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Q9N9W8 (PSB3_GIAIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-3

EC=3.4.25.1
Gene names
Name:PRSBETA3
OrganismGiardia intestinalis (Giardia lamblia)
Taxonomic identifier5741 [NCBI]
Taxonomic lineageEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Proteasome subunit beta type-3
PRO_0000148063

Sequences

Sequence LengthMass (Da)Tools
Q9N9W8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F9D8025ADD5E5647

FASTA20723,022
        10         20         30         40         50         60 
MGNIWEYNGS ALIGIKGXDC VALAADKRLG CSYQTLTIGN EERIFRLSQS CLLGLAGLQT 

        70         80         90        100        110        120 
DVLTTYRQIR MKSNLYHLQE DREIRPRATA KMISSFLYKH RFGPYFISPI IAGFEADGKP 

       130        140        150        160        170        180 
YLGAMDTIGC LDDCTNFQIA GTASDFLLGL CETHVKPDMS EDEILPLMEQ IIRSATNRDA 

       190        200 
YSGWGAHVVV LRRDGTTSDI PISTRMD 

« Hide

References

[1]"Evidence for the existence of a 26S proteasome in Giardia lamblia."
Emmerlich V., Riekenberg S., Bakker-Grunwald T., Scholze H.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Portland-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ297366 mRNA. Translation: CAB97490.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB3_GIAIN
AccessionPrimary (citable) accession number: Q9N9W8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries