Reviewed, UniProtKB/Swiss-Prot Q9NAR7 (ADH_BACOL)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase
    EC=1.1.1.1

Gene names

Name:

ADH

Organism

Bactrocera oleae (Olive fruit fly)

Taxonomic identifier

104688 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Tephritoidea › Tephritidae › Bactrocera › Daculus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Alcohol dehydrogenase		PRO_0000054450
Regions
	Nucleotide binding	9 – 33	25	NAD By similarity
Sites
	Active site	150	1	Proton acceptor By similarity
	Binding site	137	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9NAR7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 033592FD0968EADB	FASTA	258	27,830
	10 20 30 40 50 60 MGLSGKNVVF VGGLGFIGYE ACKQIMTKNV ASFFVFDVLE NAENIKALQA INPKTKVYYT 70 80 90 100 110 120 KFDITNKASI KSAFADVIAK VQYIDVLVNG AGILTDPNVE LTMNINLIGL INTTLEAIPL 130 140 150 160 170 180 MDKNKKGRGG LIVNIASVLG LEPAPPAAIY CASKFGVMGF SRSISDPYYY NLTGIAVATF 190 200 210 220 230 240 CPGLTETPLK NNIATKYTFE YSKVIGDKLN NTKTQKPEAC GAHLAQVLDT AENGGIYISN 250 QGTLSKVTPT VYWQPTFN

References

[1]

"Acquisition of a potential marker for insect transformation: isolation of a novel alcohol dehydrogenase gene from Bactrocera oleae by functional complementation in yeast." Benos P., Tavernarakis N., Brogna S., Thireos G., Savakis C. Mol. Gen. Genet. 263:90-95(2000) [PubMed: 10732677] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ250007 mRNA. Translation: CAB94710.1.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.1. 279317.
Family and domain databases
InterPro	IPR002426. Ceratitis_ADH. IPR002198. DH_sc/Rdtase_SDR. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01169. CERATITISADH. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_BACOL

Accession

Primary (citable) accession number: Q9NAR7
Secondary accession number(s): P82461

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)