Acetylcholinesterase 4 precursor - Caenorhabditis briggsae

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Q9NDG8 (ACE4_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 3, 2012. Version 68. History...

Clusters with 100%, 90%, 50% identity |

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Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Acetylcholinesterase 4
Short name=AChE 4
EC=3.1.1.7

Gene names

Name:	ace-4
ORF Names:	CBG02827

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	604 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Rapidly hydrolyzes choline released into the synapse By similarity.
Catalytic activity	Acetylcholine + H₂O = choline + acetate.
Subcellular location	Cell junction › synapse By similarity. Secreted By similarity. Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the type-B carboxylesterase/lipase family.

Ontologies

Keywords
Biological process	Neurotransmitter degradation
Cellular component	Cell junction Cell membrane Membrane Secreted Synapse
Domain	Signal
Molecular function	Hydrolase Serine esterase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neurotransmitter catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acetylcholinesterase activity Inferred from electronic annotation. Source: EC carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

23

Potential

Chain

581

Acetylcholinesterase 4

PRO_0000008611

Sites

Active site

1

Acyl-ester intermediate By similarity

Active site

1

Charge relay system By similarity

Active site

1

Charge relay system By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9NDG8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 73D4B6A653B325C4
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604

69,952

        10         20         30         40         50         60 
MKPKLVFLPF LIFITVFIEE SEAVHPVVLE TKLGDIRGNE FFFLSKKIRT FFGVPFAEPP 

        70         80         90        100        110        120 
VEEFRFRKPR EKKQWKKLFD ATKPANACFQ TRDNYNTSFW GSEMWNANTQ ISEDCLYLNI 

       130        140        150        160        170        180 
WAPADAYNLT VMVWFFGGGF YSGSPSLSIY DGRALAATQH VIVVNINYRL GPFGFLYLDH 

       190        200        210        220        230        240 
PDAPGNMGLL DQQLALHWIR QNIVSFGGNP DKVSVFGQSA GAASIVAHLI APGSRGLFKN 

       250        260        270        280        290        300 
AILQSGSLEN TWAINSPFRA KQKSEKLLEL VGCNKTTVEN SMSCLRLVSP EQLSLSTWNI 

       310        320        330        340        350        360 
SLTYLEFPFV IVSRDKHFFG HLDARAALRE GDFNRDVNLM IGMNKDEGNY WNIYQLPQFF 

       370        380        390        400        410        420 
DKAEPPELTR HQFDNLIDST FSIQPDIIRS AAKYIYSDPN CTDHGRKTRF YAGQMNQIVG 

       430        440        450        460        470        480 
DYFFSCDSLW LADQFFLFLQ ICSTPNGSLK NPPKVFVYYF TQSSSANPWP KWTGAMHGYE 

       490        500        510        520        530        540 
IEYVFGVPLS YSKIYKRREQ IFSRKIMQFW ASFAKNGTPR LRVLKNSEHW PEFNEHNNYR 

       550        560        570        580        590        600 
WMQLRSGSNI RPIKRRKETE CQFWRRVKDT EYTAYLTQEY SSSCHINSYR ILLFIPFFFI 


FSAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A fourth acetylcholinesterase gene in Caenorhabditis briggsae." Combes D., Grauso M., Fedon Y., Toutant J.-P., Arpagaus M. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: AF16.
[2]	"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF159505 mRNA. Translation: AAF80378.1. HE601438 Genomic DNA. Translation: CAP23764.1.
3D structure databases
ProteinModelPortal	Q9NDG8.
ModBase	Search...
Protein family/group databases
MEROPS	S09.980.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG02827; CBG02827; CBG02827.
Organism-specific databases
WormBase	CBG02827; CBP37642; WBGene00025805; Cbr-ace-4.
Phylogenomic databases
HOGENOM	HOG000091866.
Family and domain databases
InterPro	IPR002018. CarbesteraseB. IPR019826. Carboxylesterase_B_AS. IPR019819. Carboxylesterase_B_CS. IPR000997. Cholinesterase. [Graphical view]
Pfam	PF00135. COesterase. 1 hit. [Graphical view]
PRINTS	PR00878. CHOLNESTRASE.
PROSITE	PS00122. CARBOXYLESTERASE_B_1. 1 hit. PS00941. CARBOXYLESTERASE_B_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACE4_CAEBR

Accession

Primary (citable) accession number: Q9NDG8
Secondary accession number(s): A8WTF3, Q620F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	October 1, 2000
Last modified:	October 3, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents