTAGGQSIV SMPNLGQGAS PSQFQTQLRL 2650 2660 2670 2680 2690 2700 AAVPTSPATQ TTQLVTTKGI PVSALQQGGK TTVIPVTQQS GGAHIQLYRQ RSLKVLQTTT 2710 2720 2730 2740 2750 2760 QAVPSGSAGA TGATANLVQA GGTIIQASNM ATHVTSQKVA VSGMPGTSTT VQAGNVVSSV 2770 2780 2790 2800 2810 2820 QMHGQARTQF IKQMAAGKQQ LQRQVVSADG TTTTTAAGDM LLVKRHNILA AQKAQQASGA 2830 2840 2850 2860 2870 2880 LFTTTTGQQQ QQQQQQGQLP VAGQPQQVTQ HQIASLVKAS TAAAASGSSV NAGGVTVSAT 2890 2900 2910 2920 2930 2940 NPTVQAGSVN MTLPQLKPGS QIKVTMPNQM RHLQMQQQLT MPRKISRMTQ LVSASGQPTA 2950 2960 2970 2980 2990 3000 TNIITTTGPQ QQQQGVTVSG GGTLPTVASQ QQQQQHQQKV GGGNSVQAQL LHIQNTKGLS 3010 3020 3030 3040 3050 3060 NSVTMQQIQQ VMRSGQQGTL ATTNLVLGKT SVGRVIPVSV ASQANQRQTI QVVSAASAQA 3070 3080 3090 3100 3110 3120 LAAGNLRTHV AGPSIASTLK VAAPGSAGGQ TTQQTLIAAL QHNQRQNASP VRLQTTAGGN 3130 3140 3150 3160 3170 3180 LLAVVQQQQQ QQHTSIAGPT AGPAEVMTIT QTTTTLPTVG SLQQQQQQQQ QQGGISQPTT 3190 QQVRKLVQKK ILIRSEKE
	Isoform B [UniParc]. Checksum: 4A500F08369326EC	FASTA	2,497	274,615
	10 20 30 40 50 60 MNEGNSAGGG HEGLSPAPPA VPDRVTPHST EISVAPANST STTVRAAGSV GAALPATRHH 70 80 90 100 110 120 QHIATQVKGI ASSSSKQQKQ LASAQLPVPL SPLPQQQQQT AEATAAAAAP AHSNVSVSSS 130 140 150 160 170 180 TIEASVLPPQ AKRQRLDDNE DRTSAASIVG PAESSNIVSS LLPASVASSS EVGGLSSTAL 190 200 210 220 230 240 QDLNALKKRI LQQKLQILRN LKERHLENVS EYFYLQNGGS MMDYPAWRKK TPTPQFISYS 250 260 270 280 290 300 NANRIDQLIH EDKPSTSAAA AAAQNQKYTT QQTDSVESSL VSGIGTGATK GAPLDGNISN 310 320 330 340 350 360 STVKTNTQSQ VPSKIGSFTE STPAATESNS STTVPGTATS GAATSTSATS AEASGNVLAV 370 380 390 400 410 420 EAEIKIPAVG ATPVAISTKL PAAVVQLTQQ GGTPLLPCNT SAGSTALRRP QGQNNASSGS 430 440 450 460 470 480 AAASGGGGSL TPTPLYTGNG PAALGGSGGL TPGTPTSGSL LSPALGGGSG TPNSAAQEFS 490 500 510 520 530 540 FKAKQEVYVM QRISELQREG LWTERRLPKL QEPSRPKAHW DYLLEEMVWL AADFAQERKW 550 560 570 580 590 600 KKNAAKKCAK MVQKYFQDKA TAAQRAEKAQ ELQLKRVASF IAREVKSFWS NVEKLVEYKH 610 620 630 640 650 660 QTKIEEKRKQ ALDQHLSFIV DQTEKFSQQL VEGMNKSVAD TPSLNSSRLT SPKRESDDDF 670 680 690 700 710 720 RPESGSEDDE ETIAKAEEDA ADVKEEVTAL AKESEMDFDD FLNDLPPGYL ENRDKLMKEE 730 740 750 760 770 780 QSSAIKTETP DDSDDSEFEA KEASDDDENT ISKQEEAEQE IDHKKEIDEL EADNDLSVEQ 790 800 810 820 830 840 LLAKYKSEQP PSPKRRKLAP RDPELDSDDD STAVDSTEES EDAATEDEED LSTVKTDTDM 850 860 870 880 890 900 EEQDEQEDGL KSLMADADAT SGAAGSGSTA GASGNKDDML NDAAALAESL QPKGNTLSST 910 920 930 940 950 960 NVVTPVPFLL KHSLREYQHI GLDWLVTMNE RKLNGILADE MGLGKTIQTI ALLAHLACAK 970 980 990 1000 