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Q9NAV8

- Q9NAV8_9ANNE

UniProt

Q9NAV8 - Q9NAV8_9ANNE

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Protein
Submitted name: Dehaloperoxidase A
Gene
N/A
Organism
Amphitrite ornata
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561CyanideImported
Binding sitei56 – 561Heme (covalent)
Metal bindingi90 – 901Iron (heme axial ligand); via tele nitrogenImported

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
  5. peroxidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase, PeroxidaseImported

    Keywords - Biological processi

    Oxygen transportUniRule annotation, Transport

    Keywords - Ligandi

    HemeUniRule annotationImported, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Dehaloperoxidase AImported
    OrganismiAmphitrite ornataImported
    Taxonomic identifieri129555 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaScolecidaTerebellidaAmphitrite

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EW6X-ray1.78A/B2-138[»]
    1EWAX-ray2.50A/B2-138[»]
    2QFKX-ray1.62A/B2-138[»]
    2QFNX-ray1.62A/B1-138[»]
    3DR9X-ray1.26A/B2-138[»]
    3K3UX-ray1.63A/B2-138[»]
    3KUNX-ray1.26A/B2-138[»]
    3KUOX-ray1.26A/B2-138[»]
    3LB1X-ray1.76A/B2-138[»]
    3LB2X-ray1.06A/B2-138[»]
    3LB3X-ray1.85A/B2-138[»]
    3LB4X-ray1.56A/B2-138[»]
    3MOUX-ray1.71A/B2-138[»]
    3MYMX-ray1.72A/B2-138[»]
    3MYNX-ray2.19A/B2-138[»]
    3O7NX-ray1.72A/B2-138[»]
    3OJ1X-ray1.52A/B2-138[»]
    3OK5X-ray1.72A/B2-138[»]
    3ORDX-ray2.22A/B2-138[»]
    4DWTX-ray2.05A/B2-138[»]
    4DWUX-ray1.44A/B2-138[»]
    4FH6X-ray1.44A/B2-138[»]
    4FH7X-ray1.74A/B2-138[»]
    4GZGX-ray1.49A/B2-138[»]
    4HSWX-ray1.22A/B2-138[»]
    4HSXX-ray1.12A/B2-138[»]
    4ILZX-ray1.91A/B2-138[»]
    4JACX-ray1.93A/B1-138[»]
    4JYQX-ray1.80A/B2-138[»]
    4KJTX-ray1.44A/B2-138[»]
    4KMVX-ray1.44A/B2-138[»]
    4KMWX-ray1.79A/B2-138[»]
    4KN3X-ray1.78A/B2-138[»]
    ProteinModelPortaliQ9NAV8.
    SMRiQ9NAV8. Positions 2-138.

    Miscellaneous databases

    EvolutionaryTraceiQ9NAV8.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 312Sulfate 4 binding
    Regioni38 – 403Sulfate 8 binding

