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Q9NB71

- HIW_DROME

UniProt

Q9NB71 - HIW_DROME

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Protein

E3 ubiquitin-protein ligase highwire

Gene
hiw, CG32592
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4991 – 504252RING-type; atypicalAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. ubiquitin-protein transferase activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult walking behavior Source: FlyBase
  2. autophagy Source: FlyBase
  3. BMP signaling pathway Source: UniProtKB
  4. locomotion Source: FlyBase
  5. negative regulation of BMP signaling pathway Source: UniProtKB
  6. negative regulation of synaptic growth at neuromuscular junction Source: UniProtKB
  7. protein ubiquitination Source: UniProtKB
  8. regulation of synaptic growth at neuromuscular junction Source: FlyBase
  9. regulation of terminal button organization Source: FlyBase
  10. synapse organization Source: FlyBase
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase highwire (EC:6.3.2.-)
Alternative name(s):
Protein pam/highwire/rpm-1
Gene namesi
Name:hiw
ORF Names:CG32592
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030600. hiw.

Subcellular locationi

Nucleus By similarity By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: FlyBase
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Flies display NMJ synapses that grow exuberantly and are expanded in both the number of boutons and in the extent and length of branches.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 52335233E3 ubiquitin-protein ligase highwirePRO_0000055971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei213 – 2131Phosphoserine1 Publication
Modified residuei216 – 2161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NB71.

Expressioni

Tissue specificityi

Nervous system specific expression. Stage 13 embryos show expression in the CNS at the longitudinal axon tracts around which the synaptic neuropil forms. Expression outside the CNS starts at stage 16 in presynaptic terminals at the periactive zone which surround the active zone. NMJ and CNS expression is also seen in third instar larvae (at protein level).1 Publication

Gene expression databases

BgeeiQ9NB71.

Interactioni

Protein-protein interaction databases

BioGridi58787. 4 interactions.
IntActiQ9NB71. 1 interaction.
STRINGi7227.FBpp0073787.

Structurei

3D structure databases

ProteinModelPortaliQ9NB71.
SMRiQ9NB71. Positions 589-784, 928-1079, 1431-1587, 2015-2170, 2958-3001, 4991-5046.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati615 – 66652RCC1 1Add
BLAST
Repeati669 – 72456RCC1 2Add
BLAST
Repeati768 – 81851RCC1 3Add
BLAST
Repeati931 – 98353RCC1 4Add
BLAST
Repeati984 – 103350RCC1 5Add
BLAST
Repeati1035 – 108450RCC1 6Add
BLAST
Repeati2906 – 300095FilaminAdd
BLAST
Domaini4195 – 4374180DOCAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1436 – 1587152PHR domain 1 By similarityAdd
BLAST
Regioni2014 – 2169156PHR domain 2 By similarityAdd
BLAST

Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners By similarity.

Sequence similaritiesi

Belongs to the highwire family.
Contains 1 DOC domain.
Contains 1 filamin repeat.
Contains 6 RCC1 repeats.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4991 – 504252RING-type; atypicalAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5184.
GeneTreeiENSGT00390000011403.
InParanoidiQ9NB71.
KOiK10693.
OMAiEILDECH.
OrthoDBiEOG75B84C.
PhylomeDBiQ9NB71.

Family and domain databases

Gene3Di2.130.10.30. 4 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12846:SF17. PTHR12846:SF17. 1 hit.
PfamiPF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00184. RING. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NB71-1 [UniParc]FASTAAdd to Basket

