Q9NAS5 (TPM_ANISI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Tropomyosin Alternative name(s): Allergen=Ani s 3
Organism	Anisakis simplex (Herring worm)
Taxonomic identifier	6269 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Nematoda › Chromadorea › Ascaridida › Ascaridoidea › Anisakidae › Anisakis › Anisakis simplex complex

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE. A.simplex is a fish parasite that, when accidentally ingested by humans, may cause allergic reactions in sensitized individuals.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Disease	Allergen
Domain	Coiled coil Repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Tropomyosin		PRO_0000205643
Regions
	Coiled coil	1 – 284	284	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9NAS5 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 18E979DA698F62FE	FASTA	284	33,203
	10 20 30 40 50 60 MDAIKKKMQA MKIEKDNALD RADAAEEKVR QMTDKLERIE EELRDTQKKM MQTENDLDKA 70 80 90 100 110 120 QEDLSTANSN LEEKEKKVQE AEAEVAALNR RMTLLEEELE RAEERLKLAT AKLEEATHTA 130 140 150 160 170 180 DESERVRKVM ENRSFQDEER ANTVESQLKE AQMLAEEADR KYDEVARKLT MVEADLERAE 190 200 210 220 230 240 ERAETGENKI VELEEELRVV GNNLKSLEVS EEKALQREDS YEEQIRTVSA RLKEAETRAE 250 260 270 280 FAERSVQKLQ KEVDRLEDEL VHEKERYKSI SEELDQTFQE LSGY

References

[1]	"Cloning and high level expression in Escherichia coli of an Anisakis simplex tropomyosin isoform." Asturias J.A., Eraso E., Martinez A. Mol. Biochem. Parasitol. 108:263-267(2000) [PubMed: 10838230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y19221 mRNA. Translation: CAB93501.1.
3D structure databases
ProteinModelPortal	Q9NAS5.
SMR	Q9NAS5. Positions 1-283.
ModBase	Search...
Protein family/group databases
Allergome	3081. Ani s 3.0101. 37. Ani s 3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPM_ANISI

Accession

Primary (citable) accession number: Q9NAS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	October 1, 2000
Last modified:	January 11, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)