    Sequence similaritiesi

    Belongs to the globin family.UniRule annotation

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    SUPFAMiSSF46458. SSF46458. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NAV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFKQDIATI RGDLRTYAQD IFLAFLNKYP DERRYFKNYV GKSDQELKSM    50
    AKFGDHTEKV FNLMMEVADR ATDCVPLASD ANTLVQMKQH SSLTTGNFEK 100
    LFVALVEYMR ASGQSFDSQS WDRFGKNLVS ALSSAGMK 138
    Length:138
    Mass (Da):15,660
    Last modified:October 1, 2000 - v1
    Checksum:iE63F8C82A7CB90A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF284381 mRNA. Translation: AAF97245.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF284381 mRNA. Translation: AAF97245.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EW6 X-ray 1.78 A/B 2-138 [» ]
    1EWA X-ray 2.50 A/B 2-138 [» ]
    2QFK X-ray 1.62 A/B 2-138 [» ]
    2QFN X-ray 1.62 A/B 1-138 [» ]
    3DR9 X-ray 1.26 A/B 2-138 [» ]
    3K3U X-ray 1.63 A/B 2-138 [» ]
    3KUN X-ray 1.26 A/B 2-138 [» ]
    3KUO X-ray 1.26 A/B 2-138 [» ]
    3LB1 X-ray 1.76 A/B 2-138 [» ]
    3LB2 X-ray 1.06 A/B 2-138 [» ]
    3LB3 X-ray 1.85 A/B 2-138 [» ]
    3LB4 X-ray 1.56 A/B 2-138 [» ]
    3MOU X-ray 1.71 A/B 2-138 [» ]
    3MYM X-ray 1.72 A/B 2-138 [» ]
    3MYN X-ray 2.19 A/B 2-138 [» ]
    3O7N X-ray 1.72 A/B 2-138 [» ]
    3OJ1 X-ray 1.52 A/B 2-138 [» ]
    3OK5 X-ray 1.72 A/B 2-138 [» ]
    3ORD X-ray 2.22 A/B 2-138 [» ]
    4DWT X-ray 2.05 A/B 2-138 [» ]
    4DWU X-ray 1.44 A/B 2-138 [» ]
    4FH6 X-ray 1.44 A/B 2-138 [» ]
    4FH7 X-ray 1.74 A/B 2-138 [» ]
    4GZG X-ray 1.49 A/B 2-138 [» ]
    4HSW X-ray 1.22 A/B 2-138 [» ]
    4HSX X-ray 1.12 A/B 2-138 [» ]
    4ILZ X-ray 1.91 A/B 2-138 [» ]
    4JAC X-ray 1.93 A/B 1-138 [» ]
    4JYQ X-ray 1.80 A/B 2-138 [» ]
    4KJT X-ray 1.44 A/B 2-138 [» ]
    4KMV X-ray 1.44 A/B 2-138 [» ]
    4KMW X-ray 1.79 A/B 2-138 [» ]
    4KN3 X-ray 1.78 A/B 2-138 [» ]
    ProteinModelPortali Q9NAV8.
    SMRi Q9NAV8. Positions 2-138.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q9NAV8.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46458. SSF46458. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The crystal structure and amino acid sequence of dehaloperoxidase from Amphitrite ornata indicate common ancestry with globins."
      LaCount M.W., Zhang E., Chen Y.P., Han K., Whitton M.M., Lincoln D.E., Woodin S.A., Lebioda L.
      J. Biol. Chem. 275:18712-18716(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    2. "Amphitrite ornata, a marine worm, contains two dehaloperoxidase genes."
      Han K., Woodin S.A., Lincoln D.E., Fielman K.T., Ely B.
      Mar. Biotechnol. 3:287-292(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "X-ray crystal structural analysis of the binding site in the ferric and oxyferrous forms of the recombinant heme dehaloperoxidase cloned from Amphitrite ornata."
      de Serrano V., Chen Z., Davis M.F., Franzen S.
      Acta Crystallogr. D 63:1094-1101(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    4. "Distal histidine conformational flexibility in dehaloperoxidase from Amphitrite ornata."
      Chen Z., de Serrano V., Betts L., Franzen S.
      Acta Crystallogr. D 65:34-40(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    5. "The V59W mutation blocks the distal pocket of the hemoglobin dehaloperoxidase from Amphitrite ornata."
      Davis M.F., de Serrano V., Gracz H., Vendreix F.A.P., Somasundram A., Negrerie M., Franzen S.
      Submitted (OCT-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    6. "X-ray structure of the metcyano form of dehaloperoxidase from Amphitrite ornata: evidence for photoreductive dissociation of the iron-cyanide bond."
      de Serrano V.S., Davis M.F., Gaff J.F., Zhang Q., Chen Z., D'Antonio E.L., Bowden E.F., Rose R., Franzen S.
      Acta Crystallogr. D 66:770-782(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS) OF 2-138 IN COMPLEX WITH CYANIDE AND HEME.
    7. "Internal binding of halogenated phenols in dehaloperoxidase-hemoglobin inhibits peroxidase function."
      Thompson M.K., Davis M.F., de Serrano V., Nicoletti F.P., Howes B.D., Smulevich G., Franzen S.
