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Q9NDA2 (PSA7_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-7

EC=3.4.25.1
Alternative name(s):
20S proteasome subunit alpha-4
Gene names
Name:PSA4
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Proteasome subunit alpha type-7
PRO_0000124158

Sequences

Sequence LengthMass (Da)Tools
Q9NDA2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: B2C522510C068670

FASTA24727,865
        10         20         30         40         50         60 
MSYDRAITVF SPDGHLFQVE YAQEAVRKGL CAVGVKGKDS IIFAVEKKSV QKLQDSRTTR 

        70         80         90        100        110        120 
KIYKLDEHIY LASAGLSADA RVVVNHAQLE CQRFRLSYED AIDVDLLVRY VARVQQRSTQ 

       130        140        150        160        170        180 
SSGSRPYGVS TIIGGFNENG QPQLWKTEPS GTSSAWNAAA IGRNDKVVLE FMEKNYQDGM 

       190        200        210        220        230        240 
TRDRCVHFAI KALLEAVESG SKNIELLVLE RGKAAYMSDT ELHRFVVEVE KEREEEAARR 


RRLAEED 

« Hide

References

[1]"Functional assignment of the 20 S proteasome from Trypanosoma brucei using mass spectrometry and new bioinformatics approaches."
Huang L., Jacob R.J., Pegg S.C.H., Baldwin M.A., Wang C.C., Burlingame A.L., Babbitt P.C.
J. Biol. Chem. 276:28327-28339(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 427.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF169652 mRNA. Translation: AAF89684.1.

3D structure databases

ProteinModelPortalQ9NDA2.
SMRQ9NDA2. Positions 2-239.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA7_TRYBB
AccessionPrimary (citable) accession number: Q9NDA2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries