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Protein

Therostasin

Gene
N/A
Organism
Theromyzon tessulatum (Duck leech)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent inhibitor of factor Xa. It also inhibits trypsin in a weaker manner.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI15.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Therostasin
OrganismiTheromyzon tessulatum (Duck leech)
Taxonomic identifieri13286 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudineaRhynchobdellidaGlossiphoniidaeTheromyzon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000000170120 – 101TherostasinAdd BLAST82

Expressioni

Tissue specificityi

Salivary glands.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9NBW4.
SMRiQ9NBW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 46Antistasin-like 1PROSITE-ProRule annotationAdd BLAST26
Domaini49 – 75Antistasin-like 2PROSITE-ProRule annotationAdd BLAST27

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004094. Antistasin-like.
IPR019764. Endothelin_toxin_CS.
IPR011061. Hirudin/antistatin.
PfamiView protein in Pfam
PF02822. Antistasin. 1 hit.
SUPFAMiSSF57262. SSF57262. 1 hit.
PROSITEiView protein in PROSITE
PS51252. ANTISTASIN. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NBW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLAVLLLV ACFCSVAFGD CENTECPRAC PGEYEFDEDG CNTCLCKGCN
60 70 80 90 100
DAQCRIYCPL GFTTDANGCE SFCTCNTRET VCQNVVCSGK RVCNPRSGRC

E
Length:101
Mass (Da):10,951
Last modified:October 1, 2000 - v1
Checksum:i8935C05F89AB8B98
GO

Mass spectrometryi

Molecular mass is 8991 Da from positions 20 - 101. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239803 mRNA. Translation: AAF73958.1.

Similar proteinsi

Entry informationi

Entry nameiTHST_THETS
AccessioniPrimary (citable) accession number: Q9NBW4
Secondary accession number(s): P82355
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 10, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families