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Q9NDG8

- ACE4_CAEBR

UniProt

Q9NDG8 - ACE4_CAEBR

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Protein

Acetylcholinesterase 4

Gene

ace-4

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Rapidly hydrolyzes choline released into the synapse.By similarity

Catalytic activityi

Acetylcholine + H2O = choline + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei219 – 2191Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei347 – 3471Charge relay systemBy similarity
Active sitei477 – 4771Charge relay systemBy similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Neurotransmitter degradation

Protein family/group databases

MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase 4 (EC:3.1.1.7)
Short name:
AChE 4
Gene namesi
Name:ace-4
ORF Names:CBG02827
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG02827; CBP37642; WBGene00025805; Cbr-ace-4.

Subcellular locationi

Cell junctionsynapse By similarity. Secreted By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
  4. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 604581Acetylcholinesterase 4PRO_0000008611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi88 ↔ 115By similarity
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi273 ↔ 284By similarity
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi426 ↔ 561By similarity
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9NDG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000091866.
InParanoidiQ9NDG8.
OrthoDBiEOG7RBZ7R.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NDG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPKLVFLPF LIFITVFIEE SEAVHPVVLE TKLGDIRGNE FFFLSKKIRT
60 70 80 90 100
FFGVPFAEPP VEEFRFRKPR EKKQWKKLFD ATKPANACFQ TRDNYNTSFW
110 120 130 140 150
GSEMWNANTQ ISEDCLYLNI WAPADAYNLT VMVWFFGGGF YSGSPSLSIY
160 170 180 190 200
DGRALAATQH VIVVNINYRL GPFGFLYLDH PDAPGNMGLL DQQLALHWIR
210 220 230 240 250
QNIVSFGGNP DKVSVFGQSA GAASIVAHLI APGSRGLFKN AILQSGSLEN
260 270 280 290 300
TWAINSPFRA KQKSEKLLEL VGCNKTTVEN SMSCLRLVSP EQLSLSTWNI
310 320 330 340 350
SLTYLEFPFV IVSRDKHFFG HLDARAALRE GDFNRDVNLM IGMNKDEGNY
360 370 380 390 400
WNIYQLPQFF DKAEPPELTR HQFDNLIDST FSIQPDIIRS AAKYIYSDPN
410 420 430 440 450
CTDHGRKTRF YAGQMNQIVG DYFFSCDSLW LADQFFLFLQ ICSTPNGSLK
460 470 480 490 500
NPPKVFVYYF TQSSSANPWP KWTGAMHGYE IEYVFGVPLS YSKIYKRREQ
510 520 530 540 550
IFSRKIMQFW ASFAKNGTPR LRVLKNSEHW PEFNEHNNYR WMQLRSGSNI
560 570 580 590 600
RPIKRRKETE CQFWRRVKDT EYTAYLTQEY SSSCHINSYR ILLFIPFFFI

FSAF
Length:604
Mass (Da):69,952
Last modified:October 1, 2000 - v1
Checksum:i73D4B6A653B325C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159505 mRNA. Translation: AAF80378.1.
HE601438 Genomic DNA. Translation: CAP23764.3.

Genome annotation databases

EnsemblMetazoaiCBG02827; CBG02827; CBG02827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159505 mRNA. Translation: AAF80378.1 .
HE601438 Genomic DNA. Translation: CAP23764.3 .

3D structure databases

ProteinModelPortali Q9NDG8.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG02827 ; CBG02827 ; CBG02827 .

Organism-specific databases

WormBasei CBG02827 ; CBP37642 ; WBGene00025805 ; Cbr-ace-4.

Phylogenomic databases

HOGENOMi HOG000091866.
InParanoidi Q9NDG8.
OrthoDBi EOG7RBZ7R.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00878. CHOLNESTRASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A fourth acetylcholinesterase gene in Caenorhabditis briggsae."
    Combes D., Grauso M., Fedon Y., Toutant J.-P., Arpagaus M.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AF16.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiACE4_CAEBR
AccessioniPrimary (citable) accession number: Q9NDG8
Secondary accession number(s): A8WTF3, Q620F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3