Enolase - Trypanosoma brucei brucei

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Unreviewed, UniProtKB/TrEMBL Q9NDH8 (Q9NDH8_TRYBB)

Last modified June 16, 2009. Version 37. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names	Recommended name: Enolase RuleBase RU000654V7 EC=4.2.1.11
Organism	Trypanosoma brucei brucei EMBL AAF73201.1
Taxonomic identifier	5702 [NCBI]
Taxonomic lineage	Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2-phospho-D-glycerate = phosphoenolpyruvate + H₂O. RuleBase RU000654V7
Cofactor	Magnesium. Required for catalysis and for stabilizing the dimer By similarity. RuleBase RU000654V7
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. RuleBase RU000654V7
Sequence similarities	Belongs to the enolase family. RuleBase RU000654V7

Ontologies

Keywords
Biological process	Glycolysis RuleBase RU000654V7
Ligand	Magnesium RuleBase RU000654V7
Molecular function	Lyase RuleBase RU000654V7
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: InterPro
Cellular component	phosphopyruvate hydratase complex Inferred from electronic annotation. Source: InterPro
Molecular function	phosphopyruvate hydratase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9NDH8-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2573F8AF223ED360
Show »

429

46,592

        10         20         30         40         50         60 
MTIQKVHGRE VLDSRGNPTV EVEVTTERGV FRSAVPSGAS TGVYEACELR DGDKKRYVGK 

        70         80         90        100        110        120 
GCLQAVKNVN EVIGPALIGR DELKQEELDT LMLRLDGTPN KGKLGANAIL GCSMAISKAA 

       130        140        150        160        170        180 
AAAKGVPLYR YLASLAGTKE LRLPVPCFNV INGGKHAGNA LPFQEFMIAP VKATSFSEAL 

       190        200        210        220        230        240 
RMGSEVYHSL RGIIKKKYGQ DAVNVGDEGG FAPPIKDINE PLPILMEAIE EAGHRGKFAI 

       250        260        270        280        290        300 
CMDCAASETY DEKKQQYNLT FKSPEPTWVT AEQLRETYCK WAHDYPIVSI EDPYDQDDFA 

       310        320        330        340        350        360 
GFAGITEALK GKTQIVGDDL TVTNTERIKM AIEKKACNSL LLKINQIGTI SEAIASSKLC 

       370        380        390        400        410        420 
MENGWSVMVS HRSGETEDTY IADLVVALGS GQIKTGAPCR GERTAKLNQL LRIEEELGAH 


AKFGFPGWS

References

[1]	"Enolase from Trypanosoma brucei, from the amitochondriate protist Mastigamoeba balamuthi, and from the chloroplast and cytosol of Euglena gracilis: pieces in the evolutionary puzzle of the eukaryotic glycolytic pathway." Hannaert V., Brinkmann H., Nowitzki U., Lee J.A., Albert M.A., Sensen C.W., Gaasterland T., Muller M., Michels P., Martin W. Mol. Biol. Evol. 17:989-1000(2000) [PubMed: 10889212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 427 EMBL AAF73201.1.
[2]	"Compartment-specific forms of the glycolytic enzyme enolase from Trypanosoma brucei and Euglena gracilis and a surprising evolutionary history of the genes." Hannaert V., Albert M.-A., Brinkmann H., Nowitzki U., Michels P.A.M., Martin W. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 427 EMBL AAF73201.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

AF152348 Genomic DNA. Translation: AAF73201.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OEP	X-ray	2.30	A	1-429	[»]

ModBase

Phylogenomic databases

OMA

Q9NDH8. RNAKYNQ.

Enzyme and pathway databases

BRENDA

Family and domain databases

InterPro

IPR000941. Enolase.
[Graphical view]

PANTHER

PTHR11902. Enolase. 1 hit.

Pfam

PF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
[Graphical view]

PIRSF

PIRSF001400. Enolase. 1 hit.

PRINTS

PR00148. ENOLASE.

ProDom

PD000902. Enolase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR01060. eno. 1 hit.

PROSITE

PS00164. ENOLASE. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

Q9NDH8_TRYBB

Accession

Primary (citable) accession number: Q9NDH8

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information