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Q9NB71 (HIW_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase highwire

EC=6.3.2.-
Alternative name(s):
Protein pam/highwire/rpm-1
Gene names
Name:hiw
ORF Names:CG32592
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length5233 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth. Ref.1

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Nucleus By similarity UniProtKB O75592.

Tissue specificity

Nervous system specific expression. Stage 13 embryos show expression in the CNS at the longitudinal axon tracts around which the synaptic neuropil forms. Expression outside the CNS starts at stage 16 in presynaptic terminals at the periactive zone which surround the active zone. NMJ and CNS expression is also seen in third instar larvae (at protein level). Ref.1

Domain

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners By similarity.

Disruption phenotype

Flies display NMJ synapses that grow exuberantly and are expanded in both the number of boutons and in the extent and length of branches. Ref.1

Sequence similarities

Belongs to the highwire family.

Contains 1 DOC domain.

Contains 1 filamin repeat.

Contains 6 RCC1 repeats.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence AAF48411.2 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAM29381.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
Ubl conjugation pathway
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from physical interaction PubMed 15046722. Source: UniProtKB

adult walking behavior

Non-traceable author statement PubMed 12490252. Source: FlyBase

autophagy

Inferred from direct assay PubMed 19786572. Source: FlyBase

locomotion

Non-traceable author statement PubMed 12490252. Source: FlyBase

negative regulation of BMP signaling pathway

Inferred from genetic interaction PubMed 15046722. Source: UniProtKB

negative regulation of synaptic growth at neuromuscular junction

Inferred from mutant phenotype PubMed 15046722. Source: UniProtKB

protein ubiquitination

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of synaptic growth at neuromuscular junction

Inferred from mutant phenotype Ref.1PubMed 16237161. Source: FlyBase

regulation of terminal button organization

Inferred from mutant phenotype PubMed 23904612. Source: FlyBase

synapse organization

Inferred from direct assay PubMed 19786572. Source: FlyBase

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasmic membrane-bounded vesicle

Inferred from direct assay Ref.1. Source: FlyBase

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from direct assay Ref.1. Source: FlyBase

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 15046722PubMed 17697379. Source: UniProtKB

ubiquitin-protein transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 52335233E3 ubiquitin-protein ligase highwire
PRO_0000055971

Regions

Repeat615 – 66652RCC1 1
Repeat669 – 72456RCC1 2
Repeat768 – 81851RCC1 3
Repeat931 – 98353RCC1 4
Repeat984 – 103350RCC1 5
Repeat1035 – 108450RCC1 6
Repeat2906 – 300095Filamin
Domain4195 – 4374180DOC
Zinc finger4991 – 504252RING-type; atypical
Region1436 – 1587152PHR domain 1 By similarity
Region2014 – 2169156PHR domain 2 By similarity

Amino acid modifications

Modified residue2131Phosphoserine Ref.5
Modified residue2161Phosphoserine Ref.5

Experimental info

Sequence conflict1371N → D in AAF76150. Ref.1
Sequence conflict6041C → R in AAF76150. Ref.1
Sequence conflict16201F → S in AAF76150. Ref.1
Sequence conflict46521G → E in AAF76150. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9NB71 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: E5220FFDC91A58E7

FASTA5,233565,631
        10         20         30         40         50         60 
MVGLLNPLKY GDHFYELYTN STRRKMQHDR KVLTKRKSRK DKSAAAMAAA AAAAVLEGNA 

        70         80         90        100        110        120 
GAGGLVNPLD PPLVKEQLMI LPSFPVAHIE LDPNASKFAV FSAIRSTVLE AETRYSLFQE 

       130        140        150        160        170        180 
GGAPSGQSGS NQKKWSNNVN SACCMMCAHS CMISNLLDCS CHAHMAMHGA VGPGNAGPGG 

       190        200        210        220        230        240 
PVGVLVDGRI PAPVPVVVGG PGLPAEKRPR RDSANSDADS DTEEPTEREP VYATVPLIVG 

       250        260        270        280        290        300 
AGLRSLFELI ADARHVHPLL CTKALKALLD VIQGQQPESF KLEPEELINP LYDLLLDLAT 

       310        320        330        340        350        360 
MPAALNSATG AEANWSAMAC AALLGLCIAR GDTGKMLKAI AAMLMTPRQL SAQIVQLPVV 

       370        380        390        400        410        420 
LATLQHTVIS AALNKPTRPD FHSHGVPHNS LIDEFPVKLP PLSTGAPITS PAMACDGVFV 

       430        440        450        460        470        480 
YLLYGGTLLK IGTGFGGSYK GHIYAQNEDF SHERSAWLGY SGGQLYFRRT CRRSAGDQLQ 

       490        500        510        520        530        540 
MVGLDTLAIK AMSPLSMLHM REGLNYVLFT DDDSLHAICS NRDDTLVVKK LNLYHNSYNI 

       550        560        570        580        590        600 
DPPPFELPLQ LARKKFRTLG YAAFEDELLN QYQIQRIQSA HNSFEPKLPA PCRDADVDVM 

       610        620        630        640        650        660 
GMACGKEFGL VRASNGRVYY YGKSAALGLK CVGRTPTLKL TELVISKAAN IVHVAVGHDG 

       670        680        690        700        710        720 
IHALLVNDDG TVFFAGTARR GEDGDSSKNR RQPKAVKPKK MTKIDGHVVV HAACNNGTSA 

       730        740        750        760        770        780 
FVTKTGKLIM YGKDTAHCDA MGFVSELLEQ HVTKVALGKA HCVALNAKGQ LFSFGLNNKG 

       790        800        810        820        830        840 
QCGRIFNKLQ PVKDVPPFAS SSTAAACFAS LLPLDKRLKL DFSTLCDYDD HNLVQGQCRV 

       850        860        870        880        890        900 
CVICRECTGY NVSCVSALNV PLDQRLAGSI CPCGHGDAGC AKCGLCAACI ALQDSDEAKT 

       910        920        930        940        950        960 
ELKPPPSDVQ QRQQRSKTLI MRRKERKGEL ETGAAGGGAA TPTDLDKDPP RVAPLAPQLL 

       970        980        990       1000       1010       1020 
QLTSSSPVVQ VACGLHHTVV LTLAGEVYTF GSNQYGQLGS GDLQPVSGPV RVQVPGAISQ 

      1030       1040       1050       1060       1070       1080 
VAAGSNHTVL LTSKGMVYTF GNYQKGQLGR LPSDYGLKPP PQDDDSPVGA GSDGGAGGSP 

      1090       1100       1110       1120       1130       1140 
TVAPVGMPGP ERSQSPANVQ PSGSKEMPPL LPVLTQRQKF LWNCSPGAVF GLGPCYGKKV 

      1150       1160       1170       1180       1190       1200 
TWIGANGDQT FIKIDESLIT AQMLPKMHVV ANKKTILLIP SIPLSFHTLS INRRDGSCTA 

      1210       1220       1230       1240       1250       1260 
HYRGQTNFVK LMQAQPEQQQ PEINSNLDVA VTPVADSPAH ASTSSLLAAL TGTATAGVPI 

      1270       1280       1290       1300       1310       1320 
NEQMSRSMHE ARNQIFEEQL PEVGSSAAAA AVAAPGTPVS AGSVPRSRRG GKQGTSSPEP 

      1330       1340       1350       1360       1370       1380 
IPSPPQLAFT MDPTYNVLWV FDGAARKLRC HNVVASDIND SDANAATYRS LLSPELSLPD 

      1390       1400       1410       1420       1430       1440 
RVDSRVARSQ ASLNLLACLD ILTSAQDNIP GCFEQPLLKQ TQQTAETQAG EFQVVNRFDN 

      1450       1460       1470       1480       1490       1500 
FGGGWGYSGH SVEAIRFSAD TDIVICGFGM FGGRGEYSCK LKLFDLGGDG GGYEKEGILI 

      1510       1520       1530       1540       1550       1560 
SETKEVPYEC GARSKHHILL PKPVSAVAGR WYLVWARIAG PSSDCGSCGQ ASVTTEDQVV 

      1570       1580       1590       1600       1610       1620 
FSFKSSKKAN NGTDVNSGQI PAILYRLVTQ DCKQTPAQMD ADPVQRISRA FANSVSRECF 

      1630       1640       1650       1660       1670       1680 
ESLVVLLSWS WDCFKLQLRE ERDRSRPLQL QQSLQYLGYV IKSCLRLLRK YTIEIYPQRN 

      1690       1700       1710       1720       1730       1740 
SSTSVATGGG SNAAHGSGVV TTAKSVQSKP NKDKNTPRVV GNAGVMAKYF GDPSTSVAPA 

      1750       1760       1770       1780       1790       1800 
MISSASSGGA PSTSASAAVA PGSGTPVTRK TNMENIQLAE CIGNVRALLI GIFCDDIFKD 

