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Q9NB71

- HIW_DROME

UniProt

Q9NB71 - HIW_DROME

Protein

E3 ubiquitin-protein ligase highwire

Gene

hiw

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth.1 Publication

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4991 – 504252RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. ubiquitin-protein transferase activity Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adult walking behavior Source: FlyBase
    2. autophagy Source: FlyBase
    3. BMP signaling pathway Source: UniProtKB
    4. locomotion Source: FlyBase
    5. negative regulation of BMP signaling pathway Source: UniProtKB
    6. negative regulation of synaptic growth at neuromuscular junction Source: UniProtKB
    7. protein ubiquitination Source: UniProtKB
    8. regulation of synaptic growth at neuromuscular junction Source: FlyBase
    9. regulation of terminal button organization Source: FlyBase
    10. synapse organization Source: FlyBase
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase highwire (EC:6.3.2.-)
    Alternative name(s):
    Protein pam/highwire/rpm-1
    Gene namesi
    Name:hiwImported
    ORF Names:CG32592
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0030600. hiw.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: FlyBase
    2. nucleus Source: UniProtKB-SubCell
    3. plasma membrane Source: FlyBase

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Flies display NMJ synapses that grow exuberantly and are expanded in both the number of boutons and in the extent and length of branches.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 52335233E3 ubiquitin-protein ligase highwirePRO_0000055971Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei213 – 2131Phosphoserine1 Publication
    Modified residuei216 – 2161Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9NB71.

    Expressioni

    Tissue specificityi

    Nervous system specific expression. Stage 13 embryos show expression in the CNS at the longitudinal axon tracts around which the synaptic neuropil forms. Expression outside the CNS starts at stage 16 in presynaptic terminals at the periactive zone which surround the active zone. NMJ and CNS expression is also seen in third instar larvae (at protein level).1 Publication

    Gene expression databases

    BgeeiQ9NB71.

    Interactioni

    Protein-protein interaction databases

    BioGridi58787. 4 interactions.
    IntActiQ9NB71. 1 interaction.
    STRINGi7227.FBpp0073787.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NB71.
    SMRiQ9NB71. Positions 589-784, 928-1079, 1431-1587, 2015-2170, 2958-3001, 4991-5046.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati615 – 66652RCC1 1Sequence AnalysisAdd
    BLAST
    Repeati669 – 72456RCC1 2Sequence AnalysisAdd
    BLAST
    Repeati768 – 81851RCC1 3Sequence AnalysisAdd
    BLAST
    Repeati931 – 98353RCC1 4Sequence AnalysisAdd
    BLAST
    Repeati984 – 103350RCC1 5Sequence AnalysisAdd
    BLAST
    Repeati1035 – 108450RCC1 6Sequence AnalysisAdd
    BLAST
    Repeati2906 – 300095FilaminSequence AnalysisAdd
    BLAST
    Domaini4195 – 4374180DOCPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1436 – 1587152PHR domain 1By similarityAdd
    BLAST
    Regioni2014 – 2169156PHR domain 2By similarityAdd
    BLAST

    Domaini

    The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners By similarity.By similarity

    Sequence similaritiesi

    Belongs to the highwire family.Curated
    Contains 1 DOC domain.PROSITE-ProRule annotation
    Contains 1 filamin repeat.PROSITE-ProRule annotation
    Contains 6 RCC1 repeats.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4991 – 504252RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5184.
    GeneTreeiENSGT00390000011403.
    InParanoidiQ9NB71.
    KOiK10693.
    OMAiEILDECH.
    OrthoDBiEOG75B84C.
    PhylomeDBiQ9NB71.

