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Q9NDJ2

- DOM_DROME

UniProt

Q9NDJ2 - DOM_DROME

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Protein

Helicase domino

Gene

dom

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis.6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi939 – 9468ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. DNA-dependent ATPase activity Source: FlyBase
  4. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. cell cycle Source: UniProtKB-KW
  3. chromatin organization Source: FlyBase
  4. dendrite guidance Source: FlyBase
  5. dendrite morphogenesis Source: FlyBase
  6. gene silencing Source: FlyBase
  7. hemopoiesis Source: FlyBase
  8. histone acetylation Source: UniProtKB
  9. histone exchange Source: UniProtKB
  10. instar larval or pupal development Source: FlyBase
  11. negative regulation of gene expression Source: FlyBase
  12. negative regulation of hemocyte proliferation Source: FlyBase
  13. neurogenesis Source: FlyBase
  14. oogenesis Source: FlyBase
  15. positive regulation of gene silencing by miRNA Source: FlyBase
  16. positive regulation of Notch signaling pathway Source: FlyBase
  17. regulation of alternative mRNA splicing, via spliceosome Source: FlyBase
  18. regulation of transcription, DNA-templated Source: UniProtKB-KW
  19. transcription, DNA-templated Source: UniProtKB-KW
  20. wing disc pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein, Helicase, Hydrolase

Keywords - Biological processi

Cell cycle, Differentiation, Oogenesis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase domino (EC:3.6.4.-)
Gene namesi
Name:dom
ORF Names:CG9696
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0020306. dom.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. histone acetyltransferase complex Source: FlyBase
  2. NuA4 histone acetyltransferase complex Source: UniProtKB
  3. nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31983198Helicase dominoPRO_0000311238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei656 – 6561Phosphoserine1 Publication
Modified residuei664 – 6641Phosphoserine1 Publication
Modified residuei666 – 6661Phosphoserine1 Publication
Modified residuei729 – 7291Phosphothreonine1 Publication
Modified residuei733 – 7331Phosphoserine1 Publication
Modified residuei736 – 7361Phosphoserine1 Publication
Modified residuei744 – 7441Phosphoserine1 Publication
Modified residuei838 – 8381Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NDJ2.

Expressioni

Tissue specificityi

Isoform B is present at high levels in ovary, in follicle cells, nurse cells and oocyte. Isoform B is also present in germline and somatic stem cells from the germarium. Isoform A is undetectable in adult ovary (at protein level).2 Publications

Developmental stagei

Isoform A and isoform B are present in 0-12 hours embryonic extracts. During embryonic development, isoform A expression is restricted to the developing nervous system, whereas isoform B is ubiquitously expressed. During postembryonic development, isoform B is found in brain, imaginal disks, lymph glands and salivary glands and isoform A is found in some brain regions, photoreceptor cells and sensory organ precursors (at protein level).1 Publication

Gene expression databases

BgeeiQ9NDJ2.
ExpressionAtlasiQ9NDJ2. differential.

Interactioni

Subunit structurei

Component of the Tip60 chromatin-remodeling complex which contains Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.1 Publication

Protein-protein interaction databases

BioGridi69802. 20 interactions.
DIPiDIP-60953N.
IntActiQ9NDJ2. 1 interaction.
STRINGi7227.FBpp0071529.

Structurei

3D structure databases

ProteinModelPortaliQ9NDJ2.
SMRiQ9NDJ2. Positions 889-1204, 1644-1829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini507 – 57973HSAPROSITE-ProRule annotationAdd
BLAST
Domaini926 – 1091166Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1662 – 1812151Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini2136 – 220570Myb-likePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili187 – 21226Sequence AnalysisAdd
BLAST
Coiled coili666 – 69631Sequence AnalysisAdd
BLAST
Coiled coili741 – 78444Sequence AnalysisAdd
BLAST
Coiled coili1951 – 199646Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 995Poly-Gln
Compositional biasi101 – 11111Poly-AlaAdd
BLAST
Compositional biasi425 – 4284Poly-Gly
Compositional biasi1242 – 12498Poly-Leu
Compositional biasi2322 – 3188867Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 HSA domain.PROSITE-ProRule annotation
Contains 1 Myb-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00530000063427.
InParanoidiQ9NDJ2.
KOiK11320.
OMAiRYETHIQ.
OrthoDBiEOG79CXXJ.
PhylomeDBiQ9NDJ2.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR013999. HAS_subgr.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR017877. Myb-like_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9NDJ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNEGNSAGGG HEGLSPAPPA VPDRVTPHST EISVAPANST STTVRAAGSV
60 70 80 90 100
GAALPATRHH QHIATQVKGI ASSSSKQQKQ LASAQLPVPL SPLPQQQQQT
110 120 130 140 150
AEATAAAAAP AHSNVSVSSS TIEASVLPPQ AKRQRLDDNE DRTSAASIVG
160 170 180 190 200
PAESSNIVSS LLPASVASSS EVGGLSSTAL QDLNALKKRI LQQKLQILRN
210 220 230 240 250
LKERHLENVS EYFYLQNGGS MMDYPAWRKK TPTPQFISYS NANRIDQLIH
260 270 280 290 300
EDKPSTSAAA AAAQNQKYTT QQTDSVESSL VSGIGTGATK GAPLDGNISN
310 320 330 340 350
STVKTNTQSQ VPSKIGSFTE STPAATESNS STTVPGTATS GAATSTSATS
360 370 380 390 400
AEASGNVLAV EAEIKIPAVG ATPVAISTKL PAAVVQLTQQ GGTPLLPCNT
410 420 430 440 450
SAGSTALRRP QGQNNASSGS AAASGGGGSL TPTPLYTGNG PAALGGSGGL
460 470 480 490 500
TPGTPTSGSL LSPALGGGSG TPNSAAQEFS FKAKQEVYVM QRISELQREG
510 520 530 540 550
LWTERRLPKL QEPSRPKAHW DYLLEEMVWL AADFAQERKW KKNAAKKCAK
560 570 580 590 600
MVQKYFQDKA TAAQRAEKAQ ELQLKRVASF IAREVKSFWS NVEKLVEYKH
610 620 630 640 650
QTKIEEKRKQ ALDQHLSFIV DQTEKFSQQL VEGMNKSVAD TPSLNSSRLT
660 670 680 690 700
SPKRESDDDF RPESGSEDDE ETIAKAEEDA ADVKEEVTAL AKESEMDFDD
710 720 730 740 750
FLNDLPPGYL ENRDKLMKEE QSSAIKTETP DDSDDSEFEA KEASDDDENT
760 770 780 790 800
ISKQEEAEQE IDHKKEIDEL EADNDLSVEQ LLAKYKSEQP PSPKRRKLAP
810 820 830 840 850
RDPELDSDDD STAVDSTEES EDAATEDEED LSTVKTDTDM EEQDEQEDGL
860 870 880 890 900
KSLMADADAT SGAAGSGSTA GASGNKDDML NDAAALAESL QPKGNTLSST
910 920 930 940 950
NVVTPVPFLL KHSLREYQHI GLDWLVTMNE RKLNGILADE MGLGKTIQTI
960 970 980 990 1000
ALLAHLACAK GNWGPHLIVV PSSVMLNWEM EFKKWCPGFK ILTYYGSQKE
1010 1020 1030 1040 1050
RKLKRVGWTK PNAFHVCITS YKLVVQDQQS FRRKKWKYLI LDEAQNIKNF
1060 1070 1080 1090 1100
KSQRWQLLLN FSTERRLLLT GTPLQNDLME LWSLMHFLMP YVFSSHREFK
1110 1120 1130 1140 1150
EWFSNPMTGM IEGNMEYNET LITRLHKVIR PFLLRRLKKE VEKQMPKKYE
1160 1170 1180 1190 1200
HVITCRLSNR QRYLYEDFMS RAKTRETLQT GNLLSVINVL MQLRKVCNHP
1210 1220 1230 1240 1250
NMFEARPTIS PFQMDGITFH TPRLVCDIME YDPFTQINLE TLNLLLLHLE
1260 1270 1280 1290 1300
QTMTAYVSHK SRLLAPPRKL IEDIDTAPLP APRCPNGKYR FHIRVRSAEL
1310 1320 1330 1340 1350
AQRIKLNAVK VGASPAMRLE GSKIMPMRNL LPSGRVLKRV SASINPVNMA
1360 1370 1380 1390 1400
LKPVVINSVV TTTSSSTTAS SPTGALSVLS NSKLLGARSQ INAPTPAKVA
1410 1420 1430 1440 1450
KTMQDGKPFF YLTPATNSGA AGARLTLTSK TTASASTTTS RTTVTASTTS
1460 1470 1480 1490 1500
GQQLIRDPIV KDLATHVKST VQKQSIANGK TEPEEETEAE DPYKVQELIQ
1510 1520 1530 1540 1550
MRKEQRLAAL KRMAMINRRR TDATPIYGED CREAIQRCMQ ATRSLKRSTW
1560 1570 1580 1590 1600
QTRGYANCCT AMAHRNGWSL NHLLKSFEER CADLKPVFAN FVIYVPSVCA
1610 1620 1630 1640 1650
PRIRRYVQNL SSTHWQHEQR IENIVDQALR PKLALLHPII SEMTTKFPDP
1660 1670 1680 1690 1700
RLIQYDCGKL QTMDRLLRQL KVNGHRVLIF TQMTKMLDVL EAFLNYHGHI
1710 1720 1730 1740 1750
YLRLDGSTRV EQRQILMERF NGDKRIFCFI LSTRSGGVGI NLTGADTVIF
1760 1770 1780 1790 1800
YDSDWNPTMD AQAQDRCHRI GQTRDVHIYR LVSERTIEVN ILKKANQKRM
1810 1820 1830 1840 1850
LSDMAIEGGN FTTTYFKSST IKDLFTMEQS EQDESSQEKS ENKDRIVATT
1860 1870 1880 1890 1900
TLSDTPSTVV ETEKQSLRAF EHALAAAEDE QDVQATKTAK AEVAADLAEF
1910 1920 1930 1940 1950
DENIPIATED PNAEGGPQVE LSKADLEMQN LVKQLSPIER YAMRFVEETG
1960 1970 1980 1990 2000
AAWTAEQLRA AEAELEAQKR EWEANRLAAM HKEEELLKQE TEAEEMLTYS
2010 2020 2030 2040 2050
RKDSSNQVWI SRNTMEQMPM WCPPTPPQDN DNDIYIDYSL SFMYELEPIA
2060 2070 2080 2090 2100
ETDLPPVYVR KEHKRSRTDA GYDGSRRPNK MRREDNYVPP RSLFDRPTPQ
2110 2120 2130 2140 2150
LARLRRELKS QRFRGSFKPN MPIPGLKPQL PTKPLTEPEA MAEWCVFEDM
2160 2170 2180 2190 2200
AILHVLVNLQ GLPCSLMLLS PGQTPNWDLV SEMVNFCSKT YRSARQCRWR
2210 2220 2230 2240 2250
YETHIQPREE GKVVESPKKQ KKLKPTLRTE YLKSPLRYLR TTQLYVSDNN
2260 2270 2280 2290 2300
ASFYKTMRSR FDSIKTAYLK KAPPPKRQFS APSLMNPKHM EVLQEFGILN
2310 2320 2330 2340 2350
YDQPVSPQNI AAMKANKIRE KQRGQQMSQP PVGVGVVQQM QQQSQQQQQP
2360 2370 2380 2390 2400
APPPLPQQQQ PQQVVQQVQQ QQQQQQQQQQ QQVVQQQLPT VSNVQQTLPV
2410 2420 2430 2440 2450
QQTVELVQQQ PTTTTTVAVP AAGGQLQQLQ IQHLTSSNVS PGQQTAILLH
2460 2470 2480 2490 2500
QPQQQLRTHP GQGGQSNTQQ LVKTIVGTSS SLTAGQLQQL AQQSAVASGG
2510 2520 2530 2540 2550
QSSVSVVLTT PVQTLPSVVQ PQIGSGAQIV SISSQTLPVN SSPQLGSIVQ
2560 2570 2580 2590 2600
TQSLPQVVSV STLPTVGTVL TTTANQPQQQ HQTTAVTTLN TTMLRGQRIV
2610 2620 2630 2640 2650
STAAGNTLQQ RTTAGGQSIV SMPNLGQGAS PSQFQTQLRL AAVPTSPATQ
2660 2670 2680 2690 2700
TTQLVTTKGI PVSALQQGGK TTVIPVTQQS GGAHIQLYRQ RSLKVLQTTT
2710 2720 2730 2740 2750
QAVPSGSAGA TGATANLVQA GGTIIQASNM ATHVTSQKVA VSGMPGTSTT
2760 2770 2780 2790 2800
VQAGNVVSSV QMHGQARTQF IKQMAAGKQQ LQRQVVSADG TTTTTAAGDM
2810 2820 2830 2840 2850
LLVKRHNILA AQKAQQASGA LFTTTTGQQQ QQQQQQGQLP VAGQPQQVTQ
2860 2870 2880 2890 2900
HQIASLVKAS TAAAASGSSV NAGGVTVSAT NPTVQAGSVN MTLPQLKPGS
2910 2920 2930 2940 2950
QIKVTMPNQM RHLQMQQQLT MPRKISRMTQ LVSASGQPTA TNIITTTGPQ
2960 2970 2980 2990 3000
QQQQGVTVSG GGTLPTVASQ QQQQQHQQKV GGGNSVQAQL LHIQNTKGLS
3010 3020 3030 3040 3050
NSVTMQQIQQ VMRSGQQGTL ATTNLVLGKT SVGRVIPVSV ASQANQRQTI
3060 3070 3080 3090 3100
QVVSAASAQA LAAGNLRTHV AGPSIASTLK VAAPGSAGGQ TTQQTLIAAL
3110 3120 3130 3140 3150
QHNQRQNASP VRLQTTAGGN LLAVVQQQQQ QQHTSIAGPT AGPAEVMTIT
3160 3170 3180 3190
QTTTTLPTVG SLQQQQQQQQ QQGGISQPTT QQVRKLVQKK ILIRSEKE
Length:3,198
Mass (Da):350,239
Last modified:November 13, 2007 - v2
Checksum:iE65C3E86E1E64AB7
GO
Isoform B (identifier: Q9NDJ2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2009-3198: WISRNTMEQM...KKILIRSEKE → NTKTDSNSNK...GNASSSGTAR

