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Q9NB71

- HIW_DROME

UniProt

Q9NB71 - HIW_DROME

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Protein

E3 ubiquitin-protein ligase highwire

Gene

hiw

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4991 – 504252RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: UniProtKB
  3. zinc ion binding Source: FlyBase

GO - Biological processi

  1. adult walking behavior Source: FlyBase
  2. autophagy Source: FlyBase
  3. BMP signaling pathway Source: UniProtKB
  4. locomotion Source: FlyBase
  5. negative regulation of BMP signaling pathway Source: UniProtKB
  6. negative regulation of synaptic growth at neuromuscular junction Source: UniProtKB
  7. protein ubiquitination Source: UniProtKB
  8. regulation of synaptic growth at neuromuscular junction Source: FlyBase
  9. regulation of terminal button organization Source: FlyBase
  10. synapse organization Source: FlyBase
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase highwire (EC:6.3.2.-)
Alternative name(s):
Protein pam/highwire/rpm-1
Gene namesi
Name:hiwImported
ORF Names:CG32592
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030600. hiw.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: FlyBase
  2. nucleus Source: UniProtKB-KW
  3. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Flies display NMJ synapses that grow exuberantly and are expanded in both the number of boutons and in the extent and length of branches.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 52335233E3 ubiquitin-protein ligase highwirePRO_0000055971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei213 – 2131Phosphoserine1 Publication
Modified residuei216 – 2161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NB71.

Expressioni

Tissue specificityi

Nervous system specific expression. Stage 13 embryos show expression in the CNS at the longitudinal axon tracts around which the synaptic neuropil forms. Expression outside the CNS starts at stage 16 in presynaptic terminals at the periactive zone which surround the active zone. NMJ and CNS expression is also seen in third instar larvae (at protein level).1 Publication

Gene expression databases

BgeeiQ9NB71.

Interactioni

Protein-protein interaction databases

BioGridi58787. 4 interactions.
IntActiQ9NB71. 1 interaction.
STRINGi7227.FBpp0073787.

Structurei

3D structure databases

ProteinModelPortaliQ9NB71.
SMRiQ9NB71. Positions 589-784, 928-1064, 1431-1587, 2015-2170, 2925-2953.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati615 – 66652RCC1 1Sequence AnalysisAdd
BLAST
Repeati669 – 72456RCC1 2Sequence AnalysisAdd
BLAST
Repeati768 – 81851RCC1 3Sequence AnalysisAdd
BLAST
Repeati931 – 98353RCC1 4Sequence AnalysisAdd
BLAST
Repeati984 – 103350RCC1 5Sequence AnalysisAdd
BLAST
Repeati1035 – 108450RCC1 6Sequence AnalysisAdd
BLAST
Repeati2906 – 300095FilaminSequence AnalysisAdd
BLAST
Domaini4195 – 4374180DOCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1436 – 1587152PHR domain 1By similarityAdd
BLAST
Regioni2014 – 2169156PHR domain 2By similarityAdd
BLAST

Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners By similarity.By similarity

Sequence similaritiesi

Belongs to the highwire family.Curated
Contains 1 DOC domain.PROSITE-ProRule annotation
Contains 1 filamin repeat.PROSITE-ProRule annotation
Contains 6 RCC1 repeats.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4991 – 504252RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5184.
GeneTreeiENSGT00390000011403.
InParanoidiQ9NB71.
KOiK10693.
OMAiEILDECH.
OrthoDBiEOG75B84C.
PhylomeDBiQ9NB71.