    Family and domain databases

    Gene3Di2.130.10.30. 4 hits.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR004939. APC_su10/DOC_dom.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR008979. Galactose-bd-like.
    IPR027047. Highwire/Pam/Rpm-1.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR012983. PHR.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    IPR003646. SH3-like_bac-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR12846:SF17. PTHR12846:SF17. 1 hit.
    PfamiPF08005. PHR. 2 hits.
    PF00415. RCC1. 1 hit.
    PF08239. SH3_3. 1 hit.
    [Graphical view]
    PRINTSiPR00633. RCCNDNSATION.
    SMARTiSM00184. RING. 2 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF50985. SSF50985. 2 hits.
    SSF81296. SSF81296. 2 hits.
    PROSITEiPS51284. DOC. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    PS00626. RCC1_2. 2 hits.
    PS50012. RCC1_3. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NB71-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGLLNPLKY GDHFYELYTN STRRKMQHDR KVLTKRKSRK DKSAAAMAAA     50
    AAAAVLEGNA GAGGLVNPLD PPLVKEQLMI LPSFPVAHIE LDPNASKFAV 100
    FSAIRSTVLE AETRYSLFQE GGAPSGQSGS NQKKWSNNVN SACCMMCAHS 150
    CMISNLLDCS CHAHMAMHGA VGPGNAGPGG PVGVLVDGRI PAPVPVVVGG 200
    PGLPAEKRPR RDSANSDADS DTEEPTEREP VYATVPLIVG AGLRSLFELI 250
    ADARHVHPLL CTKALKALLD VIQGQQPESF KLEPEELINP LYDLLLDLAT 300
    MPAALNSATG AEANWSAMAC AALLGLCIAR GDTGKMLKAI AAMLMTPRQL 350
    SAQIVQLPVV LATLQHTVIS AALNKPTRPD FHSHGVPHNS LIDEFPVKLP 400
    PLSTGAPITS PAMACDGVFV YLLYGGTLLK IGTGFGGSYK GHIYAQNEDF 450
    SHERSAWLGY SGGQLYFRRT CRRSAGDQLQ MVGLDTLAIK AMSPLSMLHM 500
    REGLNYVLFT DDDSLHAICS NRDDTLVVKK LNLYHNSYNI DPPPFELPLQ 550
    LARKKFRTLG YAAFEDELLN QYQIQRIQSA HNSFEPKLPA PCRDADVDVM 600
    GMACGKEFGL VRASNGRVYY YGKSAALGLK CVGRTPTLKL TELVISKAAN 650
    IVHVAVGHDG IHALLVNDDG TVFFAGTARR GEDGDSSKNR RQPKAVKPKK 700
    MTKIDGHVVV HAACNNGTSA FVTKTGKLIM YGKDTAHCDA MGFVSELLEQ 750
    HVTKVALGKA HCVALNAKGQ LFSFGLNNKG QCGRIFNKLQ PVKDVPPFAS 800
    SSTAAACFAS LLPLDKRLKL DFSTLCDYDD HNLVQGQCRV CVICRECTGY 850
    NVSCVSALNV PLDQRLAGSI CPCGHGDAGC AKCGLCAACI ALQDSDEAKT 900
    ELKPPPSDVQ QRQQRSKTLI MRRKERKGEL ETGAAGGGAA TPTDLDKDPP 950
    RVAPLAPQLL QLTSSSPVVQ VACGLHHTVV LTLAGEVYTF GSNQYGQLGS 1000
    GDLQPVSGPV RVQVPGAISQ VAAGSNHTVL LTSKGMVYTF GNYQKGQLGR 1050
    LPSDYGLKPP PQDDDSPVGA GSDGGAGGSP TVAPVGMPGP ERSQSPANVQ 1100
    PSGSKEMPPL LPVLTQRQKF LWNCSPGAVF GLGPCYGKKV TWIGANGDQT 1150
    FIKIDESLIT AQMLPKMHVV ANKKTILLIP SIPLSFHTLS INRRDGSCTA 1200
    HYRGQTNFVK LMQAQPEQQQ PEINSNLDVA VTPVADSPAH ASTSSLLAAL 1250