      1810       1820       1830       1840       1850       1860 
IATDEGYELS LEILDECHLS FVACFDAFYP TSSLKWNCLC DLLAQMDRGA LHSRLLSAIL 

      1870       1880       1890       1900       1910       1920 
AGLCSPSVKL RATFSLLSAA GNERQSIISP SDNSGLPMLS STDAHPYPVL VEQMIYRTQQ 

      1930       1940       1950       1960       1970       1980 
EKSDFLSNSW TFKDVLVRLL DIIASPIRSR IEAIYSRSLG SLGYPGGKDC VNQGLIDNCC 

      1990       2000       2010       2020       2030       2040 
HLLARVLAEI VYQTAMGEYD KLFMPPRTLH STGARFARCD VSRTWNTGNF GPDAIAFAVD 

      2050       2060       2070       2080       2090       2100 
RPGVAIAGAM VYSGSGSYDY QLELLYDNTA DLQPQHKWET LESVSGSYDQ DAVHNDLAEI 

      2110       2120       2130       2140       2150       2160 
KFDHPVHIKE NARYALRLCS QGARTCSGDA GMPAVRGPCG AQFHFYACDL SFNGTTPARG 

      2170       2180       2190       2200       2210       2220 
QLPCILYYST PMKQDGHSAS GRTGDGSNVA THLEDRIMLL GPHEVSTRDT ALQIAADITK 

      2230       2240       2250       2260       2270       2280 
KCTELLILAR NAMAASCSPS DNSSNHTQTI DSEHNITPIE EHMDINWANN SRTAALPTAI 

      2290       2300       2310       2320       2330       2340 
DPQLSTARDL GKRIESFSKG LMETLKFDKR STNPFEMEIE IGATEVEESA DLRNGQSQSV 

      2350       2360       2370       2380       2390       2400 
SQSQSQSQSV PINGNERTAD FEFAEQSAQQ SMPQHLHSDS EEAPLEVAGM AAGGGVSVAD 

      2410       2420       2430       2440       2450       2460 
GSGGVAGVGS QAAAVQLLEV FNLAASNMFH TLLPLVYAHI ANLACSDPKS SVQILGLIKE 

      2470       2480       2490       2500       2510       2520 
ILPHIAALNQ LHVSKDQRQP EPAIFATQTS GSGNSNSSST TSNHYCVVES DHPYKSASIS 

      2530       2540       2550       2560       2570       2580 
SYRVEFPPCV QWLTIEFDPQ CGTAQLEDYL LLSIPMRPAS QAPPVPHVDD YLEQADNNVN 

      2590       2600       2610       2620       2630       2640 
GAGDRRRNTG GGIAGSGAAP NTHQRSASVQ LTMASCCRSP GCGNAPGSAA APSSMPLRSQ 

      2650       2660       2670       2680       2690       2700 
DPNDREWIVV KKFNTASTWL HNVLILPGNC VEFSLETASL YAQDPHNNRY GFKCLVVGYD 

      2710       2720       2730       2740       2750       2760 
NPTSINASNS CLIRLEQELA YLGGMCSANL MKKELNLPDD KDVEDMSGIE ETINTHHTLL 

      2770       2780       2790       2800       2810       2820 
SKGFALSEPQ LTVHQALESY LPIGSQSNER QFLKDFISGA PGSSGARLAA WLQPESRLDP 

      2830       2840       2850       2860       2870       2880 
NKCELNTITE PLRYGWPSQV TVTIRDQYGD AVLVPELKVE IKAIPTGSGP NGSATGTGTS 

      2890       2900       2910       2920       2930       2940 
CTSVAEVSAP GPNLWMRRAS RDTWGWGGMA PPPRINYEPT VKDKMVFKAI TFMKPYANYS 

      2950       2960       2970       2980       2990       3000 
FEELRYASPV QTRVTELLNA KDMEDGTFSV QWTPSSVGAY CLAVTIDGIP LEEVYRVDVK 

      3010       3020       3030       3040       3050       3060 
EGILPPPTQR NSAQRRPQAP SKLRRFQARH SSGLRIRSHP TLQSEQVGVV RVGGVISFID 

      3070       3080       3090       3100       3110       3120 
EIENDDGVWL RLSTESIRQH CTMGWYPTEA WCLQFNQHLA RMLLQPVTDK EVNPVRKGVG 

      3130       3140       3150       3160       3170       3180 
AEEDVEEQPP VTPSASGEAS PEPEPDPSPV LSPAKTKPGR FLSGHQSTNP FLYPAKHADL 