1010 1020 GNWGPHLIVV PSSVMLNWEM EFKKWCPGFK ILTYYGSQKE RKLKRVGWTK PNAFHVCITS 1030 1040 1050 1060 1070 1080 YKLVVQDQQS FRRKKWKYLI LDEAQNIKNF KSQRWQLLLN FSTERRLLLT GTPLQNDLME 1090 1100 1110 1120 1130 1140 LWSLMHFLMP YVFSSHREFK EWFSNPMTGM IEGNMEYNET LITRLHKVIR PFLLRRLKKE 1150 1160 1170 1180 1190 1200 VEKQMPKKYE HVITCRLSNR QRYLYEDFMS RAKTRETLQT GNLLSVINVL MQLRKVCNHP 1210 1220 1230 1240 1250 1260 NMFEARPTIS PFQMDGITFH TPRLVCDIME YDPFTQINLE TLNLLLLHLE QTMTAYVSHK 1270 1280 1290 1300 1310 1320 SRLLAPPRKL IEDIDTAPLP APRCPNGKYR FHIRVRSAEL AQRIKLNAVK VGASPAMRLE 1330 1340 1350 1360 1370 1380 GSKIMPMRNL LPSGRVLKRV SASINPVNMA LKPVVINSVV TTTSSSTTAS SPTGALSVLS 1390 1400 1410 1420 1430 1440 NSKLLGARSQ INAPTPAKVA KTMQDGKPFF YLTPATNSGA AGARLTLTSK TTASASTTTS 1450 1460 1470 1480 1490 1500 RTTVTASTTS GQQLIRDPIV KDLATHVKST VQKQSIANGK TEPEEETEAE DPYKVQELIQ 1510 1520 1530 1540 1550 1560 MRKEQRLAAL KRMAMINRRR TDATPIYGED CREAIQRCMQ ATRSLKRSTW QTRGYANCCT 1570 1580 1590 1600 1610 1620 AMAHRNGWSL NHLLKSFEER CADLKPVFAN FVIYVPSVCA PRIRRYVQNL SSTHWQHEQR 1630 1640 1650 1660 1670 1680 IENIVDQALR PKLALLHPII SEMTTKFPDP RLIQYDCGKL QTMDRLLRQL KVNGHRVLIF 1690 1700 1710 1720 1730 1740 TQMTKMLDVL EAFLNYHGHI YLRLDGSTRV EQRQILMERF NGDKRIFCFI LSTRSGGVGI 1750 1760 1770 1780 1790 1800 NLTGADTVIF YDSDWNPTMD AQAQDRCHRI GQTRDVHIYR LVSERTIEVN ILKKANQKRM 1810 1820 1830 1840 1850 1860 LSDMAIEGGN FTTTYFKSST IKDLFTMEQS EQDESSQEKS ENKDRIVATT TLSDTPSTVV 1870 1880 1890 1900 1910 1920 ETEKQSLRAF EHALAAAEDE QDVQATKTAK AEVAADLAEF DENIPIATED PNAEGGPQVE 1930 1940 1950 1960 1970 1980 LSKADLEMQN LVKQLSPIER YAMRFVEETG AAWTAEQLRA AEAELEAQKR EWEANRLAAM 1990 2000 2010 2020 2030 2040 HKEEELLKQE TEAEEMLTYS RKDSSNQVNT KTDSNSNKRR LVRENRRNSA QKLSRSVSSH 2050 2060 2070 2080 2090 2100 STGSNNKNSK SATTRGNSQN SLNQTVPVGS GISRVNRTGA GVSSSSRGKS NSTKSTGKGT 2110 2120 2130 2140 2150 2160 DAAPQVRRQT RLHSLGAVNM ASARTPPTRK TTRTALAASA AASTLEDASL IVEERPKRQS 2170 2180 2190 2200 2210 2220 ANIAMSKMMK TPFKQNVPSN ISIKTTPPKR GRRDSVAAAA TRSKLLERRA TIAAPLKHMD 2230 2240 2250 2260 2270 2280 DESDQDEEEQ EEQESEEDTE GEEANATVDD DEEGEEELAS LDEETIQTGS QTNDEEDDDE 2290 2300 2310 2320 2330 2340 EEVGEEGMVD IDTEDSEADV KSSSTYGTAA DGKPEEAESL DGWDAHDQVQ DTTMTSSTYY 2350 2360 2370 2380 2390 2400 NVSEESDTDE HHDSKAEAKE PPQNSDKSDE SEAVGHTPRT RSRGTVKINL WTLDVSPVAN 2410 2420 2430 2440 2450 2460 ALNKSSANRS LKKAPRTEST PKESQSEPRR KITQPKLPKK EETNNKSNSN IGTLHRWISK 2470 2480 2490 SPRVMLRSTP VTAASASSSA AVSGVSGGNA SSSGTAR