    TGTATAGVPI NEQMSRSMHE ARNQIFEEQL PEVGSSAAAA AVAAPGTPVS 1300
    AGSVPRSRRG GKQGTSSPEP IPSPPQLAFT MDPTYNVLWV FDGAARKLRC 1350
    HNVVASDIND SDANAATYRS LLSPELSLPD RVDSRVARSQ ASLNLLACLD 1400
    ILTSAQDNIP GCFEQPLLKQ TQQTAETQAG EFQVVNRFDN FGGGWGYSGH 1450
    SVEAIRFSAD TDIVICGFGM FGGRGEYSCK LKLFDLGGDG GGYEKEGILI 1500
    SETKEVPYEC GARSKHHILL PKPVSAVAGR WYLVWARIAG PSSDCGSCGQ 1550
    ASVTTEDQVV FSFKSSKKAN NGTDVNSGQI PAILYRLVTQ DCKQTPAQMD 1600
    ADPVQRISRA FANSVSRECF ESLVVLLSWS WDCFKLQLRE ERDRSRPLQL 1650
    QQSLQYLGYV IKSCLRLLRK YTIEIYPQRN SSTSVATGGG SNAAHGSGVV 1700
    TTAKSVQSKP NKDKNTPRVV GNAGVMAKYF GDPSTSVAPA MISSASSGGA 1750
    PSTSASAAVA PGSGTPVTRK TNMENIQLAE CIGNVRALLI GIFCDDIFKD 1800
    IATDEGYELS LEILDECHLS FVACFDAFYP TSSLKWNCLC DLLAQMDRGA 1850
    LHSRLLSAIL AGLCSPSVKL RATFSLLSAA GNERQSIISP SDNSGLPMLS 1900
    STDAHPYPVL VEQMIYRTQQ EKSDFLSNSW TFKDVLVRLL DIIASPIRSR 1950
    IEAIYSRSLG SLGYPGGKDC VNQGLIDNCC HLLARVLAEI VYQTAMGEYD 2000
    KLFMPPRTLH STGARFARCD VSRTWNTGNF GPDAIAFAVD RPGVAIAGAM 2050
    VYSGSGSYDY QLELLYDNTA DLQPQHKWET LESVSGSYDQ DAVHNDLAEI 2100
    KFDHPVHIKE NARYALRLCS QGARTCSGDA GMPAVRGPCG AQFHFYACDL 2150
    SFNGTTPARG QLPCILYYST PMKQDGHSAS GRTGDGSNVA THLEDRIMLL 2200
    GPHEVSTRDT ALQIAADITK KCTELLILAR NAMAASCSPS DNSSNHTQTI 2250
    DSEHNITPIE EHMDINWANN SRTAALPTAI DPQLSTARDL GKRIESFSKG 2300
    LMETLKFDKR STNPFEMEIE IGATEVEESA DLRNGQSQSV SQSQSQSQSV 2350
    PINGNERTAD FEFAEQSAQQ SMPQHLHSDS EEAPLEVAGM AAGGGVSVAD 2400
    GSGGVAGVGS QAAAVQLLEV FNLAASNMFH TLLPLVYAHI ANLACSDPKS 2450
    SVQILGLIKE ILPHIAALNQ LHVSKDQRQP EPAIFATQTS GSGNSNSSST 2500
    TSNHYCVVES DHPYKSASIS SYRVEFPPCV QWLTIEFDPQ CGTAQLEDYL 2550
    LLSIPMRPAS QAPPVPHVDD YLEQADNNVN GAGDRRRNTG GGIAGSGAAP 2600
    NTHQRSASVQ LTMASCCRSP GCGNAPGSAA APSSMPLRSQ DPNDREWIVV 2650
    KKFNTASTWL HNVLILPGNC VEFSLETASL YAQDPHNNRY GFKCLVVGYD 2700
    NPTSINASNS CLIRLEQELA YLGGMCSANL MKKELNLPDD KDVEDMSGIE 2750
    ETINTHHTLL SKGFALSEPQ LTVHQALESY LPIGSQSNER QFLKDFISGA 2800
    PGSSGARLAA WLQPESRLDP NKCELNTITE PLRYGWPSQV TVTIRDQYGD 2850
    AVLVPELKVE IKAIPTGSGP NGSATGTGTS CTSVAEVSAP GPNLWMRRAS 2900
    RDTWGWGGMA PPPRINYEPT VKDKMVFKAI TFMKPYANYS FEELRYASPV 2950
    QTRVTELLNA KDMEDGTFSV QWTPSSVGAY CLAVTIDGIP LEEVYRVDVK 3000
    EGILPPPTQR NSAQRRPQAP SKLRRFQARH SSGLRIRSHP TLQSEQVGVV 3050
    RVGGVISFID EIENDDGVWL RLSTESIRQH CTMGWYPTEA WCLQFNQHLA 3100
    RMLLQPVTDK EVNPVRKGVG AEEDVEEQPP VTPSASGEAS PEPEPDPSPV 3150
    LSPAKTKPGR FLSGHQSTNP FLYPAKHADL AEREAQVQEE REKEEEQVDD 3200
    EDADDREPEQ EALPAVELLP AHIGSAIAGV VGGGAIKLQA LQKWFKGDAV 3250
    DGPQPLTPSH SPPLAGVSVR ELVRAMGGQD SPRGNGNRSQ QEQDPEFSLA 3300