Show »
Length:2,497
Mass (Da):274,615
Checksum:i4A500F08369326EC
GO

Sequence cautioni

The sequence AAL13882.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1598 – 15981V → G in AAF82185. (PubMed:11262242)Curated
Sequence conflicti1598 – 15981V → G in AAK53539. (PubMed:11262242)Curated
Sequence conflicti1611 – 16122SS → LL in AAF82185. (PubMed:11262242)Curated
Sequence conflicti1611 – 16122SS → LL in AAK53539. (PubMed:11262242)Curated
Sequence conflicti1619 – 16191Q → P in AAF82185. (PubMed:11262242)Curated
Sequence conflicti1619 – 16191Q → P in AAK53539. (PubMed:11262242)Curated
Sequence conflicti1631 – 16311P → A in AAF82185. (PubMed:11262242)Curated
Sequence conflicti1631 – 16311P → A in AAK53539. (PubMed:11262242)Curated
Sequence conflicti2157 – 21571V → G in AAF82185. (PubMed:11262242)Curated
Sequence conflicti2198 – 21981R → P in AAF82185. (PubMed:11262242)Curated
Sequence conflicti2340 – 23401M → MQQQSQQ in AAF82185. (PubMed:11262242)Curated
Sequence conflicti2369 – 23713Missing in AAF82185. (PubMed:11262242)Curated
Sequence conflicti2514 – 25141T → S in AAF82185. (PubMed:11262242)Curated
Isoform B (identifier: Q9NDJ2-2)
Sequence conflicti2127 – 21271P → A in AAK53539. (PubMed:11262242)Curated
Sequence conflicti2174 – 21741K → N in AAK53539. (PubMed:11262242)Curated
Sequence conflicti2180 – 21801N → T in AAK53539. (PubMed:11262242)Curated
Sequence conflicti2222 – 22221E → D in AAK53539. (PubMed:11262242)Curated
Sequence conflicti2229 – 22291E → D in AAK53539. (PubMed:11262242)Curated
Sequence conflicti2287 – 22871G → E in AAK53539. (PubMed:11262242)Curated
Sequence conflicti2471 – 24711V → G in AAK53539. (PubMed:11262242)Curated
Sequence conflicti2474 – 24741A → T in AAK53539. (PubMed:11262242)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2009 – 31981190WISRN…RSEKE → NTKTDSNSNKRRLVRENRRN SAQKLSRSVSSHSTGSNNKN SKSATTRGNSQNSLNQTVPV GSGISRVNRTGAGVSSSSRG KSNSTKSTGKGTDAAPQVRR QTRLHSLGAVNMASARTPPT RKTTRTALAASAAASTLEDA SLIVEERPKRQSANIAMSKM MKTPFKQNVPSNISIKTTPP KRGRRDSVAAAATRSKLLER RATIAAPLKHMDDESDQDEE EQEEQESEEDTEGEEANATV DDDEEGEEELASLDEETIQT GSQTNDEEDDDEEEVGEEGM VDIDTEDSEADVKSSSTYGT AADGKPEEAESLDGWDAHDQ VQDTTMTSSTYYNVSEESDT DEHHDSKAEAKEPPQNSDKS DESEAVGHTPRTRSRGTVKI NLWTLDVSPVANALNKSSAN RSLKKAPRTESTPKESQSEP RRKITQPKLPKKEETNNKSN SNIGTLHRWISKSPRVMLRS TPVTAASASSSAAVSGVSGG NASSSGTAR in isoform B. 1 PublicationVSP_029443Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076776 mRNA. Translation: AAF82185.1.
AF254373 mRNA. Translation: AAK53539.1.
AE013599 Genomic DNA. Translation: AAM70871.1.
AE013599 Genomic DNA. Translation: AAM70872.2.
AY058653 mRNA. Translation: AAL13882.1. Different initiation.
RefSeqiNP_524833.2. NM_080094.4. [Q9NDJ2-1]
NP_788424.1. NM_176244.3. [Q9NDJ2-2]