Family and domain databases

Gene3Di2.130.10.30. 4 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12846:SF17. PTHR12846:SF17. 1 hit.
PfamiPF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM00184. RING. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NB71-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGLLNPLKY GDHFYELYTN STRRKMQHDR KVLTKRKSRK DKSAAAMAAA
60 70 80 90 100
AAAAVLEGNA GAGGLVNPLD PPLVKEQLMI LPSFPVAHIE LDPNASKFAV
110 120 130 140 150
FSAIRSTVLE AETRYSLFQE GGAPSGQSGS NQKKWSNNVN SACCMMCAHS
160 170 180 190 200
CMISNLLDCS CHAHMAMHGA VGPGNAGPGG PVGVLVDGRI PAPVPVVVGG
210 220 230 240 250
PGLPAEKRPR RDSANSDADS DTEEPTEREP VYATVPLIVG AGLRSLFELI
260 270 280 290 300
ADARHVHPLL CTKALKALLD VIQGQQPESF KLEPEELINP LYDLLLDLAT
310 320 330 340 350
MPAALNSATG AEANWSAMAC AALLGLCIAR GDTGKMLKAI AAMLMTPRQL
360 370 380 390 400
SAQIVQLPVV LATLQHTVIS AALNKPTRPD FHSHGVPHNS LIDEFPVKLP
410 420 430 440 450
PLSTGAPITS PAMACDGVFV YLLYGGTLLK IGTGFGGSYK GHIYAQNEDF
460 470 480 490 500
SHERSAWLGY SGGQLYFRRT CRRSAGDQLQ MVGLDTLAIK AMSPLSMLHM
510 520 530 540 550
REGLNYVLFT DDDSLHAICS NRDDTLVVKK LNLYHNSYNI DPPPFELPLQ
560 570 580 590 600
LARKKFRTLG YAAFEDELLN QYQIQRIQSA HNSFEPKLPA PCRDADVDVM
610 620 630 640 650
GMACGKEFGL VRASNGRVYY YGKSAALGLK CVGRTPTLKL TELVISKAAN
660 670 680 690 700
IVHVAVGHDG IHALLVNDDG TVFFAGTARR GEDGDSSKNR RQPKAVKPKK
710 720 730 740 750
MTKIDGHVVV HAACNNGTSA FVTKTGKLIM YGKDTAHCDA MGFVSELLEQ
760 770 780 790 800
HVTKVALGKA HCVALNAKGQ LFSFGLNNKG QCGRIFNKLQ PVKDVPPFAS
810 820 830 840 850
SSTAAACFAS LLPLDKRLKL DFSTLCDYDD HNLVQGQCRV CVICRECTGY
860 870 880 890 900
NVSCVSALNV PLDQRLAGSI CPCGHGDAGC AKCGLCAACI ALQDSDEAKT
910 920 930 940 950
ELKPPPSDVQ QRQQRSKTLI MRRKERKGEL ETGAAGGGAA TPTDLDKDPP
960 970 980 990 1000
RVAPLAPQLL QLTSSSPVVQ VACGLHHTVV LTLAGEVYTF GSNQYGQLGS
1010 1020 1030 1040 1050
GDLQPVSGPV RVQVPGAISQ VAAGSNHTVL LTSKGMVYTF GNYQKGQLGR
1060 1070 1080 1090 1100
LPSDYGLKPP PQDDDSPVGA GSDGGAGGSP TVAPVGMPGP ERSQSPANVQ
1110 1120 1130 1140 1150
PSGSKEMPPL LPVLTQRQKF LWNCSPGAVF GLGPCYGKKV TWIGANGDQT
1160 1170 1180 1190 1200
FIKIDESLIT AQMLPKMHVV ANKKTILLIP SIPLSFHTLS INRRDGSCTA
1210 1220 1230 1240 1250
HYRGQTNFVK LMQAQPEQQQ PEINSNLDVA VTPVADSPAH ASTSSLLAAL
1260 1270 1280 1290 1300
TGTATAGVPI NEQMSRSMHE ARNQIFEEQL PEVGSSAAAA AVAAPGTPVS
1310 1320 1330 1340 1350
AGSVPRSRRG GKQGTSSPEP IPSPPQLAFT MDPTYNVLWV FDGAARKLRC
1360 1370 1380 1390 1400
HNVVASDIND SDANAATYRS LLSPELSLPD RVDSRVARSQ ASLNLLACLD
1410 1420 1430 1440 1450
ILTSAQDNIP GCFEQPLLKQ TQQTAETQAG EFQVVNRFDN FGGGWGYSGH
1460 1470 1480 1490 1500
SVEAIRFSAD TDIVICGFGM FGGRGEYSCK LKLFDLGGDG GGYEKEGILI
1510 1520 1530 1540 1550
SETKEVPYEC GARSKHHILL PKPVSAVAGR WYLVWARIAG PSSDCGSCGQ
1560 1570 1580 1590 1600
ASVTTEDQVV FSFKSSKKAN NGTDVNSGQI PAILYRLVTQ DCKQTPAQMD
1610 1620 1630 1640 1650
ADPVQRISRA FANSVSRECF ESLVVLLSWS WDCFKLQLRE ERDRSRPLQL
1660 1670 1680 1690 1700
QQSLQYLGYV IKSCLRLLRK YTIEIYPQRN SSTSVATGGG SNAAHGSGVV
1710 1720 1730 1740 1750
TTAKSVQSKP NKDKNTPRVV GNAGVMAKYF GDPSTSVAPA MISSASSGGA
1760 1770 1780 1790 1800
PSTSASAAVA PGSGTPVTRK TNMENIQLAE CIGNVRALLI GIFCDDIFKD
1810 1820 1830 1840 1850
IATDEGYELS LEILDECHLS FVACFDAFYP TSSLKWNCLC DLLAQMDRGA
1860 1870 1880 1890 1900
LHSRLLSAIL AGLCSPSVKL RATFSLLSAA GNERQSIISP SDNSGLPMLS
1910 1920 1930 1940 1950
STDAHPYPVL VEQMIYRTQQ EKSDFLSNSW TFKDVLVRLL DIIASPIRSR
1960 1970 1980 1990 2000
IEAIYSRSLG SLGYPGGKDC VNQGLIDNCC HLLARVLAEI VYQTAMGEYD
2010 2020 2030 2040 2050
KLFMPPRTLH STGARFARCD VSRTWNTGNF GPDAIAFAVD RPGVAIAGAM
2060 2070 2080 2090 2100
VYSGSGSYDY QLELLYDNTA DLQPQHKWET LESVSGSYDQ DAVHNDLAEI
2110 2120 2130 2140 2150
KFDHPVHIKE NARYALRLCS QGARTCSGDA GMPAVRGPCG AQFHFYACDL
2160 2170 2180 2190 2200
SFNGTTPARG QLPCILYYST PMKQDGHSAS GRTGDGSNVA THLEDRIMLL
2210 2220 2230 2240 2250
GPHEVSTRDT ALQIAADITK KCTELLILAR NAMAASCSPS DNSSNHTQTI
2260 2270 2280 2290 2300
DSEHNITPIE EHMDINWANN SRTAALPTAI DPQLSTARDL GKRIESFSKG
2310 2320 2330 2340 2350
LMETLKFDKR STNPFEMEIE IGATEVEESA DLRNGQSQSV SQSQSQSQSV
2360 2370 2380 2390 2400
PINGNERTAD FEFAEQSAQQ SMPQHLHSDS EEAPLEVAGM AAGGGVSVAD
2410 2420 2430 2440 2450
GSGGVAGVGS QAAAVQLLEV FNLAASNMFH TLLPLVYAHI ANLACSDPKS
2460 2470 2480 2490 2500
SVQILGLIKE ILPHIAALNQ LHVSKDQRQP EPAIFATQTS GSGNSNSSST
2510 2520 2530 2540 2550
TSNHYCVVES DHPYKSASIS SYRVEFPPCV QWLTIEFDPQ CGTAQLEDYL
2560 2570 2580 2590 2600
LLSIPMRPAS QAPPVPHVDD YLEQADNNVN GAGDRRRNTG GGIAGSGAAP
2610 2620 2630 2640 2650
NTHQRSASVQ LTMASCCRSP GCGNAPGSAA APSSMPLRSQ DPNDREWIVV
2660 2670 2680 2690 2700
KKFNTASTWL HNVLILPGNC VEFSLETASL YAQDPHNNRY GFKCLVVGYD
2710 2720 2730 2740 2750
NPTSINASNS CLIRLEQELA YLGGMCSANL MKKELNLPDD KDVEDMSGIE
2760 2770 2780 2790 2800
ETINTHHTLL SKGFALSEPQ LTVHQALESY LPIGSQSNER QFLKDFISGA
2810 2820 2830 2840 2850
PGSSGARLAA WLQPESRLDP NKCELNTITE PLRYGWPSQV TVTIRDQYGD
2860 2870 2880 2890 2900
AVLVPELKVE IKAIPTGSGP NGSATGTGTS CTSVAEVSAP GPNLWMRRAS
2910 2920 2930 2940 2950
RDTWGWGGMA PPPRINYEPT VKDKMVFKAI TFMKPYANYS FEELRYASPV
2960 2970 2980 2990 3000
QTRVTELLNA KDMEDGTFSV QWTPSSVGAY CLAVTIDGIP LEEVYRVDVK
3010 3020 3030 3040 3050
EGILPPPTQR NSAQRRPQAP SKLRRFQARH SSGLRIRSHP TLQSEQVGVV
3060 3070 3080 3090 3100
RVGGVISFID EIENDDGVWL RLSTESIRQH CTMGWYPTEA WCLQFNQHLA
3110 3120 3130 3140 3150
RMLLQPVTDK EVNPVRKGVG AEEDVEEQPP VTPSASGEAS PEPEPDPSPV
3160 3170 3180 3190 3200
LSPAKTKPGR FLSGHQSTNP FLYPAKHADL AEREAQVQEE REKEEEQVDD
3210 3220 3230 3240 3250
EDADDREPEQ EALPAVELLP AHIGSAIAGV VGGGAIKLQA LQKWFKGDAV
3260 3270 3280 3290 3300
DGPQPLTPSH SPPLAGVSVR ELVRAMGGQD SPRGNGNRSQ QEQDPEFSLA
3310 3320 3330 3340 3350
SMRRPNYSAS QTAALLSTPK HTPKRSAVVA SETSGLEDEL SLLQITTTTT
3360 3370 3380 3390 3400
GQGEQQSELQ LATTSTASSA SKRNPMGPIK RAMPPSFAES IRAVFAALLW
3410 3420 3430 3440 3450
HEGVVHDAMA CASFLKFHPG LPKEGATVVT RRGESGDPRL QLSREQKAQQ
3460 3470 3480 3490 3500
RHSVEVANAG NYLNIRPSTL ETLTKSGNCS LHNRSKYRKN LLSGGGGAIN
3510 3520 3530 3540 3550
SGDDTAQKLQ ALPEMVSVLP PALRCLVYLW EQICSGCVQI VQSNALEQRE
3560 3570 3580 3590 3600
PRLLSPGSRD LNGDADTEGK EGKNSDQASA GEKDLGRKCK RKKKDDGSWC
3610 3620 3630 3640 3650
EICELFLPMP VTYHMRIAHP GCGKSAKGKG YNSVGIFCEG WAGNCGEGGK
3660 3670 3680 3690 3700
GASSWFLMCD PCRDRYLASC RSANNINSAA RQLESSAAEG NELNLFGVKS
3710 3720 3730 3740 3750
TTLIANAEVY TTMRENATFL LELCSSSSSA SGAAGSLAAT SSSSKRSPQQ
3760 3770 3780 3790 3800
MSVVAMPVVI EHQLGNSDLK PSTSRCSRMA RLSGSKFCPG VGSGAFRKSF
3810 3820 3830 3840 3850
VGGPPTAPEN VWLAPESFAC LECLGTAGHE DLPYEMFGLG PNSNDNGYDR
3860 3870 3880 3890 3900
PLSEISYESC EPNNYDMLSG SLAPGTTAAA SVGGGNLSKF HRSYSMGQGW
3910 3920 3930 3940 3950
ASLAQHNHPP PHHPQQQHHQ QQQMNLQLQQ HQAPPVDGQP KVVYRRRNNS