References

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[1]	"The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes." Ruhf M.-L., Braun A., Papoulas O., Tamkun J.W., Randsholt N., Meister M. Development 128:1429-1441(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING (ISOFORMS AND B). Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 782-2046 (ISOFORM A). Strain: Berkeley. Tissue: Embryo.
[5]	"Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions." Kusch T., Florens L., Macdonald W.H., Swanson S.K., Glaser R.L., Yates J.R. III, Abmayr S.M., Washburn M.P., Workman J.L. Science 306:2084-2087(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE TIP60 COMPLEX.
[6]	"Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway." Eissenberg J.C., Wong M., Chrivia J.C. Mol. Cell. Biol. 25:6559-6569(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Stem cell self-renewal controlled by chromatin remodeling factors." Xi R., Xie T. Science 310:1487-1489(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[8]	"Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development." Gause M., Eissenberg J.C., Macrae A.F., Dorsett M., Misulovin Z., Dorsett D. Mol. Cell. Biol. 26:2347-2359(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression." Lu J., Ruhf M.-L., Perrimon N., Leder P. Proc. Natl. Acad. Sci. U.S.A. 104:9381-9386(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-656; SER-664; SER-666; THR-729; SER-733; SER-736; SER-744 AND THR-838, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF076776 mRNA. Translation: AAF82185.1. AF254373 mRNA. Translation: AAK53539.1. AE013599 Genomic DNA. Translation: AAM70871.1. AE013599 Genomic DNA. Translation: AAM70872.2. AY058653 mRNA. Translation: AAL13882.1. Different initiation.
RefSeq	NP_524833.2. NM_080094.3. NP_788424.1. NM_176244.2.
UniGene	Dm.7802.
3D structure databases
HSSP	HSSP built from PDB template 1Z63 based on UniProtKB Q97XQ5.
ProteinModelPortal	Q9NDJ2.
SMR	Q9NDJ2. Positions 889-1204, 1644-1829.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NDJ2. 1 interaction.
STRING	7227.FBpp0071529.
Proteomic databases
PaxDb	Q9NDJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0071603; FBpp0071529; FBgn0020306.
GeneID	45655.
KEGG	dme:Dmel_CG9696.
UCSC	CG9696-RA. d. melanogaster.
Organism-specific databases
CTD	45655.
FlyBase	FBgn0020306. dom.
Phylogenomic databases
eggNOG	COG0553.
GeneTree	ENSGT00530000063427.
InParanoid	Q9NDJ2.
KO	K11320.
OMA	TENDASA.
OrthoDB	EOG4C5B08.
PhylomeDB	Q9NDJ2.
Gene expression databases
Bgee	Q9NDJ2.
Family and domain databases
InterPro	IPR013999. HAS_subgr. IPR014012. Helicase/SANT-assoc_DNA-bd. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR006562. HSA. IPR017877. Myb-like_dom. IPR000330. SNF2_N. [Graphical view]
Pfam	PF00271. Helicase_C. 1 hit. PF07529. HSA. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00573. HSA. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51204. HSA. 1 hit. PS50090. MYB_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	45655.
NextBio	838265.

Entry information

Entry name

DOM_DROME

Accession

Primary (citable) accession number: Q9NDJ2
Secondary accession number(s): Q7YZ94 , Q95TN6, Q968U6, Q9I7V8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project