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Q9NB97

- Q9NB97_DROME

UniProt

Q9NB97 - Q9NB97_DROME

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Protein

Transporter

Gene

DAT

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cocaine binding Source: FlyBase
  2. dopamine transmembrane transporter activity Source: FlyBase
  3. neurotransmitter:sodium symporter activity Source: InterPro

GO - Biological processi

  1. cation transmembrane transport Source: GOC
  2. circadian sleep/wake cycle Source: FlyBase
  3. dopamine transport Source: FlyBase
  4. sleep Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

SymportUniRule annotationSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiREACT_257046. Na+/Cl- dependent neurotransmitter transporters.
REACT_271468. Dopamine clearance from the synaptic cleft.

Names & Taxonomyi

Protein namesi
Recommended name:
TransporterUniRule annotation
Gene namesi
Name:DATImported
ORF Names:CG8380Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0034136. DAT.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ9NB97.

Expressioni

Gene expression databases

BgeeiQ9NB97.
ExpressionAtlasiQ9NB97. differential.

Structurei

3D structure databases

ProteinModelPortaliQ9NB97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NB97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPTGHISKS KTPTPRDNDN NSISDERETW SGKVDFLLSV IGFAVDLANV
60 70 80 90 100
WRFPYLCYKN GGGAFLVPYG IMLVVGGIPL FYMELALGQH NRKGAITCWG
110 120 130 140 150
RLVPLFKGIG YAVVLIAFYV DFYYNVIIAW SLRFFFASFT NSLPWTSCNN
160 170 180 190 200
IWNTPNCRPF ESQNASRVPV IGNYSDLYAM GNQSLLYNET YMNGSSLDTS
210 220 230 240 250
AVGHVEGFQS AASEYFNRYI LELNRSEGIH DLGAIKWDMA LCLLIVYLIC
260 270 280 290 300
YFSLWKGIST SGKVVWFTAL FPYAVLLILL IRGLTLPGSF LGIQYYLTPN
310 320 330 340 350
FSAIYKAEVW VDAATQVFFS LGPGFGVLLA YASYNKYHNN VYKDALLTSF
360 370 380 390 400
INSATSFIAG FVIFSVLGYM AHTLGVRIED VATEGPGLVF VVYPAAIATM
410 420 430 440 450
PASTFWALIF FMMLLTLGLD SSFGGSEAII TALSDEFPKI KRNRELFVAG
460 470 480 490 500
LFSLYFVVGL ASCTQGGFYF FHLLDRYAAG YSILVAVFFE AIAVSWIYGT
510 520 530 540 550
NRFSEDIRDM IGFPPGRYWQ VCWRFVAPIF LLFITVYGLI GYEPLTYADY
560 570 580 590 600
VYPSWANALG WCIAGSSVVM IPAVAIFKLL STPGSLRQRF TILTTPWRDQ
610 620 630
QSMAMVLNGV TTEVTVVRLT DTETAKEPVD V
Length:631
Mass (Da):70,349
Last modified:October 1, 2000 - v1
Checksum:iABF3B53F5A91ED89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260833 mRNA. Translation: AAF76882.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260833 mRNA. Translation: AAF76882.1 .

3D structure databases

ProteinModelPortali Q9NB97.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9NB97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0034136. DAT.

Enzyme and pathway databases

Reactomei REACT_257046. Na+/Cl- dependent neurotransmitter transporters.
REACT_271468. Dopamine clearance from the synaptic cleft.

Gene expression databases

Bgeei Q9NB97.
ExpressionAtlasi Q9NB97. differential.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of neurotransmitter transporters from Drosophila melanogaster."
    Porzgen P., Sonders M.S., Reed A.I., Ingram S.L., Amara S.G.
    Abstr. - Soc. Neurosci. 25:160-160(1999)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeadImported.
  2. "The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines."
    Porzgen P., Park S.K., Hirsh J., Sonders M.S., Amara S.G.
    Mol. Pharmacol. 59:83-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeadImported.

Entry informationi

Entry nameiQ9NB97_DROME
AccessioniPrimary (citable) accession number: Q9NB97
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)