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Q9NDG8

- ACE4_CAEBR

UniProt

Q9NDG8 - ACE4_CAEBR

Protein

Acetylcholinesterase 4

Gene

ace-4

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Rapidly hydrolyzes choline released into the synapse.By similarity

    Catalytic activityi

    Acetylcholine + H2O = choline + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei219 – 2191Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei347 – 3471Charge relay systemBy similarity
    Active sitei477 – 4771Charge relay systemBy similarity

    GO - Molecular functioni

    1. acetylcholinesterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. neurotransmitter catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Keywords - Biological processi

    Neurotransmitter degradation

    Protein family/group databases

    MEROPSiS09.980.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylcholinesterase 4 (EC:3.1.1.7)
    Short name:
    AChE 4
    Gene namesi
    Name:ace-4
    ORF Names:CBG02827
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG02827; CBP37642; WBGene00025805; Cbr-ace-4.

    Subcellular locationi

    Cell junctionsynapse By similarity. Secreted By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell
    4. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Secreted, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 604581Acetylcholinesterase 4PRO_0000008611Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi88 ↔ 115By similarity
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi273 ↔ 284By similarity
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi426 ↔ 561By similarity
    Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NDG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000091866.
    OrthoDBiEOG7RBZ7R.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    PRINTSiPR00878. CHOLNESTRASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NDG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPKLVFLPF LIFITVFIEE SEAVHPVVLE TKLGDIRGNE FFFLSKKIRT    50
    FFGVPFAEPP VEEFRFRKPR EKKQWKKLFD ATKPANACFQ TRDNYNTSFW 100
    GSEMWNANTQ ISEDCLYLNI WAPADAYNLT VMVWFFGGGF YSGSPSLSIY 150
    DGRALAATQH VIVVNINYRL GPFGFLYLDH PDAPGNMGLL DQQLALHWIR 200
    QNIVSFGGNP DKVSVFGQSA GAASIVAHLI APGSRGLFKN AILQSGSLEN 250
    TWAINSPFRA KQKSEKLLEL VGCNKTTVEN SMSCLRLVSP EQLSLSTWNI 300
    SLTYLEFPFV IVSRDKHFFG HLDARAALRE GDFNRDVNLM IGMNKDEGNY 350
    WNIYQLPQFF DKAEPPELTR HQFDNLIDST FSIQPDIIRS AAKYIYSDPN 400
    CTDHGRKTRF YAGQMNQIVG DYFFSCDSLW LADQFFLFLQ ICSTPNGSLK 450
    NPPKVFVYYF TQSSSANPWP KWTGAMHGYE IEYVFGVPLS YSKIYKRREQ 500
    IFSRKIMQFW ASFAKNGTPR LRVLKNSEHW PEFNEHNNYR WMQLRSGSNI 550
    RPIKRRKETE CQFWRRVKDT EYTAYLTQEY SSSCHINSYR ILLFIPFFFI 600
    FSAF 604
    Length:604
    Mass (Da):69,952
    Last modified:October 1, 2000 - v1
    Checksum:i73D4B6A653B325C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159505 mRNA. Translation: AAF80378.1.
    HE601438 Genomic DNA. Translation: CAP23764.3.

    Genome annotation databases

    EnsemblMetazoaiCBG02827; CBG02827; CBG02827.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159505 mRNA. Translation: AAF80378.1 .
    HE601438 Genomic DNA. Translation: CAP23764.3 .

    3D structure databases

    ProteinModelPortali Q9NDG8.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.980.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG02827 ; CBG02827 ; CBG02827 .

    Organism-specific databases

    WormBasei CBG02827 ; CBP37642 ; WBGene00025805 ; Cbr-ace-4.

    Phylogenomic databases

    HOGENOMi HOG000091866.
    OrthoDBi EOG7RBZ7R.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    IPR000997. Cholinesterase.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR00878. CHOLNESTRASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A fourth acetylcholinesterase gene in Caenorhabditis briggsae."
      Combes D., Grauso M., Fedon Y., Toutant J.-P., Arpagaus M.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AF16.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiACE4_CAEBR
    AccessioniPrimary (citable) accession number: Q9NDG8
    Secondary accession number(s): A8WTF3, Q620F3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3