      3190       3200       3210       3220       3230       3240 
AEREAQVQEE REKEEEQVDD EDADDREPEQ EALPAVELLP AHIGSAIAGV VGGGAIKLQA 

      3250       3260       3270       3280       3290       3300 
LQKWFKGDAV DGPQPLTPSH SPPLAGVSVR ELVRAMGGQD SPRGNGNRSQ QEQDPEFSLA 

      3310       3320       3330       3340       3350       3360 
SMRRPNYSAS QTAALLSTPK HTPKRSAVVA SETSGLEDEL SLLQITTTTT GQGEQQSELQ 

      3370       3380       3390       3400       3410       3420 
LATTSTASSA SKRNPMGPIK RAMPPSFAES IRAVFAALLW HEGVVHDAMA CASFLKFHPG 

      3430       3440       3450       3460       3470       3480 
LPKEGATVVT RRGESGDPRL QLSREQKAQQ RHSVEVANAG NYLNIRPSTL ETLTKSGNCS 

      3490       3500       3510       3520       3530       3540 
LHNRSKYRKN LLSGGGGAIN SGDDTAQKLQ ALPEMVSVLP PALRCLVYLW EQICSGCVQI 

      3550       3560       3570       3580       3590       3600 
VQSNALEQRE PRLLSPGSRD LNGDADTEGK EGKNSDQASA GEKDLGRKCK RKKKDDGSWC 

      3610       3620       3630       3640       3650       3660 
EICELFLPMP VTYHMRIAHP GCGKSAKGKG YNSVGIFCEG WAGNCGEGGK GASSWFLMCD 

      3670       3680       3690       3700       3710       3720 
PCRDRYLASC RSANNINSAA RQLESSAAEG NELNLFGVKS TTLIANAEVY TTMRENATFL 

      3730       3740       3750       3760       3770       3780 
LELCSSSSSA SGAAGSLAAT SSSSKRSPQQ MSVVAMPVVI EHQLGNSDLK PSTSRCSRMA 

      3790       3800       3810       3820       3830       3840 
RLSGSKFCPG VGSGAFRKSF VGGPPTAPEN VWLAPESFAC LECLGTAGHE DLPYEMFGLG 

      3850       3860       3870       3880       3890       3900 
PNSNDNGYDR PLSEISYESC EPNNYDMLSG SLAPGTTAAA SVGGGNLSKF HRSYSMGQGW 

      3910       3920       3930       3940       3950       3960 
ASLAQHNHPP PHHPQQQHHQ QQQMNLQLQQ HQAPPVDGQP KVVYRRRNNS TSEGDGSLLI 

      3970       3980       3990       4000       4010       4020 
CYPSEHLRRL VPQKLLASVS VMQTASGEGT GKDHATGTLG LDQSAGQNGG GNLLLTRPAM 

      4030       4040       4050       4060       4070       4080 
AFITQKHELD RLRAAMRRSL RIAACRIYAL QALNWLLRSV TQGVCLHDLM WWFVSSLNPT 

      4090       4100       4110       4120       4130       4140 
GGHQPVERGE EASEPALEHP VAYTQISGRF AHLITQSLHV FLQSVADLTL HLPLGSPLQR 

      4150       4160       4170       4180       4190       4200 
VAIQCFGIRF RQADHQFLHS SHVFGNISKI LSKSDEQNDA MAVSTILKPD CDVEHNQVHS 

      4210       4220       4230       4240       4250       4260 
VATGGSSGAG ARLLCYTDLA GMFEVTVSSR PAMAESLTDN STETFWESDE EDRNKCKIIE 

      4270       4280       4290       4300       4310       4320 
LSLTKLNYAC RYLLVHIDNS RDIQNKVLNV VFYAGQSLGD TNIIKSADVD PKACSWISAK 

      4330       4340       4350       4360       4370       4380 
ICDDSCTHFR LELHGPENTL RVRQIKLLGL PIGGAVGSDD SSDHKHQPHL RLSHASRIQQ 

      4390       4400       4410       4420       4430       4440 
QICEAETLRV FRLITGQVFG KLISNVSSDL VPPDSAGIGP PSGGAASTSL LADSLDLREH 

      4450       4460       4470       4480       4490       4500 
MVGILFSRSK LSHLQKQVIV HIVHAIRKEA QRAKEDWELA NLAHVLKQSP QQQTAPALAA 

      4510       4520       4530       4540       4550       4560 
SASCESTPER SRAPDTYCFE MLSMVLALSG SVVGRSYLSQ QHGLLRDLLG LLHTGSDRVQ 