    SMRRPNYSAS QTAALLSTPK HTPKRSAVVA SETSGLEDEL SLLQITTTTT 3350
    GQGEQQSELQ LATTSTASSA SKRNPMGPIK RAMPPSFAES IRAVFAALLW 3400
    HEGVVHDAMA CASFLKFHPG LPKEGATVVT RRGESGDPRL QLSREQKAQQ 3450
    RHSVEVANAG NYLNIRPSTL ETLTKSGNCS LHNRSKYRKN LLSGGGGAIN 3500
    SGDDTAQKLQ ALPEMVSVLP PALRCLVYLW EQICSGCVQI VQSNALEQRE 3550
    PRLLSPGSRD LNGDADTEGK EGKNSDQASA GEKDLGRKCK RKKKDDGSWC 3600
    EICELFLPMP VTYHMRIAHP GCGKSAKGKG YNSVGIFCEG WAGNCGEGGK 3650
    GASSWFLMCD PCRDRYLASC RSANNINSAA RQLESSAAEG NELNLFGVKS 3700
    TTLIANAEVY TTMRENATFL LELCSSSSSA SGAAGSLAAT SSSSKRSPQQ 3750
    MSVVAMPVVI EHQLGNSDLK PSTSRCSRMA RLSGSKFCPG VGSGAFRKSF 3800
    VGGPPTAPEN VWLAPESFAC LECLGTAGHE DLPYEMFGLG PNSNDNGYDR 3850
    PLSEISYESC EPNNYDMLSG SLAPGTTAAA SVGGGNLSKF HRSYSMGQGW 3900
    ASLAQHNHPP PHHPQQQHHQ QQQMNLQLQQ HQAPPVDGQP KVVYRRRNNS 3950
    TSEGDGSLLI CYPSEHLRRL VPQKLLASVS VMQTASGEGT GKDHATGTLG 4000
    LDQSAGQNGG GNLLLTRPAM AFITQKHELD RLRAAMRRSL RIAACRIYAL 4050
    QALNWLLRSV TQGVCLHDLM WWFVSSLNPT GGHQPVERGE EASEPALEHP 4100
    VAYTQISGRF AHLITQSLHV FLQSVADLTL HLPLGSPLQR VAIQCFGIRF 4150
    RQADHQFLHS SHVFGNISKI LSKSDEQNDA MAVSTILKPD CDVEHNQVHS 4200
    VATGGSSGAG ARLLCYTDLA GMFEVTVSSR PAMAESLTDN STETFWESDE 4250
    EDRNKCKIIE LSLTKLNYAC RYLLVHIDNS RDIQNKVLNV VFYAGQSLGD 4300
    TNIIKSADVD PKACSWISAK ICDDSCTHFR LELHGPENTL RVRQIKLLGL 4350
    PIGGAVGSDD SSDHKHQPHL RLSHASRIQQ QICEAETLRV FRLITGQVFG 4400
    KLISNVSSDL VPPDSAGIGP PSGGAASTSL LADSLDLREH MVGILFSRSK 4450
    LSHLQKQVIV HIVHAIRKEA QRAKEDWELA NLAHVLKQSP QQQTAPALAA 4500
    SASCESTPER SRAPDTYCFE MLSMVLALSG SVVGRSYLSQ QHGLLRDLLG 4550
    LLHTGSDRVQ RQVTALLRRI LPEITPESFA ELLGVQRLPP ADYSIAHQSA 4600
    SDFDMSRLGL LDIFLAVIAK SLQLQVKVKT TVASTGPSGS GGVSGSSSGN 4650
    GGAVLKAGQQ EKTPAFVRLW SSLDLSVQQL RSRPPTGEPG TTDPFQFDAL 4700
    PPRKESKRNL NQRWFLNGVI STKQAESIIS LIRDLASGKL SEKWSQITKA 4750
    AIAESVLNLT RLEEIYRSPE HCTKTSTLWL ALASLCVLER DHVEKLSSGQ 4800
    WSKLCDTRPL CSNHDDGETA AIIQCETCGS LCGDCDRFLH LNRKTRSHKR 4850
    TVCKEEEEAI RVELHESCGR TKLFWLLALA DSKTLKAMVE FRDGSHTIIS 4900
    GPQEAVGRCR FCGLTGNSGL LEIGNVCADA QCQEYAANSC LKTKPCGHAC 4950
    GGVTGERKCL PCLQHVCHTR ENELAEELRD PKLTQDADDM CMICFVEALS 5000
    CAPSIHLECG HVFHYHCCKA VLEKRWSGPR ITFGFSLCPI CKADIQHPLL 5050
    SDILEPINGL KQDVKRKALM RIKYEGVVKD TDSKNVNMTQ LAMDRYAYYV 5100
    CFKCQKAYYG GEARCDAEIG EKFDPEELVC GGCSDVARAQ MCPKHGTDFL 5150
    EYKCRYCCSV AVFFCFGTTH FCDTCHDDFQ RLTNIPKVKL PQCPAGPKAK 5200
    QLLGDECPLH VMHPPTGEEF ALGCGVCRNA QTF 5233
    Length:5,233
    Mass (Da):565,631
    Last modified:June 21, 2005 - v2
    Checksum:iE5220FFDC91A58E7
    GO