« Hide

MVGLLNPLKY GDHFYELYTN STRRKMQHDR KVLTKRKSRK DKSAAAMAAA     50
AAAAVLEGNA GAGGLVNPLD PPLVKEQLMI LPSFPVAHIE LDPNASKFAV 100
FSAIRSTVLE AETRYSLFQE GGAPSGQSGS NQKKWSNNVN SACCMMCAHS 150
CMISNLLDCS CHAHMAMHGA VGPGNAGPGG PVGVLVDGRI PAPVPVVVGG 200
PGLPAEKRPR RDSANSDADS DTEEPTEREP VYATVPLIVG AGLRSLFELI 250
ADARHVHPLL CTKALKALLD VIQGQQPESF KLEPEELINP LYDLLLDLAT 300
MPAALNSATG AEANWSAMAC AALLGLCIAR GDTGKMLKAI AAMLMTPRQL 350
SAQIVQLPVV LATLQHTVIS AALNKPTRPD FHSHGVPHNS LIDEFPVKLP 400
PLSTGAPITS PAMACDGVFV YLLYGGTLLK IGTGFGGSYK GHIYAQNEDF 450
SHERSAWLGY SGGQLYFRRT CRRSAGDQLQ MVGLDTLAIK AMSPLSMLHM 500
REGLNYVLFT DDDSLHAICS NRDDTLVVKK LNLYHNSYNI DPPPFELPLQ 550
LARKKFRTLG YAAFEDELLN QYQIQRIQSA HNSFEPKLPA PCRDADVDVM 600
GMACGKEFGL VRASNGRVYY YGKSAALGLK CVGRTPTLKL TELVISKAAN 650
IVHVAVGHDG IHALLVNDDG TVFFAGTARR GEDGDSSKNR RQPKAVKPKK 700
MTKIDGHVVV HAACNNGTSA FVTKTGKLIM YGKDTAHCDA MGFVSELLEQ 750
HVTKVALGKA HCVALNAKGQ LFSFGLNNKG QCGRIFNKLQ PVKDVPPFAS 800
SSTAAACFAS LLPLDKRLKL DFSTLCDYDD HNLVQGQCRV CVICRECTGY 850
NVSCVSALNV PLDQRLAGSI CPCGHGDAGC AKCGLCAACI ALQDSDEAKT 900
ELKPPPSDVQ QRQQRSKTLI MRRKERKGEL ETGAAGGGAA TPTDLDKDPP 950
RVAPLAPQLL QLTSSSPVVQ VACGLHHTVV LTLAGEVYTF GSNQYGQLGS 1000
GDLQPVSGPV RVQVPGAISQ VAAGSNHTVL LTSKGMVYTF GNYQKGQLGR 1050
LPSDYGLKPP PQDDDSPVGA GSDGGAGGSP TVAPVGMPGP ERSQSPANVQ 1100
PSGSKEMPPL LPVLTQRQKF LWNCSPGAVF GLGPCYGKKV TWIGANGDQT 1150
FIKIDESLIT AQMLPKMHVV ANKKTILLIP SIPLSFHTLS INRRDGSCTA 1200
HYRGQTNFVK LMQAQPEQQQ PEINSNLDVA VTPVADSPAH ASTSSLLAAL 1250
TGTATAGVPI NEQMSRSMHE ARNQIFEEQL PEVGSSAAAA AVAAPGTPVS 1300
AGSVPRSRRG GKQGTSSPEP IPSPPQLAFT MDPTYNVLWV FDGAARKLRC 1350
HNVVASDIND SDANAATYRS LLSPELSLPD RVDSRVARSQ ASLNLLACLD 1400
ILTSAQDNIP GCFEQPLLKQ TQQTAETQAG EFQVVNRFDN FGGGWGYSGH 1450
SVEAIRFSAD TDIVICGFGM FGGRGEYSCK LKLFDLGGDG GGYEKEGILI 1500
SETKEVPYEC GARSKHHILL PKPVSAVAGR WYLVWARIAG PSSDCGSCGQ 1550
ASVTTEDQVV FSFKSSKKAN NGTDVNSGQI PAILYRLVTQ DCKQTPAQMD 1600
ADPVQRISRA FANSVSRECF ESLVVLLSWS WDCFKLQLRE ERDRSRPLQL 1650
QQSLQYLGYV IKSCLRLLRK YTIEIYPQRN SSTSVATGGG SNAAHGSGVV 1700
TTAKSVQSKP NKDKNTPRVV GNAGVMAKYF GDPSTSVAPA MISSASSGGA 1750
PSTSASAAVA PGSGTPVTRK TNMENIQLAE CIGNVRALLI GIFCDDIFKD 1800
IATDEGYELS LEILDECHLS FVACFDAFYP TSSLKWNCLC DLLAQMDRGA 1850
LHSRLLSAIL AGLCSPSVKL RATFSLLSAA GNERQSIISP SDNSGLPMLS 1900
STDAHPYPVL VEQMIYRTQQ EKSDFLSNSW TFKDVLVRLL DIIASPIRSR 1950
IEAIYSRSLG SLGYPGGKDC VNQGLIDNCC HLLARVLAEI VYQTAMGEYD 2000
KLFMPPRTLH STGARFARCD VSRTWNTGNF GPDAIAFAVD RPGVAIAGAM 2050
VYSGSGSYDY QLELLYDNTA DLQPQHKWET LESVSGSYDQ DAVHNDLAEI 2100
KFDHPVHIKE NARYALRLCS QGARTCSGDA GMPAVRGPCG AQFHFYACDL 2150
SFNGTTPARG QLPCILYYST PMKQDGHSAS GRTGDGSNVA THLEDRIMLL 2200
GPHEVSTRDT ALQIAADITK KCTELLILAR NAMAASCSPS DNSSNHTQTI 2250
DSEHNITPIE EHMDINWANN SRTAALPTAI DPQLSTARDL GKRIESFSKG 2300
LMETLKFDKR STNPFEMEIE IGATEVEESA DLRNGQSQSV SQSQSQSQSV 2350
PINGNERTAD FEFAEQSAQQ SMPQHLHSDS EEAPLEVAGM AAGGGVSVAD 2400
GSGGVAGVGS QAAAVQLLEV FNLAASNMFH TLLPLVYAHI ANLACSDPKS 2450
SVQILGLIKE ILPHIAALNQ LHVSKDQRQP EPAIFATQTS GSGNSNSSST 2500
TSNHYCVVES DHPYKSASIS SYRVEFPPCV QWLTIEFDPQ CGTAQLEDYL 2550
LLSIPMRPAS QAPPVPHVDD YLEQADNNVN GAGDRRRNTG GGIAGSGAAP 2600
NTHQRSASVQ LTMASCCRSP GCGNAPGSAA APSSMPLRSQ DPNDREWIVV 2650
KKFNTASTWL HNVLILPGNC VEFSLETASL YAQDPHNNRY GFKCLVVGYD 2700
NPTSINASNS CLIRLEQELA YLGGMCSANL MKKELNLPDD KDVEDMSGIE 2750
ETINTHHTLL SKGFALSEPQ LTVHQALESY LPIGSQSNER QFLKDFISGA 2800
PGSSGARLAA WLQPESRLDP NKCELNTITE PLRYGWPSQV TVTIRDQYGD 2850
AVLVPELKVE IKAIPTGSGP NGSATGTGTS CTSVAEVSAP GPNLWMRRAS 2900
RDTWGWGGMA PPPRINYEPT VKDKMVFKAI TFMKPYANYS FEELRYASPV 2950
QTRVTELLNA KDMEDGTFSV QWTPSSVGAY CLAVTIDGIP LEEVYRVDVK 3000
EGILPPPTQR NSAQRRPQAP SKLRRFQARH SSGLRIRSHP TLQSEQVGVV 3050
RVGGVISFID EIENDDGVWL RLSTESIRQH CTMGWYPTEA WCLQFNQHLA 3100
RMLLQPVTDK EVNPVRKGVG AEEDVEEQPP VTPSASGEAS PEPEPDPSPV 3150
LSPAKTKPGR FLSGHQSTNP FLYPAKHADL AEREAQVQEE REKEEEQVDD 3200
EDADDREPEQ EALPAVELLP AHIGSAIAGV VGGGAIKLQA LQKWFKGDAV 3250
DGPQPLTPSH SPPLAGVSVR ELVRAMGGQD SPRGNGNRSQ QEQDPEFSLA 3300
SMRRPNYSAS QTAALLSTPK HTPKRSAVVA SETSGLEDEL SLLQITTTTT 3350
GQGEQQSELQ LATTSTASSA SKRNPMGPIK RAMPPSFAES IRAVFAALLW 3400
HEGVVHDAMA CASFLKFHPG LPKEGATVVT RRGESGDPRL QLSREQKAQQ 3450
RHSVEVANAG NYLNIRPSTL ETLTKSGNCS LHNRSKYRKN LLSGGGGAIN 3500
SGDDTAQKLQ ALPEMVSVLP PALRCLVYLW EQICSGCVQI VQSNALEQRE 3550
PRLLSPGSRD LNGDADTEGK EGKNSDQASA GEKDLGRKCK RKKKDDGSWC 3600
EICELFLPMP VTYHMRIAHP GCGKSAKGKG YNSVGIFCEG WAGNCGEGGK 3650
GASSWFLMCD PCRDRYLASC RSANNINSAA RQLESSAAEG NELNLFGVKS 3700
TTLIANAEVY TTMRENATFL LELCSSSSSA SGAAGSLAAT SSSSKRSPQQ 3750
MSVVAMPVVI EHQLGNSDLK PSTSRCSRMA RLSGSKFCPG VGSGAFRKSF 3800
VGGPPTAPEN VWLAPESFAC LECLGTAGHE DLPYEMFGLG PNSNDNGYDR 3850
PLSEISYESC EPNNYDMLSG SLAPGTTAAA SVGGGNLSKF HRSYSMGQGW 3900
ASLAQHNHPP PHHPQQQHHQ QQQMNLQLQQ HQAPPVDGQP KVVYRRRNNS 3950
TSEGDGSLLI CYPSEHLRRL VPQKLLASVS VMQTASGEGT GKDHATGTLG 4000
LDQSAGQNGG GNLLLTRPAM AFITQKHELD RLRAAMRRSL RIAACRIYAL 4050
QALNWLLRSV TQGVCLHDLM WWFVSSLNPT GGHQPVERGE EASEPALEHP 4100
VAYTQISGRF AHLITQSLHV FLQSVADLTL HLPLGSPLQR VAIQCFGIRF 4150
RQADHQFLHS SHVFGNISKI LSKSDEQNDA MAVSTILKPD CDVEHNQVHS 4200
VATGGSSGAG ARLLCYTDLA GMFEVTVSSR PAMAESLTDN STETFWESDE 4250
EDRNKCKIIE LSLTKLNYAC RYLLVHIDNS RDIQNKVLNV VFYAGQSLGD 4300
TNIIKSADVD PKACSWISAK ICDDSCTHFR LELHGPENTL RVRQIKLLGL 4350
PIGGAVGSDD SSDHKHQPHL RLSHASRIQQ QICEAETLRV FRLITGQVFG 4400
KLISNVSSDL VPPDSAGIGP PSGGAASTSL LADSLDLREH MVGILFSRSK 4450
LSHLQKQVIV HIVHAIRKEA QRAKEDWELA NLAHVLKQSP QQQTAPALAA 4500
SASCESTPER SRAPDTYCFE MLSMVLALSG SVVGRSYLSQ QHGLLRDLLG 4550
LLHTGSDRVQ RQVTALLRRI LPEITPESFA ELLGVQRLPP ADYSIAHQSA 4600
SDFDMSRLGL LDIFLAVIAK SLQLQVKVKT TVASTGPSGS GGVSGSSSGN 4650
GGAVLKAGQQ EKTPAFVRLW SSLDLSVQQL RSRPPTGEPG TTDPFQFDAL 4700
PPRKESKRNL NQRWFLNGVI STKQAESIIS LIRDLASGKL SEKWSQITKA 4750
AIAESVLNLT RLEEIYRSPE HCTKTSTLWL ALASLCVLER DHVEKLSSGQ 4800
WSKLCDTRPL CSNHDDGETA AIIQCETCGS LCGDCDRFLH LNRKTRSHKR 4850
TVCKEEEEAI RVELHESCGR TKLFWLLALA DSKTLKAMVE FRDGSHTIIS 4900
GPQEAVGRCR FCGLTGNSGL LEIGNVCADA QCQEYAANSC LKTKPCGHAC 4950
GGVTGERKCL PCLQHVCHTR ENELAEELRD PKLTQDADDM CMICFVEALS 5000
CAPSIHLECG HVFHYHCCKA VLEKRWSGPR ITFGFSLCPI CKADIQHPLL 5050
SDILEPINGL KQDVKRKALM RIKYEGVVKD TDSKNVNMTQ LAMDRYAYYV 5100
CFKCQKAYYG GEARCDAEIG EKFDPEELVC GGCSDVARAQ MCPKHGTDFL 5150
EYKCRYCCSV AVFFCFGTTH FCDTCHDDFQ RLTNIPKVKL PQCPAGPKAK 5200
QLLGDECPLH VMHPPTGEEF ALGCGVCRNA QTF 5233
Length:5,233
Mass (Da):565,631
Last modified:June 21, 2005 - v2
Checksum:iE5220FFDC91A58E7
GO

Sequence cautioni

The sequence AAM29381.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAF48411.2 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371N → D in AAF76150. 1 Publication
Sequence conflicti604 – 6041C → R in AAF76150. 1 Publication
Sequence conflicti1620 – 16201F → S in AAF76150. 1 Publication
Sequence conflicti4652 – 46521G → E in AAF76150. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262977 mRNA. Translation: AAF76150.1.
AE014298 Genomic DNA. Translation: AAF48411.2. Sequence problems.
AY113376 mRNA. Translation: AAM29381.1. Different initiation.
RefSeqiNP_511159.3. NM_078604.3.
UniGeneiDm.3259.

Genome annotation databases

EnsemblMetazoaiFBtr0073970; FBpp0073787; FBgn0030600.
GeneIDi32429.
KEGGidme:Dmel_CG32592.
UCSCiCG32592-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262977 mRNA. Translation: AAF76150.1 .
AE014298 Genomic DNA. Translation: AAF48411.2 . Sequence problems.
AY113376 mRNA. Translation: AAM29381.1 . Different initiation.
RefSeqi NP_511159.3. NM_078604.3.
UniGenei Dm.3259.

3D structure databases

ProteinModelPortali Q9NB71.
SMRi Q9NB71. Positions 589-784, 928-1079, 1431-1587, 2015-2170, 2958-3001, 4991-5046.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 58787. 4 interactions.
IntActi Q9NB71. 1 interaction.
STRINGi 7227.FBpp0073787.

Proteomic databases

PaxDbi Q9NB71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0073970 ; FBpp0073787 ; FBgn0030600 .
GeneIDi 32429.
KEGGi dme:Dmel_CG32592.
UCSCi CG32592-RA. d. melanogaster.

Organism-specific databases

CTDi 32429.
FlyBasei FBgn0030600. hiw.

Phylogenomic databases

eggNOGi COG5184.
GeneTreei ENSGT00390000011403.
InParanoidi Q9NB71.
KOi K10693.
OMAi EILDECH.
OrthoDBi EOG75B84C.
PhylomeDBi Q9NB71.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi hiw. drosophila.
GenomeRNAii 32429.
NextBioi 778423.
PROi Q9NB71.

Gene expression databases

Bgeei Q9NB71.

Family and domain databases

Gene3Di 2.130.10.30. 4 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR12846:SF17. PTHR12846:SF17. 1 hit.
Pfami PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00184. RING. 2 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEi PS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: Canton-S.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4083-5233.
    Strain: Berkeley.
    Tissue: Larva and Pupae.
  5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213 AND SER-216, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiHIW_DROME
AccessioniPrimary (citable) accession number: Q9NB71
Secondary accession number(s): Q8MZ36, Q9VXZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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