Genome annotation databases

EnsemblMetazoaiFBtr0071603; FBpp0071529; FBgn0020306. [Q9NDJ2-1]
GeneIDi45655.
KEGGidme:Dmel_CG9696.
UCSCiCG9696-RA. d. melanogaster. [Q9NDJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076776 mRNA. Translation: AAF82185.1 .
AF254373 mRNA. Translation: AAK53539.1 .
AE013599 Genomic DNA. Translation: AAM70871.1 .
AE013599 Genomic DNA. Translation: AAM70872.2 .
AY058653 mRNA. Translation: AAL13882.1 . Different initiation.
RefSeqi NP_524833.2. NM_080094.4. [Q9NDJ2-1 ]
NP_788424.1. NM_176244.3. [Q9NDJ2-2 ]

3D structure databases

ProteinModelPortali Q9NDJ2.
SMRi Q9NDJ2. Positions 889-1204, 1644-1829.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 69802. 20 interactions.
DIPi DIP-60953N.
IntActi Q9NDJ2. 1 interaction.
STRINGi 7227.FBpp0071529.

Proteomic databases

PaxDbi Q9NDJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0071603 ; FBpp0071529 ; FBgn0020306 . [Q9NDJ2-1 ]
GeneIDi 45655.
KEGGi dme:Dmel_CG9696.
UCSCi CG9696-RA. d. melanogaster. [Q9NDJ2-1 ]

Organism-specific databases

CTDi 45655.
FlyBasei FBgn0020306. dom.

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00530000063427.
InParanoidi Q9NDJ2.
KOi K11320.
OMAi RYETHIQ.
OrthoDBi EOG79CXXJ.
PhylomeDBi Q9NDJ2.

Miscellaneous databases

GenomeRNAii 45655.
NextBioi 838265.
PROi Q9NDJ2.

Gene expression databases

Bgeei Q9NDJ2.
ExpressionAtlasi Q9NDJ2. differential.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR013999. HAS_subgr.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR017877. Myb-like_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS50090. MYB_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes."
    Ruhf M.-L., Braun A., Papoulas O., Tamkun J.W., Randsholt N., Meister M.
    Development 128:1429-1441(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING (ISOFORMS AND B).
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 782-2046 (ISOFORM A).
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions."
    Kusch T., Florens L., Macdonald W.H., Swanson S.K., Glaser R.L., Yates J.R. III, Abmayr S.M., Washburn M.P., Workman J.L.
    Science 306:2084-2087(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE TIP60 COMPLEX.
  6. "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway."
    Eissenberg J.C., Wong M., Chrivia J.C.
    Mol. Cell. Biol. 25:6559-6569(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Stem cell self-renewal controlled by chromatin remodeling factors."
    Xi R., Xie T.
    Science 310:1487-1489(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  8. "Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development."
    Gause M., Eissenberg J.C., Macrae A.F., Dorsett M., Misulovin Z., Dorsett D.
    Mol. Cell. Biol. 26:2347-2359(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression."
    Lu J., Ruhf M.-L., Perrimon N., Leder P.
    Proc. Natl. Acad. Sci. U.S.A. 104:9381-9386(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-656; SER-664; SER-666; THR-729; SER-733; SER-736; SER-744 AND THR-838, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiDOM_DROME
AccessioniPrimary (citable) accession number: Q9NDJ2
Secondary accession number(s): Q7YZ94
, Q95TN6, Q968U6, Q9I7V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3