    Sequence cautioni

    The sequence AAM29381.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAF48411.2 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti137 – 1371N → D in AAF76150. (PubMed:10839352)Curated
    Sequence conflicti604 – 6041C → R in AAF76150. (PubMed:10839352)Curated
    Sequence conflicti1620 – 16201F → S in AAF76150. (PubMed:10839352)Curated
    Sequence conflicti4652 – 46521G → E in AAF76150. (PubMed:10839352)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF262977 mRNA. Translation: AAF76150.1.
    AE014298 Genomic DNA. Translation: AAF48411.2. Sequence problems.
    AY113376 mRNA. Translation: AAM29381.1. Different initiation.
    RefSeqiNP_511159.3. NM_078604.3.
    UniGeneiDm.3259.

    Genome annotation databases

    EnsemblMetazoaiFBtr0073970; FBpp0073787; FBgn0030600.
    GeneIDi32429.
    KEGGidme:Dmel_CG32592.
    UCSCiCG32592-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF262977 mRNA. Translation: AAF76150.1 .
    AE014298 Genomic DNA. Translation: AAF48411.2 . Sequence problems.
    AY113376 mRNA. Translation: AAM29381.1 . Different initiation.
    RefSeqi NP_511159.3. NM_078604.3.
    UniGenei Dm.3259.

    3D structure databases

    ProteinModelPortali Q9NB71.
    SMRi Q9NB71. Positions 589-784, 928-1079, 1431-1587, 2015-2170, 2958-3001, 4991-5046.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 58787. 4 interactions.
    IntActi Q9NB71. 1 interaction.
    STRINGi 7227.FBpp0073787.

    Proteomic databases

    PaxDbi Q9NB71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0073970 ; FBpp0073787 ; FBgn0030600 .
    GeneIDi 32429.
    KEGGi dme:Dmel_CG32592.
    UCSCi CG32592-RA. d. melanogaster.

    Organism-specific databases

    CTDi 32429.
    FlyBasei FBgn0030600. hiw.

    Phylogenomic databases

    eggNOGi COG5184.
    GeneTreei ENSGT00390000011403.
    InParanoidi Q9NB71.
    KOi K10693.
    OMAi EILDECH.
    OrthoDBi EOG75B84C.
    PhylomeDBi Q9NB71.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi hiw. drosophila.
    GenomeRNAii 32429.
    NextBioi 778423.
    PROi Q9NB71.

    Gene expression databases

    Bgeei Q9NB71.

    Family and domain databases

    Gene3Di 2.130.10.30. 4 hits.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR004939. APC_su10/DOC_dom.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR008979. Galactose-bd-like.
    IPR027047. Highwire/Pam/Rpm-1.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR012983. PHR.
    IPR009091. RCC1/BLIP-II.
    IPR000408. Reg_chr_condens.
    IPR003646. SH3-like_bac-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR12846:SF17. PTHR12846:SF17. 1 hit.
    Pfami PF08005. PHR. 2 hits.
    PF00415. RCC1. 1 hit.
    PF08239. SH3_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00633. RCCNDNSATION.
    SMARTi SM00184. RING. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF50985. SSF50985. 2 hits.
    SSF81296. SSF81296. 2 hits.
    PROSITEi PS51284. DOC. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    PS00626. RCC1_2. 2 hits.
    PS50012. RCC1_3. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
      Strain: Canton-SImported.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley1 Publication.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4083-5233.
      Strain: BerkeleyImported.
      Tissue: Larva1 Publication and Pupae1 Publication.
    5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213 AND SER-216, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiHIW_DROME
    AccessioniPrimary (citable) accession number: Q9NB71
    Secondary accession number(s): Q8MZ36, Q9VXZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3