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Q9NB97

- Q9NB97_DROME

UniProt

Q9NB97 - Q9NB97_DROME

Protein

Transporter

Gene

DAT

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cocaine binding Source: FlyBase
    2. dopamine transmembrane transporter activity Source: FlyBase
    3. neurotransmitter:sodium symporter activity Source: InterPro

    GO - Biological processi

    1. circadian sleep/wake cycle Source: FlyBase
    2. dopamine transport Source: FlyBase
    3. sleep Source: FlyBase

    Keywords - Biological processi

    SymportUniRule annotationSAAS annotation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TransporterUniRule annotation
    Gene namesi
    Name:DATImported
    ORF Names:CG8380Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0034136. DAT.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: FlyBase

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9NB97.

    Expressioni

    Gene expression databases

    BgeeiQ9NB97.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NB97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sodium:neurotransmitter symporter (SNF) family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    InParanoidiQ9NB97.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NB97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPTGHISKS KTPTPRDNDN NSISDERETW SGKVDFLLSV IGFAVDLANV    50
    WRFPYLCYKN GGGAFLVPYG IMLVVGGIPL FYMELALGQH NRKGAITCWG 100
    RLVPLFKGIG YAVVLIAFYV DFYYNVIIAW SLRFFFASFT NSLPWTSCNN 150
    IWNTPNCRPF ESQNASRVPV IGNYSDLYAM GNQSLLYNET YMNGSSLDTS 200
    AVGHVEGFQS AASEYFNRYI LELNRSEGIH DLGAIKWDMA LCLLIVYLIC 250
    YFSLWKGIST SGKVVWFTAL FPYAVLLILL IRGLTLPGSF LGIQYYLTPN 300
    FSAIYKAEVW VDAATQVFFS LGPGFGVLLA YASYNKYHNN VYKDALLTSF 350
    INSATSFIAG FVIFSVLGYM AHTLGVRIED VATEGPGLVF VVYPAAIATM 400
    PASTFWALIF FMMLLTLGLD SSFGGSEAII TALSDEFPKI KRNRELFVAG 450
    LFSLYFVVGL ASCTQGGFYF FHLLDRYAAG YSILVAVFFE AIAVSWIYGT 500
    NRFSEDIRDM IGFPPGRYWQ VCWRFVAPIF LLFITVYGLI GYEPLTYADY 550
    VYPSWANALG WCIAGSSVVM IPAVAIFKLL STPGSLRQRF TILTTPWRDQ 600
    QSMAMVLNGV TTEVTVVRLT DTETAKEPVD V 631
    Length:631
    Mass (Da):70,349
    Last modified:October 1, 2000 - v1
    Checksum:iABF3B53F5A91ED89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260833 mRNA. Translation: AAF76882.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260833 mRNA. Translation: AAF76882.1 .

    3D structure databases

    ProteinModelPortali Q9NB97.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9NB97.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0034136. DAT.

    Phylogenomic databases

    InParanoidi Q9NB97.

    Gene expression databases

    Bgeei Q9NB97.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of neurotransmitter transporters from Drosophila melanogaster."
      Porzgen P., Sonders M.S., Reed A.I., Ingram S.L., Amara S.G.
      Abstr. - Soc. Neurosci. 25:160-160(1999)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HeadImported.
    2. "The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines."
      Porzgen P., Park S.K., Hirsh J., Sonders M.S., Amara S.G.
      Mol. Pharmacol. 59:83-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HeadImported.

    Entry informationi

    Entry nameiQ9NB97_DROME
    AccessioniPrimary (citable) accession number: Q9NB97
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)