      Biophys. J. 99:1586-1595(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.06 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    8. "Characterization of the Inhibitor Binding Site of the Dehaloperoxidase-Hemoglobin from Amphitrite ornata using High-Pressure Xenon Derivatization."
      de Serrano V.S., Franzen S.
      Submitted (APR-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.71 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    9. "Mutation of Methionine-86 in Dehaloperoxidase-hemoglobin: Effects of the Asp-His-Fe Triad in a 3/3 Globin."
      D'Antonio E.L., D'Antonio J., Grazs H., de Serrano V.S., Thompson M.K., Ghiladi R.A., Franzen S., Bowden E.F.
      Submitted (MAY-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 2-138 IN COMPLEX WITH CYANIDE AND HEME.
    10. "The V59W mutation blocks the distal pocket of the hemoglobin - dehaloperoxidase from Amphitirite ornata."
      Davis M.F., de Serrano V.S., Gracz H., Vendreix F.A.P., Somasundram A., Negrerie M., Franzen S.
      Submitted (JUL-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    11. "Effect of the H55D mutation on the kinetics and structure of dehaloperoxidase-hemoglobin A."
      Zhao J., De Serrano V.S., S. Franzen.
      Submitted (AUG-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    12. "Effect of the H55D mutation on the kinetics and structure of dehaloperoxidase-hemoglobin A."
      Zhao J., De Serrano V.S., Franzen S.
      Submitted (AUG-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS) OF 2-138.
    13. "Structural evidence for stabilization of inhibitor binding by a protein cavity in the dehaloperoxidase-hemoglobin from Amphitrite ornata."
      de Serrano V., Franzen S.
      Biopolymers 98:27-35(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 2-138.
    14. "A unique role for the distal histidine observed in carbonmonoxy dehaloperoxidase-hemoglobin A structures."
      de Serrano V.S., Zhao J., Franzen S.
      Submitted (FEB-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    15. "The role of distal histidine in carbonmonoxide DHP structure."
      Zhao J., Franzen S.
      Submitted (SEP-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.49 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    16. "Role of polarity of the distal pocket in the control of inhibitor binding in dehaloperoxidase-hemoglobin."
      Plummer A., Thompson M.K., Franzen S.
      Biochemistry 52:2218-2227(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.12 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    17. "Structural and kinetic study of an internal substrate binding site in dehaloperoxidase-hemoglobin A from Amphitrite ornata."
      Zhao J., de Serrano V., Zhao J., Le P., Franzen S.
      Biochemistry 52:2427-2439(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    18. "Complexes of dual-function hemoglobin/dehaloperoxidase with substrate 2,4,6-trichlorophenol are inhibitory and indicate binding of halophenol to compound I."
      Wang C., Lovelace L.L., Sun S., Dawson J.H., Lebioda L.
      Biochemistry 52:6203-6210(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    19. "The role of T56 in controlling the flexibility of the distal histidine in dehaloperoxidase-hemoglobin from Amphitrite ornata."
      Jiang S., Wright I., Swartz P., Franzen S.
      Biochim. Biophys. Acta 1834:2020-2029(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) IN COMPLEX WITH HEME.
    20. "Observation of protein valves for the control of the internal flow of small molecules using time-resolved X-ray crystallography."
      Zhao J., Srajer V., Franzen S.
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.
    21. "Influence of heme environment structure on dioxygen affinity for the dual function Amphitrite ornata hemoglobin/dehaloperoxidase. Insights into the evolutional structure-function adaptations."
      Sun S., Sono M., Wang C., Du J., Lebioda L., Dawson J.H.
      Arch. Biochem. Biophys. 545:108-115(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 2-138 IN COMPLEX WITH HEME.

    Entry informationi

    Entry nameiQ9NAV8_9ANNE
    AccessioniPrimary (citable) accession number: Q9NAV8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: September 3, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3

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