3960 3970 3980 3990 4000
TSEGDGSLLI CYPSEHLRRL VPQKLLASVS VMQTASGEGT GKDHATGTLG
4010 4020 4030 4040 4050
LDQSAGQNGG GNLLLTRPAM AFITQKHELD RLRAAMRRSL RIAACRIYAL
4060 4070 4080 4090 4100
QALNWLLRSV TQGVCLHDLM WWFVSSLNPT GGHQPVERGE EASEPALEHP
4110 4120 4130 4140 4150
VAYTQISGRF AHLITQSLHV FLQSVADLTL HLPLGSPLQR VAIQCFGIRF
4160 4170 4180 4190 4200
RQADHQFLHS SHVFGNISKI LSKSDEQNDA MAVSTILKPD CDVEHNQVHS
4210 4220 4230 4240 4250
VATGGSSGAG ARLLCYTDLA GMFEVTVSSR PAMAESLTDN STETFWESDE
4260 4270 4280 4290 4300
EDRNKCKIIE LSLTKLNYAC RYLLVHIDNS RDIQNKVLNV VFYAGQSLGD
4310 4320 4330 4340 4350
TNIIKSADVD PKACSWISAK ICDDSCTHFR LELHGPENTL RVRQIKLLGL
4360 4370 4380 4390 4400
PIGGAVGSDD SSDHKHQPHL RLSHASRIQQ QICEAETLRV FRLITGQVFG
4410 4420 4430 4440 4450
KLISNVSSDL VPPDSAGIGP PSGGAASTSL LADSLDLREH MVGILFSRSK
4460 4470 4480 4490 4500
LSHLQKQVIV HIVHAIRKEA QRAKEDWELA NLAHVLKQSP QQQTAPALAA
4510 4520 4530 4540 4550
SASCESTPER SRAPDTYCFE MLSMVLALSG SVVGRSYLSQ QHGLLRDLLG
4560 4570 4580 4590 4600
LLHTGSDRVQ RQVTALLRRI LPEITPESFA ELLGVQRLPP ADYSIAHQSA
4610 4620 4630 4640 4650
SDFDMSRLGL LDIFLAVIAK SLQLQVKVKT TVASTGPSGS GGVSGSSSGN
4660 4670 4680 4690 4700
GGAVLKAGQQ EKTPAFVRLW SSLDLSVQQL RSRPPTGEPG TTDPFQFDAL
4710 4720 4730 4740 4750
PPRKESKRNL NQRWFLNGVI STKQAESIIS LIRDLASGKL SEKWSQITKA
4760 4770 4780 4790 4800
AIAESVLNLT RLEEIYRSPE HCTKTSTLWL ALASLCVLER DHVEKLSSGQ
4810 4820 4830 4840 4850
WSKLCDTRPL CSNHDDGETA AIIQCETCGS LCGDCDRFLH LNRKTRSHKR
4860 4870 4880 4890 4900
TVCKEEEEAI RVELHESCGR TKLFWLLALA DSKTLKAMVE FRDGSHTIIS
4910 4920 4930 4940 4950
GPQEAVGRCR FCGLTGNSGL LEIGNVCADA QCQEYAANSC LKTKPCGHAC
4960 4970 4980 4990 5000
GGVTGERKCL PCLQHVCHTR ENELAEELRD PKLTQDADDM CMICFVEALS
5010 5020 5030 5040 5050
CAPSIHLECG HVFHYHCCKA VLEKRWSGPR ITFGFSLCPI CKADIQHPLL
5060 5070 5080 5090 5100
SDILEPINGL KQDVKRKALM RIKYEGVVKD TDSKNVNMTQ LAMDRYAYYV
5110 5120 5130 5140 5150
CFKCQKAYYG GEARCDAEIG EKFDPEELVC GGCSDVARAQ MCPKHGTDFL
5160 5170 5180 5190 5200
EYKCRYCCSV AVFFCFGTTH FCDTCHDDFQ RLTNIPKVKL PQCPAGPKAK
5210 5220 5230
QLLGDECPLH VMHPPTGEEF ALGCGVCRNA QTF
Length:5,233
Mass (Da):565,631
Last modified:June 21, 2005 - v2
Checksum:iE5220FFDC91A58E7
GO

Sequence cautioni

The sequence AAM29381.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAF48411.2 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371N → D in AAF76150. (PubMed:10839352)Curated
Sequence conflicti604 – 6041C → R in AAF76150. (PubMed:10839352)Curated
Sequence conflicti1620 – 16201F → S in AAF76150. (PubMed:10839352)Curated
Sequence conflicti4652 – 46521G → E in AAF76150. (PubMed:10839352)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262977 mRNA. Translation: AAF76150.1.
AE014298 Genomic DNA. Translation: AAF48411.2. Sequence problems.
AY113376 mRNA. Translation: AAM29381.1. Different initiation.
RefSeqiNP_511159.3. NM_078604.4.

Genome annotation databases

EnsemblMetazoaiFBtr0073970; FBpp0073787; FBgn0030600.
GeneIDi32429.
KEGGidme:Dmel_CG32592.
UCSCiCG32592-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262977 mRNA. Translation: AAF76150.1 .
AE014298 Genomic DNA. Translation: AAF48411.2 . Sequence problems.
AY113376 mRNA. Translation: AAM29381.1 . Different initiation.
RefSeqi NP_511159.3. NM_078604.4.

3D structure databases

ProteinModelPortali Q9NB71.
SMRi Q9NB71. Positions 589-784, 928-1064, 1431-1587, 2015-2170, 2925-2953.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 58787. 4 interactions.
IntActi Q9NB71. 1 interaction.
STRINGi 7227.FBpp0073787.

Proteomic databases

PaxDbi Q9NB71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0073970 ; FBpp0073787 ; FBgn0030600 .
GeneIDi 32429.
KEGGi dme:Dmel_CG32592.
UCSCi CG32592-RA. d. melanogaster.

Organism-specific databases

CTDi 32429.
FlyBasei FBgn0030600. hiw.

Phylogenomic databases

eggNOGi COG5184.
GeneTreei ENSGT00390000011403.
InParanoidi Q9NB71.
KOi K10693.
OMAi EILDECH.
OrthoDBi EOG75B84C.
PhylomeDBi Q9NB71.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi hiw. drosophila.
GenomeRNAii 32429.
NextBioi 778423.
PROi Q9NB71.

Gene expression databases

Bgeei Q9NB71.

Family and domain databases

Gene3Di 2.130.10.30. 4 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR027047. Highwire/Pam/Rpm-1.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR12846:SF17. PTHR12846:SF17. 1 hit.
Pfami PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
[Graphical view ]
PRINTSi PR00633. RCCNDNSATION.
SMARTi SM00184. RING. 2 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEi PS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    Strain: Canton-SImported.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley1 Publication.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4083-5233.
    Strain: BerkeleyImported.
    Tissue: Larva1 Publication and Pupae1 Publication.
  5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213 AND SER-216, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiHIW_DROME
AccessioniPrimary (citable) accession number: Q9NB71
Secondary accession number(s): Q8MZ36, Q9VXZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3