      4570       4580       4590       4600       4610       4620 
RQVTALLRRI LPEITPESFA ELLGVQRLPP ADYSIAHQSA SDFDMSRLGL LDIFLAVIAK 

      4630       4640       4650       4660       4670       4680 
SLQLQVKVKT TVASTGPSGS GGVSGSSSGN GGAVLKAGQQ EKTPAFVRLW SSLDLSVQQL 

      4690       4700       4710       4720       4730       4740 
RSRPPTGEPG TTDPFQFDAL PPRKESKRNL NQRWFLNGVI STKQAESIIS LIRDLASGKL 

      4750       4760       4770       4780       4790       4800 
SEKWSQITKA AIAESVLNLT RLEEIYRSPE HCTKTSTLWL ALASLCVLER DHVEKLSSGQ 

      4810       4820       4830       4840       4850       4860 
WSKLCDTRPL CSNHDDGETA AIIQCETCGS LCGDCDRFLH LNRKTRSHKR TVCKEEEEAI 

      4870       4880       4890       4900       4910       4920 
RVELHESCGR TKLFWLLALA DSKTLKAMVE FRDGSHTIIS GPQEAVGRCR FCGLTGNSGL 

      4930       4940       4950       4960       4970       4980 
LEIGNVCADA QCQEYAANSC LKTKPCGHAC GGVTGERKCL PCLQHVCHTR ENELAEELRD 

      4990       5000       5010       5020       5030       5040 
PKLTQDADDM CMICFVEALS CAPSIHLECG HVFHYHCCKA VLEKRWSGPR ITFGFSLCPI 

      5050       5060       5070       5080       5090       5100 
CKADIQHPLL SDILEPINGL KQDVKRKALM RIKYEGVVKD TDSKNVNMTQ LAMDRYAYYV 

      5110       5120       5130       5140       5150       5160 
CFKCQKAYYG GEARCDAEIG EKFDPEELVC GGCSDVARAQ MCPKHGTDFL EYKCRYCCSV 

      5170       5180       5190       5200       5210       5220 
AVFFCFGTTH FCDTCHDDFQ RLTNIPKVKL PQCPAGPKAK QLLGDECPLH VMHPPTGEEF 

      5230 
ALGCGVCRNA QTF 

« Hide

References

« Hide 'large scale' references
[1]"Highwire regulates synaptic growth in Drosophila."
Wan H.I., DiAntonio A., Fetter R.D., Bergstrom K., Strauss R., Goodman C.S.
Neuron 26:313-329(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
Strain: Canton-S.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4083-5233.
Strain: Berkeley.
Tissue: Larva and Pupae.
[5]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213 AND SER-216, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF262977 mRNA. Translation: AAF76150.1.
AE014298 Genomic DNA. Translation: AAF48411.2. Sequence problems.
AY113376 mRNA. Translation: AAM29381.1. Different initiation.
RefSeqNP_511159.3. NM_078604.3.
UniGeneDm.3259.

3D structure databases

ProteinModelPortalQ9NB71.
SMRQ9NB71. Positions 589-784, 928-1079, 1431-1587, 2015-2170, 2958-3001, 4991-5046.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid58787. 4 interactions.
IntActQ9NB71. 1 interaction.
STRING7227.FBpp0073787.

Proteomic databases

PaxDbQ9NB71.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0073970; FBpp0073787; FBgn0030600.
GeneID32429.
KEGGdme:Dmel_CG32592.
UCSCCG32592-RA. d. melanogaster.

Organism-specific databases

CTD32429.
FlyBaseFBgn0030600. hiw.

Phylogenomic databases

eggNOGCOG5184.
GeneTreeENSGT00390000011403.
InParanoidQ9NB71.
KOK10693.
OMAEILDECH.
OrthoDBEOG75B84C.
PhylomeDBQ9NB71.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

BgeeQ9NB71.

Family and domain databases

Gene3D2.130.10.30. 4 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERPTHR12846:SF17. PTHR12846:SF17. 1 hit.
PfamPF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
[Graphical view]
PRINTSPR00633. RCCNDNSATION.
SMARTSM00184. RING. 2 hits.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRShiw. drosophila.
GenomeRNAi32429.
NextBio778423.
PROQ9NB71.

Entry information

Entry nameHIW_DROME
AccessionPrimary (citable) accession number: Q9NB71
Secondary accession number(s): Q8MZ36, Q9VXZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase